|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 3 | BRAINSTEM CAVERNOUS MALFORMATIONS显示文摘 | Bradley A. Gross H. Hunt Batjer Issam A. Awad Bernard R. Bendok | 2009 | Neurosurgery2009，，5： | 1 |
| 4 | Triphala , an Ayurvedic formulation improves the antioxidant status on TNBS induced IBD in rats显示文摘 | Soumya J. Koppikar Suresh D. Jagtap Prasad P. Devarshi Nivedita M. Jangle Vitthal B. Awad Asmita A. Wele Abhay M. Harsulkar | 2014 | European Journal of Integrative Medicine2014，，： | 1 |
| 5 | Laparoscopic Right Hemicolectomy With Transvaginal Colon Extraction Using a Laparoscopic Posterior Colpotomy: A 2-year Series From a Single Institution显示文摘 | Ziad T. Awad Irfan Qureshi Brent Seibel Sunil Sharma Mark A. Dobbertien | 2011 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2011，，6： | 1 |
| 6 | Recommendations for the Management of Patients With Unruptured Intracranial Aneurysms: A Statement for Healthcare Professionals From the Stroke Council of the American Heart Association显示文摘 | Joshua B. Bederson Issam A. Awad David O. Wiebers David Piepgras E. Clarke Haley Thomas Brott George Hademenos Douglas Chyatte Robert Rosenwasser Cynthia Caroselli | 2000 | Stroke: Journal of the American Heart Association2000，，11： | 1 |
| 7 | Enhanced bioavailability of metoclopramide HCl by intranasal administration of a mucoadhesive in situ gel with modulated rheological and mucociliary transport properties显示文摘 | Noha M. Zaki Gehanne A. Awad Nahed D. Mortada Seham S. Abd ElHady | 2007 | European Journal of Pharmaceutical Sciences2007，，4： | 1 |
| 8 | BRAF Mutations in Colorectal Cancer Are Associated With Distinct Clinical Characteristics and Worse Prognosis显示文摘 | Matthew F. Kalady Kathryn L. DeJulius Julian A. Sanchez Awad Jarrar Xiuli Liu Elena Manilich Marek Skacel James M. Church | 2012 | Diseases of the Colon & Rectum2012，，2： | 1 |
| 9 | Material properties of nanoclay PVC composites显示文摘 | Walid H. Awad Günter Beyer Daphne Benderly Wouter L. Ijdo Ponusa Songtipya Maria del Mar Jimenez-Gasco E. Manias Charles A. Wilkie | 2009 | Polymer2009，，8： | 1 |
| 10 | Impact of Protocol Deviations in Acute Ischemic Stroke Treated With Intravenous rt-PA Within 4.5 Hours After Symptom Onset显示文摘 | Y. J. Alderazi J. Chang J. P. Yang M. Teleb K. Chapple A. Awad Lucas Restrepo | 2012 | The Neurohospitalist2012，，3： | 1 |
| 11 | Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation1显示文摘 | George V. Mazariegos Jorge Reyes Steve A. Webber Angus W. Thomson Lynn Ostrowski Mamun Abmed Gina Pillage Joan Martell Mohammed R. Awad Adriana Zeevi | 2002 | Transplantation2002，，8： | 1 |
| 12 | Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity显示文摘 | R. Charles Nichols Thomas J. George Robert A. Zaiden Ziad T. Awad Horacio J. Asbun Soon Huh Meng Wei Ho Nancy P. Mendenhall Christopher G. Morris bradford S. Hoppe | 2013 | Acta Oncologica2013，，3： | 1 |
| 13 | Antioxidant potential of sesame ( Sesamum indicum ) cake extract in stabilization of sunflower and soybean oils显示文摘 | Adel A.A. Mohdaly Iryna Smetanska Mohamed Fawzy Ramadan Mohamed A. Sarhan Awad Mahmoud | 2011 | Industrial Crops & Products2011，，1： | 1 |
| 14 | ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer显示文摘 | Justin F. Gainor Anna M. Varghese Sai-Hong Ignatius Ou Sheheryar Kabraji Mark M. Awad Ryohei Katayama Amanda Pawlak Mari Mino-Kenudson Beow Y. Yeap Gregory J. Riely A. John Iafrate Maria E. Arcila Marc Ladanyi Jeffrey A. Engelman Dora Dias-Santagata Alice | 2013 | Clinical Cancer Research2013，，15： | 1 |
| 15 | DSG2 Mutations Contribute to Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy显示文摘 | Mark M. Awad Darshan Dalal Eunpi Cho Nuria Amat-Alarcon Cynthia James Crystal Tichnell April Tucker Stuart D. Russell David A. Bluemke Harry C. Dietz Hugh Calkins Daniel P. Judge | 2006 | The American Journal of Human Genetics2006，，1： | 1 |
| 16 | Current Updates in Perioperative Management of Intracerebral Hemorrhage显示文摘 | Patrick C. Hsieh Issam A. Awad Christopher C. Getch Bernard R. Bendok Szymon S. Rosenblatt H. Hunt Batjer | 2008 | Neurosurgery Clinics of North America2008，，3： | 1 |
