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| 1 | Rice Gene Network Inferred from Expression Profiling of Plants Overexpressing OsWRKY13, a Positive Regulator of Disease Resistance显示文摘积累的信息显示植物疾病电阻发信号小径经常与调整发展过程或不能生活的压力回答的另外的小径交往。然而,串音的这些类型的分子的机制仍然保持糟糕在大多数情况中理解。这里,我们报导那 OsWRKY13,到细菌、真菌的病原体的米饭电阻的使活跃之物,看起来在导致病原体的水杨酸盐依赖者防卫小径和五条另外的生理的小径之中为串音作为一个会聚的点工作。OsWRKY13-overexpressing 线的表达式侧面的染色体宽的分析建议 OsWRKY13 直接或间接地调整潜在地根据基因本体论数据库的分类涉及不同生理的进程的超过 500 基因的表达式。由比较在已知的小径或在 OsWRKY13-overexpressing 和野类型的植物之间的病原体感染和显型的细胞的过程工作的基因的表示模式,我们的数据建议 OsWRKY13 也在病原体感染期间是另外的生理的过程的一个管理者。联系 OsWRKY13 的疾病抵抗小径 synergistically 与 glutathione/glutaredoxin 系统和 flavonoid 生合成小径经由 OsWRKY13 交往监视氧化还原作用动态平衡并且分别地,通常认为地在 OsWRKY13-overexpressing 线提高抗菌剂 flavonoid phytoalexins 的生合成。同时,联系 OsWRKY13 的疾病抵抗小径看起来经由 OsWRKY13 与调停 SNAC1 的不能生活的压力防卫小径, jasmonic 酸发信号小径,和 terpenoid 新陈代谢小径反对地交往压制盐和冷防卫回答以及通常认为地延迟米饭生长和开发。 | Deyun Qiu Jun Xiao Weibo Xie Hongbo Liu Xianghua Li Lizhong Xiong Shiping Wang | 2008 | Molecular Plant2008，1，3： | 38 |
| 2 | Targeting NF-κB pathway for the therapy of diseases:mechanism and clinical study显示文摘NF-κB pathway consists of canonical and non-canonical pathways.The canonical NF-κB is activated by various stimuli,transducing a quick but transient transcriptional activity,to regulate the expression of various proinflammatory genes and also serve as the critical mediator for inflammatory response.Meanwhile,the activation of the non-canonical NF-κB pathway occurs through a handful of TNF receptor superfamily members.Since the activation of this pathway involves protein synthesis,the kinetics of non-canonical NF-κB activation is slow but persistent,in concordance with its biological functions in the development of immune cell and lymphoid organ,immune homeostasis and immune response.The activation of the canonical and non-canonical NF-κB pathway is tightly controlled,highlighting the vital roles of ubiquitination in these pathways.Emerging studies indicate that dysregulated NF-κB activity causes inflammation-related diseases as well as cancers,and NF-κB has been long proposed as the potential target for therapy of diseases.This review attempts to summarize our current knowledge and updates on the mechanisms of NF-κB pathway regulation and the potential therapeutic application of inhibition of NF-κB signaling in cancer and inflammatory diseases. | Hui Yu Liangbin Lin Zhiqiang Zhang Huiyuan Zhang Hongbo Hu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 35 |
| 3 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 4 | Temperature variations in the past 6000 years inferred from δ^(18)O of peat cellulose from Hongyuan,China显示文摘Trends of the temperature variations recorded in δ18O in Hongyuan peat cellulose are similar to those recorded in δ18O of Jinchuan peat cellulose and in δ18O of Dunde ice core. Climate events have been identified to be globally homogeneous. Two notable climate transition periods have been detected in the past 6000 years, namely 4000 aBP with climate shifting from cold to warm and 1500 aBP with climate shifting from warm to relatively cold. Power spectrum analysis was performed to investigate the periodical signals in the δ18O time series. Typical periodicities of 1200-1087 a, 752 a, 444 a, 325 a, 213 a, 127-123 a, 88 a, 79 a were discovered, indicating an integrated influence on Hongyuan climate from solar, monsoon and ocean activities. Solar forcing has been addressed to be the main driving forcing of Hongyuan climate. | XU Hai, HONG Yetang, LIN Qinghua, HONG Bing, JIANG Hongbo & ZHU YongxuanInstitute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China Graduate School of Chinese Academy of Sciences, Beijing 100039, China | 2002 | Chinese Science Bulletin2002，47，18： | 31 |
