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| 1 | Hepatogenic differentiation of human mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells显示文摘AIM: To investigate and compare the hepatogenic transdifferentiation of adipose tissue-derived stem cells (ADSC) and bone marrow-derived mesenchymal stem cells (BMSC) in vitro. Transdifferentiation of BMSC into hepatic cells in vivo has been described. Adipose tissue represents an accessible source of ADSC, with similar characteristics to BMSC.METHODS: BMSCs were obtained from patients under-going total hip arthroplasty and ADSC from human adi-pose tissue obtained from lipectomy. Cells were grown in medium containing 15% human serum. Cultures were serum deprived for 2 d before cultivating under similar pro-hepatogenic conditions to those of liver develop-ment using a 2-step protocol with sequential addition of growth factors, cytokines and hormones. Hepatic differ-entiation was RT-PCR-assessed and liver-marker genes were immunohistochemically analysed. RESULTS: BMSC and ADSC exhibited a fibroblastic mor-phology that changed to a polygonal shape when cells differentiated. Expression of stem cell marker Thy1 de-creased in differentiated ADSC and BMSC. However, the expression of the hepatic markers, albumin and CYPs increased to a similar extent in differentiated BMSC and ADSC. Hepatic gene activation could be attributed to in-creased liver-enriched transcription factors (C/EBPβ and HNF4α), as demonstrated by adenoviral expression vec-tors.CONCLUSION: Mesenchymal stem cells can be induced to hepatogenic transdifferentiation in vitro. ADSCs have a similar hepatogenic differentiation potential to BMSC, but a longer culture period and higher proliferation ca-pacity. Therefore, adipose tissue may be an ideal source of large amounts of autologous stem cells, and may become an alternative for hepatocyte regeneration, liver cell transplantation or preclinical drug testing. | Raquel Taléns-Visconti Ana Bonora Ramiro Jover Vicente Mirabet Francisco Carbonell José Vicente Castell María José Gómez-Lechón | 2006 | World Journal of Gastroenterology2006，12，36： | 35 |
| 2 | Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy显示文摘Molecular advances support the existence of an alternative pathway of colorectal carcinogenesis that is based on the hypermethylation of specific DNA regions that silences tumor suppressor genes. This alternative pathway has been called the serrated pathway due to the serrated appearance of tumors in histological analysis. New classifications for colorectal cancer(CRC) were proposed recently based on genetic profiles that show four types of molecular alterations: BRAF gene mutations, KRAS gene mutations, microsatellite instability, and hypermethylation of Cp G islands. This review summarizes what is known about the serrated pathway of CRC, including CRC molecular and clinical features, prognosis, and response to chemotherapy. | Oscar Murcia Miriam Juárez Eva Hernández-Illán Cecilia Egoavil Mar Giner-Calabuig María Rodríguez-Soler Rodrigo Jover | 2016 | World Journal of Gastroenterology2016，22，13： | 18 |
| 3 | Serrated polyposis syndrome:Molecular,pathological and clinical aspects显示文摘Hyperplastic polyps have traditionally been considered not to have malignant potential.New pathological classification of serrated polyps and recent discoveries about the serrated pathway of carcinogenesis have revolutionized the concepts and revitalized the research in this area.Until recently,it has been thought that most colorectal cancers arise from conventional adenomas via the traditional tumor suppressor pathway initiated by a mutation of the APC gene,but it has been found thatthis pathway accounts for only approximately 70%-80% of colorectal cancer(CRC)cases.The majority of the remaining colorectal cancer cases follow an alternative pathway leading to CpG island methylator phenotype carcinoma with BRAF mutation and with or without microsatellite instability.The mechanism of carcinomas arising from this alternative pathway seems to begin with an activating mutation of the BRAF oncogene.Serrated polyposis syndrome is a relatively rare condition characterized by multiple and/or large serrated polyps of the colon.Clinical characteristics,etiology and relationship of serrated polyposis syndrome to CRC