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| 1 | 藏北那曲地区大气边界层特征分析显示文摘利用'全球协调加强观测计划(CEOP)亚澳季风之青藏高原试验'(CAMP/Tibet)2002年8月预试验期间(PIOP)藏北高原观测站(BJ站和安尼站)的无线电探空仪的探空资料,分析了藏北那曲地区的大气边界层位温、比湿、风速的日变化特征及稳定边界层和对流边界层特征。结果表明,藏北那曲地区边界层日变化大,对流混合层高度最高可达1800m,下雨天形成对流边界层的时间晚于阴天和晴天的时间。 | 李茂善 马耀明 胡泽勇 马伟强 王介民 OGINO Shin-ya | 2004 | 高原气象2004，23，5： | 46 |
| 2 | 藏北高原地区干、雨季大气边界层结构的不同特征显示文摘利用2004年4月预试验期(PIOP)和8月加强期(IOP)的无线电探空仪观测资料,分析了藏北高原地区干、雨季大气边界层结构的不同特征.结果显示:藏北高原地区边界层虚位温、比湿等日变化大,对流混合层高度较高,高度干季在2 211~4 430m之间,雨季在1 006~2 212m之间,干季的对流混合层高度明显高于雨季时的对流混合层高度.干季的比湿明显小于湿季比湿,在干季和雨季都存在逆湿现象;干季时水平风风向基本以偏西风为主,雨季低层2 500m以下基本以偏东风为主,上层以偏西风为主;干季近地层水平风速都较小,随高度增加风速迅速增大,雨季边界层内风速都较小. | 李茂善 马耀明 马伟强 Ishikawa Hirohiko 孙方林 Ogino Shin-Ya | 2011 | 冰川冻土2011，33，1： | 22 |
| 3 | Toll-like receptor signaling in colorectal cancer:carcinogenesis to cancer therapy显示文摘Toll-like receptors(TLRs)are germ line encoded innate immune sensors that recognize conserved microbial structures and host alarmins,and signal expression of major histocompatibility complex proteins,costimulatory molecules,and inflammatory mediators by macrophages,neutrophils,dendritic cells,and other cell types.These protein receptors are characterized by their ability to respond to invading pathogens promptlyby recognizing particular TLR ligands,including flagellin and lipopolysaccharide of bacteria,nucleic acids derived from viruses,and zymosan of fungi.There are2 major TLR pathways;one is mediated by myeloid differentiation factor 88(MYD88)adaptor proteins,and the other is independent of MYD88.The MYD88-dependent pathway involves early-phase activation of nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(NF-κB1)and all the TLRs,except TLR3,have been shown to activate this pathway.TLR3and TLR4 act via MYD88-independent pathways with delayed activation of NF-κB signaling.TLRs play a vital role in activating immune responses.TLRs have been shown to mediate inflammatory responses and maintain epithelial barrier homeostasis,and are highly likely to be involved in the activation of a number of pathways following cancer therapy.Colorectal cancer(CRC)is one of the most common cancers,and accounts for almost half a million deaths annually worldwide.Inflammation is considered a risk factor for many common malignancies including cancers of the colorectum.The key molecules involved in inflammation-driven carcinogenesis include TLRs.As sensors of cell death and tissue remodeling,TLRs may have a universal role in cancer;stimulation of TLRs to activate the innate immune system has been a legitimate therapeutic strategy for some years.TLRs 3/4/7/8/9 are all validated targets for cancer therapy,and a number of companies are developing agonists and vaccine adjuvants.On the other hand,antagonists may favor inhibition of signaling responsible for autoimmune responses.In this paper,we review TLR signaling in CRC from carcinogenesis to cancer therapy. | Ting-Ting Li Shuji Ogino Zhi Rong Qian | 2014 | World Journal of Gastroenterology2014，20，47： | 18 |
| 4 | Promising biological therapies for ulcerative colitis: A review of the literature显示文摘Ulcerative colitis(UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. There is no single known unifying cause, and the pathogenesis is multifactorial, with genetics, environmental factors, microbiota, and the immune system all playing roles. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants(including purine antimetabolites, cyclosporine, and tacrolimus), and surgery. Therapeutic goals for UC are evolving. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab, an anti-tumor necrosis factor(TNF)-α monoclonal antibody, is the first biological agent for the treatment of UC. Over the last decade, infliximab and adalimumab(anti-TNF-α agents) have been used for moderate to severe UC, and have been shown to be effective in inducing and maintaining remission. Recent studies have indicated that golimumab(another anti-TNF-α agent), tofacitinib(a Janus kinase inhibitor), and vedolizumab and etrolizumab(integrin antagonists), achieved good clinical remission and response rates in UC. Recently, golimumab and vedolizumab have been approved for UC by the United States Food and Drug Administration. Vedolizumab may be used as a first-line alternative to anti-TNF-α therapy