|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Risk factors affecting pancreatic fistulas after pancreaticoduodenectomy显示文摘AIM: To analyze the risk factors of pancreatic leakage after pancreaticoduodenectomy.METHODS: We retrospectively reviewed 172 consecutive patients who had undergone pancreatico-duodenectomy at Inha University Hospital between April 1996 and March 2006. We analyzed the pancreatic fistula rate according to the clinical characteristics, the pathologic and laboratory findings, and the anastomotic methods.RESULTS: The incidence of developing pancreatic fistulas in patients older than 60 years of age was 21.7% (25/115), while the incidence was 8.8% (5/57) for younger patients; the difference was significant (P = 0.03). Patients with a dilated pancreatic duct had a lower rate of post-operative pancreatic fistulas than patients with a non-dilated duct (P = 0.001). Other factors, including clinical features, anastomotic methods, and pathologic diagnosis, did not show any statistical difference. CONCLUSION: Our study demonstrated that pancreatic fistulas are related to age and a dilated pancreatic duct. The surgeon must take these risk factors into consideration when performing a pancre-aticoduodenectomy. | Yun-Mee Choe Keon-Young Lee Cheong-Ah Oh Joung-Bum Lee Sun Keun Choi Yoon-Seok Hur Sei-Joong Kim Young Up Cho Seung-Ik Ahn Kee-Chun Hong Seok-Hwan Shin Kyung-Rae Kim | 2008 | World Journal of Gastroenterology2008，14，45： | 32 |
| 2 | Selective COX-2 inhibitor,NS-398,suppresses cellular proliferation in human hepatocellular carcinoma cell lines via cell cycle arrest显示文摘AIM: To investigate the growth inhibitory mechanism of NS-398, a selective cyclooxygenase-2 (COX-2) inhibitor, in two hepatocellular carcinoma (HCC) cell lines (HepG2 and Huh7). METHODS: HepG2 and Huh7 cells were treated with NS-398. Its effects on cell viability, cell proliferation, cell cycles, and gene expression were respectively evaluated by water-soluble tetrazolium salt (WST-1) assay, 4’-6-diamidino-2-phenylindole (DAPI) staining, flow cytometer analysis, and Western blotting, with dimethyl sulfoxide (DMSO) as positive control. RESULTS: NS-398 showed dose- and time-dependent growth-inhibitory effects on the two cell lines. Proliferating cell nuclear antigen (PCNA) expressions in HepG2 and Huh7 cells, particularly in Huh7 cells were inhibited in a time- and dose-independent manner. NS-398 caused cell cycle arrest in the G1 phase with cell accumulation in the sub-G1 phase in HepG2 and Huh7 cell lines. No evidence of apoptosis was observed in two cell lines. CONCLUSION: NS-398 reduces cell proliferation by inducing cell cycle arrest in HepG2 and Huh7 cell lines, and COX-2 inhibitors may have potent chemoprevention effects on human hepatocellular carcinoma. | Ji Yeon Baek Wonhee Hur Jin Sang Wang Si Hyun Bae Seung Kew Yoon | 2007 | World Journal of Gastroenterology2007，13，8： | 27 |
| 3 | Salinity intrusion characteristics analysis using EFDC model in the downstream of Geum River显示文摘As social interest in the environmental conservation and ecological restoration has recently increased,more research works have been done to resolve problems concerning environmental management of estuaries.In this study,a three-dimensional numerical model,Environmental Fluid Dynamics Code (EFDC) was used in the analysis of the salinity intrusion characteristics in the downstream of Geum River.The numerical simulation was performed to investigate the influence range for salinity intrusion when the gates were fully opened.The conditions used for simulation were the four flow regimes in Geum River Basin,Korea.Results indicated that the ranges of salinity intrusion from the barrage were 50.72 km (drought flow),48.87 km (low flow),46.56 km (normal flow) and 42.10 km (flood flow).These results indicated that the EFDC model used for numerical simulation has high accuracy.The result concluded in this study can be used as a basis in understanding the extent of salinity intrusion effects at different flow rates. | Sangman Jeong Kyusung Yeon Youngteck Hur Kukryul Oh | 2010 | Journal of Environmental Sciences2010，22，6： | 22 |
