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| 1 | A review on the eco-geography of soil fauna in China显示文摘这评论在过去的 30 年里在中国在土壤动物志 eco 地理总结主要研究调查结果。题目区域和主要结果是包括生物多样性和土壤动物志社区的 eco 地质的分发的 overviewed。在空间从的土壤动物志和动态范围的生态的分布的研究热带,对适度的区域副热带,并且在来自玷污环境的土壤动物志的森林,草地,沙漠,沼泽地,到城市的生态系统的农田,回答和指示的范畴。象火那样的集中的骚乱完成,放牧,耕作,土壤动物志上的授精包括敏感(例如线虫) 并且稀罕的组和社区索引。土壤动物志的功能包括环境建设,环境纯化,崽分解并且元素骑车被讨论。在在土壤生态系统的土壤动物志和另外的生物区系之间的相互作用并且连接在之间未葬、地下差异和在中国的土壤动物志社区上的全球变化的效果也被包括。最后,作者在土壤动物志指出了普通兴趣 eco 地理学习动物志 taxa,它包括分子生物学的申请进土壤;土壤动物志社区差异的功能和机制;在之间的相互作用未葬、地下生态系统;土壤动物志社区和功能上的骚乱,污染,生物侵略,和全球变化的效果。评论是为支持土壤动物志提供一个科学基础 eco 地理的在中国的研究。 | YIN Xiuqin SONG Bo DONG Weihua XIN Weidong WANG Yeqiao | 2010 | Journal of Geographical Sciences2010，20，3： | 93 |
| 2 | NK cell-based immunotherapy for malignant diseases显示文摘生来的杀手(NK ) 房间对癌症在主人免疫起关键作用。在反应,癌症开发机制逃离 NK 房间攻击或导致有缺点的 NK 房间。当前的 NK 基于房间的癌症免疫疗法试图用几条途径克服 NK 房间麻痹。一条途径使用扩展 allogeneic NK 房间,它没被象自体同源的 NK 房间一样的自我 histocompatibility 抗原禁止,为采纳细胞的免疫疗法。另一条采纳转移途径使用稳定的 allogeneic NK 房间线,它为质量控制和大规模生产是更实际的。第三条途径是新鲜 NK 房间或 NK 房间线的基因修正高度表示 cytokines, Fc 受体或妄想的肿瘤抗原受体。治疗学的 NK 细胞能从各种各样的来源被导出,包括细胞,干细胞或甚至导致的 pluripotent 干细胞( iPSCs ),和许多激发器能被用于的外设或绳索血在实验室或好生产实践( GMP )的大规模生产设备包括可溶的生长因素,使不能调动的分子或抗体,和另外的细胞的使活跃之物。到在临床的试用的癌症的对待几类型的 NK 房间治疗的一张表这里被考察。基于 NK 的免疫疗法的几条不同途径例如织物特定的 NK 房间,漂亮面向受体的 NK 房间和化学上对待的 NK 房间,被讨论。一些新技术或策略到由非侵略的成像的监视器 NK 房间治疗,预定 NK 房间治疗由的效率在 vivo 实验并且在临床的试用评估 NK 房间治疗途径也被介绍。 | Min Cheng Yongyan Chen Weihua Xiao Rui Sun Zhigang Tian | 2013 | Cellular & Molecular Immunology2013，10，3： | 61 |
| 3 | Epidemiology of fungal infections in China显示文摘与 immunocompromised 主人的增加的数字,真菌的感染的流行病学的特征经历了世界范围的庞大的变化,在中国包括。在这份报纸,我们越过中国在真菌病上考察了存在数据总结可得到的流行病学的侧面。我们发现在中国的表面的真菌的感染的一般发生是稳定的,但是癣 capitis 的发生减少了,传播线路变化了。由对比,侵略真菌的感染的全面发生继续升起了。candidemia 的出现由除 C 以外的 Candida 种类引起了。albicans 和不平常的 Candida 种类最近在中国增加了的包括的一些。曲霉属菌引起的感染也在最近的年里宣传了,特别地与 azole 抵抗的曲霉属菌 fumigatus 的出现。cryptococcosis 的一个增加的趋势在中国被注意了,与 Cryptococcus neoformans var。grubii 圣 5 遗传型作为占优势的病原体孤立。回顾的研究建议了在中国的 Pneumocystis 肺病的流行病学的特征可能类似于在另外的发展中的国家的那些。地方性的真菌的感染例如在东北中国的 sporotrichosis,必须引起研究,诊断,并且处理警戒。当前,在中国的真菌病上的流行病学的数据可变、碎片。因此,关于在中国的真菌的感染的全国流行病学的研究是对改进国家健康的重要需要。 | Min Chen Yuan Xu Nan Hong Yali Yang Wenzhi Lei Lin Du Jingjun Zhao Xia Lei Lin Xiong Langqi Cai Hui Xu Weihua Pan Wanqing Liao | 2018 | Frontiers of Medicine2018，12，1： | 49 |
| 4 | Nitric Oxide Signaling in Plant Responses to Abiotic Stresses显示文摘Nitric oxide (NO) plays important roles in diverse physiological processes in plants. NO can provoke both beneficial and harmful effects, which depend on the concentration and location of NO in plant cells. This review is focused on NO synthesis and the functions of NO in plant responses to abiotic environmental stresses. Abiotic stresses mostly induce NO production in plants. NO alleviates the harmfulness of reactive oxygen species, and reacts with other target molecules, and regulates the expression of stress responsive genes under various stress conditions. | Weihua Qiao Liu-Min Fan | 2008 | Journal of Integrative Plant Biology2008，50，10： | 33 |
| 5 | An improved algorithm for fluid-structure interaction of high-speed trains under crosswind显示文摘Based on the train-track coupling dynamics and high-speed train aerodynamics,this paper deals with an improved algorithm for fluid-structure interaction of high-speed trains.In the algorithm,the data communication between fluid solver and structure solver is avoided by inserting the program of train-track coupling dynamics into fluid dynamics program,and the relaxation factor concerning the load boundary of the fluid-structure interface is introduced to improve the fluctuation and convergence of aerodynamic forces.With this method,the fluid-structure dynamics of a highspeed train are simulated under the condition that the velocity of crosswind is 13.8 m/s and the train speed is 350 km/h.When the relaxation factor equals 0.5,the fluctuation of aerodynamic forces is lower and its convergence is faster than in other cases.The side force and lateral displacement of the head train are compared between off-line simulation and co-simulation.Simulation results show that the fluid-structure interaction has a significant influence on the aerodynamics and attitude of the head train under crosswind conditions.In addition,the security indexes of the head train worsen after the fluid-structure interaction calculation.Therefore,the fluid-structure interaction calculation is necessary for high-speed trains. | Tian LI Jiye ZHANG Weihua ZHANG | 2011 | Journal of Modern Transportation2011，19，2： | 29 |
