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| 1 | Risk assessment of heavy metals in soils and vegetables around nonferrous metals mining and smelting sites,Baiyin,China显示文摘A field survey was conducted to investigate the metal and arsenic contamination in soils and vegetables on four villages (Shuichuan (SCH), Beiwan (BWA), Dongwan (DWA) and Wufe (WFE)) located along, Baiyin, China, and to evaluate the possible health risks to local population through foodchain. Results show that the most significantly contaminated soils occurred upstream at SCH where Cd, Cu and As concentrations exceeded maximum allowable concentrations for Chinese agricultural soil. Further downstream the degree of contamination semi-systematically decreased in concentrations of metal. Generally, the leafy vegetables were more heavily contaminated than non-leafy vegetables. Chinese cabbage is the most severely contaminated, the concentrations of Cd exceeded the maximum permit levels (0.05 mg/kg) by 4.5 times. Bio-accumulate factor also shows that an entry of Cd to food chain plants is the greatest potential. Furthermore, the estimated daily intake amounts of the considered toxic elements (Cd, Pb and Cu) from the vegetables grown at SCH and BWA and DWA have exceeded the recommended dietary allowance levels. Thus, the vegetables grown in three villages above, which affected by Baiyin mining and smelting have a health hazard for human consumption. | LI Yu WANG Yan-bin GOU Xin SU Yi-bing WANG Gang | 2006 | Journal of Environmental Sciences2006，18，6： | 84 |
| 2 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 3 | A Review of Methods for Studying Microbial Diversity in Soils显示文摘Soil microorganisms play a central role in decomposing organic matter, in determining the release of mineral nutrients, and in nutrient cycling. Recently, extensive studies have focused on soil microbial diversity. However, understanding the diversity of this complex microbial community in the soil environment is a challenging task. Thus, it is important to master and comprehend appropriate methods for studying soil microbial diversity. Concepts of soil microbial diversity and major methods of study are briefly introduced in this paper. Then, the application of biochemical-based and molecular-based techniques in this area, and their advantages and disadvantages are evaluated. Based on recent related research, perspectives for studying microbial diversity in soils are presented. | LIU Bing-Ru JIA Guo-Mei CHEN Jian WANG Gang | 2006 | Pedosphere2006，16，1： | 73 |
| 4 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 5 | Activated Expression of WRKY57 Confers Drought Tolerance in Arabidopsis显示文摘干旱是限制世界范围的农业庄稼的生产率的最严肃的环境因素之一。然而,在植物位于干旱忍耐下面的机制是不清楚的。WRKY 抄写因素被知道在改编工作到不能生活的压力。由屏蔽联系 WRKY 的 T-DNA 插入异种的一个水池,我们孤立 gain-of-function 变异的、获得的干旱忍耐(adt ) ,出现改进干旱忍耐。在干旱压力条件下面, adt 比野类型的植物积累了骆驼毛的织物的高水平。有气孔的孔分析显示 adt 比野类型的植物对骆驼毛的织物更敏感。分子的基因分析表明在 adt 的 T-DNA 插入导致了编码 WRKR57 蛋白质的 WRKY 基因的激活的表示。WRKY57 的组成的表示也授与类似的干旱忍耐。一致地与高骆驼毛的织物内容和提高的干旱忍耐,三压力应答的基因(RD29A, NCED3,和 ABA3 ) 在 adt 是起来调整的。薄片试金证明 WRKY57 能直接绑 RD29A 和 NCED3 倡导者序列的 W 盒子。在骆驼毛的织物处理期间,,另外,种子萌芽和 adt 的早幼苗生长在高渗透的条件下面被禁止, adt 显示出更高的种子萌芽频率。在摘要,我们的结果建议 WRKY57 的激活的表示由骆驼毛的织物层次的举起改进了 Arabidopsis 的干旱忍耐。WRKY57 的功能的建立将通过基因操作途径启用植物干旱忍耐的改进。 | Yanjuan Jiang Gang Liang Diqiu Yu | 2012 | Molecular Plant2012，5，6： | 62 |
| 6 | Indo-Western Pacific Ocean Capacitor and Coherent Climate Anomalies in Post-ENSO Summer: A Review显示文摘ENSO induces coherent climate anomalies over the Indo-western Pacific, but these anomalies outlast SST anomalies of the equatorial Pacific by a season, with major effects on the Asian summer monsoon. This review provides historical accounts of major milestones and synthesizes recent advances in the endeavor to understand summer variability over the Indo-Northwest Pacific region. Specifically, a large-scale anomalous anticyclone(AAC) is a recurrent pattern in post-El Ni ?no summers, spanning