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| 1 | 亚洲玉米螟对Cry1Ab蛋白抗性的遗传规律与分子机理显示文摘 | 何康来 常雪 常雪艳 王振营 Natalie Ferry Angharad M.R.Gatehouse | 2007 | 植物保护2007，33，5： | 6 |
| 2 | 基因对于儿童肥胖的影响在小于胎龄儿童中或不重要显示文摘小于胎龄儿在日后的生活中面临着更高的患肥胖症和代谢性疾病的风险,目前认为这种风险主要与小于胎龄儿出生后生长加速有关。研究人员对奥克兰出生体重协作研究项目中的小于胎龄儿和适于胎龄儿做了研究,测量并计算这些儿童的BMI-Z评分,研究与成人肥胖相关的常见基因变异是否会与小于胎龄儿出生后生长加速有关。研究者将547名欧洲儿童(228名小于胎龄儿和319名适于胎龄儿)进行基因分型,他们被分为共计37个单核苷酸多态性(SNPs)候选基因。重复测量儿童的BMI,并以Z评分法评估肥胖程度。 | Dug Yeo Han Rinki Murphy Angharad R Morgan 郭婧 张帆 | 2013 | 营养健康新观察2013，0，1： | 2 |
| 3 | Targeting inflammation in pancreatic cancer: Clinical translation显示文摘Preclinical modelling studies are beginning to aid development of therapies targeted against key regulators of pancreatic cancer progression. Pancreatic cancer is an aggressive, stromally-rich tumor, from which few people survive. Within the tumor microenvironment cellular and extracellular components exist, shielding tumor cells from immune cell clearance, and chemotherapy, enhancing progression of the disease. The cellular component of this microenvironment consists mainly of stellate cells and inflammatory cells. New findings suggest that manipulation of the cellular component of the tumor microenvironment is possible to promote immune cell killing of tumor cells. Here we explore possible immunogenic therapeutic strategies. Additionally extracellular stromal elements play a key role in protecting tumor cells from chemotherapies targeted at the pancreas. We describe the experimental findings and the pitfalls associated with translation of stromally targeted therapies to clinical trial. Finally, we discuss the key inflammatory signal transducers activated subsequent to driver mutations in oncogenic Kras in pancreatic cancer. We present the preclinical findings that have led to successful early trials of STAT3 inhibitors in pancreatic adenocarcinoma. | Colin William Steele Nina Angharad Kaur Gill Nigel Balfour Jamieson Christopher Ross Carter | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 4 | Resuscitation-promofing factors possess a lysozyme-like domain显示文摘 | Martin CG Nicholas HK Angharad PD | 2004 | Trends in biochemical sciences2004，29，1： | 1 |
| 5 | Resuscitationpromoting factors possess a lysozyme-like domain显示文摘 | Martin CG Nilas HK Angharad PD | 2004 | Trends Biochemical Sci2004，29，1： | 1 |
| 6 | Resuscitation-promoting factors possess a lysozyme-like domain显示文摘 | Martin CG Nicholas HK Angharad PD | 2004 | Trends in biochemical sciences2004，29，1： | 1 |
| 7 | Resuscitationpromoting factors possess a lysozyme-like domain显示文摘 | Martin CG Nicholas HK Angharad PD | 2004 | Trends in biochemical sciences2004，29，1： | 1 |
| 8 | Differences in Matrix Metalloproteinase-1 and Matrix Metalloproteinase-12 Transcript Levels Among Carotid Atherosclerotic Plaques With Different Histopathological Characteristics显示文摘 | Angharad R. Morgan Kittipan Rerkasem Patrick J. Gallagher Baiping Zhang Gareth E. Morris Philip C. Calder Robert F. Grimble Per Eriksson William L. McPheat Clifford P. Shearman Shu Ye | 2004 | Stroke: Journal of the American Heart Association2004，，6： | 1 |