in patients with an inadequate response to corticosteroids and/or immunosuppressants. Here, we provide updated information on various biological agents in the treatment of UC. | Hirotada Akiho Azusa Yokoyama Shuichi Abe Yuichi Nakazono Masatoshi Murakami Yoshihiro Otsuka Kyoko Fukawa Mitsuru Esaki Yusuke Niina Haruei Ogino | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 5 | Different characteristics of the structure of atmospheric boundary layer between dry and rainy periods over the northern Tibetan Plateau显示文摘In this paper, based on in-situ observational data of the Coordinated Enhanced Observing Period (CEOP) Asia-Australia Monsoon Project (CAMP) on the Tibetan Plateau (CAMP-Tibet), structure of the Atmospheric Boundary Layer (ABL) was preliminarily studied during the dry and rainy seasons. The main results show: (a) Diurnal variation of the ABL is obvious over the northern Tibetan Plateau area. The height of the ABL is different with the season change, which ranges from 2,211 m to 4,430 m during the pre-monsoon season and from 1,006 m to 2,212 m during the monsoon season. The ABL height is higher during the dry period than during the rainy period. (b) The humidity is lower during the dry period than during the rainy period, and there are reverse humidity during both periods. (c) Horizontal wind direction is mostly west during the dry period, east under the height of 2,500 m and west above the height of 2,500 m during the rainy period. The wind speed is low during both the rainy and dry periods in the lower ABL layer. The wind speed is stronger within the upper ABL during the dry period than during the rainy period. | Ishikawa Hirohiko Shinya Ogino | 2011 | Research in Cold and Arid Regions2011，3，6： | 6 |
| 6 | Duplication cyst of the small intestine found by double-balloon endoscopy:A case report显示文摘A 35-year-old man was admitted due to bloody stool and anemia. The bleeding source could not be detected by esophagogastroduodenoscopy or colonoscopy. Double balloon endoscopy (DBE) revealed a diverticulum-like hole in which coagula stuck in the ileum at 1 meter on the oral side from the ileocecal valve. The adjacent mucosa just to the oral side of the hole was elevated like a submucosal tumor. The lesion was considered the source of bleeding and removed surgically. It was determined to be a cyst with an ileal structure on the mesenteric aspect accompanying gastric mucosa. The diagnosis was a duplication cyst of the ileum,which is a rare entity that can cause gastrointestinal bleeding. In the present case,DBE was used to fi nd the hemorrhagic duplication cyst in the ileum. | Haruei Ogino Toshiaki Ochiai Norimoto Nakamura Daisuke Yoshimura Teppei Kabemura Tetsuya Kusumoto Hiroshi Matsuura Akihiko Nakashima Kuniomi Honda Kazuhiko Nakamura | 2008 | World Journal of Gastroenterology2008，14，24： | 5 |
| 7 | A pedunculated polyp-shaped small-bowel lymphangioma causing gastrointestinal bleeding and treated by double-balloon enteroscopy显示文摘We report a rare case of a small-bowel lymphangioma causing massive gastrointestinal (GI) bleeding that we successfully diagnosed and treated using double-balloon enteroscopy (DBE). An 81-year-old woman suffering from repeated GI bleeding of unknown origin underwent a capsule endoscopy at a previous hospital. She was suspected of having bleeding from the jejunum, and was referred to our department for diagnosis and treatment. An oral DBE revealed a 20 mm × 10 mm, regularly surfaced, white to yellowish, elongated, pedunculated jejunal polyp with small erosions at 10 cm distal to the ligament of Treiz. Since no other source of bleeding was identified by endoscopy in the deep jejunum, anendoscopic polypectomy (EP) was performed for this lesion. A subsequent histopathological examination of the resected polyp showed clusters of lymphatic vessels with marked cystic dilatation in the submucosa and the deep layer of the lamina propria mucosae. These characteristics are consistent with the typical features of small-bowel lymphangioma with erosions. Although clip-ping hemostasis was performed during EP, re-bleeding occurred. Finally, a complete hemostasis was achieved by performing an additional argon plasma coagulation. | Akihiko Kida Koichiro Matsuda Satoshi Hirai Akiyoshi Shimatani Yousuke Horita Katsushi Hiramatsu Mitsuru Matsuda Hidero Ogino Shin Ishizawa Yatsugi Noda | 2012 | World Journal of Gastroenterology2012，18，34： | 5 |
