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| 1 | HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity显示文摘 | Clement V Sanchez P de Tribolet N Radovanovic I Ruiz i Altaba A | 2007 | 中国神经肿瘤杂志2007，5，2： | 96 |
| 2 | 走向更新的拉奥孔显示文摘教条主义与当今绘画中“非客观主义”或“抽象”纯粹主义之间的不妥协,不能因为是一个立体主义艺术观点的征兆就不予考虑.纯粹主义者对艺术提出过份的要求,因为他们一般将艺术看得比其他事物重要得多。出于同样的原因,他们对艺术也更为关切。纯粹主义主要是转换一种极端的关切,一种对艺术命运的忧虑,和对其地位的牵挂。我们必须尊重这种心态.当纯粹主义者坚持在现在和将来都要把“文学性”与题材从造型艺术中排除出去的时候,我们大多数人都会立即指责他是一种非历史的观点.要说明这点并不困难。 | Clement Greenberg 易英 | 1991 | 世界美术1991，，4： | 68 |
| 3 | 小麦农杆菌介导转基因植株的稳定获得和检测显示文摘以预培养 4 d的小麦幼胚愈伤组织为受体 ,L B培养基上激活培养 3 d或 AB培养基上激活培养 4 d,并在WCC培养基中重悬的 C5 8c1农杆菌菌系为供体 ,将含有目的基因、标记基因的 p PTN2 4 9、p PTN 2 5 4、p PTN2 70、p SIS-GFP等重组 DNA质粒转入了小麦 ,经在含 10~ 5 0 mg/ L geneticin( G4 18)、5 0 mg/ L cefotaxime、5 0 m g/ L vancomycin、5 0 m g/ L ticillicin选择培养基上多次选择 ,移栽前利用 npt EL ISA检测 ,移栽后利用叶片离体退绿、PCR和 South-ern blot 4种方法综合检测 ,共获得了 2 9株转基因植株 ,转化频率平均为 0 .82 %。在所获得的转基因植株中 ,单拷贝整合植株占 65 .5 2 %。研究结果还表明 ,不同基因型的转化效率显著不同 ,除了 Bobwhite外 ,笔者也从扬麦 10号获得了转基因植株 ;EL ISA测定值的高低与外源 DNA整合的拷贝数有一定关系 ;初步建立了农杆菌介导稳定转化小麦的技术体系。 | 叶兴国 Shirley Sato 徐惠君 杜丽璞 Tom Clemente | 2001 | 中国农业科学2001，34，5： | 66 |
| 4 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 5 | Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions显示文摘Non-alcoholic fatty liver disease(NAFLD) in children is becoming a major health concern. A 'multiple-hit' pathogenetic model has been suggested to explain the progressive liver damage that occurs among children with NAFLD. In addition to the accumulation of fat in the liver, insulin resistance(IR) and oxidative stress due to genetic/epigenetic background, unfavorable lifestyles, gut microbiota and gut-liver axis dysfunction, and perturbations of trace element homeostasis have been shown to be critical for disease progression and the development of more severe inflammatory and fibrotic stages [non-alcoholic steatohepatitis(NASH)]. Simple clinical and laboratory parameters, such as age, history, anthropometrical data(BMI and waist circumference percentiles), blood pressure, surrogate clinical markers of IR(acanthosis nigricans), abdominal ultrasounds, and serum transaminases, lipids and glucose/insulin profiles, allow a clinician to identify children with obesity and obesity-related conditions, including NAFLD and cardiovascular and metabolic risks. A liver biopsy(the 'imperfect' gold standard) is required for a definitive NAFLD/NASH diagnosis, particularly to exclude other treatable conditions or when advanced liver disease is expected on clinical and laboratory grounds and preferably prior to any controlled trial of pharmacological/surgical treatments. However, a biopsy clearly cannot represent a screening procedure. Advancements in diagnostic serum and imaging