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| 1 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 2 | 城市交通控制的演变——政策与技术变更显示文摘在过去的一个世纪里,城市交通控制始终在演变,以适应日益复杂的政策目标和不断增长的交通需求。一个高效的交通控制系统可以带来很多收益,例如缓解拥堵、提高经济效益以及改善道路安全和空气质量。车辆检测和通信技术方面取得的显著进步为交通控制系统的调控能力带来了一系列阶段性变化:从早期(固定配时)信号控制发展到现代化的集成系统。多种类型的交通控制系统在全球不同地区建设完成,每种系统都有各自的优势和不足。首先通过对比分析目前占据领先地位的商用系统(以及一些较少为人所知的系统),凸显交通控制系统的关键特征和差异,然后评估目前的交通控制系统是否能实现现代交通政策的职能和需求。最后,探讨了当前及未来的交通政策,以及未来10年交通控制发展的技术性蓝图,指出交通控制有望通过技术进步从有限数据时代迈入大数据时代。 | Andrew Hamilton Ben Waterson Tom Cherrett Andrew Robinson Ian Snell 王金秋 | 2014 | 城市交通2014，12，5： | 3 |
| 3 | A Prospective Randomized Trial of Intravitreal B evacizumab o r L aser T herapy in the Management of Diabetic Macular Edema (BOLT Study)显示文摘 | Michel Michaelides Andrew Kaines Robin D. Hamilton Samantha Fraser-Bell Ranjan Rajendram Fahd Quhill Christopher J. Boos Wen Xing Catherine Egan Tunde Peto Catey Bunce R. David Leslie Philip G. Hykin | 2010 | Ophthalmology2010，，6： | 2 |
| 4 | Compact Hilbert indices: Space-filling curves for domains with unequal side lengths显示文摘 | Chris H. Hamilton Andrew Rau-Chaplin | 2007 | Information Processing Letters2007，，5： | 1 |
| 5 | A probabilistic quantitative microbial risk assessment model of norovirus disease burden from wastewater irrigation of vegetables in Shepparton, Australia显示文摘 | Hoi-Fei Mok S.Fiona Barker Andrew J. Hamilton | 2014 | Water Research2014，，： | 1 |
| 6 | Left Ventricular Thrombus Enhancement After Intravenous Injection of Echogenic Immunoliposomes: Studies in a New Experimental Model显示文摘 | Andrew Hamilton Shao-Ling Huang Drew Warnick Adam Stein Mark Rabbat Taruna Madhav Bonnie Kane Ashwin Nagaraj Melvin Klegerman Robert MacDonald David McPherson | 2002 | Circulation: Journal of the American Heart Association2002，，23： | 1 |
| 7 | 925j Optimising post-operative Crohn’s disease management: best drug therapy alone versus colonoscopic monitoring with treatment step-up. The POCER study.显示文摘 | Peter De Cruz Michael A. Kamm Amy L. Hamilton Kathryn J. Ritchie Soula Krejany Alexandra Gorelik Danny Liew Lani Prideaux Ian C. Lawrance Jane M. Andrews Peter A. Bampton Miles Sparrow Timothy H. Florin Peter R. Gibson Henry Debinski Richard B. Gearry Fin | 2013 | Gastroenterology2013，，5： | 1 |
| 8 | In Vivo Molecular Imaging of Acute and Subacute Thrombosis Using a Fibrin-Binding Magnetic Resonance Imaging Contrast Agent显示文摘 | René M. Botnar Alexandra S. Perez Sonia Witte Andrea J. Wiethoff James Laredo James Hamilton William Quist Edward C. Parsons Anand Vaidya Andrew Kolodziej John A. Barrett Philip B. Graham Robert M. Weisskoff Warren J. Manning Michael T. Johnstone | 2004 | Circulation: Journal of the American Heart Association2004，，16： | 1 |
| 9 | Quantitative immunoblot assay for assessment of liposomal antibody conjugation efficiency 显示文摘 | Klegerman Melvin E Hamilton Andrew J Huang Shao-ling | 2002 | Analytical Biochemistry2002，300，： | 1 |
| 10 | A transgene with repeated DNA causes high frequency, post- transcriptional suppression of ACC-oxidase gene expression in tomato显示文摘 | Andrew J Hamilton Stephen Brown Han Yuanhai | 1998 | Plant Journal1998，15，6： | 1 |