| 8 | Fe-doped TiO_2/SiO_2 nanofibrous membranes with surface molecular imprinted modification for selective photodegradation of 4-nitrophenol显示文摘In this study, Fe-doped TiO_2/SiO_2(Fe@TS) nanofibrous membranes with molecular imprinted modification, were fabricated by a combination of sol-gel process, electrospinning, calcination and liquid phase deposition techniques. The precursor sol was prepared from one-pot condensation of poly(vinylpyrrolidone), ferric chloride hexahydrate, tetraethyl orthosilicate and titanium n-butoxide in the mixture solvents of N,N-dimethylformamide and ethyl alcohol. Fibrous membrane wasthen fabricated by electrospinning, followed by calcination to form the Fe@TS composite. The physicochemical properties of Fe@TS were characterized. Thereafter, 4-nitrophenol(4 NP) was used as the template to deposit onto nanofibrous Fe@TS membranes, with a thin layer of molecular imprinted polymer in liquid phase. The photodegradation capabilities of 4 NP and methyl orange wereexamined in both single and binary systems. The results demonstrated that molecular imprinted Fe@TS membranes exhibited excellent selectivity for photodegradation of 4 NP. | Xiaoqiang Li Jidong Wang Mengjuan Li Yang Jin Zhijie Gu Changchun Liu Kenji Ogino | 2018 | Chinese Chemical Letters2018，29，3： | 5 |
| 9 | Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma显示文摘Synovial sarcoma(SS) is genetically characterized by chromosomal translocation, which generates SYT-SSX fusion transcripts. Although SS can occur in any body part, primary gastric SS is substantially rare. Here we describe a detection of the fusion gene sequence of gastric SS in plasma cell-free DNA(cf DNA). A gastric submucosal tumor was detected in the stomach of a 27-year-old woman and diagnosed as SS. Candidate intronic primers were designed to detect the intronic fusion breakpoint and this fusion sequence was confirmed in intron 10 of SYT and intron 5 of SSX2 by genomic polymerase chain reaction(PCR) and direct sequencing. A locked nucleic acid(LNA) probe specificto the fusion sequence was designed for detecting the fusion sequence in plasma and the fusion sequence was detected in preoperative plasma cfD NA, while not detected in postoperative plasma cfD NA. This technique will be useful for monitoring translocation-derived diseases such as SS. | Shinpei Ogino Hirotaka Konishi Daisuke Ichikawa Junichi Hamada Katsutoshi Shoda Tomohiro Arita Shuhei Komatsu Atsushi Shiozaki Kazuma Okamoto Sanae Yamazaki Satoru Yasukawa Eiichi Konishi Eigo Otsuji | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 10 | A Prospective Cohort Study Shows Unique Epigenetic, Genetic, and Prognostic Features of Synchronous Colorectal Cancers显示文摘 | Katsuhiko Nosho Shoko Kure Natsumi Irahara Kaori Shima Yoshifumi Baba Donna Spiegelman Jeffrey A. Meyerhardt Edward L. Giovannucci Charles S. Fuchs Shuji Ogino | 2009 | Gastroenterology2009，，5： | 4 |
| 11 | Molecular Classification and Correlates in Colorectal Cancer显示文摘 | Shuji Ogino Ajay Goel | 2008 | The Journal of Molecular Diagnostics2008，，1： | 3 |
| 12 | 通过DNA甲基化定量分析和前瞻性队列研究可以最佳地表现结肠直肠癌CpG岛甲基化表型的特征 | Ogino S. Cantor M. Kawasaki T. 周智勇 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，11： | 3 |
| 13 | 采用X射线吸收光谱表征单原子催化剂:至关重要与持久挑战(英文)显示文摘X射线吸收光谱(XAS)可为负载型单中心(单原子或单核金属络合物)催化剂的结构和电子特性提供重要信息.虽然XAS技术可表征真实反应条件下、无需长程有序结构的催化剂,并且可提供对于负载型单中心催化剂非常重要的金属-载体界面信息;但是它给出的信息是包括与催化有关或无关的所有负载型金属物种的平均信息.负载型催化剂的准确表征具有长期挑战性,也限制了我们准确地理解催化剂的构效关系.为了更好地利用XAS表征技术,深入研究催化剂的构效关系,并最终用其指导设计开发出高效的催化剂,制备具有均一结构活性位的负载型单中心催化剂,并采用XAS及相关技术对其表征至关重要.本文列举了一些实例以说明XAS在表征具有均一结构活性位的负载型单中心催化剂方面的能力,以及XAS如何与其他技术(如扫描透射电子显微镜和红外光谱)互补,为以分子筛和金属-有机骨架材料为载体而制得的具有均一结构活性位的负载型单中心催化剂提供原子尺度的信息. | Isao Ogino | 2017 | Chinese Journal of Catalysis2017，38，9： | 3 |
| 14 | Microsatellite Instability and BRAF Mutation Testing in Colorectal Cancer Prognostication显示文摘 | Paul Lochhead Aya Kuchiba Yu Imamura Xiaoyun Liao Mai Yamauchi Reiko Nishihara Zhi Rong Qian Teppei Morikawa Jeanne Shen Jeffrey A. Meyerhardt Charles S. Fuchs Shuji Ogino | 2013 | JNCI Journal of the National Cancer Institute2013，，15： | 3 |
