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| 1 | The mechanisms of sorafenib resistance in hepatocellular carcinoma:theoretical basis and therapeutic aspects显示文摘Sorafenib is a multikinase inhibitor capable of facilitating apoptosis,mitigating angiogenesis and suppressing tumor cell proliferation.In late-stage hepatocellular carcinoma(HCC),sorafenib is currently an effective first-line therapy.Unfortunately,the development of drug resistance to sorafenib is becoming increasingly common.This study aims to identify factors contributing to resistance and ways to mitigate resistance.Recent studies have shown that epigenetics,transport processes,regulated cell death,and the tumor microenvironment are involved in the development of sorafenib resistance in HCC and subsequent HCC progression.This study summarizes discoveries achieved recently in terms of the principles of sorafenib resistance and outlines approaches suitable for improving therapeutic outcomes for HCC patients. | Weiwei Tang Ziyi Chen Wenling Zhang Ye Cheng Betty Zhang Fan Wu Qian Wang Shouju Wang Dawei Rong F.P.Reiter E.N.De Toni Xuehao Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 19 |
| 2 | Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease:Need for mucosal viral load measurement显示文摘AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus(HCMV)and Epstein-Barr virus(EBV)infection in inflammatory bowel disease(IBD).METHODS:A cohort of 40 IBD patients(17 refractory)and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest.Viral infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry,and correlations with clinical and endoscopic indexes of activity,and risk factors were investigated.RESULTS:All refractory patients carried detectable levels of HCMV and/or EBV mucosal load as comparedto 13/23(56.5%)non-refractory and 13/40(32.5%)controls.The median DNA value was significantly higher in refractory(HCMV 286 and EBV 5.440 copies/105cells)than in non-refractory(HCMV 0 and EBV 6copies/105 cells;P<0.05 and<0.001)IBD patients and controls(HCMV and EBV 0 copies/105 cells;P<0.001 for both).Refractory patients showed DNA peak values≥103 copies/105 cells in diseased mucosa in comparison to non-diseased mucosa(P<0.0121 for HCMV and<0.0004 for EBV),while non-refractory patients and controls invariably displayed levels below this threshold,thus allowing us to differentiate viral colitis from mucosal infection.Moreover,the mucosal load positively correlated with the values found in the peripheral blood,whilst no correlation with the number of positive cells at immunohistochemistry was found.Steroid use was identified as a significant risk factor for both HCMV(P=0.018)and EBV(P=0.002)colitis.Finally,a course of specific antiviral therapy with ganciclovir was successful in all refractory patients with HCMV colitis,whilst refractory patients with EBV colitis did not show any improvement despite steroid tapering and discontinuation of the other medications.CONCLUSION:Viral colitis appeared to contribute to mucosal lesions in refractory IBD,and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specimens. | Rachele Ciccocioppo Francesca Racca Stefania Paolucci Giulia Campanini Lodovica Pozzi Elena Betti Roberta Riboni Alessandro Vanoli Fausto Baldanti Gino Roberto Corazza | 2015 | World Journal of Gastroenterology2015，21，6： | 12 |