the tropical Northwest Pacific and North Indian oceans. Regarding the ocean memory that anchors the summer AAC, competing hypotheses emphasize either SST cooling in the easterly trade wind regime of the Northwest Pacific or SST warming in the westerly monsoon regime of the North Indian Ocean. Our synthesis reveals a coupled ocean–atmosphere mode that builds on both mechanisms in a two-stage evolution. In spring, when the northeast trades prevail, the AAC and Northwest Pacific cooling are coupled via wind–evaporation–SST feedback. The Northwest Pacific cooling persists to trigger a summer feedback that arises from the interaction of the AAC and North Indian Ocean warming, enabled by the westerly monsoon wind regime. This Indo-western Pacific ocean capacitor(IPOC) effect explains why El Ni ?no stages its last act over the monsoonal Indo-Northwest Pacific and casts the Indian Ocean warming and AAC in leading roles. The IPOC displays interdecadal modulations by the ENSO variance cycle, significantly correlated with ENSO at the turn of the 20 th century and after the 1970 s, but not in between. Outstanding issues, including future climate projections, are also discussed. | Shang-Ping XIE Yu KOSAKA Yan DU Kaiming HU Jasti S.CHOWDARY Gang HUANG | 2016 | Advances in Atmospheric Sciences2016，33，4： | 75 |
| 7 | Effects of different resuscitation fluid on severe acute pancreatitis显示文摘AIM: To compare effects of different resuscitation fluid on microcirculation, inflammation, intestinal barrier and clinical results in severe acute pancreatitis (SAP). METHODS: One hundred and twenty patients with SAP were enrolled at the Pancreatic Disease Institute between January 2007 and March 2010. The patients were randomly treated with normal saline (NS group), combination of normal saline and hydroxyethyl starch (HES) (SH group), combination of normal saline, hydroxyethyl starch and glutamine (SHG group) in resuscitation. The ratio of normal saline to HES in the SH and SHG groups was 3:1. The glutamine (20% glutamine dipeptide, 100 mL/d) was supplemented into the resuscitation liquid in the SHG group. Complications and outcomes including respiratory and abdominal infection, sepsis, abdominal hemorrhage, intra-abdominal hypertension, abdominal compartment syndrome (ACS), renal failure, acute respiratory distress syndrome (ARDS), multiple organ dysfunction syndrome (MODS), operation intervention, length of intensive care unit stay, length of hospital stay, and mortality at 60 d were compared. Moreover, blood oxygen saturation (SpO 2 ), gastric intramucosal pH value (pHi), intra-abdominal pressure (IAP), inflammation cytokines, urine lactulose/mannitol (L/M) ratio, and serum endotoxin were investigated to evaluate the inflammatory reaction and gut barrier. RESULTS: Compared to the NS group, patients in the SH and SHG groups accessed the endpoint more quickly (3.9 ± 0.23 d and 4.1 ± 0.21 d vs 5.8 ± 0.25 d, P < 0.05) with less fluid volume (67.26 ± 28.53 mL/kg/d, 61.79 ± 27.61 mL/kg per day vs 85.23 ± 21.27 mL/kg per day, P < 0.05). Compared to the NS group, incidence of renal dysfunction, ARDS, MODS and ACS in the SH and SHG groups was obviously lower. Furthermore, incidence of respiratory and abdominal infection was significantly decreased in the SH and SHG groups, while no significant difference in sepsis was seen. Moreover, less operation time was needed in the SH and SHG group than the NS group, but the difference was not significant. The mortality did not differ significantly among these groups. Blood SpO 2 and gastric mucosal pHi in the SH and SHG groups increased more quickly than in the NS group, while IAP was significantly decreased in the SH and SHG group. Moreover, the serum tumor necrosis factor-α, interleukin-8 and C-reactive protein levels in the SH and SHG groups were obviously lower than in the NS group at each time point. Furthermore, urine L/M ratio and serum endotoxin were significantly lower in the SH group and further decreased in the SHG group.CONCLUSION: Results indicated that combination of normal saline, HES and glutamine are more efficient in resuscitation of SAP by relieving inflammation and sustaining the intestinal barrier. | Gang Zhao Jun-Gang Zhang He-Shui Wu Jin Tao Qi Qin Shi-Chang Deng Yang Liu Lin Liu Bo Wang Kui Tian Xiang Li Shuai Zhu Chun-You Wang | 2013 | World Journal of Gastroenterology2013，19，13： | 56 |
