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| 1 | 不同食用油和烹调方式的油烟成分分析显示文摘目的:分析不同食用油和不同烹调方式的油烟成分及其对健康危害。方法:应用粉尘采样器(15 L/min×20 min)和大气采样器(0.1 L/min×30 min)采集不同的食用油(菜籽油、花生油、大豆油、玉米油)及不同烹调方式(炸上排、炸蔬菜、炸鱼、煎鱼、炒菜)的油烟样品并分析。结果:菜籽油、大豆油及煎鱼、炒菜的油烟浓度均较高;烷烃类的含量以大豆油、炸蔬菜较高,炒菜较低;抗氧化剂存在不同油与食物中。结论:在本实验条件下,单纯食用油烹调比加入食物烹调的油烟浓度大;大豆油的油烟浓度及有机物含量均较高,炒菜的油烟浓度较大但有机物的含量最小。 | 徐幽琼 Ignatius T.S.Yu 林捷 张伟 柯华 陈国兴 | 2012 | 中国卫生检验杂志2012，22，10： | 14 |
| 2 | Burden of diabetic foot ulcer in Nigeria: Current evidence from the multicenter evaluation of diabetic foot ulcer in Nigeria显示文摘BACKGROUND Nigeria bears the greatest burden of diabetes prevalence in Sub-Saharan Africa. Diabetic foot ulcer (DFU) is a serious and potentially life-threatening complication of diabetes. Significant improvements in diabetic foot incidence and outcomes have been recorded in many Western countries in the past decade. However, the current burden of DFU in Nigeria is largely unknown. AIM To evaluate the patients’ profile, ulcer characteristics, associated co-morbidities and outcome of patients with DFU in Nigeria. METHODS Multicenter evaluation of diabetic foot ulcer in Nigeria was a one year multicenter observational study of patients hospitalized for DFU in six tertiary health institutions in Nigeria from March 2016 to March 2017. Demographic and diabetes information, ulcer characteristics and associated co-morbidities were assessed. Relevant laboratory and imaging studies were performed. All patients received appropriate multi-disciplinary care and were followed up until discharge or death. Outcome variables of interest were ulcer healing, lower extremity amputation (LEA), duration of hospitalization and mortality. RESULTS A total of 336 patients (55.1% male) with mean age of 55.9 ± 12.5 years were enrolled into this study. Majority (96.1%) had type 2 diabetes. Only 25.9% of the subjects had prior foot care knowledge. Most of the subjects presented late to the hospital and median (IQR) duration of ulcer at presentation was 39 (28-54) d. Ulcers were already advanced (Wagner grades ≥ 3) in 79.2% of the subjects while 76.8% of the ulcers were infected at the time of admission. The commonest comorbidities were systemic hypertension, anemia and hyperglycemic emergencies. One hundred and nineteen subjects (35.4%) suffered LEA while 10.4% left against medical advice. The median (IQR) duration of hospitalization was 52.0 (29-66) d with case fatality rate of 20.5%. CONCLUSION The burden of DFU in Nigeria is very high. The major gaps include low level of foot care knowledge among diabetic patients, overdependence on self-medication and unorthodox medicine following development of foot ulceration, late hospital presentation, and high amputation and mortality rates. Extensive foot care education within the framework of a multi-disciplinary foot care team is highly desirable. | Ejiofor Ugwu Olufunmilayo Adeleye Ibrahim Gezawa Innocent Okpe Marcelina Enamino Ignatius Ezeani | 2019 | World Journal of Diabetes2019，10，3： | 5 |
| 3 | Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity显示文摘In addition to susceptibility to infections,conventional primary immunodeficiency disorders(PIDs)and inborn errors of immunity(IEI)can cause immune dysregulation,manifesting as lymphoproliferative and/or autoimmune disease.Autoimmunity can be the prominent phenotype of PIDs and commonly includes cytopenias and rheumatological diseases,such as arthritis,systemic lupus erythematosus(SLE),and Sjogren’s syndrome(SjS).Recent advances in understanding the genetic basis of systemic autoimmune diseases and PIDs suggest an at least partially shared genetic background and therefore common pathogenic mechanisms.Here,we explore the interconnected pathogenic pathways of autoimmunity and primary immunodeficiency,highlighting the mechanisms breaking the different layers of immune tolerance to self-antigens in selected IEI. | Georgios Sogkas Faranaz Atschekzei Ignatius Ryan Adriawan Natalia Dubrowinskaja Torsten Witte Reinhold Ernst Schmidt | 2021 | Cellular & Molecular Immunology2021，18，5： | 4 |