| 11 | Arrhythmia and Mortality After the Mustard Procedure: A 30-Year Single-Center Experience显示文摘 | Mark Gelatt Robert M Hamilton Brian W McCrindle Michael Connelly Andrew Davis Louise Harris Robert M Gow William G Williams George A Trusler Robert M Freedom | 1997 | Journal of the American College of Cardiology1997，，1： | 1 |
| 12 | The potential of handheld trauma sonography in the air medical transport of the trauma victim显示文摘 | Andrew W. Kirkpatrick Karen Breeck Julielynn Wong Douglas R. Hamilton Paul B. McBeth Bruce Sawadsky Mike J. Betzner | 2005 | Air Medical Journal2005，，： | 1 |
| 13 | FAST at MACH 20: Clinical Ultrasound Aboard the International Space Station显示文摘 | Ashot E. Sargsyan Douglas R. Hamilton Jeffrey A. Jones Shannon Melton Peggy A. Whitson Andrew W. Kirkpatrick David Martin Scott A. Dulchavsky | 2005 | The Journal of Trauma: Injury, Infection, and Critical Care2005，，： | 1 |
| 14 | Gastric Cancer: Establishing Predictors of Biologic Behavior with Use of Population-Based Data显示文摘 | B. J. Dicken MD L. D. Saunders PhD G. S. Jhangri MSc C. Gara FRCSC C. Cass PhD S. Andrews MD S. M. Hamilton FRCSC | 2004 | Annals of Surgical Oncology2004，，6： | 1 |
| 15 | Prospective Evaluation of Thoracic Ultrasound in the Detection of Pneumothorax显示文摘 | Scott A. Dulchavsky Karl L. Schwarz Andrew W. Kirkpatrick Roger D. Billica David R. Williams Lawrence N. Diebel Mark R. Campbell Ashot E. Sargysan Douglas R. Hamilton | 2001 | The Journal of Trauma: Injury, Infection, and Cri2001，，： | 1 |
| 16 | Transgenic potato plants with enhanced resistance to the peach-potato aphid Myzus persicae显示文摘 | Angharad M. R. Gatehouse Rachel E. Down Kevin S. Powell Nicolas Sauvion Yvan Rahbé Christine A. Newell Andrew Merryweather William D. O. Hamilton John A. Gatehouse | 1996 | Entomologia Experimentalis et Applicata1996，，3： | 1 |
| 17 | Sensitivity of maize hybrids to chilling and their combining abilities at two developmental stages显示文摘 | Hodges D M Andrews C J Johnson D A Hamilton R I | 1997 | Crop Science1997，，37： | 1 |
| 18 | Antioxidant enzyme and compound respones to chilling stress and their combining abilities in differentially sensitive maize hybrids显示文摘 | Hodges D M Andrews C J Johnson D A Hamilton R I | 1997 | Crop Science1997，，37： | 1 |
| 19 | A Systematic Review and Meta-Analysis on the Use of Preemptive Hemodynamic Intervention to Improve Postoperative Outcomes in Moderate and High-Risk Surgical Patients显示文摘 | Mark A. Hamilton Maurizio Cecconi Andrew Rhodes | 2011 | Anesthesia & Analgesia2011，，6： | 1 |
| 20 | A Prospective Randomized Trial of Intravitreal B evacizumab o r L aser T herapy in the Management of Diabetic Macular Edema (BOLT Study)显示文摘 | Michel Michaelides Andrew Kaines Robin D. Hamilton Samantha Fraser-Bell Ranjan Rajendram Fahd Quhill Christopher J. Boos Wen Xing Catherine Egan Tunde Peto Catey Bunce R. David Leslie Philip G. Hykin | 2010 | Ophthalmology2010，，6： | 1 |
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