| 4 | Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma显示文摘AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon cancer.METHODS:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal adenocarcinomas.Medical records were reviewed and clinicopathological analysis was performed.RESULTS:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 expression.Two hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 expression.Five hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 expression.Upon clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 expression.CONCLUSION:CD markers were related to invasiveness and differentiation of colorectal adenocarcinoma.However,CD expression was not closely related to survival. | Dongho Choi Hyo Won Lee Kyung Yul Hur Jae Joon Kim Gyeong-Sin Park Si-Hyong Jang Young Soo Song Ki-Seok Jang Seung Sam Paik | 2009 | World Journal of Gastroenterology2009，15，18： | 14 |
| 5 | Intrahepatic biliary cystadenoma:Is there really an almost exclusively female predominance?显示文摘Biliary cystic tumors,such as cystadenomas and cystadenocarcinomas,are rare cystic tumors of the liver,accounting for less than 5% of all intrahepatic cysts of biliary origin.Biliary cystadenomas have been known to occur predominantly in women (> 85%),and 38%-44% of biliary cystadenocarcinomas have occurred in males.We wrote this letter to comment on a brief article (World J Gasteroenterol 2011 January 21;17(3):361-365) regarding a case of intrahepatic biliary cystic neoplasm treated with surgery.The adenoma-carcinoma sequence is the possible mechanism of carcinogenesis.If the carcinogenesis of biliary cystadenocarcinoma occurs in the adenoma-carcinoma sequence,we believe that the male-to-female ratio of cystadenoma should be higher than the incidence rate that has been reported to date. | Ho Hyun Kim Young Hoe Hur Yang Seok Koh Chol Kyoon Cho Jin Woong Kim | 2011 | World Journal of Gastroenterology2011，17，25： | 12 |
| 6 | Glacier Extent and Volume Change(1966~2000) on the Su-lo Mountain in Northeastern Tibetan Plateau,China显示文摘The topographic maps of 1:50,000 scales,aerial photographs taken in 1966,one Landsat image taken in 1999,and SRTM data from 2000 were used to quantify the losses in area and volume of the glaciers on the Su-lo Mountain,in the northeastern Tibetan Plateau,China in the past 30 years.The total glacier area decreased from 492.9km2 in 1966 to 458.2km2 in 1999.The volume loss of the studied glaciers reached 1.4 km3 from 1966 to 2000.This agrees with documented changes in other mountain glaciers of the whole Tibetan Plateau. | WANG Yetang HOU Shugui HONG Sungmin HUR Soon Do LIU Yaping | 2008 | Journal of Mountain Science2008，5，4： | 10 |
| 7 | Phosphorus fractionation and release characteristics of sediment in the Saemangeum Reservoir for seasonal change显示文摘Periodical algal blooms result in deposition and release of phosphorus(P) from the sediment into the water. Therefore, during seasonal changes when algal particles begin to settle to the bottom, understanding the behavior and distribution characteristics of the P in sediment is the most important key to manage the water quality of the Saemangeum Reservoir. In this study, the variation of water quality and sediment composition including chlorophyll-a(Chl-a) and P was investigated to determine the interaction between water and sediment. The study focused primarily on algal particle sedimentation that affects the P