| 8 | Characterization and assessment of volatile organic compounds (VOCs) emissions from typical industries显示文摘VOCs play an increasingly important role in affecting air quality and threatening human health in China in recent years,where industry activities show a significant contribution to VOCs emission.In this article we report our long term study of industrial VOCs emissions of six major industries (vehicle manufacturing,printing,equipment coating,electronic manufacturing,furniture manufacturing and bio-pharming) on the aspects of emission characteristics,environmental impact and health risk assessment,and control challenge analysis with the purpose to obtain in-depth understanding of industry VOCs emissions and offer some original basements for national control and management of industry VOCs emissions.This study shows that all these industries give middle or low emission with total VOCs concentration less than 1000 mg/m3 at each exhaust pipe.Benzenes,esters,alcohols,ketones,alkanes,chloroalkanes and alkenes were detected as the major emission components and the most frequently monitored VOCs were benzenes,which varied obviously with different processes and industries.The environmental impact assessments indicate that vehicle manufacturing and benzenes should be prior controlled with the purpose to reduce air pollution.While,health risk assessments suggest that furniture manufacturing and chloroalkanes should be firstly controlled.Control analysis indicates that developing technologies with low cost and high efficiency and establishing and completing specific industry emission standards/regulations are the two key issues in VOCs emission management at present stage. | WANG HaiLin NIE Lie LI Jing WANG YuFei WANG Gang WANG JunHui HAO ZhengPing | 2013 | Science China(Technological Sciences)2013，56，3： | 60 |
| 9 | Oral microbiomes: more and more importance in oral cavity and whole body显示文摘微生物在人的生活的每个角落出现,并且微生物影响人的生活的每个方面。人的口头的洞包含很多个不同产地。可变口头的微生物的协同作用和相互作用在外面对不受欢迎的刺激的侵略帮助人的身体。然而,微生物引起的植物群的不平衡贡献口头的疾病和全身的疾病。口头的 microbiomes 玩在人的微生物引起的社区和人的健康的一个重要角色。最近的使用开发了分子的方法极大地处于健康和疾病扩展了我们作文的知识和口头的 microbiome 的功能。在有在可变身体地点和可变健康状况的 microbiomes 的口头的 microbiomes 和他们的相互作用的研究在我们我们的身体的认知是批评的并且怎么在人的健康上做效果改进。 | Lu Gao Tiansong Xu Gang Huang Song Jiang Yan Gu Feng Chen | 2018 | Protein & Cell2018，9，5： | 55 |
| 10 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 11 | Functional exhaustion of antiviral lymphocytes in COVID-19 patients显示文摘In December 2019,a novel coronavirus was first reported in Wuhan,China.1 It was named by the World Health Organization as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and is responsible for coronavirus disease 2019(COVID-19).Up to 28 February 2020,79,394 cases have been confirmed according to China’s National Health Commission.Outside China,the virus has spread rapidly to over 36 countries and territories. | Yuanhong Xuand Zhigang Tian Meijuan Zheng Yong Gao Gang Wang Guobin Song Siyu Liu Dandan Sun Yuanhong Xu Zhigang Tian | 2020 | Cellular & Molecular Immunology2020，17，5： | 54 |
