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| 1 | The Hippo pathway effectors YAP and TAZ promote cell growth by modulating amino acid signaling to mTORCl显示文摘 | Carsten Gram Hansen Yuen Lam Dora Ng Wai-Ling Macrina Lam Steven W Plouffe Kun-Liang Guan | 2015 | Cell Research2015，25，12： | 19 |
| 2 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells显示文摘尽管有非酒精的脂肪肝疾病是良性的混乱的起始的信仰,纤维变性前进发生在病人的一个重要数字,这现在被认出。而且,肝的脂肪变性在大量其它为肝的纤维变性的前进作为一个风险因素被识别了肝疾病。这里,我们建立了一在里面在肝的星形的房间(HSC ) 上学习肝的类脂化合物累积的效果的 vitro 模型,肝 fibrogenesis 的中央调停人。主要人的 hepatocytes 与浸透的丰满的酸 palmitate 被孵化导致细胞内部的类脂化合物累积。随后,人的 HSC 从 steatotic 或控制 hepatocytes 与调节媒介(厘米) 被孵化。在 hepatocytes 的类脂化合物累积导致了加速了 HSC 的激活和增长的因素的版本,并且提高了他们的抵抗到 apoptosis,大部分经由 PI-3-kinase 小径的激活调停了。而且,从 steatotic hepatocytes 的厘米导致了 profibrogenic 基因 TGF- 尾, metallo-proteinase-1 (TIMP-1 ) 的织物禁止者, TIMP-2 和 matrix-metallo-proteinase-2 的表示,以及在 HSC 的原子因素的魏 B 依赖者 MCP-1 表示。在摘要,我们的在里面 vitro 数据在 vivo 为在肝的脂肪变性和 fibrogenesis 之间的 pathophysiological 连接显示潜在的机制。附此,这研究提供一在 vitro 吸引人学习导致脂肪变性的 fibrogenesis 的分子的机制,并且识别并且测试小说的模型在脂肪肝为 antifibrotic 指向治疗疾病。 | Hella Wobser Christoph Dora Thomas S Weiss Thomas Amann Cornelius Bollheimer Roland Btittner Juergen Schoelmerich Claus Helterbrand | 2009 | Cell Research2009，19，8： | 16 |
| 3 | Tech no logy Gap,Reverse Technology Spillover and Domestic Innovation Performanee in Outward Foreign Direct Investment:Evidenee from China显示文摘This research adds to the literature studying the effects of outward foreign direct investment(OF DI)on domestic innovation performance and the moderating effect of a technology gap between host and home countries.New definitions of observed technology gap and expected technology'gap are proposed.An observed technology gap captures the existing differences in technology level between establishments,regions or countries.An expected technology'gap is an indication of the effort of imitating and learning from technology leaders.The corresponding measures and effects of observed and expected technology gaps on OFDI-induced reverse technology spillover are analyzed.OFDI in developed countries promotes innovation performance.However,OFDI in emerging markets hampers innovation performance.It is also found that regions with a wider observed technology^gap and a narrower expected technology gap can benefit more from OFDI. | Jin Hong Chongvang Zhou Yanrui Wu Ruicheng Wang Dora Marinova | 2019 | China & World Economy2019，27，2： | 12 |
| 4 | Appraisal of Clinical Practice Guidelines for Ischemic Stroke Management in Chinese Medicine with Appraisal of Guidelines for Research and Evaluation Instrument:A Systematic Review显示文摘Objective:To systematically review the clinical practice guidelines(CPGs)for ischemic stroke in Chinese medicine(CM)with the Appraisal of Guidelines for Research and Evaluation(AGREE II)instrument.Methods:CM CPGs for ischemic stroke were searched in 5 online databases and hand-searches in CPGrelated handbooks published from January 1990 to December 2012.The CPGs were categorized into evidence based(EB)guideline,consensus based with no explicit consideration of evidence based(CB-EB)guideline and consensus based(CB)guideline according to the development method.Three reviewers independently appraised the CPGs based on AGREE II instrument,and compared the CPGs'recommendations on CM pattern classification and treatment.Results:Five CM CPGs for ischemic stroke were identified and included.Among them,one CPG was EB guideline,two were CB guidelines and two were CB-EB guidelines.The quality score of the EB guideline was higher than those of the