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| 1 | Genetic Analysis and Fine Mapping of a Novel Semidominant Dwarfing Gene LB4D in Rice显示文摘一个矮子变异的、指明的 LB4D,在回交的子孙之中被获得到一根野米饭基因渗入线。LB4D 的基因分析显示矮子显型被使基因相形见绌的单个 semidominant 控制,它被称为 LB4D。异种根据 internode 减小的模式作为 dn 类型矮子异种被分类。另外,赤霉素(GA ) 反应测试证明 LB4D 植物对 GA 既不缺乏也不感觉迟钝。这研究发现由 LB4D 植物的那 tiller 形成被 40% 与野类型相比减少,与被识别了的另外的主导的矮子异种相对照,显示不同相形见绌机制可能涉及 LB4D 主导的异种。在 F1 植物的植物高度的减小在不同基因背景从 27.9% ~ 38.1%,证明 LB4D 施加了更强壮的主导的相形见绌效果。用从在异质接合的 LB4D 和装饰用的梨树栽培变种 Nipponbare 之间的一个十字导出的大 F2 和 F3 人口, LB4D 基因在染色体 11 的短手臂上对在标记 Indel 4 和 Indel G 之间的 46 kb 区域局部性,并且四预言的基因在目标区域作为候选人被识别。 | Fei Liang Xiaoyun Xin Zejun Hu Jiandi Xu Gang Wei Xiaoyin Qian Jinshui Yang Haohua He Xiaojin Luo | 2011 | Journal of Integrative Plant Biology2011，53，4： | 6 |
| 2 | Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants显示文摘Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodies.This highlights a critical need to discover new therapeutic agents to overcome the variants mutations.Despite the availability of vaccines against coronavirus disease 2019(COVID-19),the use of broadly neutralizing antibodies has been considered as an alternative way for the prevention or treatment of SARS-Co V-2 variants infection.Here,we show that the nasal delivery of two previously characterized broadly neutralizing antibodies(F61 and H121)protected K18-h ACE2 mice against lethal challenge with SARS-Co V-2 variants.The broadly protective efficacy of the F61 or F61/F121 cocktail antibodies was evaluated by lethal challenge with the wild strain(WIV04)and multiple variants,including beta(B.1.351),delta(B.1.617.2),and omicron(B.1.1.529)at 200or 1000 TCID_(50),and the minimum antibody administration doses(5-1.25 mg/kg body weight)were also evaluated with delta and omicron challenge.Fully prophylactic protections were found in all challenged groups with both F61 and F61/H121 combination at the administration dose of 20 mg/kg body weight,and corresponding mice lung viral RNA showed negative,with almost all alveolar septa and cavities remaining normal.Furthermore,low-dose antibody treatment induced significant prophylactic protection against lethal challenge with delta and omicron variants,whereas the F61/H121 combination showed excellent results against omicron infection.Our findings indicated the potential use of broadly neutralizing monoclonal antibodies as prophylactic and therapeutic agent for protection of current emerged SARS-Co V-2 variants infection. | Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang | 2022 | Virologica Sinica2022，37，2： | 4 |
| 3 | Extraction of auroral oval boundaries from UVI images: A new FLICM clustering-based method and its evaluation显示文摘Based on the fuzzy local information c-means (FLICM) clustering algorithm, a new method is developed for extracting the equatorward and poleward boundaries of the auroral oval from images acquired by the Ultraviolet Imager (UVI) aboard the POLAR satellite. First, the method iteratively segments the UVI image with the FLICM clustering algorithm, according to an integrity criterion for the segmented auroral oval. Then, possible gaps in the extracted auroral oval are filled, based on prior knowledge of its shape. To evaluate the method objectively, the extracted boundaries are compared with the precipitating electron boundaries determined from DMSP satellite precipitation particle data. The evaluation results demonstrate that the proposed method generates more accurate auroral boundaries than traditional methods. | WANG Qian MENG QingHu HU ZeJun XING ZanYang LIANG JiMin HU HongQiao | 2011 | Advances in Polar Science2011，22，3： | 3 |
| 4 | In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units显示文摘The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartments.Emerging organoid technology offers new opportunities for osteochondral regeneration.In this study,we developed gelatin-based microcryogels customized using hyaluronic acid(HA)and hydroxyapatite(HYP),respectively for inducing cartilage and bone regeneration(denoted as CH-Microcryogels and OS-Microcryogels)through in vivo self-assembly into osteochondral organoids.The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs,while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure.Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation,while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response,by regulating specific signaling pathways.Finally,the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit,inducing simultaneous regeneration of both articular cartilage and subchondral bone.In conclusion,this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering. | Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing | 2023 | Bioactive Materials2023，，9： | 2 |
| 5 | Auroral event detection using spatiotemporal statistics of local motion vectors显示文摘The analysis and exploration of auroral dynamics are very significant for studying auroral mechanisms.This paper proposes a method based on auroral dynamic processes for detecting auroral events automatically.We first obtained the motion fields using the multiscale fluid flow estimator.Then,the auroral video frame sequence was represented by the spatiotemporal statistics of local motion vectors.Finally,automatic auroral event detection was achieved.The experimental results show that our methods could detect the required auroral events effectively and accurately,and that the detections were independent on any specific auroral event.The proposed method makes it feasible to statistically analyze a large number of continuous observations based on the auroral dynamic process. | WANG Qian LIANG Jimin HU Zejun | 2013 | Advances in Polar Science2013，24，3： | 1 |