| 3 | 远程护理教育的实施与评估显示文摘对在国内首次服务于护理教育的远程教育网络作全面考察并评估 ,用自行设计的调查表 ,对与远程教学课程传输有关的各类人员 (包括管理者、授课教师、技术人员、学历教育和继续教育学员 )进行询问调查。结果 :学历教育学员对远程教育大部分指标的评价均达到中等或满意以上 ,对教师的评定和各门课程的满意度均达到满意以上 ,但远程组满意程度低于医科大学组 ;86 .0 %以上的继续教育学员认为 :远程教育增加了继续教育的机会 ,远程教学内容新、容易理解 ,对护理知识的积累和护理技能的提高有帮助。 93.4%教师认为远程教学与课堂教学质量无差别。 89.9%的被调查者对远程教育表示支持。而在师生互动交流、声音图像传输、板书效果等方面遇到一些挑战 ,有待进一步改进。结论 :远程护理教育在国内的首次实施效果颇佳 ,提示应加强各部门之间的协调与合作 ,尽快提高各类人员运用远程设备的能力 ,使远程护理教育网络在护理人员的学历和继续教育中发挥更大的作用。 | 邹道慧 Nancy Edwards Betty Cragg Jean Dunning 罗茂红 宋丽欣 | 2002 | 护理研究2002，16，5： | 11 |
| 4 | Promoting human embryonic stem cell renewal or differentiation by modulating Wnt signal and culture conditions显示文摘我们以前证明 Wnt3a 能刺激人的胚胎的茎(hES ) 细胞增殖并且影响房间命运决心。当 feeder cell-derivedfactors 不在时,在一个喂入器饲料分送器免费的条件下面有教养的 hES 房间糟糕幸存并且增殖。当 feeder 房间不在时的 Addingrecombinant Wnt3a 导出因素的刺激 hES 细胞增殖而且区别。在现在的学习,我们进一步扩大了我们的分析到象 Wnt1 和 Wnt5a 那样的另外的 Wntligands。当 Wnt1 作为 Wnt3a 在 hES 房间上显示了类似的效果时,在这个系统的 Wnt5ahad 小效果。当喂入器饲料分送器导出自强因素和 bFGF 也是现在时, Wnt3a 和 Wnt1 提高了无差别的 hES 房间的增长。探索可能性由激活 Wnt 发信号支持无差别的 hES 细胞的增长,在使不朽的人的成年成纤维细胞(HAFi ) 的 weoverexpressed Wnt3a 或 Wnt1 基因在比主要老鼠支持无差别的 hES 细胞的长期的生长是优异的细胞胚胎的成纤维细胞。HAFi 房间与或没有 Wnt transgene 能被宣传 Wnt3a 基因的 indefinitely.Over 表示显著地提高了 HAFi 喂入器饲料分送器房间的能力支持我们测试了的 3 根不同 hES 房间线的无差别的生长。在 Wnt3a-overpressing HAFi 房间的 threecommonly-used 药选择基因的合作表示进一步使我们能在稳定的 transfection 或转导以后选择稀罕 hES 克隆。这些使不朽的设计喂入器饲料分送器房间(W3R ) 那列合作快车象 Wnt3a 那样的支持生长的基因和三药选择基因应该授权我们高效地为基本、翻译的研究使修改 hES 房间线基因。 | Liuhong Cai Zhaohui Ye Betty Ying Zhou Prashant Mali Canquan Zhou Linzhao Cheng | 2007 | Cell Research2007，17，1： | 7 |
| 5 | The immunology of human cytomegalovirus latency: could latent infection be cleared by novel immunotherapeutic strategies?显示文摘当跟随主要人的 cytomegalovirus (HCMV ) 感染的主人免疫者反应在停止病毒复制和传播通常是有效的时,病毒从来没被主人并且象所有 herpesviruses 一样清除,永久坚持。至少部分地,这坚持被知道被 HCMV 的能力便于在感染是实质上沉默的与的 myeloid 在房间建立潜伏,重要地新病毒生产的全部的缺乏。然而,尽管病毒的抄写计划很在潜伏期间被压制,很多病毒的基因在蛋白质水平在潜伏的感染期间被表示,这些中的许多被显示了在潜伏的房间和它的环境上有深刻效果。有趣地,许多也在 lysin 的感染期间这些联系潜伏的基因被表示。因此,一样的有势力主人免疫者回答为什么在 lysin 的感染期间产生了到这些病毒的基因产品,没在潜伏期间被认出,从而允许隐而不见地的感染的房间的清理,是远非清楚的。从潜伏的复活也是调停 HCMV 的疾病的一个主要原因,特别地在损害的免疫者和免疫者天真,并且也是可能的是在被建议了与象动脉粥样硬化和一些瘤形成那样的长期的疾病被联系的长期的无临床症状的 HCMV 感染的病毒的主要来源。因而,理解潜伏并且隐而不见地的感染的房间为什么看起来是 immunoprivileged,为 HCMV 的致病的理解是关键的并且可以帮助设计策略消除潜伏的病毒水库,至少在某些临床的背景。 | Mark R Wills Emma Poole Betty Lau Ben Krishna John H Sinclair | 2015 | Cellular & Molecular Immunology2015，12，2： | 6 |
| 6 | Handheld high-throughput plasmonic biosensor using computational on-chip imaging显示文摘We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings.This lightweight and field-portable biosensing device,weighing 60 g and 7.5 cm tall,utilizes a compact optoelectronic sensor array to record the diffraction patterns of plasmonic nanostructures under uniform illumination by a single-light emitting diode tuned to the plasmonic mode of the nanoapertures.Employing a sensitive plasmonic array design that is combined with lens-free computational imaging,we demonstrate label-free and quantitative detection of biomolecules with a protein layer thickness down to 3 nm.Integrating large-scale plasmonic microarrays,our on-chip imaging platform enables simultaneous detection of protein mono-and