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| 1 | 年龄对血清褪黑素水平及其昼夜节律性的影响显示文摘目的 研究年龄对中国成年男性血清褪黑素水平及其昼夜节律性的影响。方法 健康志愿者按年龄分为四组 :30~ 39岁组 (8例 )、40~ 49岁组 (5例 )、50~ 59岁组 (5例 )和≥ 60岁组 (7例 )。白天 (8~ 2 2时 )每 2 h、夜间 (2 2~ 8时 )每 1 h采血一次 ,放免法检测血清褪黑素浓度。采用 t检验、ANOVA及余弦法分析处理观测数据。结果 血清褪黑素水平呈明显的昼夜节律性变化 ,高峰在午夜 ,白天水平很低 ,采样时间对血清褪黑素水平具有非常显著性影响 (P<0 .0 1 )。余弦法血清 MT仅在 30~ 39岁和 40~ 49岁组中有显著昼夜节律性变化 (P<0 .0 5)。 30~ 50岁组血清褪黑素水平相似 ,≥ 60岁组夜间 (2 3~ 5时 )血清褪黑素水平明显降低 ,与 30~ 50岁组相比有非常显著性差异 (P<0 .0 1 )。结论 血清褪黑素水平及其昼夜节律性变化受年龄的影响 ,随年龄增长夜间血清褪黑素水平下降 ,并且其昼夜节律性 (50~ 59岁和≥ 60岁组 )消失。 | 赵子彦 付越榕 李玉阳 谢毅 李新华 Yvan Touitou | 2003 | 中国老年学杂志2003，23，8： | 9 |
| 2 | Diagnosis and treatment of gastroesophageal reflux disease in infants and children显示文摘 | Yvan Vandenplas(PhD.,Academic Children’s Hospital,Free University of Brussels,Laarbeeklaan 101) | 1999 | World Journal of Gastroenterology1999，5，5： | 7 |
| 3 | 老年人血清皮质醇水平与年龄、性别及疾病的相关性探讨显示文摘目的 探讨老年人早晨 (8:0 0 )血清皮质醇水平变化及年龄、性别和疾病对其的影响。方法 用ELISA法检测 1 4 5例中国人 (31 1 1 0岁 )早晨 (8:0 0 )血清皮质醇水平。结果 早晨血清皮质醇水平随着年龄增长呈上升趋势 ,与成年组 (<60岁 )比较 60岁、70岁组和 >80岁组的皮质醇水平明显增高 (P <0 0 0 1 ) ,>80岁组的皮质醇水平显著高于 60岁和 70岁组 (P <0 0 1 ) ;60岁健康组中女性血清皮质醇水平明显低于男性 (P <0 0 5) ;老年患者 (主要为心血管系统疾病 )与同龄健康老年人相比血清皮质醇水平明显升高 (P <0 0 1 )。结论 年龄、疾病以及性别对早晨血清皮质醇具有影响作用 ,增龄、心血管疾病和男性与血清皮质醇水平呈正相关。 | 赵子彦 栾杨 路方红 付越榕 谢毅 刘建平 韩凯 张秀芹 Yvan Touitou | 2004 | 中国老年学杂志2004，24，11： | 7 |
| 4 | The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide显示文摘 | Joseph F. Perz Gregory L. Armstrong Leigh A. Farrington Yvan J.F. Hutin Beth P. Bell | 2006 | Journal of Hepatology2006，，4： | 7 |
| 5 | 全球在安全、合理使用注射剂方面的最新进展显示文摘在发展中国家及处于转型期中的国家,每年要使用160亿支注射剂,相当于平均每人每年用3.4支注射剂,这表明了注射剂的大量过度使用。除此之外,约1/3的注射剂是通过未经消毒的重复使用的注射装置进行给药的。2000年1/3的新增乙型肝炎感染患者。 | Yvan Hutin | 2008 | 中国执业药师2008，0，11： | 7 |
| 6 | Pediatricians lack knowledge for the diagnosis and management of functional constipation in children over 6 mo of age显示文摘AIM To assess the knowledge of general pediatricians througout Indonesia about the diagnosis and treatment of childhood constipation.METHODS A comprehensive questionnaire was distributed to general pediatricians from several teaching hospitals and government hospitals all over Indonesia.RESULTS Data were obtained from 100 pediatricians, with a mean of 78.34 ± 18.00 mo clinical practice, from 20 cities throughout Indonesia. Suspicion of constipation in a child over 6 mo of age arises when the child presents with a decreased frequency of bowel movements(according to 87% of participants) with a mean of one bowel movement per 3.59 ± 1.0 d, hard stools(83%), blood in the stools(36%), fecal incontinence(33%), and/or difficulty in defecating(47%). Only 26 pediatricians prescribe pharmacologic treatment as first therapeutic approach, while the vast majority prefers nonpharmacologic treatment, mostly(according to 68%) The preferred nonpharmacologic treatment are high-fiber diet(96%), increased fluid intake(90%), toilet training(74%), and abdominal massage(49%). Duration of non-pharmacological treatment was limited to 1 to 2 