| 6 | Isolation and Identification of Cancer Stem-Like Cells from Murine Melanoma Cell Lines显示文摘In current study,cancer stem-like cells in the murine melanoma B16F10 cells were investigated.CD phenotypes of the B16F10 cells were analyzed by flow cytometry,and the specific CD phenotype cells from the B16F10 cells were isolated by MACS.Then we used colony formation assay in soft agar media,the cell growth assay in serum-free culture media as well as the tumorigenicity investigation of the specific CD phenotype cells in C57BL/6 mice, respectively,to identify cancer stem-like cells in the B16F10 cells.The results showed that the B16F10 cells could form spherical clones in serum-free culture media,and the rate of clonegenesis of CD133 + ,CD44 + and CD44 + CD133 + cells was higher than that of CD133 - ,CD44 - and CD44 + CD133 - cells in soft agar media,respectively. The tumorigenic potential of CD133 + ,CD44 + ,CD44 + CD133 + cells and CD44 + CD133 + CD24 + cells was stronger than that of CD133 - ,CD44 - ,CD44 + CD133 - cells and CD44 + CD133 + CD24 - cells in mice,respectively.In conclusion,the CD44 + CD133 + CD24 + cells have some biological properties of cancer stem-like cells or are highly similar to the characteristics of cancer stem cells(CSC).These results provide an important method for identifying cancer stem-like cells in B16F10 cells and for further cancer target therapy. | Jun Dou Meng Pan Ping Wen Yating Li Quan Tang Lili Chu Fengshu Zhao Chuilian Jiang Weihua Hu Kai Hu Ning Gu | 2007 | Cellular & Molecular Immunology2007，4，6： | 25 |
| 7 | Performance of the Seasonal Forecasting of the Asian Summer Monsoon by BCC_CSM1.1(m)显示文摘This paper provides a comprehensive assessment of Asian summer monsoon prediction skill as a function of lead time and its relationship to sea surface temperature prediction using the seasonal hindcasts of the Beijing Climate Center Climate System Model, BCC CSM1.1(m). For the South and Southeast Asian summer monsoon, reasonable skill is found in the model's forecasting of certain aspects of monsoon climatology and spatiotemporal variability. Nevertheless, deficiencies such as significant forecast errors over the tropical western North Pacific and the eastern equatorial Indian Ocean are also found. In particular, overestimation of the connections of some dynamical monsoon indices with large-scale circulation and precipitation patterns exists in most ensemble mean forecasts, even for short lead-time forecasts.Variations of SST, measured by the first mode over the tropical Pacific and Indian oceans, as well as the spatiotemporal features over the Ni no3.4 region, are overall well predicted. However, this does not necessarily translate into successful forecasts of the Asian summer monsoon by the model. Diagnostics of the relationships between monsoon and SST show that difficulties in predicting the South Asian monsoon can be mainly attributed to the limited regional response of monsoon in observations but the extensive and exaggerated response in predictions due partially to the application of ensemble average forecasting methods. In contrast, in spite of a similar deficiency, the Southeast Asian monsoon can still be forecasted reasonably, probably because of its closer relationship with large-scale circulation patterns and El Nino–Southern Oscillation. | LIU Xiangwen WU Tongwen YANG Song JIE Weihua NIE Suping LI Qiaoping CHENG Yanjie LIANG Xiaoyun | 2015 | Advances in Atmospheric Sciences2015，32，8： | 25 |
