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| 1 | Dynamic hip screw with locking side plate: a viable treatment option for intertrochanteric fracture显示文摘ObjectiveDynamic 新潮的螺丝钉(DHS ) 为稳定的 intertrochanteric 破裂的固定被推荐。它的手术后的开口率从 1% ~ 6%。在 osteoporotic 骨头,在 DHS 片的正常螺丝钉与锁螺丝钉相比提供更少的抛锚。这研究试图把 DHS 与锁方面板和常规方面 plate.MethodsFifty 作比较有 intertrochanteric 破裂的连续病人随机与标准 DHS (组 A ) 和锁住的 DHS 为固定被分配(Combi 板,组 B ) 。我们在 intertrochanteric 破裂为常规 DHS 和锁住的 DHS 比较了临床、放射学的结果。功能的结果用 score.ResultsCoxa valga 比在组 B 在组 A 更经常被发现的帕克活动性被评估(12% 对 0% , P = 0.42 ) 。臀部 vara 显示出一样的趋势(12% 对 8% , P = 0.81 ) 。在健全方面的 20 °
以内的手术后的颈柄角度的恢复的率比在组 A 在组 B (8% 盒子) 是更高的(4% 盒子, P = 0.98 ) 。在健全方面的 10 °
以内的子宫前倾角度恢复的率在组 B 也是更高的(100% 对 88% , s = 0.85 ) 。一般水准落后在组 A 和组 B 的螺丝钉滑动是 3.2 公里和 4.2 公里,平均破裂联合持续时间是 17.1 个星期, 16.4 个星期,和吝啬的帕克得分分别地是 5.6 和 5.8。螺丝钉开口在组 A 在一个病人被看见。没有开口在组 B 在任何病人被看见。没有耐心的发达深感染, avascular 坏死,深静脉血栓或任何东西学习表明了的在场的另外的重要 complications.ConclusionThe 有锁住的 DHS 的那对待的 intertrochanteric 破裂允许健全骨头愈合并且是没与任何主要复杂并发症联系。尽管这份报告是有希望的,因为仅仅有一种大样品尺寸的未来的研究将允许权威的结论,它应该小心地被解释。 | Nilesh Barwar Sanjay Meena Shashi Kant Aggarwal Prashant Garhwal | 2014 | Chinese Journal of Traumatology2014，17，2： | 23 |
| 2 | 在过敏 bronchopulmonary 麴菌病的胸 X 光线照相术、计算的 tomographic 表明显示文摘 AIM:To investigate the chest radiographic and high resolution computed tomography(HRCT)chest manifestations in glucocorticoid-naive allergic bronchopulmonary aspergillosis(ABPA)patients.METHODS:This is a prospective observational study and includes 60 consecutive glucocorticoid-naive patients with ABPA who underwent chest radiography and HRCT of the chest(1.25 mm every 10 mm)in the routine diagnostic workup for ABPA.RESULTS:Chest radiographs were normal in 50%of cases.Of the remainder,most patients demonstrated permanent findings in the form of parallel line and ring shadows suggesting bronchiectasis.Consolidation was detected in 17 cases but in the majority,the corresponding HRCT chest scan showed mucus-filled bronchiectatic cavities.Chest HRCT was normal in 22 patients,while central bronchiectasis(CB)was demonstrated in the remaining 38 patients.Bronchiectasis extended to the periphery in 33%-43%depending on the criteria used for defining CB.The other findings observed on HRCT were mucoid impaction,centrilobular nodules and high-attenuation mucus in decreasing order of frequency.CONCLUSION:Patients with ABPA can present with normal HRCT chest scans.Central bronchiectasis cannot be considered a characteristic feature of ABPA as peripheral bronchiectasis is commonly observed.Consolidation is an uncommon finding in ABPA. | Ritesh Agarwal Ajmal Khan Mandeep Garg Ashutosh N Aggarwal Dheeraj Gupta | 2012 | World Journal of Radiology2012，4，4： | 14 |
| 3 | Deep vein thrombosis and pulmonary embolism in cirrhotic patients:Systematic review显示文摘Patients with liver cirrhosis were traditionally believed to be protected against development of blood clots.Lately,studies have shown that these patients may probably be at an increased risk of venous thrombotic complications.Although the hemostatic changes in the chronic liver disease patients and the factors that may predict bleeding vs thrombotic complications remains an area of active research,it is believed that the coagulation cascade is delicately balanced in these patients because of parallel reduced hepatic synthesis of pro and anticoagulant factors.Thrombotic state in cirrhotic patients is responsible for not only portal or non-portal thrombosis[deep vein thrombosis(DVT)and pulmonary embolism(PE)];it has also been associated with progression of liver fibrosis.The use of anticoagulants in cirrhosis patients is a challenging,and often a scary situation.This review summarizes the current literature on the prevalence of venous thrombosis(DVT and PE),risk factors and safety of prophylactic and therapeutic anticoagulation in patients with chronic liver disease. | Ashish Aggarwal Kanika Puri Suthat Liangpunsakul | 2014 | World Journal of Gastroenterology2014，20，19： | 14 |
