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| 1 | Pyruvate kinase M2 regulates homologous recombination- mediated DNA double-strand break repair显示文摘到 genotoxic 治疗的抵抗是治疗失败和肿瘤复发的一个主要原因。激活 DNA 损坏反应(DDR ) 并且允许癌症房间逃离 genotoxic 治疗的致命的效果的内在的机制仍然保持不清楚。这里,我们揭开通过的意外机制 pyruvate kinase M2 (PKM2 ) ,在癌症房间的高度表示的 PK isoform 和癌症的一个主人管理者新陈代谢的 reprogramming,与 DDR 集成直接支持 DNA 双海滨裂缝(DSB ) 修理。响应电离放射和氧化应力,在导致它的原子累积的 T328 的 ATM phosphorylates PKM2。pT328-PKM2 被要求并且对足够支持通过到在 DNA 的 DSB 和切除术的增加 CtIPs 招募的 T126 上的交往 CtBP 蛋白质(CtIP ) 的 phosphorylation 的调停的 DNA DSB 修理结束的相应再结合(HR ) 。ATM-PKM2-CtIP 轴的混乱敏化癌症房间到许多损坏 DNA 代理人和 PARP1 抑制。而且,增加了原子 pT328-PKM2 水平在 glioblastoma 病人与显著地更坏的幸存被联系。联合,这些数据倡导者是的指向 PKM2 策略的使用不仅破坏癌症新陈代谢而且禁止抵抗的重要机制到 genotoxic 治疗的一个工具。 | Steven T. Sizemore Manchao Zhang Ju Hwan Cho Gina M. Sizemore Brian Hurwitz Balveen Kaur Norman L. Lehman Michael C. Ostrowski Pierre A. Robe Weili Miao Yinsheng Wang Arnab Chakravarti Fen Xia | 2018 | Cell Research2018，28，11： | 5 |
| 2 | Electronic warfare in the optical band:Main features,examples and selected measurement data显示文摘The paper presents the possibilities of,and methods for,acquiring,analysing and processing optical signals in order to recognise,identify and counteract threats on the contemporary battleground.The main ways electronic warfare is waged in the optical band of the electromagnetic wave spectrum have been formulated,including the acquisition of optical emitter signatures,as well as ultraviolet(UV)and thermal(IR)signatures.The physical parameters and values describing the emission of laser radiation are discussed,including their importance in terms of creating optical signatures.Moreover,it has been shown that in the transformation of optical signals into signatures,only their spectral and temporal parameters can be applied.This was confirmed in experimental part of the paper,which includes our own measurements of spectral and temporal emission characteristics for three types of binocular laser rangefinders.It has been further shown that through simple registration and quick analysis involving comparison of emission time parameters in the case of UV signatures in“solar-blind”band,various events can be identified quickly and faultlessly.The same is true for IR signatures,where the amplitudes of the recorded signal for several wavelengths are compared.This was confirmed experimentally for UV signatures by registering and then analyzing signals from several events during military exercises at a training ground,namely Rocket Propelled Grenade(RPG)launches and explosions after hitting targets,trinitrotoluene(TNT)explosions,firing armour-piercing,fin-stabilised,discarding sabots(APFSDS)or high explosive(HE)projectiles.The final section describes a proposed model database of emitters,created as a result of analysing and transforming the recorded signals into optical signatures. | Roman Ostrowski Artur Cywinski Marek Strzelec | 2021 | Defence Technology(防务技术)2021，17，5： | 3 |
| 3 | Systematic Assessment of Synthesized Tri-magnesium Phosphate Powders(Amorphous,Semi-crystalline and Crystalline) and Cements for Ceramic Bone Cement Applications显示文摘Magnesium phosphate cements have come under investigation in recent years for use as an alternative to calcium phosphate cements for bone void repair applications.Evidence indicates that magnesium phosphate cements obtain higher initial strengths after cement reaction and resorption in more clinically appropriate time frames than commercially available calcium phosphate cements.In this study,amorphous,partially amorphous and crystalline tri-magnesium phosphate powders were synthesized via an aqueous precipitation reaction with subsequent thermal treatment,and characterized using techniques such as X-ray diffraction and Fourier transform infrared spectroscopy.These materials were assessed for their functionality in cementing reaction with a 3.0 mol/L,pH 7.0 ammonium phosphate solution,including setting time and pH evolution in phosphate buffered saline solution.Results indicated that the amorphous and semi-crystalline tri-magnesium