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| 1 | Arctic Sea Ice and Eurasian Climate:A Review显示文摘The Arctic plays a fundamental role in the climate system and has shown significant climate change in recent decades,including the Arctic warming and decline of Arctic sea-ice extent and thickness. In contrast to the Arctic warming and reduction of Arctic sea ice, Europe, East Asia and North America have experienced anomalously cold conditions, with record snowfall during recent years. In this paper, we review current understanding of the sea-ice impacts on the Eurasian climate.Paleo, observational and modelling studies are covered to summarize several major themes, including: the variability of Arctic sea ice and its controls; the likely causes and apparent impacts of the Arctic sea-ice decline during the satellite era,as well as past and projected future impacts and trends; the links and feedback mechanisms between the Arctic sea ice and the Arctic Oscillation/North Atlantic Oscillation, the recent Eurasian cooling, winter atmospheric circulation, summer precipitation in East Asia, spring snowfall over Eurasia, East Asian winter monsoon, and midlatitude extreme weather; and the remote climate response(e.g., atmospheric circulation, air temperature) to changes in Arctic sea ice. We conclude with a brief summary and suggestions for future research. | GAO Yongqi SUN Jianqi LI Fei HE Shengping Stein SANDVEN YAN Qing ZHANG Zhongshi Katja LOHMANN Noel KEENLYSIDE Tore FUREVIK SUO Lingling | 2015 | Advances in Atmospheric Sciences2015，32，1： | 21 |
| 2 | Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation显示文摘血浆膜(下午) 水泡是发生的动态充满肌动朊的房间伸出,例如在胞质分裂期间,似变形虫的房间活动性和房间附件。用对 21 个肌动朊成核因素的一幅指向的 siRNA 屏幕,我们在房间粘附期间在下午 blebbing 识别一篇小说和人的透明 formin DIAPH3 的必要角色。DIAPH3 的抑制禁止了 blebbing 支持快速的房间传播包含 β 1-integrin。DIAPH3 的多重 isoforms 在 mRNA 和 isoforms, 3 和 7 是然而没导致充满肌动朊的伸出的形成的最大、很丰富的 isoforms 的蛋白质水平上被检测。更确切地说,下午 blebbing 明确地包含了低丰富 isoform 7 由透明自动调整的领域的删除引起了 filopodia 的形成的 isoform 的 1 DIAPH3 和激活。Dimerization 和肌动朊集会活动为由 DIAPH3 isoforms 的特定的房间伸出的正式就职是必要的 1 和 7。我们的数据建议包括 GTPase 有约束力的域的 N 终端区域象它在水泡和 filopodia 之间的伸出活动一样决定了 formin 的 subcellular 本地化。我们建议由 DIAPH3 的 isoform 选择的肌动朊汇编施加特定并且调整的差别在房间粘附和活动性期间工作。 | Jana Stastna Xiaoyu Pan Haicui Wang Alina Kollmannsperger Stefan Kutscheidt Volker Lohmann Robert Grosse Oliver T Fackler | 2012 | Cell Research2012，22，4： | 6 |
| 3 | Assembly of infectious hepatitis C virus particles显示文摘 | Ralf Bartenschlager Francois Penin Volker Lohmann Patrice André | 2010 | Trends in Microbiology2010，，2： | 4 |
| 4 | Metallic debris from metal-on-metal total hip arthroplasty regulates periprosthetic tissues显示文摘The era of metal-on-metal(MoM) total hip arthroplasty has left the orthopaedic community with valuable insights and lessons on periprosthetic tissue reactions to metallic debris. Various terms have been used to describe the tissue reactions. Sometimes the nomenclature can be confusing. We present a review of the concepts introduced by Willert and Semlitsch in 1977,along with further developments made in the understanding of periprosthetic tissue reactions to metallic debris. We propose that periprosthetic tissue reactions be thought of as(1) gross(metallosis, necrosis, cyst formation and pseudotumour);(2) histological(macrophage-dominated, lymphocyte-dominated or mixed);and(3) molecular(expression of inflammatory mediators and cytokines such as interleukin-6 and tumor necrosis factor-alpha). Taper corrosion and modularity are discussed, along with future research directions to elucidate the antigen-presenting pathways and materi-al-specific biomarkers which may allow early detection and intervention in a patient with adverse periprosthetic tissue reactions to metal wear debris. | Christoph H Lohmann Gurpal Singh Hans-Georg Willert Gottfried H Buchhorn | 2014 | World Journal of Orthopedics2014，5，5： | 3 |
| 5 | Restoration of HCV-specific CD8+ T-cell function by Interferon-free therapy显示文摘 | Bianca Martin Nadine Hennecke Volker Lohmann Antonin Kayser Christoph Neumann-Haefelin George Kukolj Wulf-Otto B?cher Robert Thimme | 2014 | Journal of Hepatology2014，，： | 3 |