bilayers on the same platform over a wide range of biomolecule concentrations.In this handheld device,we also employ an iterative phase retrieval-based image reconstruction method,which offers the ability to digitally image a highly multiplexed array of sensors on the same plasmonic chip,making this approach especially suitable for high-throughput diagnostic applications in field settings. | Arif E Cetin Ahmet F Coskun Betty C Galarreta Min Huang David Herman Aydogan Ozcan Hatice Altug | 2014 | Light(Science & Applications)2014，3，1： | 6 |
| 7 | New discovery rarely runs smooth: an update on progranulin/TNFR interactions显示文摘Progranulin (PGRN ) 是一个生长因素在各种各样的 pathophysiological 过程含有,包括愈合弯屈,发炎, tumorigenesis,和 neurodegeneration。PGRN 绑在肿瘤坏死因素受体(TNFR ) 并且在煽动性的关节炎有治疗学的效果,这以前被报导(唐等在科学 332:478484, 2011 ) ;然而,陈等。报导了他们的无能在他们的自己的条件下面表明 PGRN-TNFR 相互作用(陈等在 J Neurosci 33:92029213, 2013 ) 。letter-to-editor 然后被原来的组响应陈等出版。讨论了原因让后者无能概括相互作用的纸。另外,这个组出版了进一步增强了并且把的后续研究 PGRN-TNFR 的相互作用。最近,关于 PGRN-TNFR 相互作用的合法性的争论看起来被众多的实验室最后处于各种各样的条件与这些相互作用的独立证实解决。这评论在 PGRN-TNFR 相互作用的故事上介绍按年代先后的更改,加亮在各种各样的疾病和条件的这些相互作用的独立证实。 | Betty C. Wang Helen Liu Ankoor Talwar Jinlong Jian | 2015 | Protein & Cell2015，6，11： | 5 |
| 8 | 早产儿视网膜病变早期治疗(ETROP)过程中发生视网膜脱离眼的预后显示文摘研究对象:在早产儿视网膜病变早期治疗(ETROP)研究中因早产儿视网膜病变(ROP)而发生视网膜脱离眼的结构以及功能改变。
研究方法:加入ETROP研究中的新生儿患有双眼高危阈前ROP,随即对其一眼进行早期治疗,另一眼进行传统治疗。只有单眼患病的早产儿。随机对高危阈前ROP眼进行早期治疗或传统治疗。当视网膜脱离被发现时。研究者会继续观察患者病变或对其行视网膜玻璃体手术(如巩膜加压术以肜或者玻璃体切除术)。在矫正9月龄时,对患者视网膜状况进行评估并使用条栅视敏度(grating acuity)对患儿视力进行检测。
研究结果:401例高危阈前ROP患者加入了ETROP研究。63例患者(89只眼)发生了视网膜脱离。对其中56例患者(78只眼)进行了随访。21例患者(38%)的视网膜脱离发生于双眼。其中30只眼分级为4A,14只眼为4B,16只眼为5级。余下的18只视网膜脱离眼未进行分级。对11例患者(12只眼)监控病情变化,52例患者(66只眼)行玻璃体视网膜手术。行玻璃体切除伴或不伴有巩膜加压术的56只眼中有17只(30%)在患者9月龄时保持或达到了黄斑复位;仅行巩膜加压术的10只眼中,6只(60%)达到;未行手术的12只眼中,2只(17%)达到。78只眼中有13只(17%)达到了较好的视力水平(I〉1.85cycles/degree)。达到正常视力水平(≥3.70cycles/degree)的6只眼的视网膜脱离分级均为4A(其分别为6只未行手术眼中的1眼,6只行巩膜加压术眼中的3眼。18只行玻璃体切除术眼中的2眼)。对11只视网膜脱离达5级的患眼行玻璃体视网膜手术。
治疗结果为6只眼无光感,3只眼仅有光感,2只眼只能看清低视力表。结论:在ETROP的研究中,ROP导致视网膜脱离的治疗结果普遍较差。因视网膜脱离行玻璃体视网膜手术的48只眼中,有16只眼黄斑未发生脱离。手术修复4A级视网膜脱离的24只眼中,有5只(21%)在术后达到了正常视力水平。对视网膜脱离5级眼行玻璃体视网膜手术可以使其达到结构复位,但功能恢复不佳。 | Michael X. Repka Betty Tung William V. Good Michael Shapiro Antonio Capone Jr John D. Baker Charles C. Barr Dale L. Phelps W. A. J. van HewvenMD John D. Baker,MD Charles C. Barr,MD Dale L. Phelps,MD IV. A. J. van Heuven 张弛(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，3： | 4 |
| 9 | 流式细胞检验的质量控制与生物安全管理显示文摘流式细胞学检验作为医学检验领域一项新技术,其检验全程的规范化与标准化已成为亟待解决的问题。本文以淋巴细胞亚群流式分析为例,介绍流式细胞学检验全程质量控制及生物安全管理中的方法和经验。 | 吴丽娟 许东升 Betty Li | 2013 | 临床检验杂志2013，31，2： | 4 |
| 10 | 新生儿重症监护病房高危新生儿出院后随访显示文摘 | Betty Vohr 曹云 | 2008 | 中国循证儿科杂志2008，3，6： | 3 |
| 11 | Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis显示文摘While emerging data suggest nucleotide oligomerization domain receptor 1(NOD1),a cytoplasmic pattern recognition receptor,may play an important and complementary role in the immune response to bacterial infection,its role in cancer metastasis is entirely unknown.Hence,we sought to determine the effects of NOD1 on metastasis.NOD1 expression in paired human primary colon cancer,human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting(WB).Clinical significance of NOD1 was assessed using TCGA survival data.A series of in vitro