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| 1 | Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome显示文摘Accumulating evidence suggests that ketogenic diets(KDs)mediate the rise of circulating ketone bodies and exert a potential antiinflammatory effect;however,the consequences of this unique diet on colitis remain unknown.We performed a series of systematic studies using a dextran sulfate sodium(DSS)animal model of inflammatory colitis.Animals were fed with a KD,low-carbohydrate diet(LCD),or normal diet(ND).Germ-free mice were utilized in validation experiments.Colon tissues were analyzed by transcriptome sequencing,RT2 profiler PCR array,histopathology,and immunofluorescence.Serum samples were analyzed by metabolic assay kit.Fecal samples were analyzed by 16S rRNA gene sequencing,liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry.We observed that KD alleviated colitis by altering the gut microbiota and metabolites in a manner distinct from LCD.Quantitative diet experiments confirmed the unique impact of KD relative to LCD with a reproducible increase in Akkermansia,whereas the opposite was observed for Escherichia/Shigella.After colitis induction,the KD protected intestinal barrier function,and reduced the production of R0Ryt+CD3_group 3 innate lymphoid cells(ILC3s)and related inflammatory cytokines(IL-17a,IL-18,IL-22,Ccl4).Finally,fecal microbiota transplantation into germ-free mice revealed that the KD-mediated colitis inhibition and ILC3 regulation were dependent on the modification of gut microbiota.Taken together,our study presents a global view of microbiome-metabolomics changes that occur during KD colitis treatment,and identifies the regulation of gut microbiome and ILC3s as novel targets involving in IBD dietary therapy. | Cheng Kong Xuebing Yan Yongqiang Liu Linsheng Huang Yefei Zhu Jide He Renyuan Gao Matthew F.Kalady Ajay Goel Huanlong Qin Yanlei Ma | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 8 |
| 2 | Anthrax: A disease of biowarfare and public health importance显示文摘Bioterrorism has received a lot of attention in the first decade of this century. Biological agents are considered attractive weapons for bioterrorism as these are easy to obtain, comparatively inexpensive to produce and exhibit widespread fear and panic than the actual potential of physical damage. Bacillus anthracis(B. anthracis), the etiologic agent of anthrax is a Gram positive, spore forming, non-motile bacterium. This is supposed to be one of the most potent BW agents because its spores are extremely resistant to natural conditions and can survive for several decades in the environment. B.anthracis spores enter the body through skin lesion(cutaneous anthrax), lungs(pulmonary anthrax), or gastrointestinal route(gastrointestinal anthrax) and germinate, giving rise to the vegetative form. Anthrax is a concern of public health also in many countries where agriculture is the main source of income including India. Anthrax has been associated with human history for a very long time and regained its popularity after Sept 2001 incidence in United States. The present review article describes the history, biology, life cycle, pathogenicity, virulence, epidemiology and potential of B. anthracis as biological weapon. | Ajay Kumar Goel | 2015 | World Journal of Clinical Cases2015，3，1： | 6 |
| 3 | MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis显示文摘 | Keun Hur Yuji Toiyama Masanobu Takahashi Francesc Balaguer Takeshi Nagasaka Junichi Koike Hiromichi Hemmi Minoru Koi C Richard Boland Ajay Goel | 2013 | Gut2013，，9： | 6 |
| 4 | Molecular Classification and Correlates in Colorectal Cancer显示文摘 | Shuji Ogino Ajay Goel | 2008 | The Journal of Molecular Diagnostics2008，，1： | 3 |
