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| 1 | Angiotensin-receptor blockers as therapy for mild-to-moderate hypertension-associated non-alcoholic steatohepatitis显示文摘AIM: To evaluate insulin resistance, cytolysis and nonalcoholic steatohepatitis (NASH) score (NAS) using the Kleiner and Brunt criteria in 54 patients with NASH and mild-to-moderate hypertension, treated with telmisartan vs valsartan for 20 mo. METHODS: All patients met the NCEP-ATP TM(standard dose 20 mg o.d., n = 28). Treatment had to be taken daily at the same hour with no concomitant medication or alcohol consumption allowed. Neither the patient nor the medical staff was aware of treatment group allocation. Paired liver biopsies obtained at inclusion (visit 1) and end of treatment (EOT) were assessed by a single blinded pathologist, not aware of patient or treatment group. Blood pressure, BMI, ALT, AST, HOMA-IR, plasma triglycerides (TG) and total cholesterol (TC) were evaluated at inclusion and every 4 mo until EOT (visit 6). RESULTS: At EOT we noticed a significant decrease in ALT levels vs inclusion in all patients and this decrease did not differ significantly in group T vs group V. HOMA-IR significantly decreased at EOT vs inclusion in all patients but in group T, the mean HOMA-IR decrease per month was higher than in group V. NAS significantly diminished at EOT in all patients with a higher decrease in group T vs group V. CONCLUSION: Angiotensin receptor blockers seem to be efficient in hypertension-associated NASH. Telmisartan showed a higher efficacy regarding insulin resistance and histology, perhaps because of its specific PPAR-gamma ligand effect. | Eugen Florin Georgescu Reanina Ionescu Mihaela Niculescu Laurentiu Mogoanta Liliana Vancica | 2009 | World Journal of Gastroenterology2009，15，8： | 15 |
| 2 | Autophagy in colorectal cancer:An important switch from physiology to pathology显示文摘Colorectal cancer(CRC) remains a leading cause of cancer death in both men and women worldwide.Among the factors and mechanisms that are involved in the multifactorial etiology of CRC,autophagy is an important transformational switch that occurs when a cell shifts from normal to malignant.In recent years,multiple hypotheses have been considered regarding the autophagy mechanisms that are involved in cancer.The currently accepted hypothesis is that autophagy has dual and contradictory roles in carcinogenesis,but the precise mechanisms leading to autophagy in cancer are not yet fully defined and seem to be context dependent.Autophagy is a surveillance mechanism used by normal cells that protects them from the transformation to malignancy by removing damaged organelles and aggregated proteins and by reducing reactive oxygen species,mitochondrial abnormalities and DNA damage.However,autophagy also supports tumor formation by promoting access to nutrients that are critical to the metabolism and growth of tumor cells and by inhibiting cellular death and increasing drug resistance.Autophagy studies in CRC have focused on several molecules,mainly microtubule-associated protein 1 light chain 3,beclin 1,and autophagy related 5,with conflicting results.Beneficial effects were observed for some agents that modulate autophagy in CRC either alone or,more often,in combination with other agents.More extensive studies are needed in the future to clarify the roles of autophagy-related genes and modulators in colorectal carcinogenesis,and to develop potential beneficial agents for the prognosis and treatment of CRC. | Florin Burada Elena Raluca Nicoli Marius Eugen Ciurea Daniel Constantin Uscatu Mihai Ioana Dan Ionut Gheonea | 2015 | World Journal of Gastrointestinal Oncology2015，7，11： | 15 |
| 3 | The historical and current research progress on jujube–a superfruit for the future显示文摘Jujube(Ziziphus jujuba Mill.),or Chinese date,is the most important species of Rhamnaceae,a large cosmopolitan family,and is one of the oldest cultivated fruit trees in the world.It originates from the middle and lower reaches of the Yellow River,the‘mother river’of the Chinese people.It is distributed in at least 48 countries on all continents except Antarctica and is becoming increasingly important,especially in arid and semiarid marginal lands.Based on a systematic analysis of the unique characteristics of jujube,we suggest that it deserves to be recognized as a superfruit.We