| 4 | Fluid resuscitation in acute pancreatitis显示文摘Acute pancreatitis remains a clinical challenge,despite an exponential increase in our knowledge of its complex pathophysiological changes.Early fluid therapy is the cornerstone of treatment and is universally recommended;however,there is a lack of consensus regarding the type,rate,amount and end points of fluid replacement.Further confusion is added with the newer studies reporting better results with controlled fluid therapy.This review focuses on the pathophysiology of fluid depletion in acute pancreatitis,as well as the rationale for fluid replacement,the type,optimal amount,rate of infusion and monitoring of such patients.The basic goal of fluid epletion should be to prevent or minimize the systemic response to inflammatory markers.For this review,various studies and reviews were critically evaluated,along with authors’recommendations,for predicted severe or severe pancreatitis based on the available evidence. | Aakash Aggarwal Manish Manrai Rakesh Kochhar | 2014 | World Journal of Gastroenterology2014，20，48： | 14 |
| 5 | Assessment of interobserver variation in Garden classification and management of fresh intracapsular femoral neck fracture in adults显示文摘ObjectiveTo 在如果侧面的看法的增加改变整形外科的外科医生被要求仅仅在 AP 看法上分类 35 大腿骨的颈破裂并且建议管理的分类和管理 plan.MethodsTen ,骨折和管理计划基于 anteroposterior ( AP )看并且也估计的新鲜的大腿骨的颈的花园分类上估计 interobserver 协议计划。当时,一样的电影是在 10 天以后与他们的侧面的看法一起重新显示出。结果与到在二个组之间的分类和管理计划的尊重相比。Interobserver 同意用 Fleiss’ 被计算kappa.ResultsThere 仅仅仅仅在 AP 看法上的花园分类上是一个公平 interobserver 协议(kappa 价值 0.39 ) 它改善了在增加一个侧面的看法以后节制同意(kappa 价值 0.52 ) 。当仅仅在 AP 上的管理计划上的 interobserver 协议有细微改进时,仅仅看(kappa 价值 0.50 ) 并且 AP 与侧面的看法(kappa 价值 0.52 ) 结合了。侧面的看法的补充在 15.42% 盒子中改变了分类并且在 23.14% cases.ConclusionWe 改变了管理计划断定当它毫无疑问在计划大腿骨的颈骨折的治疗有一个角色,那个侧面的看法应该与怀疑的大腿骨的颈骨折在所有病人上习惯性地被获得。 | Amit Aggarwal Mahipal Singh Aditya N Aggarwal Shuchi Bhatt | 2014 | Chinese Journal of Traumatology2014，17，2： | 13 |
| 6 | Asia Pacific survey of physicians on asthma and allergic rhinitis (ASPAIR): data from China显示文摘Background:In China, the prevalence of allergic rhinitis (AR) and asthma has increased in the past decade. As these two diseases frequently coexist, the Asia-Pacific Survey of Physicians on Asthma and Allergic Rhinitis (ASPAIR) study aimed to assess physicians5 beliefs and treatment patterns of coexistent asthma-AR across six Asian countries. This analysis presents the results from China. Methods: The 200 hospital-based general physicians and pediatricians were interviewed from five cities in China. Physicians were questioned in-person about their knowledge, beliefs and management practices for patients with coexistent asthma-AR. Results: Approximately 70% of the physicians interviewed routinely evaluated their patients with asthma or AR for signs of coexistent disease. While the majority of physicians (>90% of physicians) recognized the increased burden of coexistent asthma-AR vs. one condition alone and that coexistent disease requires additional treatment, most physicians (96%) also believed that patients with coexistent asthma-AR were well managed if either condition alone improved. Similarly, although 71% of physicians selected a combination of intranasal and inhaled corticosteroids as their preferred treatment for coexistent asthma-AR, in line with treatment guidelines, two fifths of physicians indicated that treatment for coexistent disease requires too much medication and that their patients prefer oral medications and a third of physicians believed that corticosteroids should be delayed in children. Conclusions: This survey demonstrates that physicians interviewed in China have a broad understanding of coexistent asthma-AR and its impact on patients. A holistic approach to patient management with informed decisions regarding patients' overall treatment will benefit patients who suffer from coexistent disease. | David Hinds Bhumika Aggarwal Xin Du Aruni Mulgirigama Sumitra Shantakumar | 2019 | Chinese Medical Journal2019，，11： | 13 |