CB-EB and CB guidelines.Five CM patterns in the CPGs were recommended in the EB CPG.The comprehensive protocol of integrative Chinese and Westem medicine recommended in the EB CPG was mostly recommended for ischemic stroke in the CPGs.The recommendations varied based on the CM patterns.Conclusion:The quality of EB CPG was higher than those of CB and CB-EB CPGs in CM for ischemic stroke and integrative approaches were included in CPGs as major interventions. | 宇文亚 史楠楠 韩学杰 高颖 徐建龙 刘大胜 Bacon Ng Dora Tsui 钟丽丹 Eric Ziea 卞兆祥 吕爱平 | 2015 | Chinese Journal of Integrative Medicine2015，21，9： | 10 |
| 5 | Comparative genomic hybridization analysis of genetic aberrations associated with development of esophageal squamous cell carcinoma in Henan, China显示文摘AIM: To characterize cytogenetic alterations in esophageal squamous cell carcinoma (ESCC) and its metastasis. METHODS: A total of 37 cases of primary ESCC and 15 pairs of primary ESCC tumors and their matched metastatic lymph nodes cases were enrolled from Linzhou, the high incidence area for ESCC in Henan, northern China. The comparative genomic hybridization (CGH) was applied to determine the chromosomal aberrations on the DNA extracted from the frozen ESCC and metastatic lymph node samples from these patients. RESULTS: CGH showed chromosomal aberrations in all the cases. In 37 cases of primary ESCC, chromosomal profile of DNA copy number was characterized by frequently detected gains at 8q (29/37, 78%), 3q (24/37, 65%), 5p (19/37, 51%); and frequently detected losses at 3p (21/37, 57%), 8p and 9q (14/37, 38%). In 15 pairs of primary ESCC tumors and their matched metastatic lymph node cases, the majority of the chromosomal aberrations in both primary tumor and metastatic lymph node lesions were consistent with the primary ESCC cases, but new candidate regions of interest were also detected. The most significant finding is the gains of chromosome 6p with a minimum high-level amplification region at 6p12-6q12 in 7 metastatic lymph nodes butonly in 2 corresponding primary tumors (P = 0.05) and 20p with a minimum high-level amplification region at 20p12 in 11 metastatic lymph nodes but only in 5 corresponding primary tumors (P < 0.05). Another interesting finding is the loss of chromosome 10p and 10q in 8 and 7 metastatic lymph nodes but only in 2 corresponding primary tumors (P < 0.05). CONCLUSION: Using the CGH technique to detect chromosomal aberrations in both the primary tumor and its metastatic lymph nodes of ESCC, gains of 8q, 3q and 5p and loss of 3p, 8p, 9q and 13q were specifically implicated in ESCC in Linzhou population. Gains of 6p and 20p and loss of 10pq may contribute to the lymph node metastasis of ESCC. These findings suggest that the gains and losses of chromosomal regions may contain ESCC-related oncogenes and tumor suppressor genes and provide important theoretic information for identifying and cloning novel ESCC-related oncogenes and tumor suppressor genes. | Yan-Ru Qin Li-Dong Wang Zong-Min Fan Dora Kwong Xin-Yuan Guan | 2008 | World Journal of Gastroenterology2008，14，12： | 8 |
| 6 | Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China.Deletion of genomic DNA,which occurs during the complex pathogenesis process for NPC,represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs).In many circumstances,loss of TSGs can be detected as diagnostic and prognostic markers in cancer.The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC,with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions.In recent years,our research group and others have focused on the identification and characterization of novel target TSGs at 3p,such as RASSF1A,BLU,RBMS3,and CHL1,in the development and progression of NPC.In this review,we summarize recent findings of TSGs at 3p and discuss some of these genes in detail.A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis,diagnosis,and treatment. | Juan Chen Li Fu Li-Yi Zhang Dora L. Kwong Li Yan Xin-Yuan Guan | 2012 | Chinese Journal of Cancer2012，31，5： | 7 |