summarized historical research achievements from the past 3000 years and reviewed recent research advances since 1949 in seven fields,including genome sequencing and application,germplasm resources and systematic taxonomy,breeding and genetics,cultivation theory and techniques,pest control,postharvest physiology and techniques,and nutrition and processing.Based on the challenges facing the jujube industry,we discuss eight research aspects to be focused on in the future. | Mengjun Liu Jiurui Wang Lili Wang Ping Liu Jin Zhao Zhihui Zhao Shengrui Yao Florin Stănică Zhiguo Liu Lixin Wang Changwei Ao Li Dai Xiansong Li Xuan Zhao Chunxiang Jia | 2020 | Horticulture Research2020，7，1： | 10 |
| 4 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012，，9813： | 10 |
| 5 | Real-time sono-elastography in the diagnosis of diffuse liver diseases显示文摘AIM: To analyze whether computer-enhanced dynamic analysis of elastography movies is able to better characterize and differentiate between different degrees of liver fibrosis. METHODS: The study design was prospective. A total of 132 consecutive patients with chronic liver diseases and healthy volunteers were examined by transabdominal ultrasound elastography. All examinations were done by two doctors.RESULTS: Due to the limitations of the method, we obtained high-quality elastography information in only 73.48% of the patients. The κ-means clustering method was applied to assess the inter-observer diagnosis varia- bility, which showed good variability values in accordance with the experience of ultrasound examination of every observer. Cohen’sκ test indicated a moderate agreement between the study observers (κ = 0.4728). Furthermore, we compared the way the two observers clustered the patients, using the test for comparing two proportions (t value, two-sided test). There was no statistically significant difference between the two physicians, regardless of the patients’ real status. CONCLUSION: Transabdominal real-time elastography is certainly a very useful method in depicting liver hard- ness, although it is incompletely tested in large multicenter studies. | Dan Ionut Gheonea Adrian S ǎftoiu Tudorel Ciurea Florin Gorunescu Sevastita Iordache Gabriel Lucian Popescu Smaranda Belciug Marina Gorunescu Larisa Sǎndulescu | 2010 | World Journal of Gastroenterology2010，16，14： | 9 |
| 6 | Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage显示文摘 | Kyoung-Han Kim Yun Hye Kim Joe Eun Son Ju Hee Lee Sarah Kim Min Seon Choe Joon Ho Moon Jian Zhong Kiya Fu Florine Lenglin Jeong-Ah Yoo Philip J Bilan Amira Klip Andras Nagy Jae-Ryong Kim Jin Gyoon Park Samer MI Hussein Kyung-Oh Doh Chi-chung Hui Hoon-Ki Sung | 2017 | Cell Research2017，27，11： | 9 |
| 7 | IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location显示文摘AIM: To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor (GR), the tumor necrosis factor (TNF)-α and the interleukin (IL)-10 in childhood Crohn’s disease (CD) and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes. METHODS: Ten variants in GR, TNF-α and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin. RESULTS: For the GR polymorphisms (R23K and N363S) and IL-10 variants in the 5’flanking region (-1082 G > A, -819 T > C and -592 A > C), no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previously described in Caucasians (GCC, ACC and ATA) and three novel haplotypes only present in IBD patients. When we analyzed the haplotype distribution with the anatomical location of the disease, the GCC haplotype was associated with the colonic and the ACC haplotype with the terminal ileum location, respectively. The genotyping of fi ve polymorphisms in the promoter region of the TNF-α gene (-1031 T > C, -863 A > C, -857 T > C, -308 A > G and -238 A > G) revealed a significant overrepresentation of homozygous -1031 CC among CD patients (OR = 9.9) and an association with the colonic location. For TNF-α, eleven haplotypes were inferred, including two frequent ones, TCCGG and CACGG, which were significantly observed more frequently in controls and cases, respectively.CONCLUSION: This is one of the fi rst studies investigating the association between haplotype structure and disease location in a CD pediatric cohort. Our results will help to increase our understanding of the genetic determinants of childhood CD. | Rocio Sanchez Emile Levy Florin Costea Daniel Sinnett | 2009 | World Journal of Gastroenterology2009，15，30： | 9 |