| 8 | Characterization of personal exposure concentration of fine particles for adults and children exposed to high ambient concentrations in Beijing, China显示文摘In China, the health risk from overexposure to particles is becoming an important public health concern. To investigate daily exposure characteristics to PM 2.5 with high ambient concentration in urban area, a personal exposure study was conducted for school children, and office workers in Beijing, China. For all participants (N = 114), the mean personal 24-hr exposure concentration was 102.5, 14.7, 0.093, 0.528, 0.934, 0.174 and 0.703 μg/m 3 for PM 2.5 , black carbon, Mn, Al, Ca, Pb, and Fe. Children's exposure concentrations of PM 2.5 were 4-5 times higher than those in related studies. The ambient concentration of PM 2.5 (128.5 μg/m 3 ) was significantly higher than the personal exposure concentration (P < 0.05), and exceed the reference concentration (25 μg/m 3 ) of WHO air quality guideline. Good correlation relationships and significant differences were identified between ambient concentration and personal exposure concentration. The relationships indicate that the ambient concentration is the main factor influencing personal exposure concentration, but is not a good indicator of personal exposure concentration. Outdoor activities (commute mode, exposure to heating, workday or weekend travel) influenced personal exposure concentrations significantly, but the magnitude of the influence from indoor activities (exposure to cooking) was masked by the high ambient concentrations. | Xuan Du Qian Kong Weihua Ge Shaojun Zhang Lixin Fu | 2010 | Journal of Environmental Sciences2010，22，11： | 24 |
| 9 | Leaf morphology correlates with water and light availability:What consequences for simple and compound leaves?显示文摘叶子是对在进化的过程的环境变化敏感的机关并且可以作为对不能生活的应力的回答展出 phenotypic 粘性。然而,叶的肯定在不同环境的词法粘性和它的规定仍然是不清楚的。我们执行了一个模仿的实验在水和轻可获得性的不同坡度学习叶形态学的变化。就叶子和脉络的不同类型而言,当学习反对,我们选择了 Quercus acutissima 的羽状静脉的简单叶子和 Robinia 假相思树的复合叶子。我们调查了的词法参数包括能容易在这个领域里被测量的叶尺寸,形状和脉络模式。重要变化由于环境或异速生长的效果发生在许多参数。为叶有广泛地一致的趋势沿着坡度的词法变化。叶尺寸与资源的短供应变得更小。薄板区域的叶延伸和部分改变了提高资源获得和保存。在在支持和功能的结构的投资之间的交易优化了主要、次要的静脉的脉络模式。传单部分起了象叶牙齿那样的一个作用因为他们是复合的叶的不仅单个单位,而且部分。我们差不多建议那在词法变化的一样的趋势可以是重要解释让共存的种类适应类似的产地并且形成壁龛区别。 | Fei Xu Weihua Guo Weihong Xu Yinghua Wei Renqing Wang | 2009 | Progress in Natural Science:Materials International2009，19，12： | 22 |
| 10 | Cardiotoxicity of 5-fluorouracil and capecitabine in Chinese patients: a prospective study显示文摘Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in Chinese patients with malignant diseases has not been investigated to date.In the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in China.Methods:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 331 received capecitabine-based chemotherapy as either first-line or adjuvant therapy.Adverse events were reported during the treatment and up to 28 days of follow-up.Outcome measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and echocardiography.Univariate analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both agents.Results:In total,161 of 527 patients(30.6%)experienced cardiotoxicity.The incidence rate of cardiotoxicity was 33.8%(112/331)in the capecitabine group,which was significantly higher than the rate of 25%(49/196)in the 5-FU group(P=0.0042).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial infarction.Pre-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with cardiotoxicity.The odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4 chemotherapy cycles)and 1.58(hypertension versus no hypertension),respectively.Conclusions:Cardiotoxicity induced by fluoropyrimidines in the Chinese population may be underestimated in clini-cal practice.Close monitoring of patients is recommended,especially for those patients at high risk for cardiotoxicity.Possible risk factors are duration of treatment,capecitabine-based chemotherapy,pre-existing cardiac diseases and hypertension.Trial registration This study was initiated on January 22,2014 and has been retrospectively registered with the registra-tion number ChiCTR1800015434 . | Jianjun Peng Chao Dong Chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo Zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen | 2018 | Cancer Communications2018，38，1： | 23 |