| 7 | Reduction of NO by CO using Pd–CeTb and Pd–CeZr catalysts supported on SiO_2 and La_2O_3–Al_2O_3显示文摘The catalytic activity of Pd catalysts supported on Ce0.73Tb0.27 O x/Si O2, Ce0.6Zr0.4O x/Si O2,Ce0.73Tb0.27 O x/La2O3–Al2O3and Ce0.6Zr0.4O x/La2O3–Al2O3was studied using the reduction of NO by CO. The catalysts were characterized by X-ray fluorescence, surface area, X-ray diffraction, temperature-programmed reduction, CO chemisorption and oxygen storage capacity. Temperature-programmed reduction results indicated that Tb or Zr incorporation improves the reducibility and oxygen storage capacity. CO chemisorption data suggested the presence of large Pd O particles due to the low CO/Pd ratio. No significant differences were obtained in light off temperatures(T Light off) for all Pd catalysts and the most active was1.5%Pd/Ce0.6Zr0.4O x/Si O2. | Victor Ferrer Dora Finol Roger Solano Alexander Moronta Miguel Ramos | 2015 | Journal of Environmental Sciences2015，27，1： | 7 |
| 8 | Wearable Alignment‑Free Microfber‑Based Sensor Chip for Precise Vital Signs Monitoring and Cardiovascular Assessment显示文摘Continuous pulse wave signals monitoring is the essential basis for clinical cardiovascular diagnosis and treatment.Recent researches show the majority of current electronic pulse sensors usually face challenges in electrical safety concern,poor durability and demanding precision in position alignment.Thus,a highly sensitive,inherently electrical safe,robust and alignment-free device is highly desired.Here,we present a wearable alignment-free microfber-based sensor chip(AFMSC)for precise vital signs monitoring and cardiovascular health assessment.The AFMSC comprises an optical micro/nano fber sensor(MNF)and a fexible soft liquid sac while the MNF sensor is used to perceive the physiological signals and the liquid sac is used to eliminate the misalignment.The real-time and accurate monitoring of the pulse signals was realized by tracking the optical power variation of transmitted light from MNF.Then,the cardiovascular vital signs extracted from radial artery pulse signals were used to evaluate cardiovascular health condition and the results were in accordance with human physiological characteristics.Moreover,the pulse signals from diferent arterial area,the respiration signals from chest and the radial pulse signals before and after exercise were detected and analyzed.The non-invasive,continuous and accurate monitoring of cardiovascular health based on the reported wearable and alignment-free device is promising in both ftness monitoring and medical diagnostics for cardiovascular disease prevention and diagnosis. | Liangye Li Yunfei Liu Changying Song Shunfeng Sheng Liuyang Yang Zhijun Yan Dora Juan Juan Hu Qizhen Sun | 2022 | Advanced Fiber Materials2022，4，3： | 5 |
| 9 | 应用HPLC对氨基酸和肽水解稳定性的实验研究显示文摘 | 谢孟峡 Giancarlo Torsi Dora Melucci | 2000 | 化学通报2000，63，12： | 5 |
| 10 | STIRPAT模型的改进及其应用显示文摘文章将传统STIRPAT模型的驱动因素扩展为9个,并运用改进的模型对不同类型国家温室气体排放的驱动因素进行实证检验。结果发现:不同类型国家在城镇就业水平、实体经济的人口承载强度、技术水平、工业化水平等方面表现出明显差异,但不管是哪类国家,人口规模、财富水平、温室气体排放强度、能源强度都是影响各国温室气体排放的最主要因素。 | 林寿富 王善勇 Dora Marinova 赵定涛 | 2018 | 统计与决策2018，0，16： | 5 |