wk. Seventy percent of the pediatricians recommending toilet training could only mention some elements of the technique, and only 15% was able to explain it fully and correctly. Lactulose is the most frequent pharmacologic intervention used(87% of the participants), and rectal treatment with sodium citrate, sodium lauryl sulfo acetate, and sorbitol is the most frequent rectal treatment(85%). Only 51% will prescribe rectal treatment for fecal impaction. The majority of the pediatricians(69%) expect a positive response during the first week with a mean(± SD) of 4.1(± 2.56) d. Most participants(86%) treat during one month or even less. And the majority(67%) stops treatment when the frequency and/or consistency of the stools have become normal, or if the patient had no longer complaints.CONCLUSION These data provide an insight on the diagnosis and management of constipation in childhood in Indonesia. Although general pediatricians are aware of some important aspects of the diagnosis and mangement of constipation, overall knowledge is limited. Efforts should be made to improve the distribution of existing guidelines. These findings highlight and confirm the difficulties in spreading existing information from guidelines to general pediatricians. | Ariani Widodo Badriul Hegar Yvan Vandenplas | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 6 |
| 7 | Spin squeezing in Bose-Einstein condensates: Limits imposed by decoherence and non-zero temperature显示文摘 | Alice Sinatra (1) Jean-Christophe Dornstetter (1) Yvan Castin (1) | 2012 | Frontiers of physics2012，7，1： | 4 |
| 8 | 年龄对血清皮质醇和硫酸脱氢表雄酮水平及其昼夜变化的影响显示文摘目的 研究年龄对男性血清皮质醇和硫酸脱氢表雄酮 (DHEAS)水平及其昼夜节律的影响。方法 2 6名男性健康志愿者按年龄 (每增龄 10岁 )分为四组 :3 0~ (8名 )、40~ (6名 )、5 0~ (5名 )和 60~(7名 )岁组。 8:0 0~ 2 2 :0 0每 2小时 ,2 2 :0 0~ 8:0 0每小时采血一次 ,ELISA检测血清皮质醇 ,化学发光免疫法检测血清DHEAS。结果 血清皮质醇和DHEAS水平均呈明显昼夜变化 ,余弦法证实有统计学意义。皮质醇峰值 4:0 0~ 6:0 0 ,谷值 18:0 0~ 2 4:0 0 ,较白种人的峰、谷时间提前约 2h ;DHEAS峰值在 16:0 0左右。年龄对血清皮质醇水平及其昼夜变化无明显影响 ,但影响血清DHEAS水平 ,60岁组的血清DHEAS水平较其它 3组明显降低 (P <0 .0 5或P <0 .0 1) ,皮质醇 /DHEAS比值也均显著增高 (均P <0 .0 1)。结论 年龄对血清皮质醇水平及其昼夜变化无明显作用 ,但明显影响血清DHEAS水平。 | 赵子彦 付越榕 谢毅 李玉阳 李新华 Yvan Touitou | 2004 | 中华内分泌代谢杂志2004，20，6： | 3 |
| 9 | 婴儿常见胃肠道症状的实用处理法则(一)显示文摘在婴儿,特别是配方奶喂养的婴儿中功能性胃肠道(GI)症状较为常见[1]。应对这一问题,儿科医师常采用更换配方奶的方式来处理。由于治疗婴儿功能性GI症状的双盲的、安慰剂对照的、前瞻性干预的试验非常有限,本文在世界各地儿童胃肠病专科医师和过敏症专科医师一致意见的基础上,制定了婴儿常见GI的实用处理法则,并具体介绍各种婴幼儿. | Yvan Vandenplas Pedro Gutierrez-Castrellon Carlos Velasco-Benitez Jorge Palacios Domingo Jaen Hugo Ribeiro Lynette Pei-Chi Shek Bee-Wah Lee Pedro Alarcon | 2013 | 临床儿科杂志2013，31，7： | 3 |
| 10 | 反应挤出合成带不饱和官能团端基的聚己内酯显示文摘用带双键官能团的2-烯丙氧基乙醇与四丙醇钛酸酯进行酯交换,可合成用于ε-己内酯配位开环聚合的钛化合物引发剂;利用此引发剂,引发ε-己内酯聚合得到了分子链一端为双键的功能化聚己内酯。研究了物料配比和反应温度对聚合转化率和速率的影响,进而在双螺杆挤出机中实施快速本体聚合,合成了带活性双键的功能化聚己内酯。引发剂和聚合物的化学结构由1H-NMR予以表征,GPC测定的结果表明聚合物的分子量与物料摩尔比相关。 | 夏浙安 陈建定 Yvan Chalamet Amar Zerroukhi | 2005 | 功能高分子学报2005，18，3： | 3 |