phosphate powders were highly reactive with the setting solution but resulted in mechanically weak cements,while the crystalline tri-magnesium phosphate powder reacted efficiently with the cement solution and were mechanically strong following the cement reaction.X-ray diffraction and scanning electron microscopy analyses indicated significant changes in the phase composition and morphology of the cements following incubation in phosphate buffered saline.These were perceived to be detrimental to the integrity of the amorphous and semi-crystalline tri-magnesium phosphate derived cements but not to those created with fully crystalline tri-magnesium phosphate.The crystalline tri-magnesium phosphate material resulted in the most functional cement as this embodiment displayed the most clinically relevant setting time as well as the highest mechanical resilience and neutral pH during incubation in saline solution rendering them potentially viable as bone void fillers. | Nicole Ostrowski Vidisha Sharma Abhijit Roy Prashant N.Kumta | 2015 | Journal of Materials Science & Technology2015，31，5： | 3 |
| 4 | Simulation of the performance of electrical capacitance tomography for muasurement of dense phase pneumatic conveying显示文摘 | K L Ostrowski S P Luke R A Williams | 1997 | Chemical Engineering Journal1997，，6： | 1 |
| 5 | Electrophosphorescence from a conjugated copolymer doped with an iridium complex: high brightness andimproved operational stability显示文摘 | Gong X Ostrowski J C Bazan G C | 2003 | Advanced Materials2003，15，1： | 1 |
| 6 | Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines显示文摘 | Balzarini J Ostrowski T Goslinski T | 2002 | Gene Ther2002，9，17： | 1 |
| 7 | Membrane vesicles as conveyors of im- mune responses 显示文摘 | Thery C M Ostrowski E Segura | 2009 | Nature Reviews Immunology2009，9，8： | 1 |
| 8 | Membrane vesicles as conveyors of immune responses 显示文摘 | Thery C Ostrowski M Segura E | 2009 | Nat Rev Immunol2009，9，8： | 1 |
| 9 | Definition and risk factors of rapidly declining residual renal function in per- itoneal dialysis: an observational study显示文摘 | Herget-Rosenthal S von Ostrowski M Kribben A | 2012 | Kidney Blood Press Res2012，35，4： | 1 |
| 10 | Modeling and control of formations of nonholonomic mobile robots显示文摘 | Desai J P Ostrowski J P Kumar V | 2001 | IEEE Transactions on Robotics and Automation2001，17，6： | 1 |
| 11 | die Determinanten mit überwiegender hauptdiagonale显示文摘 | Ostrowskiüber | | 0，，01： | 1 |
| 12 | Chemical treatment of crystalline silicon solar cells an a method of recovering pure silicon from photovoltaic modules显示文摘 | Ewa Klugmann-Radziemska Piotr Ostrowski | | 0，，8： | 1 |
| 13 | Pretransplant Nephrectomy in Patients With Autosomal Dominant Polycystic Kidney Disease显示文摘 | J. Rozanski I. Kozlowska M. Myslak L. Domanski J. Sienko K. Ciechanowski M. Ostrowski | 2005 | Transplantation Proceedings2005，，2： | 1 |
| 14 | Molecular mechanisms of early brain injury after subarachnoid hemorrhage显示文摘 | Ostrowski R P Colohan A R Zhang J H | 2006 | Neurol Res2006，28，4： | 1 |
| 15 | An assessment of the longterm resuhs of controlling the reaccumulaion of malignant effusion using intracavity bleomycin 显示文摘 | Ostrowski M J | 1986 | Cancer1986，57，4： | 1 |
| 16 | Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain显示文摘 | OSTROWSKI M GALEOTA J A JAR A M | 2002 | J Virol2002，76，9： | 1 |
| 17 | An assessment of the long-term result of controlling the reacculction of malignant effusions uaing intracvity bleomyan显示文摘 | Ostrowski MJ | 1986 | Cancer1986，7，： | 1 |
| 18 | Modeling and control of formations of nonholonomic mobile robots显示文摘 | Desai J Ostrowski J Kumar V | 2001 | IEEE Trans on Robotics and Automation2001，17，6： | 1 |
| 19 | Exercise and IL-6 infu- sion inhibit endotoxin-induced TNF-alpha production in humans 显示文摘 | Starkie R Ostrowski SR Jauffred S | 2003 | FASEB J2003，17，8： | 1 |
| 20 | Hyperbaric oxygen for cerebral vasospasm and brain injury following subarachnoid hemorrhage显示文摘 | Robert P Ostrowski John H | | 0，，03： | 1 |
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