tools, especially for the non-invasive differentiation between NAFLD and NASH, have shown promising results, e.g., magnetic resonance elastography. Weight loss and physical activity should be the first option of intervention.Effective pharmacological treatments are still under development; however, drugs targeting IR, oxidative stress, proinflammatory pathways, dyslipidemia, gut microbiota and gut liver axis dysfunction are an option for patients who are unable to comply with the recommended lifestyle changes. When morbid obesity prevails, bariatric surgery should be considered. | Maria Grazia Clemente Claudia Mandato Marco Poeta Pietro Vajro | 2016 | World Journal of Gastroenterology2016，22，36： | 32 |
| 6 | Obesity leads to higher risk of sperm DNA damage in infertile patients显示文摘在在富饶上的男营养的影响的过去几年有成长兴趣。不孕被连接了到男过重或肥胖,并且常规精液参数值似乎在高身体团索引(BMI ) 的情况下被改变。在精子 DNA 正直上估计 BMI 的影响的一些研究被出版了,但是他们没导致强壮的一致。我们的目的是进一步探索在精子 DNA 正直和 BMI 之间的关系,通过 3 年的 multicentre 研究。在 subfertile 夫妇的 330 个男搭挡被包括。用标记的终端 uridine 刻痕结束(TUNEL ) 试金,我们在肥胖的人观察了精子 DNA 损坏的增加的率(机会比率(95 %信心间隔) :2.5 (1.2-5.1 )) 。 | Charlotte Dupont Celine Fauret Nathalie Sermondade Marouane Boubaya Florence Eustache Patrice Clement Pascal Briot Isabelle Berthaut Vincent Levy Isabelle Cedrin-Durnerin Brigitte Benzacken Pascale Chavatte-Palmer Rachel Levy | 2013 | Asian Journal of Andrology2013，15，5： | 27 |
| 7 | 乙醇汽油发动机排放特性研究显示文摘在一台JL368Q3多点电喷汽油机上,开展了乙醇汽油(不同掺混比)发动机排放特性的研究,并用GC 2010气相色谱仪测量了排气中未燃醇醛的排放浓度.试验结果表明:在发动机运转参数相同的条件下,燃用E10、E20(乙醇的体积分数分别为10%、20%)混合燃料时,发动机的CO和NOx排放有了较好的改善,降幅可分别达到15%和5%,但在高负荷时发动机的HC排放增加;乙醇汽油发动机排气中的醇醛排放随发动机的转速和负荷增加而增加,其中乙醛排放随燃料中乙醇含量的增加而增加;经过三效催化转化后,乙醇汽油发动机的醇醛在大部分工况下可以实现零排放. | 刘圣华 魏衍举 吕胜春 李晖 Eddy R.Cuty Clemente 祁东辉 | 2006 | 西安交通大学学报2006，40，7： | 25 |
| 8 | 前卫与媚俗显示文摘克莱门特·格林伯格的名字被作为二战后崛起的美国抽象表现主义流派最重要的评论家和首席推介者为中国读者所熟悉,然而在我们经常性地提到、引用和批驳格林伯格在20世纪30年代提出的一些著名观点的时候,其实国内并没有关于他的经典著作的比较好的译本,旅居美国多年的美术史学者秦兆凯本期精译了格林伯格的《前卫与媚俗》一文,并将在本栏目陆续推出一些现代艺术理论领域的经典文献的可靠译文,敬请读者关注。时光虽然过去60多年,重读《前卫与媚俗》一文,更加感叹格林伯格锐利的文化观察力的深刻前瞻性,他的观点至今对当下的中国艺术界仍有警示意义。 | 克莱门特·格林伯格(Clement Greenberg) 秦兆凯(翻译) | 2007 | 美术观察2007，，5： | 24 |
| 9 | 现代主义绘画(Modernist Painting)显示文摘《现代主义绘画》是美国艺术批评家克莱门特·格林伯格的又一篇经典批评著作,秦兆凯的译文力求准确传达原文的意旨,希望能为中国研究者提供一个准确的参考文献版本。克莱门特在文中不仅分析提示了现代主义绘画发展的形式逻辑线索,而且更重要的提示了一个至今看来仍然极为重要批评方法论——绘画首先是一个实践问题而不是理论问题,必须以绘画自身的媒介特质的规律性来评判绘画的独立审美价值,并将此作为对绘画进行欣赏和批评的基本方法。与强调形式构成因素对绘画价值判定的绝对重要性相反,中央美院李建群教授的文章介绍了美国女性主义艺术史家琳达·诺克琳以社会学方法追踪传统艺术史对女性视角和女性艺术家的压抑,不仅在一定程度上颠覆了西方艺术史传统,而且做出了以社会学方法研究和重构美术史饶有阅读趣味的范例。 | 克莱门特·格林柏格(Clement Greenberg) 秦兆凯(翻译) | 2007 | 美术观察2007，，7： | 23 |