| 5 | Far-field coseismic displacements associated with the 2011 Tohoku-oki earthquake in Japan observed by Global Positioning System显示文摘Analysis of GEONET observations covering the entire territory of Japan shows that the great Tohoku-oki earthquake that occurred on March 11, 2011 off the east coast of Honshu in Japan caused an eastward movement of the northern part of the island by as much as 5.3 m. The GPS data from TEONET in China were used to derive far-field coseismic displacements and to assess the impact of the Tohoku-oki earthquake on crustal deformation in eastern China. The results reveal that the coseismic horizontal displacements induced by the earthquake are the level of millimeters to centimeters in North and Northeast China, with a maximum of 35 mm. Strain analysis also indicates that the earthquake resulted in an increase in the tensile strain on the north-northeast trending faults in North and Northeast China. The tensile strain imposed on the Yilan-Yitong and Dunhua-Mishan faults is more significant than that imposed on the faults in North China; the maximum normal strain reaches about 40 nano-strain. Considering that the static Coulomb stress loaded on the faults is limited, its effect on the regional seismic activity may not be significant. | WANG Min LI Qiang WANG Fan ZHANG Rui WANG YanZhao SHI HongBo ZHANG PeiZhen SHEN ZhengKang | 2011 | Chinese Science Bulletin2011，56，23： | 34 |
| 6 | Carotenoid Metabolism in Plants: The Role ol Plastids显示文摘 | Tianhu Sun Hui Yuan Hongbo Cao Mohammad Yazdani Yaakov Tadmor Li Li | 2018 | Molecular Plant2018，11，1： | 33 |
| 7 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 8 | Principles and methods for the validation of quantitative remote sensing products显示文摘We first discuss the relativity of 'true value and homogeneity' for quantitative remote sensing products (QRSPs), and then propose the definitions of 'eigenaccuracy' and 'eigenhomogeneity' under practical conditions. The eigenaccuracy and eigenhomogeneity for land surface crucial parameters such as albedo, leaf area index (LAI), and surface temperature are analyzed based on a series of experiments. Secondly, we point out the differences and similarities between the scale-free phenomena of the QRSPs and the measurements of the coastline length (1-dimensional) and the curved surface area (2-dimensional). An information fractal algorithm for the QRSPs is presented. In a case study for the LAI, when the fractal dimension is 2.16, the ratio of the LAI retrieval values obtained respectively from remote sensing data of 30 m and 6 km pixel resolution can actually reach as high as 2.86 for the same 6 km pixel using the same retrieval model. Finally, we propose an operational validation method 'one test and two matches' and multipoint observation when the real situation does not allow carrying out scanning measurement without gap and overlap on the ground surface. | RenHua Zhang Jing Tian ZhaoLiang Li HongBo Su ShaoHui Chen XinZhai Tang | 2010 | Science China Earth Sciences2010，53，5： | 27 |
| 9 | Ubiquitin signaling in immune responses显示文摘 | Hongbo Hu Shao-Cong Sun | 2016 | Cell Research2016，26，4： | 27 |
| 10 | The mechanism and risk factors for immune checkpoint inhibitor pneumonitis in non-small cell lung cancer patients显示文摘Immune checkpoint inhibitors(ICIs)are new and promising therapeutic agents for non-small cell lung cancer(NSCLC).However,along with demonstrating remarkable efficacy,ICIs can also trigger immune-related adverse events.Checkpoint inhibitor pneumonitis(CIP)has been reported to have a morbidity rate of 3%to 5%and a mortality rate of 10%to 17%.Moreover,the incidence of CIP in NSCLC is higher than that in other tumor types,reaching 7%to 13%.With the increased use of ICIs in NSCLC,CIP has drawn extensive attention from oncologists and cancer researchers.Identifying high risk factors for CIP and the potential mechanism of CIP are key points in preventing and monitoring serious adverse events.In this review,the results of our analysis and summary of previous studies suggested that the risk factors for CIP may include previous lung disease,prior thoracic irradiation,and combinations with other drugs.Our review also explored potential mechanisms closely related toCIP,including increasedT cell activity against associated antigens in tumor and normal tissues,preexisting autoantibodies,and inflammatory cytokines. | Xiaoyang Zhai Jian Zhang Yaru Tian Ji Li Wang Jing Hongbo Guo Hui Zhu | 2020 | Cancer Biology & Medicine2020，17，3： | 25 |