| 12 | Influences of blood lipids on the occurrence and prognosis of hemorrhagic transformation after acute cerebral infarction: a case-control study of 732 patients显示文摘Background: To study the influence of blood lipid levels on hemorrhagic transformation(HT) and prognosis after acute cerebral infarction(ACI).Methods: Patients with ACI within 72 h of symptoms onset between January 1 st, 2015, and December 31 st, 2016, were retrospectively analyzed. Patients were divided into group A(without HT) and group B(HT). The outcomes were assessed after 3 months of disease onset using the modified Rankin Scale(m RS). An m RS score of 0–2 points indicated excellent prognosis, and an m RS score of 3–6 points indicated poor prognosis.Results: A total of 732 patients conformed to the inclusion criteria, including 628 in group A and 104 in group B. The incidence of HT was 14.2%, and the median onset time was 2 d(interquartile range, 1–7 d). The percentages of patients with large infarct size and cortex involvement in group B were 80.8% and 79.8%, respectively, which were both significantly higher than those in group A(28.7 and 33.4%, respectively). The incidence rate of atrial fibrillation(AF) in group B was significantly higher than that in group A(39.4% vs. 13.9%, P<0.001). The adjusted multivariate analysis results showed that large infarct size, cortex involvement and AF were independent risk factors of HT, while total cholesterol(TC) was a protective factor of HT(OR=0.359, 95% CI 0.136–0.944, P=0.038). With every 1 mmol/L reduction in normal TC levels, the risk of HT increased by 64.1%. The mortality and morbidity at 3 months in group B(21.2% and 76.7%, respectively) were both significantly higher than those in group A(8.0% and 42.8%, respectively). The adjusted multivariate analysis results showed that large infarct size(OR=12.178, 95% CI 5.390–27.516, P<0.001) was an independent risk factor of long-term unfavorable outcomes, whereas low-density lipoprotein cholesterol(LDL-C) was a protective factor(OR=0.538, 95% CI 0.300–0.964, P=0.037). With every 1 mmol/L reduction in normal LDL-C levels, the risk of an unfavorable outcome increased by 46.2%. Major therapies, including intravenous recombinant human tissue plasminogen activator(r TPA), intensive lipid-lowering statins and anti-platelets, were not significantly related to either HT or long-term, post-ACI poor prognosis.Conclusions: For patients with large infarct sizes, especially those with cortex involvement, AF, or lower levels of TC, the risk of HT might increase after ACI. The risk of a long-term unfavorable outcome in these patients might increase with a reduction in LDL-C. | Gang Lv Guo-Qiang Wang Zhen-Xi Xia Hai-Xia Wang Nan Liu Wei Wei Yong-Hua Huang Wei-Wei Zhang | 2019 | Military Medical Research2019，6，3： | 60 |
| 13 | Fast-track surgery could improve postoperative recovery in radical total gastrectomy patients显示文摘AIM: To assess the impact of fast-track surgery (FTS) on hospital stay, cost of hospitalization and complications after radical total gastrectomy. METHODS: A randomized, controlled clinical trial was conducted from November 2011 to August 2012 in the Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, the Fourth Military Medical University. A total of 122 gastric cancer patients who met the selection criteria were randomized into FTS and conventional care groups on the first day of hospitalization. All patients received elective standard D2 total gastrectomy. Clinical outcomes, including duration of flatus and defecation, white blood cell count, postoperative pain, duration of postoperative stay, cost of hospitalization and complications were recorded and evaluated.Two specially trained doctors who were blinded to the treatment were in charge of evaluating postoperative outcomes, discharge and follow-up. RESULTS: A total of 119 patients finished the study, including 60 patients in the conventional care group and 59 patients in the FTS group. Two patients were excluded from the FTS group due to withdrawal of consent. One patient was excluded from the conventional care group because of a non-resectable tumor. Compared with the conventional group, FTS shortened the duration of flatus (79.03 ± 20.26 hvs 60.97 ± 24.40 h, P = 0.000) and duration of defecation (93.03 ± 27.95 h vs 68.00 ± 25.42 h, P = 0.000), accelerated the