| 11 | Dynamics and Relationships of Ca,Mg,Fe in Litter,Soil Fauna and Soil in Pinus koraiensis-Broadleaf Mixed Forest显示文摘The Liangshui Natural Reserve in Heilongjiang Province of China was selected as the study area. The authors collected the samples of forest litter (Tilia amurensis, Fraxinus mandshurica, Pinus koraiensis, Acer mono, Betula costata, and mixed litter), soil in humus horizon (0-5cm) and soil horizon (5-20cm), and soil macrofauna (Oli-gochaeta, Geophiloporpha and Juliformia) from 2001 to 2002. The role of soil macrofauna in the material cycle was analyzed through comparing the macro-element contents among various parts of the subsystems and using enrichment index (EI). The results indicate that dynamic changes of various litters are very complicated. The contents of Fe in each kind of litter increase firstly, and then decrease in the study period. The changes of macro-element contents are greater in the broad-leaf litter than in the coniferous litter, and the mixed litter is in the middle level, but the differences among them are not significant. The contents of Mg and Fe in humus are higher than those in soil, but the contents of Ca in soil are higher than that in humus. The dynamic changes of macro-element contents in soil and soil fauna are not consistent with those in litter. The diplopod presented obvious enrichment of Ca and Mg (EI>1), but it does not significantly enrich Fe. Earthworm has a stronger enrichment ability of Fe than diplopod and scolopendra, but EI<1. Soil fauna can make great influences on the material cycle of the subsystems. | SONG Bo YIN Xiuqin ZHANG Yu DONG Weihua | 2008 | Chinese Geographical Science2008，18，3： | 21 |
| 12 | Angles-only initial relative orbit determination algorithm for noncooperative spacecraft proximity operations显示文摘This research furthers the development of a closed-form solution to the angles-only initial relative orbit determination problem for non-cooperative target close-in proximity operations when the camera offset from the vehicle center-of-mass allows for range observability.In previous work,the solution to this problem had been shown to be non-global optimal in the sense of least square and had only been discussed in the context of Clohessy–Wiltshire.In this paper,the emphasis is placed on developing a more compact and improved solution to the problem by using state augmentation least square method in the context of the Clohessy–Wiltshire and Tschauner–Hempel dynamics,derivation of corresponding error covariance,and performance analysis for typical rendezvous missions.A two-body Monte Carlo simulation system is used to evaluate the performance of the solution.The sensitivity of the solution accuracy to camera offset,observation period,and the number of observations are presented and discussed. | Baichun Gong Wendan Li Shuang Li Weihua Ma Lili Zheng | 2018 | Astrodynamics2018，2，3： | 20 |
| 13 | Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines显示文摘Hepatitis B virus(HBV) infection is one of the most serious and prevalent viral diseases in the world. Although several anti-HBV drugs have been used clinically, their side and adverse effects limit treatment efficacy. Therefore, it is necessary to identify novel potential anti-HBV agents. The flavonol quercetin has shown activity against some retroviruses, but its effect on HBV remains unclear. In the present study, quercetin was incubated with Hep G2.2.15 cells, as well as Hu H-7 cells transfected with an HBV plasmid. Quercetin was shown to significantly reduce Hepatitis B surface antigen(HBs Ag) and Hepatitis B e