| 10 | Assimilation of carbonate country rock by the parent magma of the Panzhihua Fe-Ti-V deposit(SW China):Evidence from stable isotopes显示文摘在西南中国的 Panzhihua 侵入是 Emeishan 大火的省的部分和大 Fe-Ti-V 矿石存款的主人。在主要侵入的炮兵阵地期间, mafic 女同性恋的多重代入侵了碳酸盐墙岩石,生产一个大接触光环。我们测量了国家岩石的侵入,他们的成分矿物质,和样品的氧同位素作文。从 Panzhihua 侵入的磁铁矿和斜长石有与 magmatic 平衡一致,并且比在导出披风的岩浆期望与高是 12 的 18O 价值从岩浆形成的 18O 价值。unmetamorphosed 国家岩石有高 18O 价值,从 13.2 (沙岩) 到 24.628.6 (白云石) 。从光环的 skarns 和云石比他们与在有邻近的 mafic 岩浆和侵入的特别众多的 mafic 女同性恋的交换平衡的液体建议相互作用的 protolith 有更低的 18O 和 13C 价值光环。这将比为导出披风的岩浆期望解释有显著地更高的价值的女同性恋的 18O 的改变。取决于为岩浆和沾染物假定的准确 18O 价值,要求生产 Panzhihua 侵入的提高的 18O 价值的吸收的数量在 8 和 13.7 wt.% 之间,假定简单混合。污染的准确机制是不清楚的,但是可以包含体积国家岩石的吸收的联合,混合与一有 CO2 富有的液体的国家岩石和交换的 melt 源于泥土和白云石的 decarbonation。这些机制,特别地后者,可能涉及 Fe-Ti-V 矿石的形成。 | Clement Ganino Chris Harris Nicholas T.Arndt Stephen A.Prevec Geoffrey H.Howarth | 2013 | Geoscience Frontiers2013，4，5： | 20 |
| 11 | 甲醇-汽油混合燃料对汽油机性能和排放的影响显示文摘通过汽油机燃用甲醇-汽油混合燃料(其中甲醇的体积分数为10%,汽油的体积分数为90%,简称M10燃料)和汽油的对比试验,研究了M10燃料对汽油机性能和排放的影响,并用气相色谱仪测量了尾气中的甲醇和甲醛排放.试验研究表明:汽油机燃用M10燃料对汽油机动力性影响不大,但汽油机有效热效率和燃油经济性提高,排温有所降低;CO和HC排放减少,NOx排放与燃用汽油时相当;甲醇和甲醛排放增加.排气经三效催化转化器后,CO、HC和NOx排放可以被控制在与常规汽油机排放相当的水平,甲醇和甲醛排放可以被控制在接近零排放的水平. | 刘圣华 李晖 吕胜春 EddyR.Cuty Clemente 祁东辉 | 2006 | 西安交通大学学报2006，40，1： | 19 |
| 12 | 运动神经肌肉电刺激对鼠骨骼肌微血管灌流的影响显示文摘在80年代初期,有文献报道应用神经肌肉电刺激(NMES)能改变周围血流动力学,并显示供给受刺激肌肉的动脉血流增加,未受刺激肢体的动脉血流减少,但并不了解其微血管床的具体反应.血流量与血流速度和灌流血管的横截面积成正比,但血流速度不能反应血液与实质组织的空间关系,而灌流血管的横截面积或微血管灌流程度可指示扩散距离、血液和实质组织的空间关系。肌肉微血管灌流程度是实质组织的氧、营养物质和代谢物的扩散距离为指示物,微血管灌流增加,则扩散距离减少,因而提高肌肉对氧、营养物质的利用,并提高代谢产物的清除率。 | Clemente FR 尤春景 | 1992 | 国外医学(物理医学与康复学分册)1992，12，2： | 15 |
| 13 | A time series for monitoring vegetation activity and phenology at 10-daily time steps covering large parts of South America显示文摘It is widely accepted that natural resources should only be sustainably exploited and utilized to effectively preserve our planet for future generations.To better manage the natural resources,and to better understand the closely linked Earth systems,the concept of Digital Earth has been strongly promoted since US Vice President Al Gore’s speech in 1998.One core element of Digital Earth is the use and integration of remote sensing data.Only satellite imagery can cover the entire globe repeatedly at a sufficient high-spatial resolution to map changes in land cover and land use,but also to detect more subtle changes related for instance to climate change.To uncover global change effects on vegetation activity and phenology,it is important to establish high quality time series characterizing the past situation against which the current state can be compared.With the present study we describe a time series of vegetation activity at 10-daily time steps between 1998 and 2008 covering large parts of South America at 1 km spatial resolution.Particular emphasis was put on noise removal.Only carefully filtered time series of vegetation indices can be used as a benchmark and for studying vegetation dynamics at a continental scale.Without temporal