| 11 | Fast and Accurate Additive Manufacturability Analysis显示文摘This paper focuses on the design optimization of complex 3D composites structures made by additive manufacturing processes. There are commercial CAD-CAM software solutions for detailed offline path programming, but there is a growing need for innovative tools and methodologies for doing trade oil studies very early at design stage. A new innovative solution has been developed on top of the CATFIBER■ software,allowing both designers and stress engineers to quickly analyze complex double-curved geometries. It also includes a variable stiffness approach with tow-steering, and structural analysis of the manufacturing defects using Digimat■ software. | Yvan Blanchard | 2019 | 纤维复合材料2019，36，2： | 3 |
| 12 | Circulating MicroRNA-208b and MicroRNA-499 Reflect Myocardial Damage in Cardiovascular Disease显示文摘 | Maarten F. Corsten Robert Dennert Sylvia Jochems Tatiana Kuznetsova Yvan Devaux Leon Hofstra Daniel R. Wagner Jan A. Staessen Stephane Heymans Blanche Schroen | 2010 | Circulation: Cardiovascular Genetics2010，，6： | 2 |
| 13 | 反应挤出原位合成聚己内酯型聚氨酯显示文摘以过量聚乙二醇(PEG)改性得到的烷氧基钛混合物为引发剂和催化剂,且控制烷氧基钛混合物中羟基与物料4,4′-二苯基甲烷二异氰酸酯(MDI)中异氰酸酯基的摩尔数相等,在反应温度为190℃、螺杆转速为100r/min的条件下,采用双螺杆挤出机使ε-己内酯(CL)原位反应挤出制备了相对分子质量分布较窄的聚己内酯型聚氨酯(PCLU)。探讨了原位反应机理,并研究了PCLU的结构与性能。结果表明,反应体系中几乎所有CL单体都参与了聚合反应;通过调节反应体系中CL相对于PEG的浓度,可合成几种聚己内酯(PCL)链段平均长度不同的PCLU;当PCL链段平均长度从20增加到35时,聚合物的拉伸强度表现出上升趋势。 | 徐睿军 夏浙安 陈建定 Yvan Chalamet Amar Zerroukhi | 2008 | 合成橡胶工业2008，31，6： | 2 |
| 14 | Review on sedation for gastrointestinal tract endoscopy in children by non-anesthesiologists显示文摘AIM: To present evidence and formulate recommendations for sedation in pediatric gastrointestinal(GI) endoscopy by non-anesthesiologists.METHODS: The databases MEDLINE, Cochrane and EMBASE were searched for the following keywords 'endoscopy, GI', 'endoscopy, digestive system' AND 'sedation', 'conscious sedation', 'moderate sedation', 'deep sedation' and 'hypnotics and sedatives' for publications in English restricted to the pediatric age. We searched additional information published between January 2011 and January 2014. Searches for(upper) GI endoscopy sedation in pediatrics and sedation guidelines by non-anesthesiologists for the adult population were performed. RESULTS: From the available studies three sedation protocols are highlighted. Propofol, which seems to offer the best balance between efficacy and safety is rarely used by non-anesthesiologists mainly because of legal restrictions. Ketamine and a combination of a benzodiazepine and an opioid are more frequently used. Data regarding other sedatives, anesthetics and adjuvant medications used for pediatric GI endoscopy are also presented.CONCLUSION: General anesthesia by a multidisciplinary team led by an anesthesiologist is preferred. The creation of sedation teams led by non-anesthesiologists and a careful selection of anesthetic drugs may offer an alternative, but should be in line with national legislation and institutional regulations. | Rok Orel Jernej Brecelj Jorge Amil Dias Claudio Romano Fernanda Barros Mike Thomson Yvan Vandenplas | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，9： | 2 |