antigen(HBe Ag), secretion and HBV genomic DNA levels in both cell lines. In addition, co-incubation with lamivudine(3TC), entecavir(ETV), or adefovir(Ade) further enhanced the quercetin-induced inhibition of HBV replication. This inhibition was partially associated with decreased heat shock proteins and HBV transcription levels. The results indicate that quercetin inhibited HBV antigen secretion and genome replication in human hepatoma cell lines, which suggests that quercetin may be a potentially effective anti-HBV agent. | Zhikui Cheng Ge Sun Wei Guo Yayun Huang Weihua Sun Fei Zhao Kanghong Hu | 2015 | Virologica Sinica2015，30，4： | 20 |
| 14 | Advances in NF-κB Signaling Transduction and Transcription显示文摘The molecular mechanisms for NF-κB signaling transduction and transcription have been the most attractive subjects for both basic research and pharmaceutical industries due to its important roles in both physiological and pathogenesis, particularly the close association of dysregulated NF-κB with tumorgenesis and inflammation. Several novel intracellular molecular events that regulate NF-κB activity have been described recently, including the discovery of an alternative signaling pathway that appears inducing a specific subset genes involved in adoptive immune response. Multi-level and multi-dimensional regulation of NF-κB activity by phosphorylation and acetylation modifications have unveiled and became the hottest targets for potentially tissue specific molecular interventions. Another emerging mechanism for NF-κB-responsive gene's regulation where NF-κB participates the transcriptional regulation independent of its cognate regulatory binding site within the target gene's promoter but facilitating the transaction activity of other involved transcription factors,that implicated an novel transcriptional activities for NF-κB. Thus, the current review will focus on these recent progresses that have been made on NF-κB signaling transduction and transcription. Cellular & Molecular Immunology. 2004;1(6):425-435. | Weihua Xiao~1 1 University of Science and Technology of China,China.2 Laboratory of Molecular Immunoregulation,NCI-Frederick,Frederick.MD 21702.USA. | 2004 | Cellular & Molecular Immunology2004，1，6： | 20 |
| 15 | Genome-scale detection of hypermethylated CpG islands in circulating cell-free DNA of hepatocellular carcinoma patients显示文摘 | Lu Wen Jingyi Li Huahu Guo Xiaomeng Liu Shengmin Zheng Dafang Zhang Weihua Zhu Jianhui Qu Limin Guo Dexiao Du Xiao Jin Yuhao Zhang Yun Gao Jie Shen Hao Ge Fuchou Tang Yanyi Huang Jirun Peng | 2015 | Cell Research2015，25，11： | 19 |
| 16 | Soil pH impact on microbial tetraether lipids and terrestrial input index (BIT) in China显示文摘The distributions of microbial tetraether lipids i.e. glycerol dialkyl glycerol tetraethers (GDGTs) were investigated in a variety of Chinese soils featured by a wide range of pH values in different climate zones. The bacterial branched GDGTs and archaeal isoprenoid GDGTs were found to be widely distributed in Chinese soils and their relative abundance was controlled primarily by soil pH. The bacterial bGDGTs usually dominate over archaeal iGDGTs in abundance when the soil pH is below 8.0. However archaeal iGDGTs become dominant and the abundance of halophilic archaea characterized by GDGT V without cyclopentyl ring increases dramatically in the alkaline soil with pH greater than 8.0. The relative abundance of archaeal iGDGTs to bacterial bGDGTs was defined here as RAI index. The RAI index decreases with elevated soil pH and a linear correlation is found between them indicating that the relative abundance of archaeal iGDGTs to bacterial bGDGTs increases with increased pH. The RAI index thus could be a novel proxy of the pH values of paleosol. The terrestrial input index BIT (Branched and Isoprenoid Tetraethers Index) decreases with increased soil pH suggesting that soil pH should be taken into consideration when the terrestrial contribution to marine sediments is estimated by BIT index. Moreover the TEX86 index cannot be used to reconstruct sea surface temperature in the sediments featured by a large terrestrial input. | YANG Huan DING WeiHua WANG JinXiang JIN ChengSheng HE GangQiang QIN YangMin XIE ShuCheng | 2012 | Science China Earth Sciences2012，55，2： | 19 |