release and mineralization of sediment. The Chl-a concentration in water showed a sharp decline in October when the algae began to die in the fall, and afterward the concentration of chemical oxygen demand(COD) and total P(TP) in the sediment increased due to the sedimentation of decaying algal particles in November.During the same period of time, the readily bio-available P(RAP) in the sediment showed a drastic increase in the upper region where the Chl-a concentration of water was high. In sequence, the high RAP zone shifted from the upper region to the lower region in the early winter. The RAP shift was considered to be derived from the physical flow of the overlying water from which the decomposing algae settled on the surface of the sediment. The Saemangeum Reservoir was constructed recently; therefore, all the types of inorganic P fractions except soluble reactive phosphorus(SRP) that exist on the bottom surface of the lake and the marsh's sediment layer were not sufficient to significantly influence the overlying water. On the other hand, the released P from the algae was distinct and sensitive to the seasonal change. In conclusion,the algal particle sedimentation was important to control eutrophication rather than P release from the mineralized inorganic P of the sediment surface layer in the Seamangeum Reservoir. | Dong-Heui Kwak Young-Tae Jeon Young Duck Hur | 2018 | International Journal of Sediment Research2018，33，3： | 8 |
| 8 | 道路两边不同距离内哺乳动物丰富度的差异(英文)显示文摘为更好地保护和管理部分哺乳类动物及其栖息地 ,自 2 0 0 1年 6月至 2 0 0 2年 3月在韩国白头大干山脉 8个被道路切割的林区内调查了道路两边一定距离内所见哺乳动物随距离增加而变化的丰富度。我们共调查了 10种哺乳类 (野猪、狍、獐、黄鼬、貉、豹猫、华南兔、松鼠、花鼠、鼹 )的各种痕迹 (粪便、足迹、食痕、卧迹及休息处 ) ,发现距道路近处两边的丰富度确有较大下降。这说明道路建设的确影响哺乳类的生境选择及其利用方式。所以今后在道路设计、管理及扩充等方面均需充分考虑和满足所有野生动物整个生命过程所需的空间要求。 | Shin-Jae RHIM Wee-Haeng HUR Young-Su PARK Seo-Youn CHOI Chang-Bae LEE 朴仁珠 Woo-Shin LEE | 2003 | 兽类学报2003，23，3： | 8 |
| 9 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 10 | 单侧小肾细胞癌射频消融术与保肾手术的效价比分析显示文摘目的评价经皮射频消融术(RF)与保留肾单位手术(NSS)治疗小的(直径≤4cm)肾细胞癌的相对成本效益,制定出社会希望支付,普遍可接受的费用水平。方法建立马尔可夫(Markov)决策分析模型,评估接受射频消融或保肾手术的65岁组小肾细胞癌病人的预期寿命及相关花费。模型的建立考虑到了肾癌的状况、治疗效果、费用及近期和远期疗效等综合因素。在假定每个质量校正生存年(QALY)费用为75000美元的前提下,分析判定优选治疗方案如何能提高性价比。在预期范围内引导完善的新式医疗保健干预措施。用敏感性来反映主要参数的变化结果。结果通过运用案例假设,NSS后有质量的生活时间略长于RF(2.5d), | P.V. Pandharipande D.A. Gervais P.R. Mueller C. Hur G.S. Gazelle. 邢艳(译) 刘文亚(校) 唐光健(校) | 2008 | 国际医学放射学杂志2008，31，5： | 7 |
| 11 | MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis显示文摘 | Keun Hur Yuji Toiyama Masanobu Takahashi Francesc Balaguer Takeshi Nagasaka Junichi Koike Hiromichi Hemmi Minoru Koi C Richard Boland Ajay Goel | 2013 | Gut2013，，9： | 6 |
| 12 | Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult显示文摘BACKGROUND:Undifferentiated embryonal sarcoma (UES) of the liver is a rare,highly malignant neoplasm with a poor prognosis occurring almost exclusively in late childhood (6-10 years of age).Only a few cases have been reported in adults accounting for less than 1% of all primary liver neoplasms.METHODS:A 47-year-old woman presented with a palpable mass in the left upper abdomen.Magnetic resonance imaging revealed a 12×10 cm cystic mass with hemorrhage in the left lateral segment of the liver.The initial impression was a hemorrhagic cystic tumor of the liver.The patient underwent a left lateral sectionectomy of the liver.Histopathology and immunohistochemistry helped make a diagnosis of UES.RESULTS:The patient recovered uneventfully and received systemic chemotherapy.Radiologic examination for follow-up revealed a metastatic lesion in the lumbar spine (L5).She was subjected to radiotherapy at the lumbar spine.She survived 48 months.CONCLUSION:Although hepatic cyst as UES of the liver is difficult to diagnose because of its rarity in adults and lack of specific findings,it should be considered in a differential diagnosis. | Ho Hyun Kim Jung Chul Kim Eun Kyu Park Young Hoe Hur Yang Seok Koh Chol Kyoon Cho Hyung Seok Kim Hyun Jong Kim | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 6 |
