|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome显示文摘Accumulating evidence suggests that ketogenic diets(KDs)mediate the rise of circulating ketone bodies and exert a potential antiinflammatory effect;however,the consequences of this unique diet on colitis remain unknown.We performed a series of systematic studies using a dextran sulfate sodium(DSS)animal model of inflammatory colitis.Animals were fed with a KD,low-carbohydrate diet(LCD),or normal diet(ND).Germ-free mice were utilized in validation experiments.Colon tissues were analyzed by transcriptome sequencing,RT2 profiler PCR array,histopathology,and immunofluorescence.Serum samples were analyzed by metabolic assay kit.Fecal samples were analyzed by 16S rRNA gene sequencing,liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry.We observed that KD alleviated colitis by altering the gut microbiota and metabolites in a manner distinct from LCD.Quantitative diet experiments confirmed the unique impact of KD relative to LCD with a reproducible increase in Akkermansia,whereas the opposite was observed for Escherichia/Shigella.After colitis induction,the KD protected intestinal barrier function,and reduced the production of R0Ryt+CD3_group 3 innate lymphoid cells(ILC3s)and related inflammatory cytokines(IL-17a,IL-18,IL-22,Ccl4).Finally,fecal microbiota transplantation into germ-free mice revealed that the KD-mediated colitis inhibition and ILC3 regulation were dependent on the modification of gut microbiota.Taken together,our study presents a global view of microbiome-metabolomics changes that occur during KD colitis treatment,and identifies the regulation of gut microbiome and ILC3s as novel targets involving in IBD dietary therapy. | Cheng Kong Xuebing Yan Yongqiang Liu Linsheng Huang Yefei Zhu Jide He Renyuan Gao Matthew F.Kalady Ajay Goel Huanlong Qin Yanlei Ma | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 8 |
| 2 | Alterations in intestinal microbiota of colorectal cancer patients receiving radical surgery combined with adjuvant CapeOx therapy显示文摘An intricate relationship exists and interactions occur between gut microbiota and colorectal cancer(CRC).Radical surgery combined with adjuvant chemotherapy(AC) serves as the mainstream therapeutic scheme for most CRC patients.The current research was conducted to assess the effect of surgery or chemotherapy on gut microbiota.Forty-three CRC patients who received radical surgery and AC were enrolled.Fecal samples were collected preoperatively,postoperatively,and after the first to fifth cycles of postoperative chemotherapy.The microbial community of each sample was analyzed using high throughput 16S rRNA amplicon sequencing.Compared with preoperative samples,fecal samples collected postoperatively exhibited a significant decrease of obligate anaerobes,tumor-related bacteria,and butyric acid-producing bacteria.However,a significant increase of some conditional pathogens was observed.In addition,the AC regimen(CapeOx) was found to alter intestinal microbiota dramatically.In particular,several changes were observed after chemotherapy including an increase of pathogenic bacteria,the 'rebound effect' of chemotherapy-adapted bacteria,the shift of lactate-utilizing microbiota from Veillonella to Butyricimonas and Butyricicoccus,as well as the decrease of probiotics.Both radical surgery and CapeOx chemotherapy exert a non-negligible effect on the gut microbiota of CRC patients.Microbiota-based intervention may be beneficial for patients during postoperative clinical management. | Cheng Kong Renyuan Gao Xuebing Yan Linsheng Huang Jide He Hao Li Jie You Huanlong Qin | 2019 | Science China(Life Sciences)2019，62，9： | 7 |
| 3 | Drinking water treatment using a submerged internal-circulation membrane coagulation reactor coupled with permanganate oxidation显示文摘A submerged internal circulating membrane coagulation reactor(MCR) was used to treat surface water to produce drinking water. Polyaluminum chloride(PACl) was used as coagulant,and a hydrophilic polyvinylidene fluoride(PVDF) submerged hollow fiber microfiltration membrane was employed. The influences of trans-membrane pressure(TMP), zeta potential(ZP) of the suspended particles in raw water, and KMnO_4 dosing on water flux and the removal of turbidity and organic matter were systematically investigated. Continuous bench-scale experiments showed that the permeate quality of the MCR satisfied the requirement for a centralized water supply, according to the Standards