| 17 | Types and Characteristics of Volcanostratigraphic Boundaries and Their Oil-Gas Reservoir Significance显示文摘Just like in sedimentary stratigraphy, the volcanostratigraphic boundary is an important factor for constructing volcanostratigraphic framework. The fundamental factor of volcanostratigraphic boundaries is to classify the types and define their characteristics. Based on field investigation and cross-wells section analysis of Mesozoic volcanostratigraphy in NE China, 5 types of volcanostratigraphic boundaries have been recognized, namely eruptive conformity boundary(ECB), eruptive unconformity boundary(EUB), eruptive interval unconformity boundary(EIUB), tectonic unconformity boundary(TUB) and intrusive contacts boundary(ICB). Except ICB, the unconformity boundaries can be divided into angular unconformity and paraconformity. The time spans and signs of these boundaries are analyzed by using age data of some volcanic fields that have been published. The time spans of ECB and EUB are from several minutes to years. In lava flows, cooling crust is distributed above and below ECB and EUB; in pyroclastic flows, airfalls and lahars, a fine layer below these boundaries has no discernable erosion at every part of the boundary. EUB may be curved or cross curved and jagged. The scale of ECB/EUB is dependent on the scale of lava flow or pyroclastic flows. The time span of EIUB is from decades to thousands of years. There is also weathered crust under EIUB and sedimentary rock beds overlie EIUB. In most instances, weathered crust and thin sedimentary beds are associated with each other laterally. The boundary is a smooth curved plane. The scale of EIUB is dependent on the scale of the volcano or volcano groups. The characteristics of TUB are similar to EIUB's. The time interval of TUB is from tens of thousands to millions of years. The scale of TUB depends on the scale of the basin or volcanic field. Both the lab data and logging data of wells in the Songliao Basin reveal that the porosity is greatly related to the boundaries in the lava flows. There is a high-porosity belt below ECB, EUB or EIUB, and the porosity decreases when it is apart from the boundary. The high-porosity belt below ECB and EUB is mainly contributed by primary porosity, such as vesicles. The high-porosity belt below EIUB is mainly contributed by primary and secondary porosity, such as association of vesicles and spongy pores, so the area near the boundary in lava flows is a very important target for reservoirs. | TANG Huafeng Phiri CRYTON GAO Youfeng HUANG Yulong BIAN Weihua | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 18 |
| 18 | Growth-associated protein 43 and neural cell adhesion molecule expression following bone marrow-derived mesenchymal stem cell transplantation in a rat model of ischemic brain injury显示文摘BACKGROUND:Transplantation of bone marrow-derived mesenchymal stem cells(BMSCs) improves motor functional recovery,but the mechanisms remain unclear.OBJECTIVE:To investigate expression of growth-associated protein 43(GAP-43) and neural cell adhesion molecule following BMSC transplantation to the lateral ventricle in rats with acute focal cerebral ischemic brain damage.DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment using immunohistochemistry was performed at the laboratories of Department of Neurology,Renmin Hospital of Wuhan University and Doctoral Scientific Research Work Station of C-BONS PHARMA,Hubei Province,China,from January 2007 to December 2008.MATERIALS:Monoclonal mouse anti-rat 5-bromo-2-deoxyuridine and neural cell adhesion molecule antibodies were purchased from Sigma,USA;monoclonal