smoothing,subtle spatio-temporal patterns in vegetation composition,density and phenology would be hidden by atmospheric noise and undetected clouds.Such noise is immanent in data that have undergone solely a maximum value compositing.Within the present study,the Whittaker smoother(WS)was applied to a SPOT VGT time series.The WS balances the fidelity to the observations with the roughness of the smoothed curve.The algorithm is extremely fast,gives continuous control over smoothness with only one parameter,and interpolates automatically.The filtering efficiently removed the negatively biased noise present in the original data,while preserving the overall shape of the curves showing vegetation growth and development.Geostatistical variogram analysis revealed a significantly increased signal-to-noise ratio compared to the raw data.Analysis of the data also revealed spatially consistent key phenological markers.Extracted seasonality parameters followed a clear meridional trend.Compared to the unfiltered data,the filtered time series increased the separability of various land cover classes.It is thus expected that the data set holds great potential for environmental and vegetation related studies within the frame of Digital Earth. | Clement Atzbergera Paul HCEilers | 2011 | International Journal of Digital Earth2011，4，5： | 14 |
| 14 | 大豆品种的再生性能及对EHA 101农杆菌的敏感性(英文)显示文摘大豆转化可利用农杆菌和子叶节转化系统 ,bar基因作为选择标记 ,草丁膦作为选择试剂。用 5 6d发芽的种子的子叶节作外植体 ,在子叶节处划 5 6下 ,用含pPTN 14 0的农杆菌EHA 10 1感染后 ,共培养 3d ,用含抗生素的洗液洗去外植体上的农杆菌 ,将外植体放入 5mg L草丁膦的长芽培养基 ,两周后统计不同大豆品种的再生率 ,4周后做GUS染色对含pPTN14 0的农杆菌的敏感性进行统计。结果得知 :黑农 35、中作 975、合丰 35、Zhongzuo 96 2是在再生方面比Thorne更好的品种。William 82、黑农 35、中作 975、PI 36 10 6 | 王岚 T Clemente 王连铮 辛世文 黄其满 | 2003 | 作物学报2003，29，5： | 14 |
| 15 | 国内外36个苜蓿品种的发芽特性综合评价显示文摘苜蓿品种的优劣影响苜蓿草地建植与生产性能,其中发芽特性是首要指标。为筛选出优良的品种用于试验研究和生产,收集了我国育成苜蓿品种14个和国外22个品种的种子(其中包衣种子8个),测定了发芽率、硬实率、苗长等12个指标,采用隶属函数平均值法综合评价了品种优劣。结果表明,供试品种的千粒重为1.56~4.87g,发芽势为49.33%~97.33%(平均为83.52%),发芽率为49.33%~97.33%(平均为86.85%),发芽指数为5.83~17.04(平均为10.90),活力指数为0.18~0.60(平均为0.390),25个品种有硬实种子,其中,新疆大叶硬实率为49.33%显著高于其他品种,将硬实种子划破种皮继续培养,发芽率均有提升。综合指标评价最高的5个品种为甘农6号、中苜3号、甘农9号、耐盐之星、前景,综合指标评价最低的5个品种为公农5号、WL 168HQ、WL 354HQ、太阳神、新疆大叶。我国品种综合指标较高,平均为0.51,国外品种平均为0.44,国内品种表现优于国外品种。 | 马婷燕 罗飞 Clement Nzabanita 李彦忠 | 2019 | 种子2019，38，1： | 13 |
| 16 | BCL、RIP细胞凋亡基因向小麦中的导入和赤霉病抗性鉴定显示文摘利用农杆菌介导法将BCL和RIP 2个与细胞凋亡有关的基因分别导人了小麦品种扬麦10号和Bobwhite,转化效率分别为1.60%和1.25%。Southern检测结果表明,细胞凋亡基因已稳定整合到小麦染色体上,多数植株为单拷贝整合。Northern检测结果表明,细胞凋亡基因能够在小麦遗传背景中高水平转录为RNA。转基因植株T1代分离比例为2.11~2.33:1,表明外源基因在后代中能够稳定遗传。BCL转基因植株和RIP转基因植株对赤霉病均表现出一定抗性,其中BCL-20、BCL-21、RIP-8、RIP-18等15个T1代植株的小穗发病率为5.6%~16.1%,可望进一步培育抗赤霉病小麦新材料。 | 叶兴国 Shirley Sato 徐惠君 杜丽璞 黄益洪 陆维忠 Tom Clemente | 2005 | 作物学报2005，31，11： | 12 |