for Drinking Water Quality of China(GB 5749-2006), as evaluated by turbidity(<1 NTU) and total organic carbon(TOC)(<5 mg/L)measurements. Besides water flux, the removal of turbidity, TOC and dissolved organic carbon(DOC) in the raw water also increased with increasing TMP in the range of 0.01–0.05 MPa. High ZP induced by PACl, such as 5–9 mV, led to an increase in the number of fine and total particles in the MCR, and consequently caused serious membrane fouling and high permeate turbidity.However, the removal of TOC and DOC increased with increasing ZP. A slightly positive ZP, such as 1–2 mV, corresponding to charge neutralization coagulation, was favorable for membrane fouling control. Moreover, dosing with KMnO_4 could further improve the removal of turbidity and DOC, thereby mitigating membrane fouling. The results are helpful for the application of the MCR in producing drinking water and also beneficial to the research and application of other coagulation and membrane separation hybrid processes. | Zhongguo Zhang Dan Liu Yu Qian Yue Wu Peiran He Shuang Liang Xiaozheng Fu Jiding Li Changqing Ye | 2017 | Journal of Environmental Sciences2017，29，6： | 3 |
| 4 | Enhanced land use/cover classification using support vector machines and fuzzy k-means clustering algorithms显示文摘 | He Tao Sun Yujun Xu Jide | 2014 | Journal of Applied Remote Sensing2014，8，1： | 1 |
| 5 | MRI-derived radiomics models for diagnosis,aggressiveness,and prognosis evaluation in prostate cancer显示文摘Prostate cancer(PCa)is a pernicious tumor with high heterogeneity,which creates a conundrum for making a precise diagnosis and choosing an optimal treatment approach.Multiparametric magnetic resonance imaging(mp-MRI)with anatomical and functional sequences has evolved as a routine and significant paradigm for the detection and characterization of PCa.Moreover,using radiomics to extract quantitative data has emerged as a promising field due to the rapid growth of artificial intelligence(AI)and image data processing.Radiomics acquires novel imaging biomarkers by extracting imaging signatures and establishes models for precise evaluation.Radiomics models provide a reliable and noninvasive alternative to aid in precision medicine,demonstrating advantages over traditional models based on clinicopathological parameters.The purpose of this review is to provide an overview of related studies of radiomics in PCa,specifically around the development and validation of radiomics models using MRI-derived image features.The current landscape of the literature,focusing mainly on PCa detection,aggressiveness,and prognosis evaluation,is reviewed and summarized.Rather than studies that exclusively focus on image biomarker identification and method optimization,models with high potential for universal clinical implementation are identified.Furthermore,we delve deeper into the critical concerns that can be addressed by different models and the obstacles that may arise in a clinical scenario.This review will encourage researchers to design models based on actual clinical needs,as well as assist urologists in gaining a better understanding of the promising results yielded by radiomics. | Xuehua ZHU Lizhi SHAO Zhenyu LIU Zenan LIU Jide HE Jiangang LIU Hao PING Jian LU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，8： | 0 |
| 6 | Toll-like receptors,a double-edged sword in immunity to malaria显示文摘Toll-like receptors(TLRs) are a central component of innate immune system and play a major role as the initiator of the innate immune responses to defend against bacteria,viruses,parasite and other pathogens.During malaria infection,TLRs signaling pathways are initialed with the recognition of Plasmodium glycosylphosphatidylinositols(GPI) and hemozoin as pathogen-associated molecular patterns(PAMPs).And then,activation of TLRs signaling induces specific biological responses against malaria parasites invasion.However,TLRs are also involved in malaria pathogenesis and enhancement of immune tolerance and evasion for malaria infection.Moreover,malaria parasites regulate selectively TLRs expression on immune cells.Thus,these evidences indicated that TLRs have contrary roles on malaria infection.Understanding the complicated roles of TLRs on malaria infection will contribute us to design more effective anti-malaria drugs or vaccines. | Chen Jide He Ying Xu Wenyue Huang Fusheng | 2009 | Journal of Medical Colleges of PLA(China)2009，24，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员