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| 1 | Association of extraintestinal manifestations of inflammatory bowel disease in a province of western Hungary with disease phenotype:Results of a 25-year follow-up study显示文摘IBD is a systemic disease associated with a large number of extraintestinal manifestations (EIMs). Our aim was to determine the prevalence of EIMs in a large IBD cohort in Veszprem Province in a 25-year follow-up study.METHODS: Eight hundred and seventy-three IBD patients were enrolled (ulcerative colitis/UC/: 619, m/f: 317/302,mean age at presentation: 38.3 years, average disease duration: 11.2 years; Crohn's disease/CD/: 254, m/f: 125/129,mean age at presentation: 32.5 years, average disease duration: 9.2 years). Intestinal, extraintestinal signs and laboratory tests were monitored regularly. Any alteration suggesting an EIMs was investigated by a specialist.RESULTS: A total of 21.3% of patients with IBD had EIM (UC: 15.0%, CD: 36.6%). Age at presentation did not affect the likelihood of EIM. Prevalence of EIMs was higher in women and in CD, ocular complications and primary sclerosing cholangitis (PSC) were more frequent in UC. In UC there was an increased tendency of EIM in patients with a more extensive disease.Joint complications were more frequent in CD (22.4% VS UC 10.2%, P<0.01). In UC positive family history increased the risk of joint complications (OR:3.63). In CD the frequency of type-1 peripheral arthritis was increased in patients with penetrating disease (P=0.028). PSC was present in 1.6% in UC and 0.8% in CD. Dermatological complications were present in 3.8% in UC and 10.2% in CD, the rate of ocular complications was around 3% in both diseases. Rare complications were glomerulonephritis, autoimmune hemolytic anaemia and celiac disease.CONCLUSION: Prevalence of EIM in Hungarian IBD patients is in concordance with data from Western countries. The high number of EIM supports a role for complex follow-up in these patients.ACKNOWLEDGEMENTDr. Zsuzsanna Erdelyi, Dr. Agnes Horvath, Dr Gabor Mester (Veszprem), Dr. Sandor Meszaros (Ajka), Dr. Csaba Molnar help in data collection and to Gabriella Demenyi for technical assistance. | Laszlo Lakatos Tunde Pandur Gyula David Zsuzsanna Balogh Pal Kuronya Arpad Tollas Peter Laszlo Lakatos | 2003 | World Journal of Gastroenterology2003，9，10： | 25 |
| 2 | 丛枝菌根真菌对番茄苗期生长及矿质营养吸收的作用显示文摘以烘干粉碎后的秸秆与灭菌后的土壤配制成栽培基质,接种5种丛枝菌根菌种接种剂进行番茄栽培试验。结果表明,各种丛枝菌根共生微生物接种后对番茄幼苗生长发育和矿质元素吸收有很好的改善和促进作用,特别是对P、K吸收作用显著,对番茄干质量有明显增加作用。通过对番茄菌根侵染情况分析发现根部丛枝菌根侵染率(F)以Glomusmosseae-1和G.mosseae-2最高,可达30%以上,而丛枝菌根形成率(a)则以G.mosseae-2最高,促进番茄生长效果最好的菌种亦为G.mosseae-2。 | 贺超兴 张志斌 王怀松 Tunde Takacs Attila AntonTun | 2006 | 中国蔬菜2006，，1： | 21 |
| 3 | 丛枝菌根真菌对番茄渗透调节物质含量的影响显示文摘采用盆栽试验研究了不同浓度NaCl(0.5%和1%)胁迫下,接种丛枝菌根真菌(AMF)对番茄生长和渗透调节物质含量的影响。结果表明:盐胁迫下,与未接菌番茄相比,接种AMF番茄能显著增加植株的生长,促进叶片和根系可溶性糖的积累,增加叶片可溶性蛋白含量及根系脯氨酸含量,使植株耐盐能力增强。接菌株可溶性糖及可溶性蛋白的增加以及根系脯氨酸的大量积累在AMF提高番茄耐盐的渗透调节机制中具有重要的作用。 | 贺忠群 贺超兴 张志斌 邹志荣 王怀松 TUNDE Takacs | 2007 | 园艺学报2007，34，1： | 18 |
| 4 | Perianal disease,small bowel disease,smoking,prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn's disease显示文摘AIM:To assess the combined effect of disease phenotype, smoking and medical therapy [steroid, azathioprine(AZA), AZA/biological therapy] on the probability of disease behavior change in a Caucasian cohort of patients with Crohn's disease(CD).METHODS:Three hundred and forty well-characterized, unrelated, consecutive CD patients were analyzed(M/F:155/185, duration:9.4 ± 7.5 years) with a complete clinical follow-up.Medical records including disease phenotype according to the Montreal classification, extraintestinal manifestations, use of medications and surgical events were analyzed retrospectively.Patients were interviewed on their smoking