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| 1 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 2 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 3 |
| 3 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 4 | Progressive silencing of the zinc transporter Zip8 (Sic39a8) in chronic cadmium-exposed lung epithelial cells显示文摘镉(Cd ) ,非本质的金属,暗地里由利用进口小径的必要金属进入房间。锌 transporters Zip8 , Zip14 ,和二价的金属 transporter ( Dmt1 ) 1 现在作为涉及细胞的 Cd 加入的几重要金属 transporters 正在出现,他们的表情被显示了下面调整在几Cd抵抗( Cd R )房间线,然而这些 transporters 的参与在在肺房间的Cd抵抗的发展期间是不清楚的。在这研究,我们因此在我们的以前确定的老鼠肺检查这些金属 transporters 的表示上皮的房间(LEC ) 和 Zip8 的水平是的表演日益增多地 silenced 当 LEC 被使适应增加 CdCl 2 的集中时(从 1 ~ 20 M ) 。细胞的 Cd 内容的随后的测量显示了那 Cd R LEC 展出 Cd 累积的显著减少,可能由于 Zip8 的损失表示。我们调查由 DNA hypermethylation 的 Zip8 基因的 epigenetic silencing 涉及 Zip8 表示的下面规定的可能性。Cd R LEC 比父母房间显示出 DNA methyltransferase 3b (Dnmt3b ) 的更高的 mRNA 水平。Cd 有 5-aza-2-deoxycytidine 的 R LEC, DNA methyltransferases 的一个禁止者,回复到在这些房间的 Cd 的 Zip8 和敏感的表示,为 Cd 进口显示 Zip8 的关键角色。一起拿,我们的结果证明 Zip8 表示的进步 silencing 在肺房间对 Cd 涉及抵抗的获得,代表抵抗导致 Cd 的 cytotoxicity 的适应幸存机制。 | Yangmin Gao Yanming Xu Dandan Wu Feiyuan Yu Lei Yang Yue Yao Zhanling Liang Andy T. Y. Lau | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 2 |
| 5 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 6 | PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells显示文摘 | Wei-Hua Yu Fu-Gui Li Xiao-Yong Chen Jian-Tao Li Yan-Heng Wu Li-Hua Huang Zhen Wang Panlong Li Tao Wang Bruce T. Lahn Andy Peng Xiang | 2011 | International Journal of Biochemistry and Cell Biology2011，，2： | 1 |
| 7 | Nonalcoholic fatty liver disease显示文摘 | Andy S Yu Emmet B Keeffe | 2002 | Gastroenterol Disord2002，2，1： | 1 |
| 8 | Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells显示文摘 | Weihua Yu Zhenguang Chen Jinli Zhang Lirong Zhang Hui Ke Lihua Huang Yanwen Peng Xiuming Zhang Shunong Li Bruce T. Lahn Andy Peng Xiang | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 9 | IFN-γ-primed human bone marrow mesenchymal stem cells induce tumor cell apoptosis in vitro via tumor necrosis factor-related apoptosis-inducing ligand显示文摘 | Jingchun Du Liwen Zhou Xiaoyong Chen Sunxing Yan Ming Ke Xiaofang Lu Zhen Wang Weihua Yu Andy Peng Xiang | 2012 | International Journal of Biochemistry and Cell Biology2012，，8： | 1 |
| 10 | 应用于聚丙烯无纺布的内添加型耐久亲水助剂显示文摘主要介绍了一种新型的内添加型表面改性剂SM-1。它在不影响聚丙烯无纺布原有性能的前提下可以赋予无纺布持久的亲水性与抗静电性。添加此亲水助剂的无纺布,其初始透水时间可以在3s以内,能够反复冲刷10次以上,同时具有很高的吸水能力。这种新型的内添加型亲水助剂能为聚丙烯无纺布带来新的价值与商机。 | Ta-Hua Yu Andy Leggio John McNamara George Menzie Shing Li Doug Horsey 火贤磊 张小翠 | 2004 | 塑料助剂2004，，5： | 1 |