| 11 | Helper T cell differentiation显示文摘CD4^(+)T helper cells are key regulators of host health and disease.In the original model,specialized subsets of T helper cells are generated following activation through lineage-specifying cytokines and transcriptional programs,but recent studies have revealed increasing complexities for CD4^(+)T-cell differentiation.Here,we first discuss CD4^(+)T-cell differentiation from a historical perspective by highlighting the major studies that defined the distinct subsets of T helper cells.We next describe the mechanisms underlying CD4^(+)T-cell differentiation,including cytokine-induced signaling and transcriptional networks.We then review current and emerging topics of differentiation,including the plasticity and heterogeneity of T cells,the tissue-specific effects,and the influence of cellular metabolism on cell fate decisions.Importantly,recent advances in cutting-edge approaches,especially systems biology tools,have contributed to new concepts and mechanisms underlying T-cell differentiation and will likely continue to advance this important research area of adaptive immunity. | Jordy Saravia Nicole M.Chapman Hongbo Chi | 2019 | Cellular & Molecular Immunology2019，16，7： | 25 |
| 12 | Regulation of TH17 cell differentiation by innate immune signals显示文摘在抗原刺激之上,天真的 T 助手房间区分进不同的系达到专业化性质和受动器功能。T H 17 房间, CD4 + 受动器 T 房间的一个最近识别的系,对真菌和细胞外的细菌在有免疫力的防卫起一个关键作用,而且贡献许多自体免疫的条件的致病。T H 17 房间被在 T 房间表明小径和 transcriptional 管理者的一个复杂网络安排。当 T 房间内在的小径的参与广泛地被描述了时,我们开始就正在欣赏怎么 T H 17 房间开发被外来的小径塑造,特别天生的有免疫力的信号。树枝状的房间(DC ) ,到天生的桥牌的最重要的房间类型和适应免疫,驱动器 T 由提供 antigenic, costimulatory 和 cytokine 的 H 17 房间区别发信号。这被 DC 被天生、煽动性的信号的识别经由模式识别受体, cytokine 受体和接着激活细胞内部的发信号网络的另外的 immunomodulatory 受体调停。特别地, p38α地图 kinase 作为一条批评小径出现了编程序 DC 依赖的 T 由在 DC 集成多重有启发性的信号的 H 17 房间区别。这里,我们在导出 DC 的天生的有免疫力的信号由驾驶 T H 17 房间区别。 | Gonghua Huang Yanyan Wang Hongbo Chi | 2012 | Cellular & Molecular Immunology2012，9，4： | 24 |
| 13 | The Chrysanthemum nankingense Genome Provides Insights into the Evolution and Diversification of Chrysanthemum Flowers and Medicinal Traits显示文摘The Asteraceae (Compositae),a large plant family of approximately 24 000-35 000 species,accounts for^10% of all angiosperm species and contributes a lot to plant diversity.The most representative members of the Asteraceae are the economically important chrysanthemums (Chrysanthemum L.)that diversified through reticulate evolution.Biodiversity is typically created by multiple evolutionary mechanisms such as wholegenome duplication 0NGD)or polyploidization and locally repetitive genome expansion.However,the lack of genomic data from chrysanthemum species has prevented an in-depth analysis of the evolutionary mechanisms involved in their diversification.Here,we used Oxford Nanopore long-read technologyto sequence the diploid Chrysanthemum nankingense genome,which represents one of the progenitor genomes of domesticated chrysanthemums.Our analysis revealed that the evolution of the C.nankingense genome was driven by bursts of repetitive element expansion and WGD events including a recentWGD that distinguishes chrysanthemum from sunflower,which diverged from chrysanthemum approximately 38.8 million years ago.Variations of ornamental and medicinal traits in chrysanthemums are linked to the expansion of candidate gene families by duplication events including paralogous gene duplication.Collectively,our study of the assembled reference genome offers new knowledge and resources to dissect the history and pattern of evolution and diversification of chrysanthemum plants,and also to accelerate their breeding and improvement. | Chi Song Yifei Liu Aiping Song Gangqiang Dong Hongbo Zhao Wei Sun Shyam Ramakrishnan Ying Wang Shuaibin Wang Tingzhao Li Yan Niu Jiafu Jiang Bin Dong Ye Xia Sumei Chen Zhigang Hu Fadi Chen Shilin Chen | 2018 | Molecular Plant2018，11，12： | 24 |