have not been clarified yet.Patients with this syndrome show a high risk of CRC and both sporadic and hereditary cases have been described.Clinical criteria have been used for diagnosis and frequent colonoscopy surveillance should be performed in order to prevent colorectal cancer.In this review,we try to gather new insights into the molecular pathogenesis of serrated polyps in order to understand their possible clinical implications and to make an approach to the management of this syndrome. | Carla Guarinos Cristina Sánchez-Fortún María Rodríguez-Soler Cristina Alenda Artemio Payá Rodrigo Jover | 2012 | World Journal of Gastroenterology2012，18，20： | 8 |
| 4 | 血液透析患者血压水平的地域和季节性差异显示文摘季节和气候对一般人群以及血液透析患者的血压调节有影响。目前这个现象在世界各地是否有所不同尚不清楚。研究者对来自7个欧洲国家(西班牙、意大利、法国、比利时、德国、英国和瑞典)2005-2011年间参加国际透析预后与实践模式研究(dialysis outcomes and practice patterns study,DOPPS)的患者进行了研究,目的是探究来自不同地理位置的血液透析患者的血压季节差异。 | 刘青 叶鹏 Duranton F Kramer A Szwarc I Bieber B Gayrard N Jover B Vetromile F Massy ZA Combe C Tentori F Jager KJ Servel MF Argilés | 2018 | 中华高血压杂志2018，26，1： | 5 |
| 5 | Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline显示文摘 | Cesare Hassan Enrique Quintero Jean-Marc Dumonceau Jaroslaw Regula Catarina Brand?o Stanislas Chaussade Evelien Dekker Mario Dinis-Ribeiro Monika Ferlitsch Antonio Gimeno-García Yark Hazewinkel Rodrigo Jover Mette Kalager Magnus Loberg Christian Pox Bjorn | 2013 | Endoscopy2013，，10： | 3 |
| 6 | Influence of personal mastery on organization- al performance through organizational learning and inno- vation in large firms and SMEs 显示文摘 | Garcia - Morales V J Llor6ns - Montes F J Verd6 - Jover A J | 2007 | Technovation2007，27，： | 1 |
| 7 | A simplified scheme for induction motor condition monitoring显示文摘 | Jover Rodriguez P V Negrea M Arkkio A | 2008 | Mechanical Systems and Signal Processing2008，，22： | 1 |
| 8 | Regression of primary gastric B-cell mucosa-associated lymphoid tissue (MALT) lymphoma after eradication of Helicobacter pylori显示文摘 | Falco Jover G Martinez EgeaA Sanchez Cuenca J | 1999 | Rev Esp Enferm Dig1999，91，8： | 1 |
| 9 | Human mesenchymal stem cells from adipose tissue: differentiation into hepatic lineage显示文摘 | R TALENS - VISCONTI A BONORA R JOVER | 2007 | Toxicol In Vitro2007，21，： | 1 |
| 10 | Preparation of a rice bran enzymatic extract with potential use as functional food显示文摘 | Juan Parrado Esther Miramontes Maria Jover | 2006 | Food Chemistry2006，98，： | 1 |
| 11 | Gut am- monia production and its modulation 显示文摘 | Romem - Gomez M Jover M Galan JJ | 2009 | Metab Brain Dis2009，24，1： | 1 |
| 12 | Increased toxicity of cocaine on human hepatocytes induced by ethanol:role of GSH显示文摘 | Ponsoda X Bort R Jover R | 1999 | Biochemical Pharmacology1999，58，10： | 1 |
| 13 | Detection of BRAF V600E Mutation in Colorectal Cancer显示文摘 | Susana Benlloch Artemio Payá Cristina Alenda Xavier Bessa Montserrat Andreu Rodrigo Jover Antoni Castells Xavier Llor F. Ignacio Aranda Bartomeu Massutí | 2006 | The Journal of Molecular Diagnostics2006，，5： | 1 |
| 14 | Prevention of brain Protein and lipid oxidation elicited by a water - soluble oryzanol enzymatic extract derived from rice bran 显示文摘 | Parrado J Miramontes E Jover M | 2003 | European Journal of Nutrition2003，42，6： | 1 |
| 15 | Occurrence and fate of benzothiazoles and benzotriazoles in constructed wetlands显示文摘 | MATAMOROS V JOVER E BAYONA J | 2010 | 61(1):191-1982010，61，1： | 1 |
| 16 | Prevention of brain protein and lipid oxidation elicited by a watersoluble oryzanol enzymatic extract derived from rice bran显示文摘 | Parrado J Miramontes E Jover M | 2003 | Eur J Nutr2003，42，6： | 1 |
| 17 | Optimization of MnOjver-tically aligned carbon nanotube composite for supercapacitor appli- cation显示文摘 | AMADE JOVER E CAGLAR B | 2011 | Journal of Power Sources2011，196，： | 1 |
| 18 | Ischemic preconditioning: neuronal survival in the face of caspase-3 activation显示文摘 | Tanaka H Yokota H Jover T | 2004 | J Neurosci2004，24，11： | 1 |
| 19 | Activation of metabotropic glutamate receptor 1 accelerates NMDA re- ceptor trafficking显示文摘 | Lan J Y Skeberdis V A Jover T | 2001 | J Neurosci2001，21，： | 1 |
| 20 | Preparation of a rice bran enzymatic extract with potential use as functional food显示文摘 | PARRADO J MIRAMONTES E JOVER M | 2006 | Food chemistry2006，，4： | 1 |
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