| 13 | ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome显示文摘 | Christophe Ginestier Min Hee Hur Emmanuelle Charafe-Jauffret Florence Monville Julie Dutcher Marty Brown Jocelyne Jacquemier Patrice Viens Celina G. Kleer Suling Liu Anne Schott Dan Hayes Daniel Birnbaum Max S. Wicha Gabriela Dontu | 2007 | Cell Stem Cell2007，，5： | 5 |
| 14 | Effect of preoperative biliary drainage on surgical results after pancreaticoduodenectomy in patients with distal common bile duct cancer:Focused on the rate of decrease in serum bilirubin显示文摘AIM: To examine if the rate of decrease in serum bilirubin after preoperative biliary drainagecan be used as a predicting factor for surgical complications and postoperative recovery after pancreaticoduodenectomy in patients with distal common bile duct cancer.METHODS: A retrospective study was performed in 49 consecutive patients who underwent pancrea-ticoduodenectomy for distal common bile duct cancer. Potential risk factors were compared between the complicated and uncomplicated groups. Also, the rates of decrease in serum bilirubin were compared pre- and postoperatively. RESULTS: Preoperative biliary drainage (PBD) was performed in 40 patients (81.6%). Postoperative morbidity and mortality rates were 46.9% (23/49) and 6.1% (3/49), respectively. The presence or absence of PBD was not different between the complicated and uncomplicated groups. In patients with PBD, neither the absolute level nor the rate of decrease in serum bilirubin was significantly different. Patients with rapid decrease preoperatively showed faster decrease during the first postoperative week (5.5 ± 4.4 μmol/L vs -1.7 ± 9.9 μmol/L, P = 0.004).CONCLUSION: PBD does not affect the surgical outcome of pancreaticoduodenectomy in patients with distal common bile duct cancer. There is a certain group of patients with a compromised hepatic excretory function, which is represented by the slow rate of decrease in serum bilirubin after PBD. | Yun Mee Choi Eung-Ho Cho Keon-Young Lee Seung-Ik Ahn Sun Keun Choi Sei Joong Kim Yoon Seok Hur Young Up Cho Kee-Chun Hong Seok-Hwan Shin Kyung Rae Kim Ze-Hong Woo | 2008 | World Journal of Gastroenterology2008，14，7： | 5 |
| 15 | 开放与腹腔镜下腹壁切口疝修补术术后并发症的分级和评估:前瞻性随机对照研究显示文摘目的介绍一种针对腹部切口疝修补术后并发症的评估方法。方法 2004-2006年间,146例病人被随机分为两组,一组接受腹腔镜切口疝修补术(腹腔镜组,n=73),另一组接受传统开放式切口疝修补术(传统组,n=73)。研究对象是术后8周内出现的并发症。利用'三步法'来评价并发症的严重性。首先,将所有并发症根据Clavien分级分类。第二步,5位研究员分别独自运用直观叙述问卷模式对并发症的严重程度分级:0表示无术后并发症,100表示术后死亡。第三步,分别用中位数、最低和最高值对腹腔镜组与传统组术后并发症进行评价。结果传统组术后并发症发生率要显著高于腹腔镜组(47.9%vs.31.5%,P=0.026),而腹腔镜组术后并发症的严重度高于传统组。非参数分析显示传统组术后并发症发生率较高(四分位数间距为:开放组0-20对比腹腔镜组0-10;P=0.049)。在敏感性比较中,中位数、最高值和最低值获得了类似结果。结论该方法可以对两种术式术后并发症的发生做出直接评价。评估方法的合法性、可靠性和普遍性有待进一步的研究证实。 | Kaafarani HMA Hur K Campasano M Reda DJ Itani KMF | 2011 | 中国实用外科杂志2011，31，4： | 4 |
| 16 | A highly sensitive chemical gas detecting transistor based on highly crystalline CVD-grown MoSe2 films显示文摘有原子厚度的分层的半导体由于他们的高级搬运人活动性,大 surface-to-volume 比率,和对他们的包围环境的快速的电的回答在高效的电子设备作为活跃元素正在变得日益重要。这里,我们报导高度敏感的 chemical-vapor-deposition-grown 的第一实现多层的 MoSe 2 地效果晶体管(联邦货物税) 在一没有 2 气体传感器。这个传感器展出了超离频敏感(S = ca。1,907 为在 300 ppm 的没有 2) ,即时反应,并且快速的开关切换。我们的 MoSe 2 气体传感器的高敏感在 2 气体专心于在离开状态政体在洞电流导致重要增加的 MoSe 2, 的 NO 劝诱的原子价乐队附近处于差距状态被归因于变化。设备建模和量运输模拟表明没有 2 集中的差距状态的变化是在 MoSe 2 的关键机制基于联邦货物税没有 2 气体传感器。这全面研究,它探讨材料生长,设备制造,描述,和设备模拟,不是仅仅为高效的化学传感器显示 MoSe 2 联邦货物税的用途,而且建立怎么出现理解化学的一个基础在分层的半导体设备影响搬运人运输。 | Jongyeol Baek Demin Yin Na Liu Inturu Omkaram Chulseung Jung Healin Im Seongin Hong Seung Min Kim Young Ki Hong Jaehyun Hur Youngki Yoon Sunkook Kim | 2017 | Nano Research2017，10，6： | 4 |