| 5 | Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer显示文摘 | Yuji Toiyama Keun Hur Koji Tanaka Yasuhiro Inoue Masato Kusunoki C. Richard Boland Ajay Goel | 2014 | Annals of Surgery2014，，4： | 3 |
| 6 | DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer显示文摘 | Yuji Toiyama Yoshinaga Okugawa Ajay Goel | 2014 | Biochemical and Biophysical Research Communications2014，，： | 2 |
| 7 | Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma显示文摘Pancreatic ductal adenocarcinoma(PDAC)is characterized by the highest mortality among carcinomas.The pathogenesis of PDAC requires elevated autophagy,inhibition of which using hydroxychloroquine has shown promise.However,current realization is impeded by its suboptimal use and unpredictable toxicity.Attempts to identify novel autophagy-modulating agents from already approved drugs offer a rapid and accessible approach.Here,using a patient-derived organoid model,we performed a comparative analysis of therapeutic responses among various antimalarial/fungal/parasitic/viral agents,through which econazole(ECON),an antifungal compound,emerged as the top candidate.Further testing in cell-line and xenograft models of PDAC validated this activity,which occurred as a direct consequence of dysfunctional autophagy.More specifically,ECON boosted autophagy initiation but blocked lysosome biogenesis.RNA sequencing analysis revealed that this autophagic induction was largely attributed to the altered expression of activation transcription factor 3(ATF3).Increased nuclear import of ATF3 and its transcriptional repression of inhibitor of differentiation-1(ID-1)led to inactivation of the AKT/mammalian target of rapamycin(m TOR)pathway,thus giving rise to autophagosome accumulation in PDAC cells.The magnitude of the increase in autophagosomes was sufficient to elicit ER stress-mediated apoptosis.Furthermore,ECON,as an autophagy inhibitor,exhibited synergistic effects with trametinib on PDAC.This study provides direct preclinical and experimental evidence for the therapeutic efficacy of ECON in PDAC treatment and reveals a mechanism whereby ECON inhibits PDAC growth. | Ningna Weng Siyuan Qin Jiayang Liu Xing Huang Jingwen Jiang Li Zhou Zhe Zhang Na Xie Kui Wang Ping Jin Maochao Luo Liyuan Peng Edouard C.Nice Ajay Goel Suxia Han Canhua Huang Qing Zhu | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 8 | Zinc mediates normalization of hepatic drug metabolizing enzymes in chlorpyrifos-induced toxicity显示文摘 | Ajay Goel Vijayta Dani D.K. Dhawan | 2006 | Toxicology Letters2006，，1： | 1 |
| 9 | Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers显示文摘 | Yoshinaga Okugawa William M. Grady Ajay Goel | 2015 | Gastroenterology2015，，5： | 1 |
| 10 | Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer显示文摘 | John M. Carethers E.Julieta Smith Cynthia A. Behling Lanchinh Nguyen Akihiro Tajima Ryan T. Doctolero Betty L. Cabrera Ajay Goel Christian A. Arnold Katsumi Miyai C.Richard Boland | 2004 | Gastroenterology2004，，2： | 1 |
| 11 | Recent insights into the pathogenesis of colorectal cancer显示文摘 | Ajay Goel Clement Richard Boland | 2010 | Current Opinion in Gastroenterology2010，，1： | 1 |
| 12 | Curcumin as “ Curecumin ”: From kitchen to clinic显示文摘 | Ajay Goel Ajaikumar B. Kunnumakkara Bharat B. Aggarwal | 2007 | Biochemical Pharmacology2007，，4： | 1 |
| 13 | Specific inhibitioff of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT29 human colon cancer cells显示文摘 | Ajay Goel Richard CB Dharam PC | 2001 | Cancer Letter2001，172，： | 1 |
| 14 | The CpG Island Methylator Phenotype and Chromosomal Instability Are Inversely Correlated in Sporadic Colorectal Cancer显示文摘 | Ajay Goel Takeshi Nagasaka Christian N. Arnold Toru Inoue Cody Hamilton Donna Niedzwiecki Carolyn Compton Robert J. Mayer Richard Goldberg Monica M. Bertagnolli C. Richard Boland | 2007 | Gastroenterology2007，，1： | 1 |
