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| 1 | Feasibility and safety of cryoballoon ablation for atrial fibrillation inpatients with congenital heart disease显示文摘BACKGROUND The prevalence of atrial fibrillation (AF) is on the rise in the aging population with congenital heart disease (CHD). A few case series have described the feasibility and early outcomes associated with radiofrequency catheter ablation of AF centered on electrically isolating pulmonary veins (PV) in patients with CHD. In contrast, cryoballoon ablation has not previously been studied in this patient population despite its theoretical advantages, which include a favorable safety profile and shorter procedural time. AIM To assess the safety and feasibility of cryoballoon ablation for AF in an initial cohort of patients with CHD. METHODS The study population consisted of consecutive patients with CHD and cryoballoon ablation for AF at the Montreal Heart Institute between December 2012 and June 2017. Procedural complications, acute success, and 1-year freedom from recurrent AF after a single procedure with or without antiarrhythmic drugs were assessed. Procedures were performed under conscious sedation. Left atrial access was obtained via a single transseptal puncture or through an existing atrial septal defect (ASD). Cryoballoon occlusion was assessed by distal injection of 50% diluted contrast into the pulmonary vein. At least one 240-second cryothermal application was performed upon obtaining complete pulmonary vein occlusion. Following ablation, patients were routinely followed at outpatient visits at 1, 3, 6, and 12 mo, and then annually. RESULTS Ten patients, median age 57.9 (interquartile range 48.2-61.7) years, 60% female, met inclusion criteria and were followed for 2.8 (interquartile range 1.4-4.5) years.Two had moderately complex CHD (sinus venosus ASD with partial anomalous pulmonary venous return;aortic coarctation with a persistent left superior vena cava), with the remainder having simple defects. AF was paroxysmal in 8 (80.0%) and persistent in 2 (20.0%) patients. The pulmonary vein anatomy was normal in 6 (60.0%) patients. Four had left common PV (n = 3) and/or 3 right PV (n = 2). Electrical pulmonary vein isolation (PVI) was acutely successful in all. One patient had transient phrenic nerve palsy that recovered during the intervention. No major complication occurred. One year after a single ablation procedure, 6 (60%) patients remained free from AF. One patient with recurrent AF had recovered pulmonary vein conduction and underwent a second PVI procedure. A second patient had ablation of an extra-pulmonary vein trigger for AF. CONCLUSION Cryoballoon ablation for AF is feasible and safe in patients with simple and moderate forms of CHD, with an excellent acute success rate and modest 1-year freedom from recurrent AF. | Sylvia Abadir Victor Waldmann Katia Dyrda Mikael Laredo Blandine Mondésert Marc Dubuc Paul Khairy | 2019 | World Journal of Cardiology2019，11，5： | 3 |
| 2 | The potential for using n-alkanes in tropical forages as a marker for the determination of dry matter by grazing ruminants显示文摘 | Simposon G D Minson D J Orpin C G | 1991 | J Agri Sci Cambridge1991，117，： | 1 |
| 3 | Acute vertebral collapse due to osteoporosis or malignancy:appearance on unenhanced and gadolinnium-enhanced MR images显示文摘 | Gueond CA Laredo JD Cherret S | 1966 | Radiology1966，199，： | 1 |
| 4 | Type Ⅱ autosomal dominant osteopetrosis (Albers-Sch(o)nberg disease):clinical and radiological manifestations in 42 patients显示文摘 | Bénichou OD Laredo JD de Vernejoul MC | | 0，，01： | 1 |
| 5 | Inhibition effects of nitrogen compounds on the hydrodesulfurization of dibenzothiophene显示文摘 | LAREDO S G C DE LOS REYES H J A LUIS CANO D J | 2001 | Applied Catalysis2001，207，12： | 1 |
| 6 | Terminology and classification of congenital vascular malformations显示文摘 | Lee B B Laredo J Lee T S | | 0，，06： | 1 |
| 7 | Metastatic melanoma to the ma- nubrium sternum显示文摘 | Laredo J Morris DJ Thurer RL | 1998 | Eur J Cardiothorac Surg1998，14，6： | 1 |
| 8 | Radiologic assessment of lumbar intervertebral instability and degenerative spondylolisthesis 显示文摘 | Nizard RS Wybier M Laredo JD | 2001 | Radiol Clin North Am2001，39，1： | 1 |
| 9 | Nitrogen compounds characterization in atmospheric gas oil and light cycleoil from a blend of Mexican crudes显示文摘 | Georgina C Laredo Sara Leyva Regina Alvarez | | 0，，： | 1 |
| 10 | Vertebral tumors and pseudotumors显示文摘 | Laredo JD Quessar A Bossard P | 2001 | Radiol Clin North Am2001，39，： | 1 |
| 11 | Stochastic volatility models as Hidden Markov models and statis- tical applications显示文摘 | Genon-Catalot V Jeantheau T Laredo C | 2000 | Bernoulli2000，6，6： | 1 |
| 12 | Self-inhibition observed during iudole and o-ethylaniline hydrogenation in the presence of dibenzothiophene显示文摘 | LAREDO G C ALTAMIRANO E DE LOS REYES J A | 2003 | Applied Catalysis A:General2003，242，2： | 1 |
| 13 | Motor and plume particle sizemeasurements in solid propellant micromotors 显示文摘 | Laredo D McCrorie J D | 1994 | Journal of Propulsion and Power1994，10，3： | 1 |
| 14 | Complications of percutaneous vertebroplasty and their prevention显示文摘 | Laredo JD Hamze B | 2005 | Semin Ultrasound CT MR2005，2，： | 1 |
| 15 | Silyl-heparin adsorption improves the in vivo thromboresistance of carbon-coated polytetrafluoroethylene vascular grafts显示文摘 | Xue L Husak V A | 2003 | The American Journal of Surgerfy2003，186，： | 1 |
| 16 | Venous malformation: treatment needs a bird's- eye view 显示文摘 | Lee B Laredo J | 2013 | Phlebology2013，28，2： | 1 |
| 17 | Influence of aging and crystallinity on the molecular motions in bisphe- nol-A polycarbonate显示文摘 | Laredo E Grimau M Muller A | 1996 | J Polym Sci: Polym Phys1996，34，17： | 1 |
| 18 | Acute vertebral collapse due to osteoporosis or malignancy : appearance on unenllanced and gadolinnium-enhanced MR images 显示文摘 | Gueond CA Laredo JD Cherret S | 1966 | Radioniogy1966，199，： | 1 |
| 19 | Motor and plume particle size measure- ments in solid propellant micromotors显示文摘 | Laredo D McCrorie II J D Vaughn J K Netzer D W | 1994 | Journal of Propulsion and Power1994，10，3： | 1 |
| 20 | Inhibition effects of nitrogen compounds on the hydrodesulfurization of dibenzothiophene:Part 2显示文摘 | Laredo G C Altamirano E De los Reyes J A | | 0，，： | 1 |
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