| 14 | Nitrogen removal and simultaneous nitrification and denitrification in a fluidized bed step-feed process显示文摘For urban wastewater treatment,we conducted a novel four-stage step-feed wastewater treatment system combined with a fluidized bed laboratory experiment to investigate chemical oxygen demand(COD),NH4+-N,and total nitrogen(TN) removal performance.The removal rates of COD,NH4+-N and TN were 88.2%,95.7%,and 86.4% with e?uent concentrations of COD,NH4+-N and TN less than 50,8,and 10 mg/L,respectively.Biomass and bacterial activities were also measured,with results showing more nitrobacteria in the activated sludge than in the biofilm;however,bacterial activity of the biofilm biomass and the activated sludge were similar.Nitrogen concentrations during the process were also detected,with simultaneous nitrification and denitrification found to be obvious. | BingWang Wei Wang Hongjun Han Hongbo Hu Haifeng Zhuang | 2012 | Journal of Environmental Sciences2012，24，2： | 22 |
| 15 | Birth of the Yangtze River: age and tectonic-geomorphic implications显示文摘Large river systems are an integral and essential component of Earth dynamics. he development of large river systems in Asia is closely linked to the evolving topography driven by both near-ield and far-ield efects of the interplay among Indian, Eurasian and Paciic plates. Plate tectonics together with climatic changes during the Cenozoic is therefore believed to have determined the evolution of Asian large rivers,yet the age of the Yangtze, the largest in Asia, has been strongly debated over a century, with estimates ranging from 40–45 Ma to a more recent initiation postdating 750 ka. In this paper, I atempt to review the competing views about the age of the Yangtze, and evaluate the estimated pre-Miocene birth of the river based on the provenance of the luvial sediments from the lower reaches. I further present new geological evidence from the upper stream in southeastern Tibetan Plateau to show the existence of a possible southward paleo-Jinshajiang during the Paleogene, and exploit when and how it might deviated eastward to give birth to the modern Yangtze River. I propose that the present Yangtze River system formed in response to the continental-scale gradient driven by upliting Tibetan Plateau and regional extension throughout eastern China, synchronous with surface uplit in southeastern Tibet and strengthening of Asian summer monsoon. | Hongbo Zheng | 2015 | National Science Review2015，2，4： | 22 |
| 16 | Observation and analysis of atmospheric volatile organic compounds in a typical petrochemical area in Yangtze River Delta, China显示文摘Volatile organic compounds(VOCs) are a kind of important precursors for ozone photochemical formation. In this study, VOCs were measured from November 5 th, 2013 to January 6 th, 2014 at the Second Jinshan Industrial Area, Shanghai, China. The results showed that the measured VOCs were dominated by alkanes(41.8%), followed by aromatics(20.1%), alkenes(17.9%), and halo-hydrocarbons(12.5%). The daily trend of the VOC concentration showed a bimodal feature due to the rush-hour traffic in the morning and at nightfall. Based on the VOC concentration, a receptor model of Positive Matrix Factorization(PMF) coupled with the information related to VOC sources was applied to identify the major VOC emissions. The result showed five major VOC sources: solvent use and industrial processes were responsible for about 30% of the ambient VOCs, followed by rubber chemical industrial emissions(23%), refinery and petrochemical industrial emissions(21%), fuel evaporations(13%) and vehicular emissions(13%). The contribution of generalized industrial emissions was about 74% and significantly higher than that made by vehicle exhaust. Using a propylene-equivalent method, alkenes displayed the highest concentration, followed by aromatics and alkanes. Based on a maximum incremental reactivity(MIR)method, the average hourly ozone formation potential(OFP) of VOCs is 220.49 ppbv. The most significant source for ozone chemical formation was identified to be rubber chemical industrial emissions, following one by vehicular emission. The data shown herein may provide useful information to develop effective VOC pollution control strategies in industrialized area. | Yunchen Zhang Rui Li Hongbo Fu Dong Zhou Jianmin Chen | 2018 | Journal of Environmental Sciences2018，30，9： | 21 |