| 15 | Hyperglycemia, Insulin Resistance, Impaired Pancreatic β-Cell Function, and Risk of Pancreatic Cancer显示文摘 | Brian M. Wolpin Ying Bao Zhi Rong Qian Chen Wu Peter Kraft Shuji Ogino Meir J. Stampfer Kaori Sato Jing Ma Julie E. Buring Howard D. Sesso I-Min Lee John Michael Gaziano Anne McTiernan Lawrence S. Phillips Barbara B. Cochrane Michael N. Pollak JoAnn E. Ma | 2013 | JNCI Journal of the National Cancer Institute2013，，14： | 2 |
| 16 | Endoscopic mucosal resection vs endoscopic submucosal dissection for superficial non-ampullary duodenal tumors显示文摘BACKGROUND The selection of endoscopic treatments for superficial non-ampullary duodenal epithelial tumors(SNADETs)is controversial.AIM To compare the efficacy and safety of endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)for SNADETs.METHODS We retrospectively analyzed the data of patients with SNADETs from a database of endoscopic treatment for SNADETs,which included eight hospitals in Fukuoka,Japan,between April 2001 and October 2017.A total of 142 patients with SNADETs treated with EMR or ESD were analyzed.Propensity score matching was performed to adjust for the differences in the patient characteristics between the two groups.We analyzed the treatment outcomes,including the rates of en bloc/complete resection,procedure time,adverse event rate,hospital stay,and local or metastatic recurrence.RESULTS Twenty-eight pairs of patients were created.The characteristics of patients between the two groups were similar after matching.The EMR group had a significantly shorter procedure time and hospital stay than those of the ESD group[median procedure time(interquartile range):6(3-10.75)min vs 87.5(68.5-136.5)min,P<0.001,hospital stay:8(6-10.75)d vs 11(8.25-14.75)d,P=0.006].Other outcomes were not significantly different between the two groups(en bloc resection rate:82.1%vs 92.9%,P=0.42;complete resection rate:71.4%vs 89.3%,P=0.18;and adverse event rate:3.6%vs 17.9%,P=0.19,local recurrence rate:3.6%vs 0%,P=1;metastatic recurrence rate:0%in both).Only one patient in the ESD group underwent emergency surgery owing to intraoperative perforation.CONCLUSION EMR has significantly shorter procedure time and hospital stay than ESD,and provides acceptable curability and safety compared to ESD.Accordingly,EMR for SNADETs is associated with lower medical costs. | Mitsuru Esaki Kazuhiro Haraguchi Kazuya Akahoshi Naru Tomoeda Akira Aso Soichi Itaba Haruei Ogino Yusuke Kitagawa Hiroyuki Fujii Kazuhiko Nakamura Masaru Kubokawa Naohiko Harada Yosuke Minoda Sho Suzuki Eikichi Ihara Yoshihiro Ogawa | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 2 |
| 17 | Mucosal necrosis of the small intestine in myopathy,encephalopathy,lactic acidosis,and stroke-like episodes syndrome显示文摘This report presents a case of massive mucosal necrosis of the small intestine in a patient with mitochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes(MELAS),which particularly affects the brain,nervous system and muscles.A 45-year-old Japanese female,with an established diagnosis of MELAS,presented with vomiting.Computed tomography showed portomesenteric venous gas and pneumatosis intestinalis.She underwent a resection of the small intestine.A microscopic study showed necrosis of the mucosa and vacuolar degeneration of smooth muscle cells in the arterial wall.Immunohistochemistry showed anti-mitochondrial antibody to be highly expressed in the crypts adjacent the necrotic mucosa.The microscopic and immunohistochemical findings suggested the presence of a large number of abnormal mitochondria in MELAS to be closely linked to mucosal necrosis of the small intestine. | Keita Fukuyama Yasuhide Ishikawa Tetsuro Ogino Hidenobu Inoue Ryoya Yamaoka Tetsuro Hirose Tomohiko Nishihira | 2012 | World Journal of Gastroenterology2012，18，41： | 2 |
| 18 | LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer显示文摘 | Ogino S Kawasaki T Nosho K | 2008 | Int J Cancer2008，122，12： | 1 |
| 19 | Protein nutrition in fish apparent and true digestibility of dietary protein by young carp显示文摘 | Ogino C Chen M S | 1973 | Bul Jpn Soc Sci Fish1973，，39： | 1 |
| 20 | Humoral immune response on human aortic valve homografts 显示文摘 | Smith JD Ogino H Hunt D | 1995 | Ann Thorac Surg1995，，： | 1 |
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