| 7 | Newer perspectives of coronary artery disease in young显示文摘Coronary artery disease(CAD) occurring in less than 45 years of age is termed as young CAD.Recent studies show a prevalence of 1.2% of CAD cases in this age group.Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%.Conventional risk factors such as smoking,diabetes,hypertension,obesity and family history seems to be as important as in older CAD subjects.But the prevalence of these risk factors seems to vary in younger subjects.By far the most commonly associated risk factor is smoking in young CAD.Several genes associated with lipoprotein metabolism are now found to be associated with young CAD like cholesterol ester transfer protein(CETP) gene,hepatic lipase gene,lipoprotein lipase gene,apo A1 gene,apo E gene and apo B.Biomarkers such as lipoprotein(a),fibrinogen,D-dimer,serum Wnt,gamma glutamyl transferase,vitamin D2 and osteocalcin are seems to be associated with premature CAD in some newer studies.In general CAD in young has better prognosis than older subjects.In terms of prognosis two risk factors obesity and current smoking are associated with poorer outcomes.Angiographic studies shows predominance of single vessel disease in young CAD patients.Like CAD in older person primary and secondary prevention plays an important role in prevention of new and further coronary events. | Amitesh Aggarwal Saurabh Srivastava M Velmurugan | 2016 | World Journal of Cardiology2016，8，12： | 13 |
| 8 | Cervical cancer: Can it be prevented?显示文摘Cervical cancer prevention requires a multipronged approach involving primary, secondary and tertiary prevention. The key element under primary prevention is human papilloma virus(HPV) vaccination. So far, only prophylactic HPV vaccines which prevent HPV infection by one or more subtypes are commercially available. Therapeutic HPV vaccines which aid in clearing established infection are still under trial. Secondary prevention entails early detection of precancerous lesions and its success is determined by the population coverage and the efficacy of the screening technique. A number of techniques are in use, including cytology, visual inspection(using the naked eye, magnivisualizer, acetic acid and Lugol's iodine), HPV testing and a combination of these methods. Updated screening guidelines have been advocated by the American Cancer Society in light of the role of HPV on cervical carcinogenesis. Recent research has also focussed on novel biomarkers that can predict progression to cancer in screen positive women and help to differentiate those who need treatment from those who can be left for follow-up. Last but not the least, effective treatment of precancerous lesions can help to reduce the incidence of invasive cervical cancer and this constitutes tertiary prevention.A combination of these approaches can help to prevent the burden of cervical cancer and its antecedent morbidity and mortality, but all of these are not feasible in all settings due to resource and allocation constraints. Thus, all countries, especially low and middle income ones, have to determine their own cocktail of approaches that work before we can say with certainty that yes, cervical cancer can be prevented. | Pakhee Aggarwal | 2014 | World Journal of Clinical Oncology2014，5，4： | 11 |
| 9 | Development and characterization of an atorvastatin solid dispersion formulation using skimmed milk for improved oral bioavailability显示文摘Atorvastatin has low aqueous solubility resulting in low oral bioavailability(12%)and thus presents a challenge in formulating a suitable dosage form.To improve the aqueous solubility,a solid dispersion formulation of atorvasta tin was prepared by lyophilization utilising skimmed milk as a carrier.Six different formulations were prepared with varying ratios of drug and carrier and the corresponding physical mixtures were also prepared.The formation of a solid dispersion formulation was confirmed by differential scanning ca lorimetry and X-ray diffraction studies.The optimum drug-to-carrier ratio of 1:9 en hanced solubility nearly 33-fold as compared to pure drug.In vitro drug release studies exhibited a cumulative release of 83.69% as compared to 22.7% for the pure drug.Additionally,scanning electron microscopy studies suggested the conversion of crystalline atorvastatin to an amorphous form.In a Triton-induced hyperlipidemia model,a 3-fold increase in the lipid lowering potential was obtained with the reformulated drug as compared to pure drug.These results suggest that solid dispersion of atorvastatin using skimmed milk as carrier is a promising approach for oral delivery of atorvastatin. | Ankush Choudhary Avtar C.Rana Geeta Aggarwal Virender Kumar Foziyah Zakir | 2012 | Acta Pharmaceutica Sinica B2012，2，4： | 10 |