| 8 | 室温下具有“内置”机制的导电油墨自烧结研究显示文摘目前,尚没有金属油墨可以在室温下只通过印刷步骤便形成导电图案的技术。例如使用纳米金属油墨在塑料电子产品上印制导电图案,必须进行额外的烧结处理,通常是通过加热至高温来实现。在烧结过程中,形成图案的纳米粒子(NPs)发生团聚以形成连续的导电层。近年来,发展了很多新型的烧结工艺,如微波、激光烧结,脉冲氙气、电子或化学烧结以及等离子烧结等,但是这些方法通常需要高成本的设备以及复杂的预处理或后处理工艺。因此,对于油墨而言,尚需研究的课题是,印制后无须额外烧结工艺即可获得高导电率。 | GROUCHKO Michael KAMYSHNY Alexander MIHAILESCU Cristina Florentina ANGHEL Dan Florin MAGDASSI Shlomo 王晓芳(编译) | 2011 | 中国印刷与包装研究2011，3，4： | 7 |
| 9 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet . 2012 (9813)2012，，9813： | 7 |
| 10 | Additive manufacturing of magnesium alloys显示文摘Magnesium alloys are a promising new class of degradable biomaterials that have a similar stiffness to bone,which minimizes the harmful effects of stress shielding.Use of biodegradable magnesium implants eliminates the need for a second surgery for repair or removal.There is a growing interest to capitalize on additive manufacturing's unique design capabilities to advance the frontiers of medicine.However,magnesium alloys are difficult to 3D print due to the high chemical reactivity that poses a combustion risk.Furthermore,the low vaporization temperature of magnesium and common biocompatible alloying elements further increases the difficulty to print fully dense structures that balance strength and corrosion requirements.The purpose of this study is to survey current techniques to 3D print magnesium constructs and provide guidance on best additive practices for these alloys. | Sam Ortgies Ali Tamayol Florin Bobaru Michael P.Sealy | 2020 | Bioactive Materials2020，5，1： | 4 |
| 11 | 欧盟反垄断公共实施与私人实施的冲突与协调——以宽大申请材料在私人诉讼中的披露问题为例显示文摘反垄断法的实施机制包括公共实施和私人实施。在任何采取二元实施机制的反垄断司法辖区,公私实施之间的冲突和协调问题均不容忽视,欧盟也不例外。宽大制度,基于其独特的价值功效,对欧盟反垄断法的公私实施都极为重要,也因而引发了强烈的冲突。应否允许卡特尔民事损害赔偿诉讼原告获取竞争执法机构掌握的宽大申请材料成为欧盟反垄断法实施面临的两难问题。对此,欧盟委员会和欧盟法院选择了不同的立场,前者对宽大申请材料给予绝对保护,后者则强调私人诉权的保障。EU第2014/104号指令延续了委员会的做法,但违反了欧盟法中的实效原则,应在坚持公共实施与私人实施同等重要的前提下,进一步完善二者的冲突协调机制。 | Danciu Florin 朱韵 | 2017 | 南京大学法律评论2017，，1： | 3 |
| 12 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012，，9813： | 3 |
| 13 | A review of the technologies for wave energy extraction显示文摘The main objective of this article is to provide a comprehensive picture of existing wave technologies being used for wave energy extraction.The overview will explain their potential and also the challenges wave technologies face.The article will also briefly discuss the benefits of combined offshore wind-wave projects,also known as hybrids.Key factors and impacts on relevant existing wave technologies will be outlined,including capacity factor and capture width.Finally the levelized cost of energy(LCOE)targets for the most promising technologies will be discussed. | Eugen Rusu Florin Onea | 2018 | Clean Energy2018，2，1： | 3 |
| 14 | IGBT:概念、发展与新结构(英文)显示文摘绝缘栅双极晶体管(IGBT)是当今最具创新性的功率器件,是目前为止唯一将MOSFET和双极结型晶体管结合在单元胞中的器件。由于MOSFET和双极结型晶体管对开关控制和导通状态都有影响,因此为了优化器件性能及安全工作区,对二者的工作状态需要仔细地折中考虑。文章阐述了IGBT技术的发展历史、器件结构及发展前景,涉及IGBT的基本概念及技术挑战,讨论了促使IGBT更新换代的主要技术进程,最后介绍了一些IGBT新型器件结构及新兴技术。 | Florin Udrea | 2017 | 大功率变流技术2017，0，5： | 3 |
| 15 | Endoscopic or percutaneous biliary drainage in hilar cholangiocarcinoma:When and how?显示文摘Hilar cholangiocarcinoma (hCCA) is a primary liver tumor associated with a dimprognosis. The role of preoperative and palliative biliary drainage has long beendebated. The most common techniques are endoscopic retrograde cholangiopancreatography(ERCP) and percutaneous transhepatic biliary drainage (PTBD);however, recently developed endoscopic ultrasound-assisted methods are gainingmore atention. Selecting the best available method in any specific scenario iscrucial, yet sometimes challenging. Thus, this review aimed to discuss theavailable techniques, indications, perks, pitfalls, and timing-related issues in themanagement of hCCA. In a preoperative setting, PTBD appears to have someadvantages: low risk of postprocedural complications (namely cholangitis) andbetter priming for surgery. For palliative purposes, we propose ERCP/PTBDdepending on the experience of the operators, but also on other factors: the levelof bilirubin (if very high, rather PTBD), length of the stenosis and the presence ofcholangitis (PTBD), ERCP failure, or altered biliary anatomy. | Tudor Mocan Adelina Horhat Emil Mois Florin Graur Cristian Tefas Rares Craciun Iuliana Nenu Mihaela Spârchez Zeno Sparchez | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 3 |