| 11 | Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant,CAL.20C显示文摘Dear Editor,New variants of SARS-CoV-2 have been emerging since the initial outbreak in 2019;1 one of the latest ones was identified in Southern California in October 2020 and was subsequently detected in 26 other states in the United States as well as other countries as of January 2021. | Zhongcheng Zhou Peng Du Meixing Yu Daniel T.Baptista-Hon Man Miao Andy P.Xiang Johnson Yiu-Nam Lau COVID-Immunity Investigation Group Gen Li Kang Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
| 12 | Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells显示文摘 | Weihua Yu Zhenguang Chen Jinli Zhang Lirong Zhang Hui Ke Lihua Huang Yanwen Peng Xiuming Zhang Shunong Li Bruce T. Lahn Andy Peng Xiang | 2008 | Molecular and Cellular Biochemistry (-)2008，，1： | 1 |
| 13 | Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos显示文摘 | Yuyu Niu Bin Shen Yiqiang Cui Yongchang Chen Jianying Wang Lei Wang Yu Kang Xiaoyang Zhao Wei Si Wei Li Andy Peng Xiang Jiankui Zhou Xuejiang Guo Ye Bi Chenyang Si Bian Hu Guoying Dong Hong Wang Zuomin Zhou Tianqing Li Tao Tan Xiuqiong Pu Fang Wang Shaohu | 2014 | Cell2014，，： | 1 |
| 14 | Evidence for a critical role of gene occlusion in cell fate restriction显示文摘尽管有它的普遍存在,细胞命运的进步限制在系区别期间是糟糕理解的现象。我们最近使用了房间熔化试金定义我们称为的 epigenetic silencing 的一个模式 “ occlusion”,不管交易的 transcriptional 使活跃之物是否是在场的,在那里影响了基因,是由行动 cis 染色质机制的 silenced。我们假设了系不恰当的基因的那吸藏能贡献房间命运限制。这里,我们由介绍细菌的人工的染色体(用绳子拖的平底渡船) 测试这个假设,它缺乏为吸藏必要的染色质修正,进老鼠成纤维细胞。我们发现相应于堵塞内长的基因的用绳子拖的平底渡船 transgenes 在大多数情况中被表示,而相应于沉默却非堵塞的内长的基因的用绳子拖的平底渡船 transgenes 没被表示。这显示在 trans 的细胞的周围在成纤维细胞支持大多数堵塞基因的表示,并且这些基因的沉默状态是完全在 cis 的吸藏的后果。为相应于堵塞 myogenic 主人管理者 Myf5 的 BAC, BAC 上的 Myf5 transgene 的表示触发了成纤维细胞获得像肌肉的显型。这些结果在房间命运限制为基因吸藏的一个关键角色提供引人注目的证据。 | Jedidiah Gaetz Kayla L Clift Croydon J Femandes Frank Fuxiang Mao Jae Hyun Lee Li Zhang Samuel W Baker Timothy J Looney Kara M Foshay Wei-Hua Yu Andy Peng Xiang Bruce T Lahn | 2012 | Cell Research2012，22，5： | 1 |
| 15 | Biodegradation and bio-sorption of antibiotics and non-steroidal anti-inflammatory drugs using immobilized cell process显示文摘 | Tsung-Hsien Yu Angela Yu-Chen Lin Sri Chandana Panchangam Pui-Kwan Andy Hong Ping-Yi Yang Cheng-Fang Lin | 2011 | Chemosphere2011，，9： | 1 |
| 16 | A process model for developing usable cross-cultural websites显示文摘 | Andy Smith Lynne Dunckley Tim French Shailey Minocha Yu Chang | 2003 | Interacting with Computers2003，，1： | 1 |
| 17 | Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells显示文摘 | Yanwen Peng Zhenguang Chen Weihua Yu Qifeng Zhou Lin Xu Frank Fuxiang Mao Gang Huang Xiuming Zhang Shunong Li Bruce T. Lahn Andy Peng Xiang | 2008 | Cell Biology International2008，，10： | 1 |
| 18 | Nonalcoholic Fatty liver disease显示文摘 | Andy S Yu MD Emmet B Keeffe MD | 2002 | Gastrointestinal Disorders2002，2，1： | 1 |
| 19 | Nonalcoholic FattyLiver Disease显示文摘 | ANDY S YU MD EMMET B | 2002 | Gastrointest Disord2002，2，1： | 1 |
| 20 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
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