| 6 | Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis显示文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear. | Tiantian Wang Lin Yang Zejun Liang Lin Wang Feijing Su Xiangxiu Wang Xuanhe You Chengqi He | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 7 | Prevalence and Factors Associated With CKD: A Population Study From Beijing显示文摘 | LuXia Zhang PuHong Zhang Fang Wang Li Zuo Ying Zhou Ying Shi Gang Li ShuFang Jiao ZeJun Liu WanNian Liang HaiYan Wang | 2008 | American Journal of Kidney Diseases2008，，3： | 1 |
| 8 | High capacity adsorption of antimony in biomass-based composite and its consequential utilization as battery anode显示文摘Antimony is more than an emerging pollutant in water but a scare resource.In this study,we report an adsorbent with the record capacity so far from the balanced view of Sb(Ⅲ) and Sb(Ⅴ).The composite adsorbent was fabricated by encapsulating hollow Fe_(3)O_(4)nanosphere with the EDTA grafted chitosan,and it has superhigh adsorption capacity of for 657.1 mg/g for Sb(Ⅲ) and 467.3 mg/g for Sb(Ⅴ),respectively.The mechanism study reveals that the adsorption of Sb initializes from the Fe_(3)O_(4),propagates along the chitosan with hydrogen bond,and terminates at the inner sphere complex with the EDTA moiety in the adsorbent.In view of the ultra-high adsorption capacity of the adsorbent,the recovered adsorbent that contains abundant (>36.4%) highly dispersed antimony nanoparticles (600-FCSE-Sb) is applied to Li-ion battery anode after reduction.This article provides a new idea for connecting water treatment and electric energy storage. | Yao Wang Xinyue Zhang Na Ju Hongna Jia Zejun Sun Jiaxing Liang Rongxiu Guo Dun Niu Hong-bin Sun | 2023 | Journal of Environmental Sciences2023，，4： | 1 |
| 9 | Preparation of superhydrophobic films on copper substrate for corrosion protection显示文摘 | Youhua Fan Zejun Chen Jin Liang Yong Wang Hong Chen | 2014 | Surface & Coatings Technology2014，，： | 1 |
| 10 | Organophosphine ligand derived sandwich-structural electrocatalyst for oxygen evolution reaction显示文摘The synchronous construction of metal phosphate and phosphorus-doped carbon structures is of great significance to innovate the design,synthesis,and application of catalysts,as these phosphoruscontaining composite materials have shown a remarkable contribution to electrocatalysts.However,their preparation procedure generally involves using large amounts of excess phosphorus sources for phosphorization,which inevitably release poisonous PH_(3) or dangerous phosphorus vapor.Here,a strategy for in-situ formation of FePO_(4) embedded in P-doped carbon 2D nano film(FePO_(4)/PdC)is developed using a highly integrated precursor,which is a small molecular organophosphine ligand,1,1’bis(diphenylphosphine)ferrocene(DPPF).The multi-source precursor DPPF that contains Fe,P,and C is molecular-vapor-deposited on the nickel foam(NF)supported ZIF-67 nanosheets to obtain the composite catalyst,namely DPPF-500/ZIF-67/NF.FePO_(4)/PdC encapsulated the ZIF-67 derived Co/N-doped carbon matrix(Co NC)to form a sandwich structure FePO_(4)/PdC@CoNC.The constructed catalyst shows good performance for OER,requiring an overpotential of only 297 m V to deliver 600 m A/cm^(2) with a Tafel slope of 42.7 m V dec^(-1).DFT calculations demonstrate that the synergistic effects between the metal active center and P-doped carbon film reduce the energy barriers and improve electron transport.This method of constructing P-containing catalysts overcomes the demand for additional P sources to realize eco-friendly fabrication and yields a unique structure with good catalytic activity. | Zejun Sun Wenjuan Xu Liutao Guo Qiang Han Jianyi Gao Jiaping Wang Yanru Feng Chengrui Li Qionglin Liang Hong-bin Sun Yang Yang | 2022 | Journal of Energy Chemistry2022，31，7： | 0 |
| 11 | Novel 2D CaCl crystals with metallicity, room-temperature ferromagnetism, heterojunction, piezoelectricity-like property and monovalent calcium ions显示文摘Under ambient conditions,the only known valence state of calcium ions is+2,and the corresponding crystals with calcium ions are insulating and nonferromagnetic.Here,using cryo-electron microscopy,we report direct observation of two-dimensional(2D)CaCl crystals on reduced graphene oxide(rGO)membranes,in which the calcium ions are only monovalent(i.e.+1).Remarkably,metallic rather than insulating properties are displayed by those CaCl crystals.More interestingly,room-temperature ferromagnetism,graphene-CaCl heterojunction,coexistence of piezoelectricity-like property and metallicity,as well as the distinct hydrogen storage and release capability of the CaCl crystals in rGO membranes are experimentally demonstrated.We note that such CaCl crystals are obtained by simply incubating rGO membranes in salt solutions below the saturated concentration,under ambient conditions.Theoretical studies suggest that the formation of those abnormal crystals is attributed to the strong cation-πinteractions of the Ca cations with the aromatic rings in the graphene surfaces.The findings highlight the realistic potential applications of such abnormal CaCl material with unusual electronic properties in designing novel transistors and magnetic devices,hydrogen storage,catalyzers,high-performance conducting electrodes and sensors,with a size down to atomic scale. | Lei Zhang Guosheng Shi Bingquan Peng Pengfei Gao Liang Chen Ni Zhong Liuhua Mu Lijuan Zhang Peng Zhang Lu Gou Yimin Zhao Shanshan Liang Jie Jiang Zejun Zhang Hongtao Ren Xiaoling Lei Ruobing Yi Yinwei Qiu Yufeng Zhang Xing Liu Minghong Wu Long Yan Chungang Duan Shengli Zhang Haiping Fang | 2021 | National Science Review2021，8，7： | 0 |
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