| 4 | Prognostic value of alcohol consumptionand some other dietary habits for survival in a cohort of Chinese men with lung cancer显示文摘Background:Alcohol consumption and some other dietary habits are thought to be associated with lung cancer incidence.However,the effects of these habits on lung cancer prognosis have been studied rarely.The purpose of this study was to address these gaps in knowledge.Methods:We studied a cohort of 1052 Chinese men in Hong Kong who were diagnosed with primary lung cancer.Cox proportional hazards models were used to determine the prognostic values of consumption of alcohol,fresh fruits or vegetables,meat,and fried or preserved food.Results:Compared with never drinkers,men who drank alcohol 1-3 days per week had a more favorable lung cancer prognosis(hazard ratio[HR]:0.82,95%confidence interval[CI]0.68-0.97);however,this survival advantage was not significant in men who drank alcohol more frequently(HR:0.91,95%CI 0.73-1.14).Compared with men who consumed preserved or fried food only occasionally,men who consumed these foods frequently had a higher risk of lung cancer mortality(HR:1.20,95%CI 1.00-1.42).Conclusions:Occasional consumption of alcohol was a favorable survival factor for Chinese men with lung cancer.However,this survival benefit did not exist for frequent drinkers of alcohol.Chinese men with lung cancer who were frequent consumers of fried or preserved food had a worse prognosis than those who consumed these foods only occasionally. | Wentao Li Lap Ah Tse Joseph S.K.Au Kai Shing Yu Feng Wang Ignatius Tak-sun Yu | 2017 | Chinese Journal of Cancer2017，36，7： | 3 |
| 5 | Bone tissue engineering in osteoporosis显示文摘 | Franz Jakob Regina Ebert Anita Ignatius Takashi Matsushita Yoshinobu Watanabe Juergen Groll Heike Walles | 2013 | Maturitas2013，，2： | 2 |
| 6 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 7 | Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in a Non-small Cell Lung Cancer Patient with De Novo MET Amplification显示文摘 | Sai-Hong Ignatius Ou Eunice L. Kwak Christina Siwak-Tapp Joni Dy Kristin Bergethon Jeffrey W. Clark D. Ross Camidge Benjamin J. Solomon Robert G. Maki Yung-Jue Bang Dong-Wan Kim James Christensen Weiwei Tan Keith D. Wilner Ravi Salgia A. John Iafrate | 2011 | Journal of Thoracic Oncology2011，，5： | 2 |
| 8 | Differential incidence trends of colon and rectal cancers in Hong Kong: an age-period-cohort analysis显示文摘Background:Colorectal cancer has been the second most common cancer among men and women in Hong Kong since 2012,but the underlying reasons for this increase remain unclear.We describe the incidence trend for colorectal cancer in Hong Kong to explore its etiology within this population.Methods:The temporal trends in colorectal cancer incidence between 1983 and 2012 were analyzed with joinpoint regressions by sex,age groups,and anatomic sites among adults using data from the Hong Kong Cancer Registry.An age-period-cohort analysis was used to evaluate the effects of age,calendar periods,and birth cohorts on the observed temporal trends.Results:The incidence of colon cancer among those aged 50 years and older in both sexes increased steadily from 1983 until the mid-1990s and was followed by a slight decrease thereafter,whereas the incidence among those aged 20-49 years decreased steadily from 1983 to 2012.In contrast,the incidence of rectal cancer steadily increased in men and remained stable in women throughout the study period.Significant period and birth cohort effects were observed for colon cancer,whereas period effects on the temporal trends were observed for male rectal cancer.Conclusions:The incidences of colon and rectal cancers have exhibited divergent patterns between 1983 and 2012 in Hong Kong,indicating heterogeneous etiologies between these two types of cancers.Surveillance of the risk factors related to colon and rectal cancers in the Hong Kong population should be performed,and the increased rectal cancer incidence in males is worthy of extra attention. | Bo Zhang Shao-Hua Xie Ignatius Tak-sun Yu | 2018 | Cancer Communications2018，38，1： | 2 |
| 9 | 南非广泛耐药结核病的远期治疗转归:一项队列研究显示文摘背景和目的:因对广泛耐药结核病(XDR-TB)的远期转归知之甚少,为此,进行队列研究观察XDR—TB患者治疗后的转归。方法:对2008年3月至2012年8月对来自南非3个省的XDR—TB指定治疗点于2002年8月至2008年2月诊断为XDR-TB的107例患者进行了一项前瞻性队列研究,所有患者均在上述治疗点收治入院直到培养转阴、死亡或者治疗失败而出院,后续治疗在医务人员直视下完成,每月进行痰涂片及培养,对56例的分离菌株行基因分型及药敏试验。 | Pietersen E Ignatius E Streicher EM 范琳 沙巍 | 2014 | 中华结核和呼吸杂志2014，37，10： | 2 |
