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| 1 | A Kelch Motif-Containing Serine/Threonine Protein Phosphatase Determines the Large Grain QTL Trait in Rice显示文摘A thorough understanding of the genetic basis of rice grain traits is critical for the improvement of rice (Oryza sativa L.) varieties.In this study,we generated an F 2 population by crossing the large-grain japonica cultivar CW23 with Peiai 64 (PA64),an elite indica small-grain cultivar.Using QTL analysis,17 QTLs for five grain traits were detected on four different chromosomes.Eight of the QTLs were newly-identified in this study.In particular,qGL3-1,a newly-identified grain length QTL with the highest LOD value and largest phenotypic variation,was fine-mapped to the 17 kb region of chromosome 3.A serine/threonine protein phosphatase gene encoding a repeat domain containing two Kelch motifs was identified as the unique candidate gene corresponding to this QTL.A comparison of PA64 and CW23 sequences revealed a single nucleotide substitution (C→A) at position 1092 in exon 10,resulting in replacement of Asp (D) in PA64 with Glu (E) in CW23 for the 364th amino acid.This variation is located at the D position of the conserved sequence motif AVLDT of the Kelch repeat.Genetic analysis of a near-isogenic line (NIL) for qGL3-1 revealed that the allele qGL3-1 from CW23 has an additive or partly dominant effect,and is suitable for use in molecular marker-assisted selection. | Zejun Hu Haohua He Shiyong Zhang Fan Sun Xiaoyun Xin Wenxiang Wang Xi Qian Jingshui Yang Xiaojin Luo | 2012 | Journal of Integrative Plant Biology2012，54，12： | 41 |
| 2 | A Novel QTL qTGW3 Encodes the GSK3/ SHAGGY-Like Kinase OsGSK5/OsSK41 that Interacts with OsARF4 to Negatively Regulate Grain Size and Weight in Rice显示文摘谷物尺寸和形状在米饭是谷物重量和产量的重要决定因素。这里,我们报导一个新主要量的特点在米饭的地点(QTL ) , qTGW3,那种控制谷物尺寸和重量。这个地点, qTGW3,编码 OsSK41 (也作为 OsGSK5 知道) , GLYCOGEN SYNTHASE KINASE 3/SHAGGY-like 家庭的一个成员。带 OsSK41 的 loss-of-function 等位基因的瑞斯 near-isogenic 线增加了谷物长度和重量。我们证明那 OsSK41 交往与并且 phosphorylates 植物生长素反应因素 4 (OsARF4 ) 。有 OsARF4 的 OsSK41 的合作表示在米饭原物增加 OsARF4 的累积。OsARF4 的功能的损失导致更大的米饭谷物。定序 RNA 分析建议 OsARF4 和 OsSK41 镇压下游的基因的一个普通集合的表示, ? 包括一些植物生长素应答的基因,在米饭谷物开发期间。在 qTGW3 的 OsSK41 的 loss-of-function 形式代表没被指向的基因编辑或 QTL 节节上升广泛地在 OsSK41 功能的米饭 breeding.?Suppression 利用了的稀罕等位基因提高米饭谷物尺寸和重量。因此,我们的学习在米饭谷物开发揭示 OsSK41 的重要角色 ?? 并且在另外的谷物庄稼在米饭并且也许为谷物产量的基因改进提供新候选人基因。 | Zejun Hu Sun-Jie Lu Mei-Jing Wang Haohua He Le Sun Hongru Wang Xue-Huan Liu Ling Jiang Jing-Liang sun Xiaoyun Xin Wei Kong Chengcai Chu Hong-Wei Xue Jinshui Yang Xiaojin Luo Jian-Xiang Liu | 2018 | Molecular Plant2018，11，5： | 47 |
| 3 | Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis显示文摘 | Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng Xu Junling Lin Qing Li Jing Dou Shewei | 2014 | Chinese Medical Journal2014，，17： | 15 |
| 4 | Blind reconnaissance of the pseudo-random sequence in DS/SS signal with negative SNR显示文摘This paper introduces a new theory and algorithm that can be used in blind detection of the carrier wave signal and the pseudo-random sequence of the direct sequence spread spectrum (DS/SS) signal with negative SNR. First, without any a priori knowledge of the DS/SS signal, the carrier wave signal can be detected from DS/SS signal with negative SNR by using stochastic differential equations and energy detection method. Based on this, the pseudo-random sequence can also be blindly detected in DS/SS signal with negative SNR by reducing noise of the nonlinear signal and the algorithm of wavelet multiscale decomposition algorithm. Finally, the computer simulation shows that we can detect the carrier wave signal with SNR=-27 dB and the pseudo-random sequence under error code ratio 10-4 with SNR =-10 dB. | HUANG XianGao HUANG Wei WANG Chao LU ZeJun HU YanHua | 2007 | Science in China(Series F)2007，50，3： | 6 |
| 5 | Fabrication of Ti/Al/Mg laminated composites by hot roll bonding and their microstructures and mechanical properties显示文摘Ti/Al/Mg laminated composites were successfully fabricated by hot roll bonding.The effects of the rolling reduction on the microstructural evolution and mechanical properties of the composites were explored.The results show that Ti/Al/Mg laminated sheets exhibit good interfacial bonding.The rolling reduction has a significant effect on the deformation inhomogeneity through the thickness of the Al layer.The initial grains of the Al layer near the Ti/Al interface are fragmented into fine equiaxed grains,and the grains at the center and near the Al/Mg interface are elongated.The R-cube shear texture of the Al layer forms near the Ti/Al interface and permeates into the center layer in the samples with greater rolling reductions.The b-fiber rolling texture of the Al layer is observed near the Al/Mg interface and increases with the increase of rolling reduction.The stress–strain curves indicate that the fracture appears first in the Mg layer.With the increasing rolling reduction,the ultimate tensile and yield strength values increase,and the elongation up to the Mg layer fracture decreases. | Pengju WANG Zejun CHEN Hongtao HUANG Jianshu LIN Boxin LI Qing LIU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 4 |
