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| 1 | Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate显示文摘Generation of widely differing and specialized cell types from a single totipotent zygote involves large-scale transcriptional changes and chromatin reorganization. Pioneer transcription factors play key roles in programming the epigenome and facilitating recruitment of additional regulatory factors during successive cell lineage specification and differentiation steps. Here we show that Isl1 acts as a pioneer factor driving cardiomyocyte lineage commitment by shaping the chromatin landscape of cardiac progenitor cells. Using an Isl1 hypomorphic mouse line which shows congenital heart defects, genome-wide profiling of Isl1 binding together with RNA- and ATAC-sequencing of cardiac progenitor cells and their derivatives, we uncover a regulatory network downstream of Isl1 that orchestrates cardiogenesis. Mechanistically, we show that Isl1 binds to compacted chromatin and works in concert with the Brg1-Baf60c-based SWI/SNF complex to promote permissive cardiac lineage-specific alterations in the chromatin landscape not only of genes with critical functions in cardiac progenitor cells, but also of cardiomyocyte structural genes that are highly expressed when Isl1 itself is no longer present. Thus, the Isl1/Brg1-Baf60c complex plays a crucial role in orchestrating proper cardiogenesis and in establishing epigenetic memory of cardiomyocyte fate commitment. | Rui Gao Xingqun Liang Sirisha Cheedipudi Julio Cordero Xue Jiang Qingquan Zhang Luca Caputo Stefan Günther Carsten Kuenne Yonggang Ren Shoumo Bhattacharya Xuejun Yuan Guillermo Barreto Yihan Chen Thomas Braun Sylvia M. Evans Yunfu Sun Gergana Dobreva | 2019 | Cell Research2019，29，6： | 5 |
| 2 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 3 | High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX显示文摘 | Indrabahadur Singh Nihan Ozturk Julio Cordero Aditi Mehta Diya Hasan Claudia Cosentino Carlos Sebastian Marcus Kruger Mario Looso Gianni Carraro Saverio Bellusci Werner Seeger Thomas Braun Raul Mostoslavsky Guillermo Barreto | 2015 | Cell Research2015，25，7： | 5 |
| 4 | 在与心肌的梗塞介绍的就医的病人的心率的预示的意义显示文摘 AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors. METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year. RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009). CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up. | Lorenzo Fácila Pedro Morillas Juan Quiles Federico Soria Alberto Cordero Pilar Mazón Manuel Anguita Cándido Martín-Luengo Jose Ramón Gonzalez-Juanatey Vicente Bertomeu | 2012 | World Journal of Cardiology2012，4，1： | 3 |
| 5 | 低聚木糖和木聚糖酶可提高猪的生产性能显示文摘鉴于木聚糖酶能够间接提高仔猪的存活率和饲料转化率,美国许多养猪生产者正在饲料中添加该酶制剂。本文详细介绍了木聚糖酶的作用方式。 | 张相鑫(译) 潘雪男(校) Laura Merriman Gustavo Cordero Pete Wilcock | 2020 | 国外畜牧学(猪与禽)2020，40，12： | 2 |
| 6 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 7 | New charge-carrier blocking materials for high efficiency OLEDs显示文摘 | Vadim I. Adamovich Steven R. Cordero Peter I. Djurovich Arnold Tamayo Mark E. Thompson Brian W. D’Andrade Stephen R. Forrest | 2003 | Organic Electronics2003，，2： | 2 |
| 8 | Liver Retransplantation in HIV‐Infected Patients: A Prospective Cohort Study显示文摘 | M. Gastaca F. Aguero A. Rimola M. Montejo P. Miralles R. Lozano L. Castells M. Abradelo M. de la Mata F. San Juan Rodríguez E. Cordero S. del Campo C. Manzardo J.O. de Urbina I. Pérez G. de la Rosa J. M. Miro | 2012 | American Journal of Transplantation2012，，9： | 2 |
| 9 | Outcome of HCV/HIV‐Coinfected Liver Transplant Recipients: A Prospective and Multicenter Cohort Study显示文摘 | J. M. Miro M. Montejo L. Castells A. Rafecas S. Moreno F. Agüero M. Abradelo P. Miralles J. Torre‐Cisneros J. D. Pedreira E. Cordero G. de la Rosa B. Moyano A. Moreno I. Perez A. Rimola | 2012 | American Journal of Transplantation2012，，7： | 2 |
| 10 | Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit显示文摘 | Robert W. Busby Alexander P. Bryant Wilmin P. Bartolini Etchell A. Cordero Gerhard Hannig Marco M. Kessler Shalina Mahajan-Miklos Christine M. Pierce Robert M. Solinga Li Jing Sun Jenny V. Tobin Caroline B. Kurtz Mark G. Currie | 2010 | European Journal of Pharmacology2010，，1： | 2 |
| 11 | 甜菜碱对猪生产性能的积极作用显示文摘甜菜碱是一种饲料添加剂,具有渗透调节能力和甲基供体的特性。在仔猪和肥育猪日粮中添加甜菜碱,不仅可以提高猪的生长性能,改善胴体特性,还可以降低日粮成本,提高养猪生产的经济效益。甜菜碱是存在于动物、细菌和植物原料中的一种天然成分。由于其具有渗透能力(能够保持水分子),通过累积可以调控盐的浓度和/或温度的变化。 | 王晶晶 靳文广 Gustavo Cordero Tiago Santos | 2014 | 国外畜牧学(猪与禽)2014，0，10： | 2 |
| 12 | Interaction of lithium with graphene: an ab initio study 显示文摘 | KHANTHA M CORDERO N A MOLINA L M | 2004 | Physical Review B2004，70，12： | 1 |
| 13 | Surface changes of alumina induced by phosphoric acid impregnation 显示文摘 | Cordero R L | 1989 | Applied Catalysis1989，56，： | 1 |
| 14 | Shear stress - strain - time behaviour of clays显示文摘 | Mesri G Rebres - Cordero E Shields D R | 1981 | Géotechnique1981，，04： | 1 |
| 15 | TheCaMV?35S promoter is highly active on floral organs and pollen of transgenic strawberry plants显示文摘 | M. Cordero Mesa N. Santiago-Doménech F. Pliego-Alfaro M. A. Quesada J. A. Mercado | 2004 | Plant Cell Reports (-)2004，，1： | 1 |
| 16 | Rocuronium vs vecuronium for neuromuscular block during transsternal thymectomy in the patient with myasthenia gravis 显示文摘 | CORDERO ESCOBAR I | 2011 | Rev Esp Anestesiol Reanim2011，58，10： | 1 |
| 17 | Capsule growth in Cryptococcus neoformans is coordinated with cell cycle progression显示文摘 | García-Rodas R Cordero RJ Trevijano-Contador N | 2014 | MBio2014，5，3： | 1 |
| 18 | Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia显示文摘 | Ramon-cueto A Cordero MI Santos-Benito FF | 2000 | Neuron2000，25，2： | 1 |
| 19 | Zinc supplementation reduced cost and duration of acute diarrhea in children 显示文摘 | Gregorio GV Dans LF Cordero CP | 2007 | J Clin Epidemiol2007，60，6： | 1 |
| 20 | Genetic variation in the interleukin-8 gene promoter and vaginal concentrations of interleukin--8 are not associated with bacterial vaginosis during pregnancy显示文摘 | Diaz-Cueto L Cuiea Flores A Ziga Cordero F | 2005 | J Reprod Immuno12005，66，2： | 1 |
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