| 17 | Serum miR-200c Is a Novel Prognostic and Metastasis-Predictive Biomarker in Patients With Colorectal Cancer显示文摘 | Yuji Toiyama Keun Hur Koji Tanaka Yasuhiro Inoue Masato Kusunoki C. Richard Boland Ajay Goel | 2014 | Annals of Surgery2014，，4： | 3 |
| 18 | Formation of CoAl layered double hydroxide on the boehmite surface and its role in tungstate sorption显示文摘Sorption of tungstate on boehmite(γ-Al OOH)is increased by co-sorption with Co^(2+)over the near-neutral p H range.Batch uptake experiments show up to a 3-fold increase in tungstate uptake over the range WO_4^(2-)=50–1000μmol/L compared to boehmite not treated with Co^(2+).Desorption experiments reveal a corresponding decrease in sorption reversibility for tungstate co-sorbed with Co^(2+).Reaction of boehmite with Co^(2+)results in the formation of Co Al layered double hydroxide(LDH),as confirmed by X-ray diffraction and X-ray absorption spectroscopy.Tungsten L_3-edge X-ray absorption near edge structure(XANES)reveals that W(VI)is octahedrally coordinated in all sorption samples,with polymeric tungstate species forming at higher tungstate concentrations.X-ray diffraction and X-ray absorption spectroscopy indicate that the mechanism for enhancement of tungstate uptake is the formation of surface complexes on boehmite at low tungstate concentrations,while exchange into the Co Al LDH becomes important at higher tungstate concentrations.The results provide a basis for developing strategies to enhance tungstate sorption and to limit its environmental mobility at near-neutral pH conditions. | Hyuck Hur Richard J.Reeder | 2018 | Journal of Environmental Sciences2018，30，3： | 3 |
| 19 | Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer显示文摘AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were enrolled.All patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 Gy.Chemotherapy of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 mo.Expression of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were analyzed.The median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong intensity.VEGF expression was found in 64 out of 90 patients.Negative and weak intensities of IL-24 expression were classified as negative expression for analysis.IL-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient characteristics.Expression of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer. | Youngmin Choi Mee-Sook Roh Young-Seoub Hong Hyung-Sik Lee Won-Joo Hur | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 20 | Perforation of the colon by invading recurrent gastrointestinal stromal tumors during sunitinib treatment显示文摘The molecular targets of sunitinib are receptor tyrosine kinases (RTKs),and this drug has also been known to exert blocking effects on the activation of KIT,which is similar to the mechanism of action of imatinib. Moreover,sunitinib has an additional anti-angiogenic effect through its inhibition of the vascular endothelial growth factor receptor activation. We report here a 70-year-old patient diagnosed with a recurrent gastrointestinal stromal tumor (GIST),which invaded the transverse colon and led to a perforation during sunitinib treatment. A computed tomography scan and 3-dimensional reconstruction showed necrosis of the recurrent hepatic mass and perforation of the invaded transverse colon. After percutaneous drainage of the intraperitoneal abscess,antibiotic treatment and restricted diet,the condition of the patient improved. The present case is the first to report that sunitinib,which is administered to treat GIST resistant to imatinib,can cause unexpected colon perforation and subsequent peritonitis. | Hoon Hur Ae Ryoung Park Sung Bae Jee Seung Eun Jung Wook Kim Hae Myung Jeon | 2008 | World Journal of Gastroenterology2008，14，39： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员