| 11 | IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice显示文摘 | Petrasek Jan Bala Shashi Csak Timea Lippai Dora Kodys Karen Menashy Victoria Barrieau Matthew Min So-Yun Kurt-Jones Evelyn A Szabo Gyongyi | 2012 | EN2012，，10： | 4 |
| 12 | Holistic Disaster Risk Evaluation for the Urban Risk Management Plan of Manizales,Colombia显示文摘Disaster risk depends on both the physical vulnerability and a wide range of social, economic, and environmental aspects of a society. For a better risk understanding, a holistic or integrated perspective was considered when risk was assessed for the city of Manizales, Colombia. This assessment accounts not only for the expected physical damage and loss, but also for the socioeconomic vulnerability factors that favor secondorder effects in a disaster. This comprehensive approach allows the identification of different aspects related to physical vulnerability, social fragility, and lack of resilience that can be improved, thus enhancing integrated disaster risk management actions. The outcomes of this comprehensive assessment are currently being used as input to update the disaster risk management plan of Manizales. | Martha Liliana Carreno Omar-Darío Cardona Alex H.Barbat Dora Catalina Suarez María del Pilar Perez Lizardo Narvaez | 2017 | International Journal of Disaster Risk Science2017，8，3： | 4 |
| 13 | Pre-ischemia electro-acupuncture potentiates the expression of Bcl-2 and transforming growth factor-beta 1 in rat brains显示文摘The expression of the anti-apoptotic molecules Bcl-2 and transforming growth factor-beta 1 is known to confer protective effects on the cerebral ischemia-reperfusion injury.The current study investigated the expression levels of Bcl-2 and transforming growth factor-beta 1 in response to multiple pre-ischemia electro-acupuncture at acupoints Zusanli(ST36)and Fengchi(GB20) stimulation.Rats were divided into five groups:uninjured,control,non-acupoint,GB20 and ST36. Rats in the non-acupoint,GB20 and ST36 groups received 30 minutes(3 times or 18 times)of electro-acupuncture stimulation before experimental cerebral ischemia was induced.Bcl-2 and transforming growth factor-beta 1 were found to be significantly increased in the ST36 groups with either 3 or 18 electro-acupuncture treatments(P<0.05).The production was higher with 18 electro-acupuncture treatments in the ST36 groups(P<0.05).In the GB20 groups,significant increase was only observed in transforming growth factor-beta 1 with 18 electro-acupuncture treatments(P<0.05).No significant elevation of the level of transforming growth factor-beta 1 was observed in the non-acupoint groups.However,the production of Bcl-2 increased with 18 treatments in the non-acupoint groups(P<0.05).The data suggest that multiple pre-ischemia electro-acupuncture at ST36 was effective in conferring neuroprotective effect on the brain by means of upregulation of Bcl-2 and transforming growth factor-beta 1 and the effect was increase with the number of treatment. | Ka Keung Yip Samuel CL Lo Kwok-fai So Dora MY Poon Mason CP Leung | 2012 | Neural Regeneration Research2012，7，24： | 3 |