and in vivo functional assays,including adhesion,migration,and metastasis,was conducted to assess the effect of NOD1.C12-iE-DAP,a highly selective NOD1 ligand derived from gram-negative bacteria,was used to activate NOD1.ML130,a specific NOD1 inhibitor,was used to block C12-iE-DAP stimulation.Stable knockdown(KD)of NOD1 in human colon cancer cells(HT29)was constructed with shRNA lentiviral transduction and the functional assays were thus repeated.Lastly,the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors.Our data demonstrate that NOD1 is highly expressed in human colorectal cancer(CRC)and human and murine CRC cell lines.Clinically,we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC.Subsequently,we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion,migration and metastasis.These effects are predominantly mediated via the p38 mitogen activated protein kinase(MAPK)pathway.This is the first study implicating NOD1 in cancer metastasis,and thus identifying this receptor as a putative therapeutic target. | Henry Y.Jiang Sara Najmeh Guy Martel Elyse MacFadden-Murphy Raquel Farias Paul Savage Arielle Leone Lucie Roussel Jonathan Cools-Lartigue Stephen Gowing Julie Berube Betty Giannias France Bourdeau Carlos HFChan Jonathan D.Spicer Rebecca McClure Morag Park Simon Rousseau Lorenzo E.Ferri | 2020 | Protein & Cell2020，11，3： | 3 |
| 12 | High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS显示文摘Discovery of drugs rapidly and effectively is an important aspect for Alzheimer's disease(AD).In this study,a novel high-throughput screening(HTS)method aims at screening the small-molecules with amyloid-β(Aβ)binding affinity from natural medicines,based on the combinational use of biolayer interferometry(BLI)and ultra-high-performance liquid chromatography coupled with diode-array detector and quadrupole/time-of-flight tandem mass spectrometry(UHPLC−DAD-Q/TOF-MS/MS)has been firstly developed.Briefly,the components in natural medicines disassociated from biotinylated Aβwere collected to analyze their potential Aβbinding affinity by UHPLC−DAD-Q/TOF-MS/MS.Here,baicalein was confirmed to exhibit the highest binding affinity with Aβin Scutellaria baicalensis.Moreover,polyporenic acid C(PPAC),dehydrotumulosic acid(DTA),and tumulosic acid(TA)in Kai-Xin-San(KXS)were also identified as potent Aβinhibitors.Further bioactivity validations indicated that these compounds could inhibit Aβfibrillation,improve the viability in Aβ-induced PC-12 cells,and decrease the Aβcontent and improve the behavioral ability in Caenorhabditis elegans.The molecular docking results confirmed that PPAC,DTA,and TA possessed good binding properties with Aβ.Collectively,the present study has provided a novel and effective HTS method for the identification of natural inhibitors on Aβfibrillation,which may accelerate the process on anti-AD drugs discovery and development. | Minsong Guo Fengdan Zhu Wenqiao Qiu Gan Qiao Betty Yuen-Kwan Law Lu Yu Jianming Wu Yong Tang Chonglin Yu Dalian Qin Xiaogang Zhou Anguo Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 13 | Requirement for cyclin D3 in germinal center formation and function显示文摘第二等的淋巴的纸巾的幼芽的中心(GC ) 对装高亲密关系的体液的有免疫力的回答批评。当多样化他们的抗体基因时,在 GC 以内的 B 房间经历快速的同种细胞的扩大和选择。