| 6 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
| 7 | Extraction of auroral oval boundaries from UVI images: A new FLICM clustering-based method and its evaluation显示文摘Based on the fuzzy local information c-means (FLICM) clustering algorithm, a new method is developed for extracting the equatorward and poleward boundaries of the auroral oval from images acquired by the Ultraviolet Imager (UVI) aboard the POLAR satellite. First, the method iteratively segments the UVI image with the FLICM clustering algorithm, according to an integrity criterion for the segmented auroral oval. Then, possible gaps in the extracted auroral oval are filled, based on prior knowledge of its shape. To evaluate the method objectively, the extracted boundaries are compared with the precipitating electron boundaries determined from DMSP satellite precipitation particle data. The evaluation results demonstrate that the proposed method generates more accurate auroral boundaries than traditional methods. | WANG Qian MENG QingHu HU ZeJun XING ZanYang LIANG JiMin HU HongQiao | 2011 | Advances in Polar Science2011，22，3： | 3 |
| 8 | A putative bHLH transcription factor is a candidate gene for male sterile 32,a locus affecting pollen and tapetum development in tomato显示文摘The tomato(Solanum lycopersicum)male sterile 32(ms32)mutant has been used in hybrid seed breeding programs largely because it produces no pollen and has exserted stigmas.In this study,histological examination of anthers revealed dysfunctional pollen and tapetum development in the ms32 mutant.The ms32 locus was fine mapped to a 28.5 kb interval that encoded four putative genes.Solyc01g081100,a homolog of Arabidopsis bHLH10/89/90 and rice EAT1,was proposed to be the candidate gene of MS32 because it contained a single nucleotide polymorphism(SNP)that led to the formation of a premature stop codon.A codominant derived cleaved amplified polymorphic sequence(dCAPS)marker,MS32D,was developed based on the SNP.Real-time quantitative reverse-transcription PCR showed that most of the genes,which were proposed to be involved in pollen and tapetum development in tomato,were downregulated in the ms32 mutant.These findings may aid in marker-assisted selection of ms32 in hybrid breeding programs and facilitate studies on the regulatory mechanisms of pollen and tapetum development in tomato. | Xiaoyan Liu Mengxia Yang Xiaolin Liu Kai Wei Xue Cao Xiaotian Wang Xiaoxuan Wang Yanmei Guo Yongchen Du Junming Li Lei Liu Jinshuai Shu Yong Qin Zejun Huang | 2019 | Horticulture Research2019，6，1： | 3 |
| 9 | Mitigating check valve slamming and subsequentwater hammer events for PPFS using MOC显示文摘The method of characteristic(MOC) was adopted to analyze the check valve-induced water hammer behaviors for a Parallel Pumps Feedwater System(PPFS) during the alternate startup process.The motion of check valve disc was simulated using inertial valve model.Transient parameters including the pressure oscillation,local flow velocity and slamming of the check valve disc etc.have been obtained.The results showed that severe slamming between the valve disc and valve seat occurred during the alternate startup of parallel pumps.The induced maximum pressure vibration amplitude is up to 5.0 MPa.The scheme of appending a damping torque to slow down the check valve closing speed was also performed to mitigate of water hammer.It has been numerically approved to be an effective approach. | TIAN Wenxi SU Guanghui WANG Gaopeng QIU Suizheng XIAO Zejun | 2009 | Nuclear Science and Techniques2009，20，2： | 2 |