| 17 | Veterinary antibiotics contamination in water, sediment, and soil near a swine manure composting facility显示文摘 | Yasser M. Awad Sung-Chul Kim Samy A. M. Abd El-Azeem Kye-Hoon Kim Kwon-Rae Kim Kangjoo Kim Choong Jeon Sang Soo Lee Yong Sik Ok | 2014 | Environmental Earth Sciences2014，，3： | 1 |
| 18 | Endogenous tissue engineering: PTH therapy for skeletal repair显示文摘 | Masahiko Takahata Hani A. Awad Regis J. O’Keefe Susan V. Bukata Edward M. Schwarz | 2012 | Cell and Tissue Research2012，，3： | 1 |
| 19 | Effect of Ciprofloxacin on S.aureus and E.coli Growth in Presence of Vitamin C Using Cup Cut Diffusion Method显示文摘Ciprofloxacin is a second-generation of fluoroquinolone,broad-spectrum antibiotic with bactericidal activity against Gram-positive and Gram-negative organisms.It is one of the most widely used antibiotics,because of its efficacy,safety,and relatively low cost.Ascorbic acid(vitamin C)is water-soluble monosaccharide antioxidant;it is essentially required by the body for its various biochemical and physiological processes.S.aureus is Gram-positive cocci;widely distributed in the environment,it is a member of the normal flora of the body.S.aureus is not always pathogenic;it is a common cause of skin infections including abscesses,respiratory infections such as sinusitis,and food poisoning.E.coli is Gram-negative bacteria,found in the environment,foods,and intestines.Most E.coli strains are harmless;it is part of the normal microbiota of the gut.However,some serotypes of E.coli cause serious food poisoning in their hosts;it can cause diarrhea,while others cause urinary tract infections,respiratory illness and pneumonia,and other illnesses.Method:Cup cut diffusion method was applied.Experiment I:is carried out to choose the concentration of vitamin C to be used in experiment II.The negative control is normal saline,added in cup in each plate,vitamin C(100 mg/mL,200 mg/mL,400 mg/mL)was added,the volume in each cup was 100μL.Experiment II:Eight groups of treatments were applied.The first is the negative control(1%normal saline),the second group is the positive control of vitamin C(200 mg/mL).The third,fourth and fifth groups are ciprofloxacin with different concentrations(10 mg/mL,20 mg/mL,40 mg/mL);the sixth,seventh and eighth are the combination of vitamin C with each concentration of ciprofloxacin(10 mg/mL,20 mg/mL,40 mg/mL).Each group includes six petri dishes.Bacterial plates were incubated at 37 oC for 24 h and 48 h.Zone of inhibition is measured in mm.Results and conclusion:Ciprofloxacin produces dose dependent increase in zone of inhibition of S.aureus and E.coli growth,after 24 and 48 hours incubation.While vitamin C in the concentration used produced inhibitory effect on the growth of S.aureus and E.coli,after 24 hours incubation,vitamin C effect was not changed after 48 hours incubation.After 24 hours incubation,vitamin C potentiated the effect of ciprofloxacin at low concentration(10 mg/mL);while vitamin C antagonized the effect of ciprofloxacin at higher concentrations(20 and 40 mg/mL)on S.aureus growth.In the same time,ciprofloxacin antagonized the inhibitory effect of vitamin C on S.aureus growth.After 48 hours incubation,S.aureus produced resistance against ciprofloxacin alone,and that combined with vitamin C compared to zone of inhibition after 24 hours.Ciprofloxacin produced dose dependent inhibition of E.coli growth after incubation for 24 and 48 hours.Vitamin C potentiated the inhibitory effect induced by ciprofloxacin(additive effect).The inhibitory effect of ciprofloxacin,vitamin C and the combination was not changed after 48 hours compared to 24 hours. | Suhera M. Aburawi Bassma M. Doro Ebtisam A. Awad | 2019 | Journal of Pharmacy and Pharmacology2019，7，8： | 1 |
| 20 | Curcumin immune-mediated and anti-apoptotic mechanisms protect against renal ischemia/reperfusion and distant organ induced injuries显示文摘 | Azza S. Awad Amany A. El-Sharif | 2011 | International Immunopharmacology2011，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员