| 9 | The effect of different types of hysterectomy on urinary and sexual functions: a prospective study显示文摘 | TA El-Toukhy Mohamed A Hefni Angharad E Davies S Mahadevan | 2004 | Journal of Obstetrics & Gynecology2004，，4： | 1 |
| 10 | Expression of multiple insecticidal genes confers broad resistance against a range of different rice pests显示文摘 | Shahina Bano Maqbool Sheikh Riazuddin Nguyen Thi Loc Angharad M.R. Gatehouse John A. Gatehouse Paul Christou | 2001 | Molecular Breeding2001，，1： | 1 |
| 11 | Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition显示文摘 | Katherine Holmes Owain Ll Roberts Angharad M. Thomas Michael J. Cross | 2007 | Cellular Signalling2007，，10： | 1 |
| 12 | Resuscitationpromoting factors possess a lysozyme-like domain显示文摘 | Martin CG Nicholas HK Angharad PD | 2004 | Trends Biochem Sci2004，29，1： | 1 |
| 13 | Linear transgene constructs lacking vector backbone sequences generate transgenic rice plants which accumulate higher levels of proteins conferring insect resistance显示文摘 | Nguyen Thi Loc Porntip Tinjuangjun Angharad M.R. Gatehouse Paul Christou John A. Gatehouse | 2002 | Molecular Breeding2002，，4： | 1 |
| 14 | Resuscitation-promoting factors possess a lysozyme-like domain显示文摘 | Martin CG Nicholas HK Angharad PD | 2004 | Trends Biochem Sci2004，29，1： | 1 |
| 15 | 细胞色素P450CYP81A6基因在水稻中的表达:组织特异性、蛋白质亚细胞定位以及对除草剂的响应(英文)显示文摘目的:分析CYP81A6基因在苯达松及甲磺隆处理下的诱导表达模式,解释该基因与两种除草剂代谢相关的可能原因。创新点:从两种除草剂降解途径中产生的小分子物质的结构相似性出发,通过基因诱导表达的特点分析,解释CYP81A6和两种除草剂降解相关的原因。方法:通过实时定量聚合酶链反应(PCR)来分析基因表达的特点;利用CYP81A6启动子与GUS报告基因构建的载体来分析组织特异性表达;通过亚细胞定位来确定CYP81A6发挥功能的场所。结论:CYP81A6基因受苯达松及甲磺隆诱导,在不同的时间点开始上调,说明了甲磺隆的降解中间产物可以诱导这个基因的表达;CYP81A6是组成型表达,在根、茎、叶中均有表达;亚细胞定位结果证明CYP81A6是一个内质网上的蛋白。 | Hai-ping LU Martin EDWARDS Qi-zhao WANG Hai-jun ZHAO Hao-wei FU Jian-zhong HUANG Angharad GATEHOUSE Qing-yao SHU | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，2： | 1 |
| 16 | Transgenic potato plants with enhanced resistance to the peach-potato aphid Myzus persicae显示文摘 | Angharad M. R. Gatehouse Rachel E. Down Kevin S. Powell Nicolas Sauvion Yvan Rahbé Christine A. Newell Andrew Merryweather William D. O. Hamilton John A. Gatehouse | 1996 | Entomologia Experimentalis et Applicata1996，，3： | 1 |
| 17 | Resuscitation-promoting factors possess a lysozyme-like domain 显示文摘 | Martin CG Nicholas HK Angharad PD | 2004 | Trends Biochem Sci2004，29，1： | 1 |
| 18 | IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn’s Disease Risk in a New Zealand Population显示文摘 | Lynnette R. Ferguson Dug Yeo Han Alan G. Fraser Claudia Huebner Wen Jiun Lam Angharad R. Morgan Antoni Castells | 2010 | Gastroenterology Research and Practice2010，，： | 1 |
| 19 | Linear transgene constructs lacking vector backbone sequences generate transgenic rice plants which accumulate higher levels of proteins conferring insect resistance显示文摘 | Nguyen Thi Loc Porntip Tinjuangjun Angharad M.R. Gatehouse Paul Christou John A. Gatehouse | 2002 | Molecular Breeding2002，，4： | 1 |
| 20 | Expression of multiple insecticidal genes confers broad resistance against a range of different rice pests显示文摘 | Shahina Bano Maqbool Sheikh Riazuddin Nguyen Thi Loc Angharad M.R. Gatehouse John A. Gatehouse Paul Christou | 2001 | Molecular Breeding2001，，1： | 1 |
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