| 15 | Curcumin as “ Curecumin ”: From kitchen to clinic显示文摘 | Ajay Goel Ajaikumar B. Kunnumakkara Bharat B. Aggarwal | 2007 | Biochemical Pharmacology2007，，4： | 1 |
| 16 | Utility of trans-vaginal ultrasound in diagnosis and follow-up of non-pregnant sexually active females with lower ureteric calculi显示文摘objective:To assess the utility of trans-vaginal ultrasonography in evaluation of non-pregnant sexually active female patients with lower ureteric calculi.Methods:A prospective study was done from January 2015 to December 2017 including non-pregnant sexually active females with suspected ureteric calculus.Trans-abdominal ultrasound was initially done in all patients.In those patients in whom trans-abdominal ultrasound was inconclusive or there was indirect evidence of lower ureteric calculus in form of ureteral dila-tion but no calculus was evident,trans-vaginal ultrasound was done.The patients with ureteric calculi detected on trans-vaginal ultrasound and kept on conservative management were also followed up with trans-vaginal ultrasound.Non-contrast computed tomography was done in patients with inconclusive trans-vaginal ultrasound.Results:As per the study protocol,156 out of the total 468 patients evaluated by trans-abdominal ultrasound were eligible for trans-vaginal ultrasound.Trans-vaginal ultrasound was done in 149 patients,as seven patients did not give consent.Seventy-nine patients were detected with a lower ureteric calculus on trans-vaginal ultrasound and 27 patients had gyne-cologic or other cause for their symptoms.Forty-three patients had an inconclusive trans-vaginal ultrasound of which 36 underwent non-contrast computed tomography,among them only one patient had a lower ureteric calculus.Stone free status could be easily demonstrated on follow-up trans-vaginal ultrasound. | Siddharth Pandey Tanica Pandey Apul Goel Ajay Aggarwal Deepanshu Sharma Tushar Pandey Satya sankhwar Gaurav Garg | 2020 | Asian Journal of Urology2020，7，1： | 1 |
| 17 | Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes显示文摘Dear Editor,Recent studies from us and others have deciphered the clinical relevance of a variety of oncohistones1 in different diseases.The H3K27M and H3K36M mutant histones exert dominant-negative effects on methylation levels of histone H3K27 and H3K36 on wildtype histone protein in pediatric brain cancers2–4 and chondroblastoma,5,6 respectively.In contrast to H3K27M and H3K36M that act in trans to cause global reduction of methylation at the respective residues,the H3G34 mutations,including H3G34V/R and H3G34W/L found in pediatric high-grade glioma and giant cell tumor of the bone,affect the H3K36 methylation in cis and alter the H3K36 methylation on the nucleosome containing the H3G34 mutation(s). | Yi Ching Esther Wan Tsz Chui Sophia Leung Dongbo Ding Xulun Sun Jiaxian Liu Lina Zhu Tze Zhen Evangeline Kang Du Yang Yuchen Zhang Jitian Zhang Chengmin Qian Michael Shing Yan Huen Qing Li Maggie Zi Ying Chow Zongli Zheng Junhong Han Ajay Goel Xin Wang Toyotaka Ishibashi Kui Ming Chan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 18 | Curcumin as “ Curecumin ”: From kitchen to clinic显示文摘 | Ajay Goel Ajaikumar B. Kunnumakkara Bharat B. Aggarwal | 2007 | Biochemical Pharmacology2007，，4： | 1 |
| 19 | Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells显示文摘 | Ajay Goel C.Richard Boland Dharam P Chauhan | 2001 | Cancer Letters2001，，2： | 1 |
| 20 | Aberrant DNA Methylation in Hereditary Nonpolyposis Colorectal Cancer Without Mismatch Repair Deficiency显示文摘 | Ajay Goel Rosa M. Xicola Thuy–Phuong Nguyen Brian J. Doyle Vanessa R. Sohn Prathap Bandipalliam Laura S. Rozek Josep Reyes Carmen Cordero Francesc Balaguer Antoni Castells Rodrigo Jover Montserrat Andreu Sapna Syngal C. Richard Boland Xavier Llor | 2010 | Gastroenterology2010，，5： | 1 |
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