| 10 | Genomic alterations and molecular subtypes of gastric cancers in Asians显示文摘Gastric cancer(GC) is a highly heterogenic disease,and it is the second leading cause of cancer death in the world.Common chemotherapies are not very effective for GC,which often presents as an advanced or metastatic disease at diagnosis.Treatment options are limited,and the prognosis for advanced GCs is poor.The landscape of genomic alterations in GCs has recently been characterized by several international cancer genome programs,including studies that focused exclusively on GCs in Asians.These studies identified major recurrent driver mutations and provided new insights into the mutational heterogeneity and genetic profiles of GCs.An analysis of gene expression data by the Asian Cancer Research Group(ACRG) further uncovered four distinct molecular subtypes with well-defined clinical features and their intersections with actionable genetic alterations to which targeted therapeutic agents are either already available or under clinical development.In this article,we review the ACRG GC project.We also discuss the implications of the genetic and molecular findings from various GC genomic studies with respect to developing more precise diagnoses and treatment approaches for GCs. | Xiang S.Ye Chunping Yu Amit Aggarwal Christoph Reinhard | 2016 | Chinese Journal of Cancer2016，35，8： | 10 |
| 11 | Cephalomedullary fixation for femoral neck/intertrochanteric and ipsilateral shaft fractures: surgical tips and pitfalls显示文摘为大腿骨的柄骨折和 ipsilateral 的 ObjectiveSurgical 管理选择近似腿节骨折从单个植入变化到双 implant 固定。特别因为不太软的织物解剖和容忍加速的康复的立即的手术后的重量,在如此的破裂的 Cephalomedullary 固定比另外的技术有相对优点。然而,外科是技术上费力的,有为这固定描述外科的技术的文学的少量。学习的目的是为大腿骨的柄骨折和 ipsilateral 描述 cephalomedullary 固定的外科的技术近似的腿节 fractureMethodsSixteen 盒子(有一个平均数的 10 男性和 6 女性 41.8 变老;年) ipsilateral ,近似腿节和柄破裂被单个阶段的 cephalomedullary 固定在第三级的水平对待在北印度的损伤中心。破裂根据 AO 分类被分类。象对每个骨折模式唯一的技术挑战一样的外科的持续时间的一个 intraoperative 记录最为所有 patientsResultsThe 被保存普通近似大腿骨的模式是在 9 个我们的病人观察的 AO B2.1。当 AO A1.2 在 3 个病人断裂时, AO B2.3 破裂在 4 个病人被看见。四 AO B2.1 和 2 AO B2.3 破裂与 Watson-Jones 途径要求了开的减小。吝啬的起作用的时间在 78 附近;当外科的经验增加了,纪录,它趋于减少。仅仅有 malreduction 的一个盒子,它要求大腿骨的柄骨折和 neck/intertrochanteric 折断的 ipsilateral 的修订 surgery.ConclusionCombination 是为损伤外科医生的一个困难的破裂模式。Cephalomedullary 钉子是一优秀植入因为这断裂,但是避免复杂并发症要求小心的插入。外科与一条明确的学习曲线是技术上费力的。不过,这些破裂的一个多数能被在这篇文章被总结了的后面的基本外科的原则被 singleimplant cephalomedullary 固定通过手术管理。 | Kamal Bali Nitesh Gahlot Sameer Aggarwal Vijay Goni | 2013 | Chinese Journal of Traumatology2013，16，1： | 9 |
| 12 | Primary hepatic tuberculosis:A rare but fatal clinical entity if undiagnosed显示文摘Hepatic tuberculosis particularly in the absence of military tuberculosis is rare.It can occur as a primary case or due to reactivation of an old tubercular focus.We report case of a 24 year old married female who died of primary hepatic tuberculosis.She had no evidence of tuberculosis elsewhere.Appropriale treatment initiated early can result in marked recovery whereas failure to recognize this entity can prove to be fatal. | Singh Sneh Jain Promil Aggarwal Garima Dhiman Pratibha Singh Sunita Sen Rajeev | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，6： | 7 |
| 13 | Comparative study of outcomes following laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy in morbidly obese patients: A case control study显示文摘AIM To compare the impact of laparoscopic Roux-en-Y gastric bypass(LRYGB) and laparoscopic sleeve gastrectomy(LSG) on weight loss and obesity related comorbidities over two year follow-up via case control study design.METHODS Forty patients undergoing LRYGB, who completed their two year follow-up were matched with 40 patients undergoing LSG for age, gender, body mass index and presence of type 2 diabetes mellitus(T2DM). Data of these patients was retrospectively reviewed to compare the outcome in terms