| 10 | Inhibition of cortical and cancellous bone formation in glucocortlcoid -treated OVX sheep显示文摘 | Schorlemmer S Ignatius A Claes L | 2005 | Bone2005，37，4： | 1 |
| 11 | Single impact trauma in human early-stage osteoarthritic cartilage:Implication of prostaglandin D2 but no additive effect of IL-1β on cell survival显示文摘 | Helga Joos Cathrin Hogrefe Lucia Rieger Lutz Dürselen Anita Ignatius Rolf Brenner | 2011 | International Journal of Molecular Medicine2011，，： | 1 |
| 12 | New insights of an old defense system: structure, function, and clinical relevance of the complement system 显示文摘 | Ehrnthaller C Ignatius A Gebhard F | 2011 | MolMed2011，17，： | 1 |
| 13 | Second-generation irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs): A better mousetrap? A review of the clinical evidence显示文摘 | Sai-Hong Ignatius Ou | 2011 | Critical Reviews in Oncology / Hematology2011，，3： | 1 |
| 14 | Next-genera- tion sequencing reveals a novel NSCLC ALK Fl174V mutation and confirms ALK G1202R mutation confers high-level resistance to alectinib ( CH5424802/RO5424802 ) in ALK-rearranged NSCLC patients who progressed on crizotinib 显示文摘 | IGNATIUS Ou SH AZADA M HSIANG DJ | 2014 | J Thorac 0n- col2014，9，4： | 1 |
| 15 | Identification of groundwater potential in hard rock aquifer systems using Remote Sensing, GIS and Magnetic Survey in Veppanthattai, Perambalur, Tamilnadu显示文摘Water is an essential natural resource without which life wouldn’t exist.The study aims to identify groundwater potential areas in Vepapanthattai taluk of Perambalur district,Tamil Nadu,India,using analytic hierarchy process(AHP)model.Remote sensing and magnetic parameters have been used to determine the evaluation indicators for groundwater occurrence under the ArcGIS environment.Groundwater occurrence is linked to structural porosity and permeability over the predominantly hard rock terrain,making magnetic data more relevant for locating groundwater potential zones in the research area.NE-SW and NW-SE trending magnetic breaks derived from reduction to pole map are found to be more significant for groundwater exploration.The lineaments rose diagram indicates the general trend of the fracture to be in the NE-SW direction.Assigned normalised criteria weights acquired using the AHP model was used to reclassify the thematic layers.As a result,the taluk’s low,moderate,and high potential zones cover 25.08%,25.68%and 49.24%of the study area,respectively.The high potential zones exhibit characteristics favourable for groundwater infiltration and storage,with factors as gentle slope of<3°,high lineament densities,magnetic breaks,magnetic low zones as indicative of dykes and cracks,lithology as colluvial deposits and land surface with dense vegetation.The depth of the fracture zones was estimated using power spectrum and Euler Deconvolution method.The groundwater potential mapping results were validated using groundwater level data measured from the wells,which indicated that the groundwater potential zoning results are consistent with the data derived from the real world. | Muthamilselvan A Anamika Sekar Emmanuel Ignatius | 2022 | Journal of Groundwater Science and Engineering2022，10，4： | 1 |
| 16 | Mechanical regula-tion of HB-GAM expression in bone cells显示文摘 | Liedert A Augat P Ignatius A | 2004 | BiochemBiophys Res Commun2004，319，3： | 1 |
| 17 | Use TAME and heavier ethers to improve gasoline properties显示文摘 | Ignatius J Jarvelin H Lindqvist P | 1995 | Hydrocarbon Processing1995，74，2： | 1 |
| 18 | Tissue engineering of bone:effects of mechanical strain on osteoblastic cells in type I collagen matrices显示文摘 | Ignatius A Blessing H Liedert A | 2005 | Biomaterials2005，26，3： | 1 |
| 19 | Early full weight bearing with flexible fixation delays fracture healing显示文摘 | Augat P Merk J Ignatius A | 1996 | Clin Orthop1996，，328： | 1 |
| 20 | Expression of apolipoprotein E during nerve degeneration and regeneration显示文摘 | Ignatius M J Gebicke-Harter P J Skene J H | 1986 | Proc Natl Acad Sci USA1986，83，4： | 1 |
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