habits at the time of diagnosis and during the regular follow-up visits.RESULTS:A change in disease behavior was observed in 30.8% of patients with an initially non-stricturing, non-penetrating disease behavior after a mean diseaseduration of 9.0 ± 7.2 years.In a logistic regression analysis corrected for disease duration, perianal disease, smoking, steroid use, early AZA or AZA/ biological therapy use were independent predictors of disease behavior change.In a subsequent Kaplan-Meier survival analysis and a proportional Cox regression analysis, disease location(P = 0.001), presence of perianal disease(P < 0.001), prior steroid use(P = 0.006), early AZA(P = 0.005) or AZA/biological therapy(P = 0.002), or smoking(P = 0.032) were independent predictors of disease behavior change.CONCLUSION:Our data suggest that perianal disease, small bowel disease, smoking, prior steroid use, early AZA or AZA/biological therapy are all predictors of disease behavior change in CD patients. | Peter Laszlo Lakatos Zsofia Czegledi Tamas Szamosi Janos Banai Gyula David Ferenc Zsigmond Tunde Pandur Zsuzsanna Erdelyi Orsolya Gemela Janos Papp Laszlo Lakatos | 2009 | World Journal of Gastroenterology2009，15，28： | 14 |
| 5 | Is early limited surgery associated with a more benign disease course in Crohn's disease?显示文摘AIM:To analyze the difference in disease course and need for surgery in patients with Crohn’s disease(CD).METHODS:Data of 506 patients with incident CD were analyzed(age at diagnosis:31.5±13.8 years).Both hospital and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which includes incident CD patients diagnosed between January 1,1977 and December 31,2008.Follow-up data were collected until December 31,2009.All patients included had at least 1year of follow-up available.Patients with indeterminate colitis at diagnosis were excluded from the analysis.RESULTS:Overall,73 patients(14.4%)required resective surgery within 1 year of diagnosis.Steroid exposure and need for biological therapy were lower in patients with early limited surgery(P<0.001 and P=0.09).In addition,surgery rates during follow-up in patients with and without early surgery differed significantly after matching on propensity scores(P<0.001,HR=0.23).The need for reoperation was also lower in patients with early limited resective surgery(P=0.038,HR=0.42)in a Kaplan-Meier and multivariate Cox regression(P=0.04)analysis.However,this advantage was not observed after matching on propensity scores(PLogrank=0.656,PBreslow=0.498).CONCLUSION:Long-term surgery rates and overall exposure to steroids and biological agents were lower in patients with early limited resective surgery,but reoperation rates did not differ. | Petra Anna Golovics Laszlo Lakatos Attila Nagy Tunde Pandur Istvan Szita Mihaly Balogh Csaba Molnar Erzsebet Komaromi Barbara Dorottya Lovasz Michael Mandel Gabor Veres Lajos S Kiss Zsuzsanna Vegh Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，43： | 3 |
| 6 | Evolution of disease phenotype in adult and pediatric onset Crohn's disease in a population-based cohort显示文摘AIM:To investigate the evolution of disease phenotypein adult and pediatric onset Crohn's disease(CD) populations,diagnosed between 1977 and 2008.METHODS:Data of 506 incident CD patients were analyzed(age at diagnosis:28.5 years,interquartile range:22-38 years).Both in-and outpatient records were collected prospectively with a complete clinical follow-up and comprehensively reviewed in the population-based Veszprem province database,which included incident patients diagnosed between January 1,1977 and December 31,2008 in adult and pediatric onset CD populations.Disease phenotype according to the Montreal classification and long-term disease course was analysed according to the age at