| 14 | The effect of flutamide on the physical working capacity and activity of some of the key enzymes for the energy supply in adult rats显示文摘学习的目的是在老鼠为精力供应在一些关键肌肉酶的物理工作能力和活动上估计雄激素受体对手的效果。年轻成年男 Wistar 老鼠被划分成二个组。一个组一个星期和作为控制为服务 8 个星期的另外的组每天收到了 flutamide 的 15 mg kg-1 6 天。在开始并且在实验的结束,所有老鼠受到 submaximal 跑耐力(SRE ) ,疲劳(MTE ) 的最大的时间,和最大的疾跑速度(女士) 测试。在试用的结束,最大的氧消费(VO2max ) 测试被执行并且睾丸激素,红血球,血红素以及 succinate 脱氢酶(同步数字系列) 的酶活动的层次,喂奶脱氢酶(LDH ) ,和 gastrocnemius 肌肉的 NAD.H2-cytochrome-c reductase (NAD.H2 ) 被测量。对待 flutamide 的老鼠的浆液睾丸激素比控制的高,它验证选择的剂量的有效性。anti-androgen-treated 组的 MTE 和 SRE 与起始的价值相比是更低的。Flutamide 处理减少了同步数字系列和 NAD.H2 的活动与控制相比。我们没在女士, VO2max,跑的经济, LDH 活动,和 hematological 变量上发现反雄激素处理的效果。我们的调查结果显示象一些关键酶的活动一样的 submaximal 和最大的跑耐力的维护把氧化能力与肌肉联系了与雄激素效果被连接由雄激素受体调停了。 | Katerina N Georgieva Penka A Angelova Fani D Gerginska Dora D Terzieva Mihaela S Shishmanova-Doseva Slavi D Delchev Valentine V Vasilev | 2017 | Asian Journal of Andrology2017，19，4： | 2 |
| 15 | Epilepsy triggered by mefloquine in an adult traveler to Uganda显示文摘We report a case of a traveler who visited Uganda for 8 d, and took mefloquine one tablet/week for malaria prophylaxis. After the second dose, he suffered from two episodes of loss of consciousness with seizures, therefore mefloquine was discontinued. During the flight back after full recovery, seizures reoccurred while he was on board, he was disembarked in Addis Ababa and then transferred to Nairobi. After repatriation to Italy, he experienced four other similar episodes. The patient was still on full dose anticonvulsant therapy one year and a half after, as any attempt at reduced dose was unsuccessful. Currently, three agents(mefloquine, atovaquone/proguanil, and doxycycline) are recommended for malaria chemoprophylaxis, with similar efficacy but different adverse event profiles, regimens, and prices. Considering that mefloquine is associated with a higher risk of neurologic and psychiatric adverse events than the alternative regimens, we suggest considering mefloquine as a second line choice after atovaquone/progua-nil and doxycycline for short-term travelers. | Federico Gobbi Andrea Rossanese Dora Buonfrate Andrea Angheben Chiara Postiglione Zeno Bisoffi | 2014 | World Journal of Clinical Cases2014，2，1： | 2 |
| 16 | Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10显示文摘 | Mingzhong Zheng Dora Bocangel Blair Doneske Abner Mhashilkar Rajagopal Ramesh Kelly K. Hunt Suhendan Ekmekcioglu R. Bryan Sutton Nancy Poindexter Elizabeth A. Grimm Sunil Chada | 2007 | Cancer Immunology Immunotherapy2007，，2： | 2 |
| 17 | Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients显示文摘 | Bertrand Baujat Hélène Audry Jean Bourhis Anthony T.C. Chan Haluk Onat Daniel T.T. Chua Dora L.W. Kwong Muhyi al-Sarraf Kwan-Hwa Chi Masato Hareyama Sing F. Leung Kullathorn Thephamongkhol Jean-Pierre Pignon | 2006 | International Journal of Radiation Oncology, Biology, Physics2006，，1： | 2 |
| 18 | Clinical assessment of patients with advanced non-small-cell lung cancer eligible for second-line chemotherapy: A prognostic score from individual data of nine randomised trials显示文摘 | Massimo Di Maio Nicola Lama Alessandro Morabito Egbert F. Smit Vassilis Georgoulias Koji Takeda Elisabeth Quoix Dora Hatzidaki Floris M. Wachters Vittorio Gebbia Chun-Ming Tsai Carlos Camps Wolfgang Schuette Paolo Chiodini Maria Carmela Piccirillo Frances | 2009 | European Journal of Cancer2009，，4： | 2 |
| 19 | Comparative proteomic analysis of esophageal squamous cell carcinoma显示文摘 | YijunQi Jen‐FuChiu LidongWang Dora L. W.Kwong Qing‐YuHe | 2005 | Proteomics2005，，11： | 2 |
| 20 | Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models显示文摘 | Ryan B. Corcoran Katherine A. Cheng Aaron N. Hata Anthony C. Faber Hiromichi Ebi Erin M. Coffee Patricia Greninger Ronald D. Brown Jason T. Godfrey Travis J. Cohoon Youngchul Song Eugene Lifshits Kenneth E. Hung Toshi Shioda Dora Dias-Santagata Anurag Sin | 2013 | Cancer Cell2013，，： | 2 |
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