decrease in white blood cell count [P < 0.05 on postoperative day (POD) 3 and 4], alleviated pain in patients after surgery (P < 0.05 on POD 1, 2 and 3), reduced complications (P < 0.05), shortened the duration of postoperative stay (7.10 ± 2.13 dvs 5.68 ± 1.22 d,P = 0.000), reduced the cost of hospitalization (43783.25 ± 8102.36 RMBvs 39597.62 ± 7529.98 RMB,P = 0.005), and promoted recovery of patients. CONCLUSION: FTS could be safely applied in radical total gastrectomy to accelerate clinical recovery of gastric cancer patients. | Fan Feng Gang Ji Ji-Peng Li Xiao-Hua Li Hai Shi Zheng-Wei Zhao Guo-Sheng Wu Xiao-Nan Liu Qing-Chuan Zhao | 2013 | World Journal of Gastroenterology2013，19，23： | 44 |
| 14 | Correlations Between Foliar Stable Carbon Isotope Composition and Environmental Factors in Desert Plant Reaumuria soongorica (Pall.) Maxim.显示文摘Leaves of 407 individuals of Reaumuria soongorica (Pall.) Maxim. collected from the major distribution areas were measured to investigate the distribution characteristics of the stable carbon isotope in this desert plant, as well as correlations between δ13C values and environmental factors. Results showed that δ13C values in R. soongorica ranged from-22.77‰. to-29.85‰. and that the mean δ13C value (-26.52‰)was higher than a previously reported δ13C value for a different desert ecosystem. This indicates that R.soongorica belongs to the C3 photosynthetic pathway and has higher water use efficiency than other species. The correlations between δ13C values and environmental factors demonstrated that the foliar δ13C values in R. soongorica increased significantly with decreasing mean annual precipitation and mean relative humidity, and decreased with decreasing duration of sunshine and evaporation. The spatial distribution trend of δ13C values in R. soongorica was not obvious and there was no significant correlation between the δ13C values and mean annual temperature. We conclude that different distribution trends in δ13C values for R. soongorica were likely caused by stomatal limitation rather than by nutrient-related changes in photosynthetic efficiency and that precipitation played an important role in the wide distribution range of R.soongorica. This pattern of δ13C values for R. soongorica reinforced that it is a super-xerophil in terms of its adaptive strategies to a desert environment. | Jian-Ying MA Tuo CHEN Wei-Ya QIANG Gang WANG | 2005 | Journal of Integrative Plant Biology2005，47，9： | 42 |
| 15 | SHRIMP zircon U-Pb dating for subduction-related gran-itic rocks in the northern part of east Junggar, Xinjiang显示文摘SHRIMP U-Pb zircon dating on the Xileketehalasu granodiorite porphyry and Kalasayi monodiorite porphyry that intrude middle Devonian Beitashan Formation at the north part of east Junggar region shows that they were formed at 381±6 Ma and 376±10 Ma respectively. They are interpreted as subduction-related granitic rocks, which is the first report that the isotopic ages for the granitic rocks range from 350 to 390 Ma. Another determined age for the Kalasayi monodiorite porphyry is 408±9 Ma, representing the age of underlain Lower Devonian volcanic rocks. Thus, the U-Pb dates suggest that the northeastward subduction of Junggar ocean from southwest occurred at 408 to 376 Ma (the real inter- val may be larger). Because the ore-bearing porphyry intruded following the formation of the volcanic rocks of middle Devonian Beitashan Formation, their tec- tonic setting is similar to the Andes Mountains that hosts world-class porphyry copper deposits, and the researched area could be regarded as a potential area for prospecting large porphyry copper deposits. | ZHANG Zhaochong YAN Shenghao CHEN Bailin ZHOU Gang HE Yongkang CHAI Fengmei HE Lixin WAN Yusheng | 2006 | Chinese Science Bulletin2006，51，8： | 43 |