尽管 GC B 房间采用一个唯一的 proliferative 程序提供这些进程,这通常被相信,很少联系 GC 的房间周期怎么被安排被知道。D 类型 cyclins 组成使房间能对生理的变化作出回应的房间周期引擎的一个重要部件。房间类型 -- 并且 D 类型 cyclins 的发展阶段特定的角色被描述了,但是 cyclin D 要求没在 GC 反应期间被探讨。在这研究,我们报导 cyclin D3 为切换的增长和 Ig 班大部分是非必需的在 vitro 激活的 B 房间。相反,在 Ccnd3 的 GC 开发 ?/ ?老鼠显著地被损害,作为是 T 房间依赖者抗体反应。在 GC 以内,尽管切换, unswitched B 房间被 cyclin D3 inactivation 影响, IgM?水池更严重地被减少。有趣地尽管有 cyclin D2 表示的补偿增加, Ccnd3 的一个重要数字 ?/ ?GC B 房间处于静止 G0 状态积累。最后,尽管 cyclin D3 inactivation 没在 GC B 房间破坏 BCL6 表示,支持 BCL6 overexpression 的效果完全堵住了 GC,建议 cyclin D3 调整 GC 形成的 BCL6 下游地行动。这是 cyclin D3 玩的第一示范在 B 房间开发的 GC 阶段的一个重要、唯一的角色。 | Jonathan U Peled J Jessica Yu Jeganathan Venkatesh Enguang Bi B Belinda Ding Melissa Krupski-Downs Rita Shaknovich Piotr Sicinski Betty Diamond Matthew D Scharff B Hilda Ye | 2010 | Cell Research2010，20，6： | 3 |
| 14 | Board composition and corporate philanthropy显示文摘 | Jia Wang Betty S. Coffey | 1992 | Journal of Business Ethics1992，，10： | 2 |
| 15 | 193nm激光引发PET表面的化学接枝显示文摘将聚对苯二甲酸乙二醇酯[Poly(ethylene terephthalate),PET]材料置于氨气气氛中,利用激光光子同时激发材料表面及氨气形成自由基,用激光引发反应并促进氨基在材料表面的接枝.改性后的测试结果表明,材料表面粗糙度没有显著变化,但水接触角的减小表明表面化学结构发生了某种变化.傅里叶变换红外光谱(FTIR/ATR)图谱在3352和1613cm-1处出现了新的氨基吸收峰,证实了表面接枝了氨基.同时X射线光电子能谱(XPS)也证明了材料表面C—N键的存在,其C1s结合能为285.5 eV,N1s为398.9 eV.飞行时间二次离子质谱(Tof-SIMS)也检测到含氨基的分子碎片,其碎片成像图显示接枝仅发生在激光辐照部位.实验结果表明,激光能在生物材料表面进行局部区域的选择性接枝. | 吴刚 王迎军 陈晓峰 叶建东 魏坤 LEON Betty | 2008 | 高等学校化学学报2008，29，8： | 2 |
| 16 | Results of Resection in Non-Oat Cell Carcinoma of the Lung with Mediastinal Lymph Node Metastases显示文摘 | NAEL MARTINI BETTY J. FLEHINGER MUHAMMAD B. ZAMAN EDWARD J. BEATTIE | 1983 | Annals of Surgery1983，，3： | 2 |
| 17 | Differential responses to artificial selection on oviposition site preferences in Drosophila melanogaster and D. simulans显示文摘在植物昆虫相互作用的偏爱表演关系是在进化生态学的一个中央主题。在许多昆虫之中,鸡蛋是脆弱的,幼虫限制了活动性,使一个适当 oviposition 地点的选择成为为女性的最重要的决定之一。我们由人工地为 2 个自然资源,葡萄和植物的一种为偏爱选择在果蝇 melanogaster Meigen 和果蝇 simulans Sturtevant 调查了 oviposition 偏爱的进化。我们的学习的主要发现是 D 的微分回答。melanogaster 和 D。simulans。尽管偏爱在 D 的试验性的人口演变。melanogaster,回答不与政体使用了的选择一致。相反,在 D 的回答。simulans 与期望一致,证明这种有为特点的可选的基因变化。而且,在 D 之间交叉。simulans 分叉的线证明涉及葡萄偏爱的基因因素看起来大部分后退。在摘要,我们的人工的选择学习建议那 D。melanogaster 和 D。simulans 为这个特点拥有不同基因体系结构。 | Eduardo M. Soto Maria I. L. Betti Juan Hurtado Esteban Hasson | 2015 | Insect Science2015，22，6： | 2 |
| 18 | Human dendritic cell-specific ICAM-3-grabbing non-integrin downstream signaling alleviates renal fibrosis via Raf-1 activation in systemic candidiasis显示文摘We generated a human dendritic cell-specific ICAM-3-grabbing non-integrin(DC-SIGN)transgenic mouse in which renal tubular epithelial cells expressed DC-SIGN.The transgenic mice were infected with Candida albicans intravenously to study how DC-SIGN expression affected the pathogenesis of systemic candidiasis.We discovered that,while C.albicans infection induced renal fibrosis in both transgenic and littermate control mice,the transgenic mice had significantly lower levels of Acta2,Col1a2,Col3a1,and Col4a1 mRNA transcripts compared to the controls.KIM-1,an emerging biomarker for kidney injury,along with Tnf,Il6,and Tgfb1 transcripts,were lower in infected transgenic mice,and yet,the levels of Il10 remained comparable to the controls.While renal CD45+infiltrating cells were the source of Tnf,Il6,and Il10,LTL+renal proximal