| 17 | 3-RRR平面并联机构的刚度特性分析显示文摘导出了3-RRR平面并联机构基于守恒协调转换刚度矩阵机构刚度结构位形部分的解析表达式和外力作用影响部分的不完全解析表达式.给出了求机构刚度映射的一般方法,求出了不同参数下3-RRR平面并联机构的刚度映射曲线,并对机构的刚度特性进行了分析和讨论.研究发现,3-RRR平面并联机构的刚度是机构构型的函数,并与驱动力和关节刚度成比例;动平台中心趋于工作空间边界刚度增大,在工作空间的边界附近形成一个刚度较强的环状区域,而在工作空间的内部形成一个刚度较弱的区域. | 李树军 Clement Gosselin | 2007 | 东北大学学报(自然科学版)2007，28，1： | 12 |
| 18 | 边疆深度贫困地区社会资本、生计策略与精准扶贫显示文摘社会资本和人力资本建设作为边疆深度贫困地区的社会无形资产,对边疆地区精准扶贫实现'两个回流'及边民生计可持续具有重要作用。本文利用2016年7月新疆克州的田野调查数据,采用logistic模型估计边疆深度贫困地区社会资本对于边民生计策略以及脱贫的影响效应,并运用定性与定量相结合的研究方法对研究结果进行解读。研究表明,地区社会资本有助于边民减贫,这种正向效应主要通过两个路径实现:一是边民借助社会网络提高对正规金融的可得性进而实现养殖扩大再生产;二是边民通过集体公共活动付酬增加转移支付收入。但社会资本通过生计策略多样化机制提升边民生计能力的减贫路径尚未形成。在边疆深度贫困地区脱贫攻坚的关键期,既要充分发挥社会资本对边民收入增收的促进作用,同时也需配套其他措施破解社会资本引导边民建立多样化生计的主要障碍,强化社会资本的能力扶持路径,实现精准脱贫的可持续。 | 刘红 Clement Tisdell 李文静 | 2019 | 商业研究2019，，5： | 12 |
| 19 | 单髁与全膝关节置换治疗内侧间室膝骨关节炎:5年假体在位率比较显示文摘背景:单髁置换越来越多的被应用于治疗单纯内侧胫股间室型膝关节骨关节炎。目的:比较膝关节单髁置换与全膝关节置换对膝关节单纯内侧间室骨关节炎的修复效果。方法:纳入单纯内侧间室型膝关节骨关节炎患者109例,根据修复方式分为两组,单髁置换组41例,全膝关节置换组68例。比较两组患者的平均住院时间、置换后并发症发生率、身体健康总评分、精神健康总评分、牛津膝关节评分以及置换后5年假体在位率。结果与结论:单髁置换组患者平均住院时间(4.21±2.44)d,较全膝关节置换组(6.11±2.23)d短(P=0.001)。两组患者置换后并发症发生率、身体健康总评分、精神健康总评分、牛津膝关节评分等方面差异均无显著性意义(P>0.05)。置换后5年,单髁置换组假体在位率(90%)较全膝关节置换组(100%)低(P<0.05)。提示对于单纯内侧胫股间室型膝关节骨关节炎患者,单髁置换与全膝关节置换具有相似的修复效果,但单髁置换后5年假体在位率稍低。 | 梁宁 Samuel Yih Shyan Wong Nick Clement Deborah MacDonald Daniel E Porter | 2015 | 中国组织工程研究2015，19，53： | 12 |
| 20 | Hepatocellular adenoma: An unsolved diagnostic enigma显示文摘Hepatocellular adenoma (HCA) is a rare benign liver tumour associated with the use of oral contraceptives or other steroid medications which occurs predominantly in young and middle-aged women. Unlike other benign liver tumours, an HCA may be complicated by bleeding and malignant transformation. HCAs have been divided into four subtypes based on molecular and pathological features: hepatocyte nuclear factor 1α-mutated HCA, inflammatory HCA,β-catenin-mutated HCA, and unclassified HCA.β-cateninmutated HCA has the highest risk of haemorrhage or malignant transformation. In the latest upgrade of the guidelines regarding the management of benign liver tumours published in 2016 by the European Association for the Study of the Liver, magnetic resonance imaging (MRI) was recognized to be superior to all other imaging modalities in detecting HCAs and in being able to subtype HCAs up to 80%, with positive identification of 1α-mutated HCA or inflammatory HCA achievable with > 90% specificity. This review analyzed the imaging features of HCA using MRI with hepato-specific contrast agents, focusing on the limitations in the HCA characterization. | Matteo Renzulli Alfredo Clemente Francesco Tovoli Salvatore Cappabianca Luigi Bolondi Rita Golfieri | 2019 | World Journal of Gastroenterology2019，25，20： | 12 |
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