| 15 | Projected Changes in Eurasian and Arctic Summer Cyclones under Global Warming in the Bergen Climate Model显示文摘Using the coupled ocean-atmosphere Bergen Climate Model,and a Lagrangian vorticity-based cyclone tracking method,the authors investigate current climate summer cyclones in the Northern Hemisphere and their change by the end of the 21st century,with a focus on Northern Eurasia and the Arctic.The two scenarios A1B and A2 for increasing greenhouse gas concentrations are considered.In the model projections,the total number of cyclones in the Northern Hemisphere is reduced by about 3% 4%,but the Arctic Ocean and adjacent coastal re-gions harbour slightly more and slightly stronger summer storms,compared to the model current climate.This in-crease occurs in conjunction with an increase in the high-latitude zonal winds and in the meridional tempera-ture gradient between the warming land and the ocean across Northern Eurasia.Deficiencies in climate model representations of the summer storm tracks at high lati-tudes are also outlined,and the need for further model inter-comparison studies is emphasized. | Yvan J. ORSOLINI Asgeir SORTEBERG | 2009 | Atmospheric and Oceanic Science Letters2009，2，1： | 2 |
| 16 | 精梳生产中的自动化显示文摘在全球超过50%的市场中都证明了这一点:采用Rieter (立达)精梳系统可获得最佳的成纱质量。立达提供的精梳自动化在提高产量和灵活性方面的情况如何呢? | Yvan Schwartz | 2013 | 纺织导报2013，，11： | 2 |
| 17 | A Practical Guide for the Diagnosis of Primary Enteric Nervous System Disorders显示文摘 | M.G. Sch?ppi A. Staiano P.J. Milla V.V. Smith J.A. Dias R. Heuschkel S. Husby M.L. Mearin A. Papadopoulou F.M. Ruemmele Yvan Vandenplas S. Koletzko | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，5： | 2 |
| 18 | 卫生保健工作者安全注射的知识、态度和实践的快速评诂显示文摘目的 收集卫生机构卫生保健工作者中关于注射的知识、态度和实践方面的定性和半定量信息 ,估计各种注射者实施的对患者、提供者和社区无害的注射的百分比。方法 采用SIGN提供的标准化工具对卫生保健工作者进行访谈。采用直接观察法 ,标准化问卷和焦点组访谈在处方者、注射者和处理医疗废弃物的后勤人员中收集定性和半定量信息。结果 每个处方者平均每周要接待 87 9名患者 ,其中 35 2 %会开出注射处方。在调查的 935份有效处方中 ,4 7 8%至少包括 1次注射。访问的 10 0名护士中 ,平均每人每周要实施 90 9次注射 ,其中 12 1%的注射是用于免疫的。在这 10 0名护士中 ,有 75 %报告在过去 1年中受到过尖锐物刺伤。每名护士平均每天要给 32名患者分配药物 ,其中 73 4 %的患者会接受注射。结论 即使在目前对AIDS的认识不断提高的情况下 ,注射在上海的使用程度仍然很高 ;一些因素提示卫生保健者对过度使用注射起到了一些作用 ;虽然在上海已经建立了一套有效的注射提供、管理、监督和废弃物处理体系 ,但是在注射者和医疗废弃物处理人员中仍时常发生尖锐物刺伤 ; | 曹阳 陈洁 曹建文 YVAN Hutin 邵瑞太 王盘石 张黎明 韩宵艳 | 2004 | 预防医学情报杂志2004，20，1： | 2 |
| 19 | In Vitro Effects of Cyclosporine A and Tacrolimus on Regulatory T-Cell Proliferation and Function显示文摘 | Céline Miroux Olivier Morales Khaldoun Ghazal Samia Ben Othman Yvan de Launoit Véronique Pancré Filomena Conti Nadira Delhem | 2012 | Transplantation Journal2012，，2： | 2 |
| 20 | The occurrence of N -nitrosamines, residual nitrite and biogenic amines in commercial dry fermented sausages and evaluation of their occasional relation显示文摘 | Eveline De Mey Katrijn De Klerck Hannelore De Maere Lore Dewulf Guy Derdelinckx Marie-Christine Peeters Ilse Fraeye Yvan Vander Heyden Hubert Paelinck | 2014 | Meat Science2014，，2： | 2 |
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