| 10 | Ultrathin zinc selenide nanosheet-based intercalation hybrid coupled with CdSe quantum dots showing enhanced photocatalytic CO_(2) reduction显示文摘Fabrication of well-designed heterojunctions is an extraordinarily attractive pathway for boosting the photocatalytic activity toward CO_(2) photoreduction.Herein,a novel kind of na nosheet-based intercalation hybrid coupled with CdSe quantum dots(QDs) was successfully fabricated by a facile solvothermal method and served as photocatalyst for full-spectrum-light-driven CO_(2) reduction.Ultra-small CdSe QDs were rationally in-situ introduced and coupled with lamellar ZnSe-intercalation hybrid nanosheet,resulting in the formation of CdSe Q.Ds/ZnSe hybrid heterojunction.Significantly,the concentration of Cd^(2+) could change directly the crystallinity and micromorphology of ZnSe intercalation hybrid,which in turn would impact on the photocatalysis activity.The optimized CdSe QDs/ZnSe hybrid-5 composite demonstrated a considerable CO yield rate of the 25.6 μmol g^(-1) h^(-1) without any additional cocatalysts or sacrificial agents assisting,making it one of the best reported performance toward CO_(2) photoreduction under full-spectrum light.The elevated CO_(2) photoreduction activity could be attributed to the special surface heterojunction,leading to improving the ability of light absorption and promoting the separation/transfer of photogenerated carriers.This present study developed a new strategy for designing inorganic-organic heterojunctions with enhanced photocatalyst for CO_(2) photoreduction and provided an available way to simultaneously mitigate the greenhouse effect and alleviate energy shortage pressure. | Zejun Zhao Zailun Liu Zhixiao Zhu Fang Wang Fei Teng Wenjun Jiang Yong Yang | 2021 | Chinese Chemical Letters2021，32，8： | 2 |
| 11 | Shining light on transition metal sulfides:New choices as highly efficient antibacterial agents显示文摘Globally,millions of people die of microbial infection-related diseases every year.The more terrible situation is that due to the overuse of antibiotics,especially in developing countries,people are struggling to fight with the bacteria variation.The emergence of super-bacteria will be an intractable environmental and health hazard in the future unless novel bactericidal weapons are mounted.Consequently,it is critical to develop viable antibacterial approaches to sustain the prosperous development of human society.Recent researches indicate that transition metal sulfides(TMSs)represent prominent bactericidal application potential owing to the meritorious antibacterial performance,acceptable biocompatibility,high solar energy utilization efficiency,and excellent photo-to-thermal conversion characteristics,and thus,a comprehensive review on the recent advances in this area would be beneficial for the future development.In this review article,we start with the antibacterial mechanisms of TMSs to provide a preliminary understanding.Thereafter,the state-of-the-art research progresses on the strategies for TMSs materials engineering so as to promote their antibacterial properties are systematically surveyed and summarized,followed by a summary of the practical application scenarios of TMSs-based antibacterial platforms.Finally,based on the thorough survey and analysis,we emphasize the challenges and future development trends in this area. | Hecheng Han Jingjing Yang Xiaoyan Li Yuan Qi Zhengyi Yang Zejun Han Yanyan Jiang Martina Stenzel Hui Li Yixin Yin Yi Du Jiurong Liu Fenglong Wang | 2021 | Nano Research2021，14，8： | 2 |
| 12 | Chinese Antarctic Magnetometer Chain at the Cusp Latitude显示文摘A Chinese Antarctic Magnetometer(CAM) chain from Zhongshan Station(ZHS) to Dome-A(DMA) has been established since February 2009.A regular magnetometer is operated at ZHS,and four low power magnetometers are operated along the interior route from ZHS to DMA in the cusp latitude,extending over a distance of 1260 km.These stations fill an important void in the Antarctic magnetometer network.Furthermore,the CAM chain is magnetically conjugated with the Arctic region reaching from the Svalbard archipelago to Daneborg,on the east coast of Greenland.Conjugate measurements using the Arctic and Antarctic magnetometers provide excellent opportunities to investigate phenomena related to the coupling of the solar wind to the magnetosphere and ionosphere,such as magnetic impulse events,flux transfer events,traveling convection vortices and ultra-low frequency waves. | LIU Yonghua HU Hongqiao YANG Huigen ZHANG Beichen SUN Bo WEI Fuhai LIU Yang LIU Jianjun WANG Rui CHEN Zhuotian HU Zejun HAN Desheng SHI Guitao HU Zhengyi WANG Tao AN Chunlei Mike Rose | 2016 | Advances in Polar Science2016，27，2： | 2 |
| 13 | Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy显示文摘Chimeric antigen receptor T cell(CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors. | Hongjun Li Zejun Wang Edikan A.Ogunnaike Qing Wu Guojun Chen Quanyin Hu Tianyuan Ci Zhaowei Chen Jinqiang Wang Di Wen Hongwei Du Jie Jiang Jie Sun Xingcai Zhang Gianpietro Dotti Zhen Gu | 2022 | National Science Review2022，9，3： | 2 |
