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| 1 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 2 | Overview of the Integrated Global Radiosonde Archive显示文摘 | Imke Durre Russelle S V David B W | 2006 | J Climate2006，19，1： | 1 |
| 3 | Testing for Unit Roots in Heterogeneous Panels 显示文摘 | ImK S Pesaran M H Shin Y | 2003 | Journal of Econometrics2003，115，1： | 1 |
| 4 | Testing and Simulation of Ceramic Micro Heat Exchangers显示文摘 | Alm B Imke U Knitter R | 2008 | Chemical Engi-neering Journal2008，135，： | 1 |
| 5 | Peptidomic analysis of human blood specimens:Comparison between plasma specimens and serum by differential peptide display显示文摘 | Tammen Harald Imke schulte Hess Rudiger | 2005 | Proteomics2005，5，： | 1 |
| 6 | Development and application of a high-throughput microneutralization assay:lack of xenotropic murine leukemia virus-related virus and/or murine leukemia virus detection in blood donors显示文摘 | Yanchen Zhou Imke Steffen Leilani Montalvo | 2012 | Transfusion2012，52，2： | 1 |
| 7 | 显示文摘 | Ismail IMK Walker PL | 1989 | Carbon1989，27，4： | 1 |
| 8 | The usefulness of tissue Doppler in aging in the determination of left ventricular diastolic filling pressure comparision with other techniques 显示文摘 | Borekei A Karaleueoglu S Ero IMK | 2006 | Acta Cardiol2006，61，2： | 1 |
| 9 | Are remnant-like particles independent predictors of coronary heart disease incidence?The honolulu heart study显示文摘 | Imke C Rodriguez BL Grove JS | 2005 | Arterioscler Thromb Vasc Biol2005，25，8： | 1 |
| 10 | Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model显示文摘 | Bill Ruben Fagiani Ernesta Zumsteg Adrian Antoniadis Helena Johansson David Haefliger Simon Albrecht Imke Hilberg Frank Christofori Gerhard | 2015 | Clinical Cancer Research2015，，21： | 1 |
| 11 | Increased levels of trkB mRNA and trkB protein-like immunoreactivity in the injured rat and cat spinal cord显示文摘 | Verge IMK Cullhein S | 1992 | Proc Nat Acad Sci USA1992，89，11： | 1 |
| 12 | Testing and simulation of ceramic micro teat exchangers显示文摘 | B Aim U Imke R Knitter | 2008 | Chemical Engineering Journal2008，135，： | 1 |
| 13 | Outcomes of the Bobath con- cept on upper limb recovery following stroke显示文摘 | Imke C Dodd KJ Brock K | 2004 | Clin Re- habil2004，18，8： | 1 |
| 14 | Porous Media Simplified Simulation of Sin- gle-and Two-phase Flow Heat Transfer in Micro-chan- nel Heat Exchangers 显示文摘 | Imke U | 2004 | Chemical Engineering Journal2004，101，13： | 1 |
| 15 | Peptidomic analysis of human blood specimens:Comparison between plasma specimens and serum by differential peptide display显示文摘 | Harald Tarmmen Imke Schulte | | 0，，： | 1 |
| 16 | Ebstein anomaly associated with left ventricular noncompaction: An autosomal dominant condition that can be caused by mutations in MYH7显示文摘 | Alexa M.C. Vermeer Klaartje van Engelen Alex V. Postma Marieke J.H. Baars Imke Christiaans Simone De Haij Sabine Klaassen Barbara J.M. Mulder Bernard Keavney | 2013 | Am. J. Med. Genet2013，，： | 1 |
| 17 | Parkinson's disease显示文摘 | | 1998 | AdvNurse Pract1998，6，1： | 1 |
| 18 | Are remnant-like particles independent predictors of coronary heart disease incidence? The honolulu heart study显示文摘 | Imke C Rodriguez B L Grove J S | 2005 | Arterioscler Thromb Vasc Biol2005，25，8： | 1 |
| 19 | Aggregates of nisin with various bactoprenol-containing cell wall precursors differ in size and membrane permeation capacity显示文摘 | Katharina Scherer Imke Wiedemann | 2013 | Biochimica et Biophysica Acta2013，，1828： | 1 |
| 20 | NOAA’S 1981-2010 U.S. CLIMATE NORMALS: An Overview显示文摘 | Arguez Anthony Durre Imke Applequist Scott Vose Russell S Squires Michael F Yin Xungang Heim Richard R Owen Timothy W | 2012 | Bulletin of the American Meteorological Society2012，，11： | 1 |
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