| 6 | Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim width in glaucoma显示文摘AIM:To evaluate and compare structural optical coherence tomography(OCT)-based parameters,such as Bruch's membrane opening-minimum rim width(BMO-MRW),and retinal nerve fiber layer(RNFL) thickness in glaucoma patients with visual field(VF) defects,and to correlate both to mean deviation(MD) values of obtained standard achromatic perimetry(SAP) examinations.METHODS:Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy individuals.All study participants underwent a full ophthalmic examination and VF testing with SAP.Peripapillary RNFL thickness and BMO-MRW were acquired with SD-OCT.Correlation analyses between obtained global functional and global as well as sectorial structural parameters were calculated.RESULTS:A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36 healthy right eyes of 36 individuals in the control group.Global MD of values correlated significantly with global RNFL(Pearson corr.coeff:0.632,P=0.001) and global BMO-MRW(Pearson corr.coeff:0.746,P<0.001) values in the glaucoma group.Global MD and sectorial RNFL or BMO-MRW values correlated less significantly.In the control group,MD values did not correlate with RNFL or BMO-MRW measurements.A subgroup analysis of myopic patients(>4 diopters) within the glaucoma group(n=6) revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL measurements.CONCLUSION:In a clinical setting,RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients. | Lukas Reznicek Sophie Burzer Andrea Laubichler Ali Nasseri Chris P Lohmann Nikolaus Feucht Michael Ulbig Mathias Maier | 2017 | International Journal of Ophthalmology(English edition)2017，10，10： | 2 |
| 7 | 羊膜深低温保存前后相关因子基因表达的稳定性研究显示文摘目的观察目的基因在新鲜和保存羊膜中表达的完整性。方法取新鲜羊膜深低温保存,以FDA/PI和台盼蓝染色确定上皮细胞活性。用real-tim e RT-PCR评估TGF-β1、EGF、IL1β和IL1RA各阶段的表达能力,结果以2△△CT表示。结果深低温保存后,羊膜上皮细胞经染色证实全部死亡,但细胞培养3周后,会有大量的新生细胞游离出来。如羊膜解冻后立即行总RNA提取,在不同阶段保存羊膜中的总RNA无明显减少,且目的基因的表达同新鲜羊膜中的相同(P>0.05)。如解冻半小时后提取总RNA,其量明显减少(P<0.01)。结论传统的羊膜深低温保存法可有效保护基因的完整性,据此我们提出一个羊膜基因保存库的新概念。 | 毕燕龙 荣翱 Karin Kobuch Chris Lohmann | 2006 | 眼科研究2006，24，3： | 2 |
| 8 | Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line显示文摘 | Lohmann V Korner F Koch J | | 0，，5424： | 2 |
| 9 | Head injury by gunshots from blank cartridges 显示文摘 | Giese A Koops E Lohmann F | 2002 | Surg Neurol2002，57，4： | 1 |
| 10 | Chirp filtering in the fractional Fourier domain显示文摘 | Dorsch R G Lohmann A W Bitran Y | 1994 | Appl Opt1994，33，32： | 1 |
| 11 | Mutations that permit efficient replication of hepatitis C virus RNA in Huh - 7 cells prevent productive replication in chimpanzees 显示文摘 | Bukh J Pietschmann T Lohmann V | 2002 | PNAS2002，99，14： | 1 |
| 12 | 显示文摘 | Sachs H G Lohmann C P Op de Laak J P | 1997 | Ophthalmologe1997，94，： | 1 |
| 13 | Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line显示文摘 | LOHMANN V KORNER F KOCH J | 1999 | Science1999，285，5424： | 1 |
| 14 | SIRT1decreases Lox-l-mediated foam cell formation in athero-genesis显示文摘 | STEIN S LOHMANN C SCHAFER N | 2010 | Eur Heart J2010，31，： | 1 |
| 15 | New derivatives of 5,10-dihydro- 11H-dibenzo diazepine- 11-ones with anticholinergic activity 显示文摘 | Rueger C Rohnert H Lohmann D | 1990 | Pharmazie1990，45，8： | 1 |
| 16 | Numerical methods for parameter estimation and optimal experiment design in chemical reaction systems显示文摘 | Lohmann T Pock H G Schloeder J P | | 0，，01： | 1 |
| 17 | Temporal and spatial differences in salinity and water chemistry in SW Florida estuaries: effects of human-impacted watersheds显示文摘 | Surge D M Lohmann K C | 2002 | Estuaries2002，25，3： | 1 |
| 18 | Abrupt climate change and transient climates during the Paleogene: Amarinepespective显示文摘 | Zachos J C Lohmann K C Walker J C G | 1993 | Journal of Geology1993，101，： | 1 |
| 19 | Roles of echocardiography in the diagnosis of occult penetrating cardiac injury显示文摘 | Lohmann C Kim DO | 1995 | J Thauma1995，38，： | 1 |
| 20 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
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