tubular epithelial cells were TGF-β1 producers in both infected transgenic and littermate controls.DC-SIGN-expressing tubular epithelial cells produced less TGF-β1 in response to C.albicans infection.In vivo experiments demonstrated that renal proximal tubular epithelial cell production of TGF-β1 was key to C.albicans-induced renal fibrosis and injury.Infection of transgenic mice induced a marked increase of phosphorylated Raf-1 and p38 in the kidney.However,ERK1/2 and JNK phosphorylation was more pronounced in the infected-littermate controls.Interestingly,treating the infected transgenic mice with a Raf-1 inhibitor increased the levels of the Tgfb1,Kim1,and Acta2 transcripts.These results indicate that DC-SIGN signaling,through activation of Raf-1 and p38 and suppression of JNK and ERK1/2 phosphorylation,reduces TGF-β1 production and C.albicans-induced renal fibrosis.Our study reveals for the first time the effect of DC-SIGN expression on C.albicans-induced renal fibrosis. | Wen-Yu Chen Sheng-Yang Wu Ta-Chun Lin Shuei-Liong Lin Betty A.Wu-Hsieh | 2019 | Cellular & Molecular Immunology2019，16，3： | 2 |
| 19 | Gene expression and physiological responses to salinity and water stress of contrasting durum wheat genotypes显示文摘Elucidating the relationships between gene expression and the physiological mechanisms remains a bottleneck in breeding for resistance to salinity and drought. This study related the expression of key target genes with the physiological performance of durum wheat under different combinations of salinity and irrigation. The candidate genes assayed included two encoding for the DREB(dehydration responsive element binding) transcription factors Ta DREB1 A and Ta DREB2 B, another two for the cytosolic and plastidic glutamine synthetase(Ta GS1 and Ta GS2), and one for the specific Na^+/H^+vacuolar antiporter(Ta NHX1). Expression of these genes was related to growth and different trait indicators of nitrogen metabolism(nitrogen content, stable nitrogen isotope composition, and glutamine synthetase and nitrate reductase activities), photosynthetic carbon metabolism(stable carbon isotope composition and different gas exchange traits) and ion accumulation. Significant interaction between genotype and growing conditions occurred for growth, nitrogen content, and the expression of most genes.In general terms, higher expression of Ta GS1, Ta GS2,Ta DREB2 B, and to a lesser extent of Ta NHX1 were associated with a better genotypic performance in growth, nitrogen, and carbon photosynthetic metabolism under salinity and water stress. However, Ta DREB1 A was increased in expression under stress compared with control conditions, with tolerant genotypes exhibiting lower expression than susceptible ones. | Salima Yousfi Antonio J.Marquez Marco Betti Jose Luis Araus Maria Dolores Serret | 2016 | Journal of Integrative Plant Biology2016，58，1： | 2 |
| 20 | Hepatitis C virus RNA localization in human carotid plaques显示文摘 | Maria Boddi Rosanna Abbate Benedetta Chellini Betti Giusti Carlo Giannini Giovanni Pratesi Luciana Rossi Carlo Pratesi Gian Franco Gensini Laura Paperetti Anna Linda Zignego | 2009 | Journal of Clinical Virology2009，，1： | 2 |
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