| 16 | Prognostic impact of body mass index on in-hospital bleeding complications after ST-segment elevation myocardial infarction显示文摘BACKGROUND ST-elevation myocardial infarction(STEMI)remains a major cause of mortality despite early revascularization and optimal medical therapy.Tailoring individual management by considering patients’specificities may help in improving post-STEMI survival.AIM To evaluate whether in-hospital bleeding complications may be involved in post STEMI prognosis among overweight patients.METHODS We prospectively included 2070 patients with a STEMI between January 2005 and December 2012 in the French observational cohort,“Registre d’Infarctus Maine-Anjou”.Bleeding Academic Research Consortium(BARC)in-hospital bleeding complications were recorded.RESULTS Of 705 patients(35.3%)were presented as being of normal weight,defined as a body mass index(BMI)<25 kg/m^2,877(43.9%)had a BMI between 25 and 30 kg/m^2and 416(20.8%)had a BMI≥30 kg/m^2.One-year cardiovascular mortality was lower for BMI≥25 kg/m^2(5.3%and 7.1%)patients than for normal weight patients(10.8%)(P=0.001).We found an interaction between the effect of BARC 3 on mortality and BMI groups.While a BARC 3 was related to a higher 1-year mortality in general(HR:2.58,95%CI:1.44-4.64,P≤0.001),prognosis was even worse in normal weight patients(HR:2.97,95%CI:1.61-5.5,P<0.001)than for patients with a BMI≥25 kg/m^2(HR:1.94,95%CI:1.02-3.69,P=0.041).CONCLUSION Normal weight patients presented higher rates of in-hospital bleeding complications and lower survival after a STEMI.Excess mortality might be due to greater vulnerability to bleeding amongst normal weight patients. | Delphine Ingremeau Sylvain Grall Florine Valliet Laurent Desprets Fabrice Prunier Alain Furber Loïc Bière | 2020 | World Journal of Cardiology2020，12，1： | 2 |
| 17 | Neural Network Analysis of Dynamic Sequences of EUS Elastography Used for the Differential Diagnosis of Chronic Pancreatitis and Pancreatic Cancer显示文摘 | Adrian Saftoiu Peter Vilmann Florin Gorunescu Dan Ionut Gheonea Marina Gorunescu Tudorel Ciurea Gabriel Lucian Popescu Alexandru Iordache Sevastita Iordache | 2008 | Gastrointestinal Endoscopy2008，，5： | 2 |
| 18 | Clinically active Crohn’s disease in the presence of a low C-reactive protein显示文摘 | Timothy H. J. Florin Ewan W. J. Paterson Elizabeth V. Fowler Graham L. Radford-Smith | 2006 | Scandinavian Journal of Gastroenterology2006，，3： | 2 |
| 19 | Evaluation of the seismic hazard for 20 cities in Romania using Monte Carlo based simulations显示文摘This work focuses on the evaluation of the seismic hazard for Romania using earthquake catalogues generated by a Monte Carlo approach. The seismicity of Romania can be attributed to the Vrancea intermediate-depth seismic source and to 13 other crustal seismic sources. The recurrence times of large magnitude seismic events(both crustal and subcrustal), as well as the moment release rates are computed using simulated earthquake catalogues. The results show that the largest contribution to the overall moment release for the crustal seismic sources is from the seismic regions in Bulgaria, while the seismic regions in Romania contribute less than 5% of the overall moment release. In addition, the computations show that the moment release rate for the Vrancea subcrustal seismic source is about ten times larger than that of all the crustal seismic sources. Finally, the Monte Carlo approach is used to evaluate the seismic hazard for 20 cities in Romania with populations larger than 100,000 inhabitants. The results show some differences between the seismic hazard values obtained through Monte-Carlo simulation and those in the Romanian seismic design code P100-1/2013, notably for cities situated in the western part of Romania that are influenced by local crustal seismic sources. | Florin Pavel Radu Vacareanu | 2017 | Earthquake Engineering and Engineering Vibration2017，16，3： | 2 |
| 20 | Combined contrast-enhanced power Doppler and real-time sonoelastography performed during EUS, used in the differential diagnosis of focal pancreatic masses (with videos)显示文摘 | Adrian S?ftoiu Sevasti?a Iordache Dan Ionu? Gheonea Carmen Popescu Anca Malo? Florin Gorunescu Tudorel Ciurea Alexandru Iordache Gabriel Lucian Popescu Cǎtǎlin Manea | 2010 | Gastrointestinal Endoscopy2010，，4： | 2 |
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