of weight loss and improvement in comorbidities, i.e., T2 DM, hypertension(HTN), obstructive sleep apnea syndrome(OSAS), hypothyroidism and gastroesophageal reflux disease(GERD).RESULTS Percentage excess weight loss(EWL%) was similar in LRYGB and LSG groups at one year follow-up(70.5% vs 66.5%, P = 0.36) while it was significantly greater for LRYGB group after two years as compared to LSG group(76.5% vs 67.9%, P = 0.04). The complication rate after LRYGB and LSG was similar(10% vs 7.5%,P = 0.99). The median duration of T2 DM and mean number of oral hypoglycemic agents were higher in LRYGB group than LSG group(7 years vs 5 years and 2.2 vs 1.8 respectively, P < 0.05). Both LRYGB and LSG had significant but similar improvement in T2 DM, HTN, OSAS and hypothyroidism. However, GERD resolved in all patients undergoing LRYGB while it resolved in only 50% cases with LSG. Eight point three percent patients developed new-onset GERD after LSG.CONCLUSION LRYGB has better outcomes in terms of weight loss two years after surgery as compared to LSG. The impact of LRYGB and LSG on T2 DM, HTN, OSAS and hypothyroidism is similar. However, LRYGB has significant resolution of GERD as compared to LSG. | Harshit Garg Pratyusha Priyadarshini Sandeep Aggarwal Samagra Agarwal Rachna Chaudhary | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，4： | 7 |
| 14 | A new microchannel capillary flow assay (MCFA) platform with lyophilized chemiluminescence reagents for a smartphone-based POCT detecting malaria显示文摘There has been a considerable development in microfluidic based immunodiagnostics over the past few years which has greatly favored the growth of novel point-of-care-testing(POCT).However,the realization of an inexpensive,low-power POCT needs cheap and disposable microfluidic devices that can perform autonomously with minimum user intervention.This work,for the first time,reports the development of a new microchannel capillary flow assay(MCFA)platform that can perform chemiluminescence based ELISA with lyophilized chemiluminescent reagents.This new MCFA platform exploits the ultra-high sensitivity of chemiluminescent detection while eliminating the shortcomings associated with liquid reagent handling,control of assay sequence and user intervention.The functionally designed microchannels along with adequate hydrophilicity produce a sequential flow of assay reagents and autonomously performs the ultra-high sensitive chemiluminescence based ELISA for the detection of malaria biomarker such as PfHRP2.The MCFA platform with no external flow control and simple chemiluminescence detection can easily communicate with smartphone via USB-OTG port using a custom-designed optical detector.The use of the smartphone for display,data transfer,storage and analysis,as well as the source of power allows the development of a smartphone based POCT analyzer for disease diagnostics.This paper reports a limit of detection(LOD)of 8 ng/mL by the smartphone analyzer which is sensitive enough to detect active malarial infection.The MCFA platform developed with the smartphone analyzer can be easily customized for different biomarkers,so a hand-held POCT for various infectious diseases can be envisaged with full networking capability at low cost. | Sthitodhi Ghosh Kashish Aggarwal Vinitha T.U Thinh Nguyen Jungyoup Han Chong H.Ahn | 2020 | Microsystems & Nanoengineering2020，6，1： | 7 |
| 15 | Helicobacter pylori:Does it add to risk of coronary artery disease显示文摘Helicobacter pylori(H. pylori) is a known pathogen implicated in genesis of gastritis, peptic ulcer disease, gastric carcinoma and gastric lymphoma. Beyond the stomach, the organism has also been implicated in the causation of immune thrombocytopenia and iron deficiency anemia. Although an area of active clinical research, the role of this gram negative organism in causation of atherosclerosis and coronary artery disease(CAD) remains enigmatic. CAD is a multifactorial disease which results from the atherosclerosis involving coronaryarteries. The major risk factors include age, diabetes mellitus, smoking, hypertension and dyslipidemia. The risk of coronary artery disease is believed to increase with chronic inflammation. Various organisms like Chlamydia and Helicobacter have been suspected to have a role in genesis of atherosclerosis via causation of chronic inflammation. This paper focuses on available evidence to ascertain if the role of H. pylori in CAD causation has been proven beyond doubt and if eradication may reduce the risk of CAD or improve outcomes in these patients. | Vishal Sharma Amitesh Aggarwal | 2015 | World Journal of Cardiology2015，7，1： | 7 |