mouse anti-rat GAP-43 antibody was purchased from Wuhan Boster,China.METHODS:Rat models of right middle cerebral artery occlusion were established using the thread method.At 1 day after middle cerebral artery occlusion,20 μL culture solution,containing 5 × 105 BMSCs,was transplanted to the left lateral ventricle using micro-injection.MAIN OUTCOME MEASURES:Scores of neurological impairment were measured to assess neural function.Expression of GAP-43 and neural cell adhesion molecule at the lesion areas was examined by immunohistochemistry.RESULTS:GAP-43 and neural cell adhesion molecule expression was low in brain tissues of the sham-operated group,but expression increased at the ischemic boundary(P < 0.05).Transplantation of BMSCs further enhanced expression of GAP-43 and neural cell adhesion molecule(P < 0.05) and remarkably improved neurological impairment of ischemic rats(P < 0.05).CONCLUSION:BMSC transplantation promoted neurological recovery in rats by upregulating expression of GAP-43 and neural cell adhesion molecule. | Yu Peng Qimei Zhang Hui You Weihua Zhuang Ying Zhang Chengyan Li | 2010 | Neural Regeneration Research2010，5，13： | 18 |
| 19 | LPI radar signal detection based on radial integration of Choi-Williams time-frequency image显示文摘This paper mainly revolves the time-frequency image of low probability of intercept(LPI) radar signals and carries out research work on image features selection and extraction and recognition. Since Choi-Williams distribution(CWD) uses the exponential kernel of bilinear generalized class of time-frequency distribution, it has an excellent time-frequency aggregation. And it is suitable for detecting LPI radar signals in a low signal-to-noise ratio(SNR) condition. A radial integration method based on the integral rotating factor is proposed to detect LPI radar signals when the signals' time-frequency image is obtained. First, the digital image processing method is used to preprocess the LPI radar signals' time-frequency images after CWD transformation; then, the radial integration method based on the integral rotating factor is used to detect LPI radar signals in the binary images. The analytic results of real data show that the method has a good performance on detecting LPI radar signals in a low SNR condition. Additionally,the method is simple and takes less logic resources and has the potential of real-time detection of LPI radar signals. | Yongjian Liu Peng Xiao Hongchao Wu Weihua Xiao | 2015 | Journal of Systems Science & Complexity2015，28，5： | 18 |
| 20 | Chinese urbanization 2050: SD modeling and process simulation显示文摘Is Chinese urbanization going to take a long time, or can its development goal be achieved by the government in a short time? What is the highest stable urbanization level that China can reach? When can China complete its urbanization? To answer these questions, this paper presents a system dynamic(SD) model of Chinese urbanization, and its validity and simulation are justified by a stock-flow test and a sensitivity analysis using real data from 1998 to 2013. Setting the initial conditions of the simulation by referring to the real data of 2013, the multi-scenario analysis from 2013 to 2050 reveals that Chinese urbanization will reach a level higher than 70% in 2035 and then proceed to a slow urbanization stage regardless of the population policy and GDP growth rate settings; in 2050, Chinese urbanization levels will reach approximately 75%, which is a stable and equilibrium level for China. Thus, it can be argued that Chinese urbanization is a long social development process that will require approximately20 years to complete and that the ultimate urbanization level will be 75–80%, which means that in the distant future, 20–25% of China's population will still settle in rural regions of China. | GU ChaoLin GUAN WeiHua LIU HeLin | 2017 | Science China Earth Sciences2017，60，6： | 16 |
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