| 14 | In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units显示文摘The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartments.Emerging organoid technology offers new opportunities for osteochondral regeneration.In this study,we developed gelatin-based microcryogels customized using hyaluronic acid(HA)and hydroxyapatite(HYP),respectively for inducing cartilage and bone regeneration(denoted as CH-Microcryogels and OS-Microcryogels)through in vivo self-assembly into osteochondral organoids.The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs,while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure.Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation,while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response,by regulating specific signaling pathways.Finally,the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit,inducing simultaneous regeneration of both articular cartilage and subchondral bone.In conclusion,this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering. | Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing | 2023 | Bioactive Materials2023，，9： | 2 |
| 15 | Deciphering active biocompatibility of iron oxide nanoparticles from their intrinsic antagonism显示文摘 | Lu Wang Zejun Wang Xiaoming Li Yi Zhang Min Yin Jiang Li Haiyun Song Jiye Shi Daishun Ling Lihua Wang Nan Chen Chunhai Fan | 2018 | Nano Research2018，11，5： | 2 |
| 16 | Ectopic overexpression of tomato JERF3 in tobacco activates downstream gene expression and enhances salt tolerance显示文摘 | Hui Wang Zejun Huang Qi Chen Zhijin Zhang Hongbo Zhang Yanming Wu Dafang Huang Rongfeng Huang | 2004 | Plant Molecular Biology2004，，2： | 1 |
| 17 | Auroral event detection using spatiotemporal statistics of local motion vectors显示文摘The analysis and exploration of auroral dynamics are very significant for studying auroral mechanisms.This paper proposes a method based on auroral dynamic processes for detecting auroral events automatically.We first obtained the motion fields using the multiscale fluid flow estimator.Then,the auroral video frame sequence was represented by the spatiotemporal statistics of local motion vectors.Finally,automatic auroral event detection was achieved.The experimental results show that our methods could detect the required auroral events effectively and accurately,and that the detections were independent on any specific auroral event.The proposed method makes it feasible to statistically analyze a large number of continuous observations based on the auroral dynamic process. | WANG Qian LIANG Jimin HU Zejun | 2013 | Advances in Polar Science2013，24，3： | 1 |
| 18 | Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis显示文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear. | Tiantian Wang Lin Yang Zejun Liang Lin Wang Feijing Su Xiangxiu Wang Xuanhe You Chengqi He | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 19 | Dynamic Response Solution of Multi-Layered Pavement Structure Under FWD Load Appling the Precise Integration Algorithm显示文摘The pavement layered structures are composed of surface layer,road base and multi-layered soil foundation.They can be undermined over time by repeated vehicle loads.In this study,a hybrid numerical method which can evaluate the displacement responses of pavement structures under dynamic falling weight deflectometer(FWD)loads.The proposed method consists of two parts:(a)the dynamic stiffness matrices of the points at the surface in the frequency domain which is based on the domain-transformation and dual vector form equation,and(b)interpolates the dynamic stiffness matrices by a continues rational function of frequency.The mixed variables formulation(MVF)can treat multiple degree of freedom systems with considering the coupling term between degree of freedoms.The accuracy of the developed method has been demonstrated by comparison between the proposed method and published results from the other method.Then the proposed method can be applied as a forward calculation technique to emulate the falling weight deflectometer test for multi-layered pavement structures. | Zejun Han Hongyuan Fang Juan Zhang Fuming Wang | 2019 | Computers, Materials & Continua2019，，6： | 1 |
| 20 | Microstructure evolution and mechanical properties of Al2O3sf/AZ91D magnesium matrix composites fabricated by squeeze casting显示文摘 | Zude Zhao Qiang Chen Zejun Tang Yanbin Wang Haiqing Ning | 2010 | Journal of Materials Science2010，，13： | 1 |
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