onset in time-dependent univariate and multivariate analysis.RESULTS:Among this population-based cohort,seventy-four(12.8%) pediatric-onset CD patients were identified(diagnosed ≤ 17 years of age).There was no significant difference in the distribution of disease behavior between pediatric(B1:62%,B2:15%,B3:23%) and adult-onset CD patients(B1:56%,B2:21%,B3:23%) at diagnosis,or during follow-up.Overall,the probability of developing complicated disease behaviour was 49.7% and 61.3% in the pediatric and 55.1% and 62.4% in the adult onset patients after 5-and 10-years of follow-up.Similarly,time to change in disease behaviour from non stricturing,non penetrating(B1) to complicated,stricturing or penetrating(B2/B3) disease was not significantly different between pediatric and adult onset CD in a Kaplan-Meier analysis.Calendar year of diagnosis(P = 0.04),ileal location(P < 0.001),perianal disease(P < 0.001),smoking(P = 0.038) and need for steroids(P < 0.001) were associated with presence of,or progression to,complicated disease behavior at diagnosis and during follow-up.A change in disease location was observed in 8.9% of patients and it was associated with smoking status(P = 0.01),but not with age at diagnosis.CONCLUSION:Long-term evolution of disease behavior was not different in pediatric-and adult-onset CD patients in this population-based cohort but was associated to location,perianal disease and smoking status. | Barbara Dorottya Lovasz Laszlo Lakatos Agnes Horvath Istvan Szita Tunde Pandur Michael Mandel Zsuzsanna Vegh Petra Anna Golovics Gabor Mester Mihaly Balogh Csaba Molnar Erzsebet Komaromi Lajos Sandor Kiss Peter Laszlo Lakatos | 2013 | World Journal of Gastroenterology2013，19，14： | 2 |
| 7 | A Prospective Randomized Trial of Intravitreal B evacizumab o r L aser T herapy in the Management of Diabetic Macular Edema (BOLT Study)显示文摘 | Michel Michaelides Andrew Kaines Robin D. Hamilton Samantha Fraser-Bell Ranjan Rajendram Fahd Quhill Christopher J. Boos Wen Xing Catherine Egan Tunde Peto Catey Bunce R. David Leslie Philip G. Hykin | 2010 | Ophthalmology2010，，6： | 2 |
| 8 | Prevalence and predictors of hospitalization in Crohn's disease in a prospective population-based inception cohort from 2000-2012显示文摘AIM: To analyze the prevalence, length and predictors of hospitalization in the biological era in the populationbased inception cohort from Veszprem province.METHODS: Data of 331 incident Crohn's disease(CD) patients diagnosed between January 1, 2000 and December 31, 2010 were analyzed(median age at diagnosis: 28; IQR: 21-40 years). Both in- and outpatient records were collected and comprehensively reviewed.RESULTS: Probabilities of first CD-related hospitalization and re-hospitalization were 32.3%, 45.5%,53.7% and 13.6%, 23.9%, 29.8%, respectively after one, three and five years of follow-up in Kaplan-Meier analysis. First-year hospitalizations were related to diagnostic procedures(37%), surgery or disease activity(27% and 21%). Non-inflammatory disease behavior at diagnosis(HR = 1.32, P = 0.001) and perianal disease(HR = 1.47, P = 0.04) were associated with time to first CD-related hospitalization, while disease behavior change(HR = 2.38, P = 0.002) and need for steroids(HR = 3.14, P = 0.003) were associated with time to first re-hospitalization in multivariate analyses.Early CD-related hospitalization(within the year of diagnosis) was independently associated with need for immunosuppressives(OR = 2.08, P = 0.001) and need for surgeries(OR = 7.25, P < 0.001) during the disease course.CONCLUSION: Hospitalization and re-hospitalization rates are still high in this cohort, especially during the first-year after the diagnosis. Non-inflammatory disease behavior at diagnosis was identified as the pivotal predictive factor of both hospitalization and rehospitalization. | Petra A Golovics Laszlo Lakatos Michael D Mandel Barbara D Lovasz Zsuzsanna Vegh Zsuzsanna Kurti Istvan Szita Lajos S Kiss Tunde Pandur Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 9 | Characterization of starches from West African Yam显示文摘 | Tunde O Roger N J | 1999 | Journal of the Science of Food and Agriculture1999，79，： | 1 |
