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| 1 | 神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐显示文摘目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。 | Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti Pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-Martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon Jean-Francois Payen Anders Perner Martin Smith Jose Suarez Walter Videtta Elisa R. Zanier Giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) | 2019 | 国际脑血管病杂志2019，27，2： | 4 |
| 2 | Pancreatic cancer stem cells:Perspectives on potential therapeutic approaches of pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma is one of the most aggressive solid tumours of the pancreas, characterised by a five-year survival rate less than 8%. Recent reports that pancreatic cancer stem cells(PCSCs) contribute to the tumorigenesis, progression, and chemoresistance of pancreatic cancer have prompted the investigation of new therapeutic approaches able to directly target PCSCs. In the present paper the non-cancer related drugs that have been proposed to target CSCs that could potentially combat pancreatic cancer are reviewed and evaluated. The role of some pathways and deregulated proteins in PCSCs as new therapeutic targets are also discussed with a focus on selected specific inhibitors. Finally, advances in the development of nanoparticles for targeting PCSCs and site-specific drug delivery are highlighted, and their limitations considered. | Claudia Di Carlo Jessica Brandi Daniela Cecconi | 2018 | World Journal of Stem Cells2018，10，11： | 3 |
| 3 | The role of transthoracic echocardiography in the diagnosis and management of acute type A aortic syndrome显示文摘 | Moreno Cecconi Fabio Chirillo Carlo Costantini Gianfranco Iacobone Ercole Lopez Raffaele Zanoli Alberto Gili Stefano Moretti Marcello Manfrin Christopher Münch Lucia Torracca Gian Piero Perna | 2012 | American Heart Journal2012，，1： | 2 |
| 4 | Proteomic changes involved in tenderization of bovine Longissimus dorsi muscle during prolonged ageing显示文摘 | Rita Polati Michele Menini Elisa Robotti Renato Millioni Emilio Marengo Enrico Novelli Stefania Balzan Daniela Cecconi | 2012 | Food Chemistry2012，，3： | 2 |
| 5 | Apoptosis-inducing factor (AIF):key to the conserved caspase-independent pathways of cell death 显示文摘 | Cande C Cecconi F Dessen P | 2002 | J Cell Sci2002，115，： | 1 |
| 6 | I)efin- ing and Identifying Communities in Networks 显示文摘 | Radicchi F Castellano C Cecconi F el al | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，9： | 1 |
| 7 | Hepatocellular carcinoma: long-term results of combined treatment with laser thermal ablation and transcatheter arterial chemoembolization 显示文摘 | Paeella CM Bizzarri G Cecconi P | 2001 | Radiology2001，219，3： | 1 |
| 8 | In vitro development of sheep preantral follicles显示文摘 | Cecconi S Barboni B Coccia M | 1999 | Biol Reprod1999，60，： | 1 |
| 9 | Defining and identifying communities in networks显示文摘 | RADICCHI F CASTELLANO C CECCONI F | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，9： | 1 |
| 10 | Minimally invasive haemodynamic monitoring显示文摘 | Christoph K Hofer Maurizio Cecconi Gernot Marx Giorgio della Rocca | 2009 | European Journal of Anaesthesiology2009，，12： | 1 |
| 11 | AJ3 toxicity in Alzheimer's disease显示文摘 | CAVALLUCCI V D' AMELIO M CECCONI F | 2012 | Mol Neurob2012，45，2： | 1 |
| 12 | cell makeover rather than cell death显示文摘 | Cecconi F Levine B The role of autophagy in mammalian develop-ment | 2008 | Dev Cell2008，15，： | 1 |
| 13 | Exploring the hidden human urinary proteome via ligand library beads显示文摘 | Castagna A Cecconi D Sennels L | 2005 | J Proteome Res2005，4，6： | 1 |
| 14 | Hepatocelluar carcinoma:long term result of combined treatment with laser thermal ablation and transcatheter arterial chemoembolization显示文摘 | PACELLA C M BIZZARRI G CECCONI P | 2001 | Radiology2001，219，3： | 1 |
| 15 | Adaptive Zooming in Web Cartography显示文摘 | Cecconi A Galanda M | 2002 | Computer Graphics Forum2002，21，： | 1 |
| 16 | Effect of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Polypeptide on Mouse Preantral Follicle Development in Vitro显示文摘 | Cecconi S Rossi G Barberi M | 2004 | Endocrinol2004，145，4： | 1 |
| 17 | Defining and identifying communities in networks显示文摘 | RADICCHI F CASTELLANO C CECCONI F | 2004 | Proceedings of the National Academy of Sciences2004，101，9： | 1 |
| 18 | Defining and Identi- fying Communities in Networks显示文摘 | Radicchi F Castellano C Cecconi F | 2004 | Proceedings of the Na- tional Academy of Science2004，101，9： | 1 |
| 19 | Defining and identifying communities in networks显示文摘 | Radicchi F Castellano C Cecconi F | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，： | 1 |
| 20 | The apoptosome:emerging insights and new potential targets for drug design显示文摘 | D'Amelio M Tino E Cecconi F | 2010 | Pharm Res2010，25，4： | 1 |
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