| 16 | Postconditioning of sevoflurane and propofol is associated with mitochondrial permeability transition pore显示文摘Background: Sevoflurane and propofol are effective cardioprotective anaesthetic agents, though the cardioprotection of propofol has not been shown in humans. Their roles and underlying mechanisms in anesthetic postconditioning are unclear. Mitochondrial permeability transition pore (MPTP) opening is a major cause of ischemia-reperfusion injury. Here we investigated sevoflurane- and propofol-induced postconditioning and their relationship with MPTP. Methods: Isolated perfused rat hearts were exposed to 40 min of ischemia followed by 1 h of reperfusion. During the first 15 min of reperfusion, hearts were treated with either control buffer (CTRL group) or buffer containing 20 μmol/L atractyloside (ATR group), 3% (v/v) sevoflurane (SPC group), 50 μmol/L propofol (PPC group), or the combination of atractyloside with respective anesthetics (SPC+ATR and PPC+ATR groups). Infarct size was determined by dividing the total necrotic area of the left ventricle by the total left ventricular slice area (percent necrotic area). Results: Hearts treated with sevoflurane or propofol showed significantly better recovery of coronary flow, end-diastolic pressures, left ventricular developed pressure and derivatives compared with controls. Sevoflurane resulted in more protective alteration of hemodynamics at most time point of reperfusion than propofol. These improvements were paralleled with the reduction of lactate dehydrogenase release and the decrease of infarct size (SPC vs CTRL: (17.48±2.70)% vs (48.47±6.03)%, P<0.05; PPC vs CTRL: (35.60±2.10)% vs (48.47±6.03)%, P<0.05). SPC group had less infarct size than PPC group (SPC vs PPC: (17.48±2.70)% vs (35.60±2.10)%, P<0.05). Atractyloside coadministration attenuated or completely blocked the cardioprotective effect of postconditioning of sevoflurane and propofol. Conclusion: Postconditioning of sevoflurane and propofol has cardio-protective effect against ischemia-reperfusion injury of heart, which is associated with inhibition of MPTP opening. Compared to propofol, sevoflurane provides superior protection of functional recovery and infarct size. | Wei HE Feng-jiang ZHANG Shao-ping WANG Gang CHEN Cong-cong CHEN Min YAN | 2008 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2008，9，2： | 48 |
| 17 | Glycemic variability in insulin treated type 2 diabetes with well-controlled hemoglobin Alc and its response to further treatment with acarbose显示文摘背景 Glycemic 可变性,一个 HbA1c 独立的风险因素,在糖尿病的复杂并发症的发展比持续多糖症有更有害的效果。这研究与 acarbose.Methods 在两次每日的 premixed 胰岛素治疗的持续时间和进一步的治疗的效果与HbA1c6.5%在类型 2 糖尿病 mellitus ( T2DM )分析了 glycemic 可变性的特征使用了 premixed 胰岛素类似物的 86 个 T2DM 病人(胰岛素 aspart 30 )两次每日、有的HbA1c 6.5%并且 20 控制了有正常葡萄糖规定( NGR )的题目用监视的连续葡萄糖( CGM )被监视系统。glycemic 旅行(魔术师) 的吝啬的振幅,每日的差别(MODD ) 的平均数被用于估计 intra 天,内部天的 glycemic 可变性。低血糖症在 CGM 被定义为葡萄糖水平 3.9 mmol/L 至少 15 分钟。根据魔术师的参考价值, T2DM 病人被分类进二个组: 有魔术师 3.4 mmol/L (L 魔术师) 和高度的 Iow 魔术师组 -- 有魔术师 3.4 mmol/L (H 魔术师) 的魔术师组。H 魔术师组与 acarbose 接受了进一步的治疗 2 个星期并且第二次在第一 CGM 以后与 CGM system.Results 被监视,有的 L 魔术师组 41 个盒子,和 H 魔术师组有 45 个盒子。T2DM 组的魔术师和 MODD 都比有 NGR (P0.01 ) 的题目的那些高。(n=11 )百分之 24 在 H 魔术师组有 13 个血糖过低的事件的一个总数, 13 个事件中的 10 个发生在夜里,(n=2 ) 同时, 5% 在 L 魔术师组有 2 个血糖过低的事件的一个总数,它也发生在夜里(血糖过低的事件:24% 对 5% , x2=6.40, P0.01 ).MAGE 价值与低血糖症价值和 2 小时的饭后的血浆葡萄糖价值被相关(r=0.32 并且 0.26,分别地 P0.05 ) 。在进一步的 acarbose 治疗以后并且第二,在 H 魔术师的价值组织的 CGM,魔术师和 MODD 都显著地被减少(40% , P0.01,并且 15% , P0.05,分别地) ,但是与 NGR (P0.05 ) 仍然保持比在这些题目高;(n=1 )2% 有 1 个血糖过低的事件的一个总数,发生显著地减少了(2% 对 24%,2=9.61, P 0.01 ).Conclusions CGM 系统能在胰岛素处理的持续时间与控制得好的 HbA1c 检测 glycemic 可变性和 T2DM 的无征状的血糖过低的事件。与 acarbose 罐头公寓 glycemic 可变性和减少两次每日的 premixed 胰岛素的联合治疗血糖过低的事件。 | SU Jian-bin WANG Xue-qin CHEN Jin-feng WU Gang JIN Yan | 2011 | Chinese Medical Journal2011，，1： | 41 |