| 16 | 英国国家基金电力能源领域重大研究计划显示文摘介绍由英国国家工程和自然科学研究委员会(EPSRC)等5个英国国家基金委员会联合设置的电力能源领域的重大研究计划——电力能源可持续生产和供给(SUPERGEN)计划,包括SUPERGEN计划的研究目的、研究方向、组织方式、资金投入等,以及2003年至今该计划所涵盖的10个研究课题的具体情况和未来的研究领域。 | 薛峰 王海风 Raj AGGARWAL | 2007 | 电力系统自动化2007，31，4： | 7 |
| 17 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet . 2012 (9859)2012，，9859： | 7 |
| 18 | 人工智能及其在含可再生能源电源的电网安全中的应用(英文)显示文摘文章概述了用于解决电网复杂问题的当前最高水平的人工智能技术,总结了可再生能源发电系统的发展现状,讨论了将可再生能源发电系统联接到电网中时需要考虑的几个问题。文中还较详细地讨论了近年来发生在欧美电网中的大停电事故。最后扼要介绍了一些基于人工智能的用于解决复杂问题的技术,特别是用于增强含有可再生能源发电的电网及老化电网的安全性的技术。 | Raj Kumar Aggarwal | 2007 | 电网技术2007，31，20： | 6 |
| 19 | Multimodality management of gallbladder cancer can lead to a better outcome:Experience from a tertiary care oncology centre in North India显示文摘BACKGROUND Surgical resection is a treatment of choice for gallbladder cancer(GBC)patients but only 10%of patients have a resectable disease at presentation.Even after surgical resection,overall survival(OS)has been poor due to high rates of recurrence.Combination of surgery and systemic therapy can improve outcomes in this aggressive disease.AIM To summarize our single-center experience with multimodality management of resectable GBC patients.METHODS Data of all patients undergoing surgery for suspected GBC from January 2012 to December 2018 was retrieved from a prospectively maintained electronic database.Information extracted included demographics,operative and perioperative details,histopathology,neoadjuvant/adjuvant therapy,follow-up,and recurrence.To know the factors associated with recurrence and OS,univariate and multivariate analysis was done using log rank test and cox proportional hazard analysis for categorical and continuous variables,respectively.Multivariate analysis was done using multiple regression analysis.RESULTS Of 274 patients with GBC taken up for surgical resection,172(62.7%)were female and the median age was 56 years.On exploration,102 patients were found to have a metastatic or unresectable disease(distant metastasis in 66 and locally unresectable in 34).Of 172 patients who finally underwent surgery,93(54%)underwent wedge resection followed by anatomical segment IVb/V resection in 66(38.4%)and modified extended right hepatectomy in 12(7%)patients.The postoperative mortality at 90 d was 4.6%.During a median follow-up period of 20 mo,71(41.2%)patients developed recurrence.Estimated 1-,3-,and 5-years OS rates were 86.5%,56%,and 43.5%,respectively.Estimated 1-and 3-year disease free survival(DFS)rates were 75%and 49.2%,respectively.On multivariate analysis,inferior OS was seen with pT3/T4 tumor(P=0.0001),perineural invasion(P=0.0096),and R+resection(P=0.0125).However,only pT3/T4 tumors were associated with a poor DFS(P<0.0001).CONCLUSION Multimodality treatment significantly improves the 5-year survival rate of patients with GBC up to 43%.R+resection,higher T stage,and perineural invasion adversely affect the outcome and should be considered for systemic therapy in addition to surgery to optimize the outcomes.Multimodality treatment of GBC has potential to improve the survival of GBC patients. | Shaifali Goel Abhishek Aggarwal Assif Iqbal Vineet Talwar Swarupa Mitra Shivendra Singh | 2021 | World Journal of Gastroenterology2021，27，45： | 5 |
| 20 | Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Rafael Lozano Mohsen Naghavi Kyle Foreman Stephen Lim Kenji Shibuya Victor Aboyans Jerry Abraham Timothy Adair Rakesh Aggarwal Stephanie Y Ahn Mohammad A AlMazroa Miriam Alvarado H Ross Anderson Laurie M Anderson Kathryn G Andrews Charles Atkinson Larry M | 2012 | The Lancet2012，，9859： | 5 |
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