| 17 | Advances in locoregional therapy for hepatocellular carcinoma combined with immunotherapy and targeted therapy显示文摘Locoregional therapies(LRTs)of hepatocellular carcinoma(HCC)represented by ablation and TACE has become the main means for the clinical treatment of unresectable HCC.Among these,TACE is used throughout the stageⅠb toⅢb of HCC treatment.In recent years,immunotherapy led by immune checkpoint inhibitors has become a hot direction in clinical research.At the same time,targeted drugs such as Sorafenib and Apatinib have played an important role in the treatment and complementary therapy of advanced HCC,and their clinical application has been quite mature.HCC is the sixth most common malignant tumor in the world.When it comes to its treatment,different therapies have different indications,and their individual efficacies are not satisfactory,which makes the exploration of the use of combination therapy in HCC treatment become a new trend.In this paper,the status of the three therapies and the progress of their combined application are briefly reviewed. | Jian Xue Hongbo Ni Fan Wang Ke Xu Meng Niu | 2021 | Journal of Interventional Medicine2021，4，3： | 21 |
| 18 | Detrital zircon U-Pb ages of Late Cenozoic sediments from the Yangtze delta:Implication for the evolution of the Yangtze River显示文摘Detrital zircon grains of Late Cenozoic sediments dated back to ca.3.6 Ma from core DY03 in the Yangtze delta were dated by LA-ICP-MS,in order to investigate the sedimentary provenance and to find some clue for the evolution of the Yangtze River.Most of the detrital zircon U-Pb ages are distributed at 100 300 Ma,350 550 Ma,600 1000 Ma,1400 2000 Ma and 2200 2800 Ma,which correspond well with the main tectonic and magmatic events in the Yangtze drainage.The detrital zircon age patterns show distinct difference between the 3 samples below 189.8 m and other 6 above 189.8 m.43% 55% zircons in the 3 samples below 189.8 m fall within Cretaceous,while ages from 150 to 2800 Ma are distributed with no obvious peaks,which indicate the sedimentary provenance may be limited to the lower Yangtze drainage.The 6 samples above 189.8 m show similar age patterns,and the ages are relatively evenly distributed,indicating the sedimentary provenance broadened distinctly.All 6 samples deposited later than ca.3.2 Ma show age information from the upper Yangtze drainage (including the Emeishan large igneous province),indicating that the Three Gorges may have already been cut through by then. | JIA JunTao ZHENG HongBo HUANG XiangTong WU FuYuan YANG ShouYe | 2010 | Chinese Science Bulletin2010，55，15： | 20 |
| 19 | Diffusion tensor imaging detects Wallerian degeneration of the corticospinal tract early after cerebral infarction显示文摘To investigate the feasibility and time window of early detection of Wallerian degeneration in the corticospinal tract after middle cerebral artery infarction,23 patients were assessed using magnetic resonance diffusion tensor imaging at 3.0T within 14 days after the infarction.The fractional anisotropy values of the affected corticospinal tract began to decrease at 3 days after onset and decreased in all cases at 7 days.The diffusion coefficient remained unchanged.Experimental findings indicate that diffusion tensor imaging can detect the changes associated with Wallerian degeneration of the corticospinal tract as early as 3 days after cerebral infarction. | Ruiman Xie Min Fang Linjiang Zhou Shanghua Fan Jianying Liu Hongbo Quan Man Luo Dongying Qiu | 2012 | Neural Regeneration Research2012，7，12： | 20 |
| 20 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
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