| 18 | Fast-track rehabilitation program vs conventional care after colorectal resection:A randomized clinical trial显示文摘AIM:To compare the fast-track rehabilitation program and conventional care for patients after resection of colorectal cancer.METHODS:One hundred and six consecutive patients who underwent fast-track rehabilitation program were encouraged to have early oral feeding and movement for early discharge,while 104 consecutive patients underwent conventional care after resection of colorectal cancer.Their gastrointestinal functions,postoperative complications and hospital stay time were recorded.RESULTS:The restoration time of gastrointestinal functions in the patients was significantly faster after fasttrack rehabilitation program than after conventional care(2.1 d vs 3.2 d,P < 0.01).The percentage of patients who developed complications was significantly lower 30 d after fast-track rehabilitation program than after conventional care(13.2% vs 26.9%,P < 0.05).Also,the percentage of patients who had general complications was significantly lower 30 d after fast-track rehabilitation program than after conventional care(6.6% vs 15.4%,P < 0.05).The postoperative hospital stay time of the patients was shorter after fast-track rehabilitation program than after conventional care(5 d vs 7 d,P < 0.01).No significant difference was observed in the readmission rate 30 d after fast-track rehabilitation program and conventional care(3.8% vs 8.7%).CONCLUSION:The fast-track rehabilitation program can significantly decrease the complications and shorten the time of postoperative hospital stay of patients after resection colorectal cancer. | Gang Wang Zhi-Wei Jiang Jing Xu Jian-Feng Gong Yang Bao Li-Fei Xie Jie-Shou Li | 2011 | World Journal of Gastroenterology2011，17，5： | 43 |
| 19 | Distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in surface water and sediments from Baiyangdian Lake in North China显示文摘Persistent organochlorine compounds,including hexachlorocyclohexanes (HCHs),dichlorodiphenyltrichloroethanes (DDTs) and polychlorinated biphenyls (PCBs) were analyzed in surface water and sediments from Baiyangdian Lake,North China.Total concentrations of HCHs,DDTs and PCBs in surface water were in the range of 3.13-10.60,4.05-20.59 and 19.46-131.62 ng/L,respectively,and total concentrations of HCHs,DDTs and PCBs in sediments were 1.75-5.70,0.91-6.48 and 5.96-29.61 ng/g dry weight,respectively.Among the groups of HCHs (sum of α-HCH,β-HCH,γ-HCH and δ-HCH) and DDTs (sum of DDT,DDD and DDE),the predominance of β-HCH,DDE and DDD in water and sediment samples was clearly observed.This observation suggested that β-HCH was resistant to biodegradation and the DDTs had been transformed to its metabolites,DDE and DDD.For PCBs,penta-,hexa-and hepta-chlorinated congeners were the most abundant compounds in the both phases.Furthermore,the partitioning of chlorinated compounds between sediment and water was investigated to understand their transport and fates in aquatic ecosystems.The results indicated that average logs of organic carbon-normalized sediment-water partition coefficients (logK'oc) for OCPs varied between 3.20 and 5.53,and for PCBs,logK'oc values ranged from 3.19 to 5.57.The observed logK'oc was lower than their equilibrium logKoc predicted from linear model,which may be attributed to the solubility enhancement effect of colloidal matter in water phase and the disequilibrium between sediment and water. | Guohua Dai Xinhui Liu Gang Liang Xu Han Liu Shi Dengmiao Cheng Wenwen Gong | 2011 | Journal of Environmental Sciences2011，23，10： | 44 |
| 20 | Prediction of urban human mobility using large-scale taxi traces and its applications显示文摘这篇论文在一个城市的出租车交通系统调查人的活动性模式。这个工作集中于预言 humanmobility fromdiscovering 模式在从城市的热点的旅客提取数量(PUQ ) 的数字。这份报纸建议改进 ARIMA 基于预言方法在一个热点预报旅客的空间时间的变化。有 4 000 出租车 GPS 的一个大规模 realworld 数据集合的评估跟踪超过一年表演一个预言错误仅仅 5.8% 。我们也探索预言途径的申请帮助司机发现他们的下位旅客。用历史的真实世界的数据的模拟结果证明与我们的指导,驱动程序能减少花的时间,距离旅行,到发现他们的下位旅客在 37.1% 和 6.4% ,分别地。 | Xiaolong LI Gang PAN Zhaohui WU Guande QI Shijian LI Daqing ZHANG Wangsheng ZHANG Zonghui WANG | 2012 | Frontiers of Computer Science2012，6，1： | 45 |
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