| 10 | Fate of sulphate removed during the treatment of circumneutral mine water and acid mine drainage with coal fly ash: Modelling and experimental approach显示文摘 | Godfrey Madzivire Wilson M. Gitari V.R. Kumar Vadapalli Tunde V. Ojumu Leslie F. Petrik | 2011 | Minerals Engineering2011，，13： | 1 |
| 11 | Combining algorithms for automatic detection of optic disc and macula in fundus images显示文摘 | Rashid Jalal Qureshi Laszlo Kovacs Balazs Harangi Brigitta Nagy Tunde Peto Andras Hajdu | 2011 | Computer Vision and Image Understanding2011，，1： | 1 |
| 12 | Cellulase production by Aspergillus flavus Linn Isolate NSPR 101 fermented in sawdust,bagasse and corncob显示文摘 | Ojumu Tunde Victor Solomon Bamidele Ogbe Betiku Eriola Layokun Stephen Kolawole Amigun Bamikole | 2003 | African Journal of Biotechnology2003，2，6： | 1 |
| 13 | Synthesis of zeolite A from coal fly ash using ultrasonic treatment : A replacement for fusion stel \ 显示文摘 | Tunde V Ojumu Pieter W | 2016 | Ultrasonics Sonochemistry2016，31，4： | 1 |
| 14 | Improved functioning in a women with schizophrenia on exclusive therapy with oestrogen pills显示文摘 | Tunde AM Singh AK Marsden K | 2008 | Australas Psychiatry2008，10，4： | 1 |
| 15 | Macroecono-mic Characteristics and Inventory Investment: A Multi- country Study 显示文摘 | Attila Chikan Erzsebet Kovacs Tunde Tatrai | 2005 | Production Economics2005，，1： | 1 |
| 16 | A Random- ized Trial to Assess Functional and Structural Effects of Ranibi- zumab versus Laser in Diabetic Macular Edema (the LUCIDATE Study)显示文摘 | Oliver Comyn Sobha Sivaprasad Tunde Peto | 2014 | Am J Ophthalmol2014，157，5： | 1 |
| 17 | Macroeconomic Characteristics and Inventory Investment: A Multicountry Study 显示文摘 | Attila Chikan Erzsebet Kovacs Tunde Tatrai | 2005 | Production Economics2005，，1： | 1 |
| 18 | Screening for Diabetic Retinopathy and Diabetic Macular Edema in the United Kingdom显示文摘 | Tunde Peto Christine Tadros | 2012 | Current Diabetes Reports2012，，4： | 1 |
| 19 | Interferon gamma boosts the nucleotide oligomerization domain 2-mediated signaling pathway in human dendritic cells in an X-linked inhibitor of apoptosis protein and mammalian target of rapamycin-dependent manner显示文摘细胞质的核苷酸 oligomerization 领域 2 (NOD2 ) 受体认出细菌的房间墙部件 muramyl dipeptide (MDP ) 。NOD2 结扎开始原子因素 kappa B 和激活 mitogen 的蛋白质 kinase 串联。然而,独自管理 MDP 是不够的在各种各样的有免疫力的房间得到强壮的 cytokine 回答,包括树枝状的房间(DC ) 。因为在煽动的纸巾的各种各样的微生物引起的产品和 cytokines 的同时的存在调制 DC 功能,我们开始了这研究检验怎么干扰素 gamma (IFN ) ,发炎的一个中央调节的人,在人的常规 DC (cDCs ) 影响调停 NOD2 的发信号小径。有 MDP 和 IFN 的 DC 的 Synergistic 刺激增加了 CD40, CD80, CD83, CD86,和人的白血球抗原 DQ 的表示蛋白质并且显著地提高了支持 inflammatory cytokines IL-1, IL-6, IL-12,和瘤坏死的生产因素(TNF ) ,以及反煽动性的 cytokine IL-10。而且, MDP 和 IFN 的同时的存在对减少 IkB 蛋白质层次必要。由调查,各种各样的机制在调停 MDP 、调停 IFN 的发信号的小径含有,我们表明支持 inflammatory cytokines 的增加的生产高度依赖于 apoptosis 蛋白质(XIAP ) 的 X 连接禁止者然而并非在细胞的 IAP1 和 IAP2 上。我们也发现表明小径的 NOD2 被 rapamycin (mTOR ) 的哺乳动物的目标调整,但是没被 phosphatidylinositol-3 kinase 或信号变换器和抄写 1 抑制的使活跃之物影响。第一次,我们的结果证明 IFN 断然影响在人的 cDCs 的调停 NOD2 的发信号,以更加依赖于 XIAP 并且部分的一种方式依赖于 mTOR。 | Tunde Fekete Gabor Koncz Brigitta Szabo Andrea Gregus Eva Rajnavolgyi | 2017 | Cellular & Molecular Immunology2017，14，4： | 1 |
| 20 | Improving the reading ability of science students through study groups and multiple intelligences显示文摘 | Tunde Owolabi Foluso Okebukola | 2009 | 美中教育评论2009，6，2： | 1 |
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