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| 1 | Signaling pathways and targeted therapy for myocardial infarction显示文摘Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. | Qing Zhang Lu Wang Shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 11 |
| 2 | The m^(6)A methylome of SARS-CoV-2 in host cells显示文摘The newly identified Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)has resulted in a global health emergency because of its rapid spread and high mortality.The molecular mechanism of interaction between host and viral genomic RNA is yet unclear.We demonstrate herein that SARS-CoV-2 genomic RNA,as well as the negative-sense RNA,is dynamically N6-methyladenosine(m^(6)A)-modified in human and monkey cells.Combined RIP-seq and miCLIP analyses identified a total of 8 m^(6)A sites at single-base resolution in the genome.Especially,epidemic strains with mutations at these identified m^(6)A sites have emerged worldwide,and formed a unique cluster in the US as indicated by phylogenetic analysis.Further functional experiments showed that m^(6)A methylation negatively regulates SARS-CoV-2 infection.SARS-CoV-2 infection also triggered a global increase in host m^(6)A methylome,exhibiting altered localization and motifs of m^(6)A methylation in mRNAs.Altogether,our results identify m^(6)A as a dynamic epitranscriptomic mark mediating the virus–host interaction. | Jun’e Liu Yan-Peng Xu Kai Li Qing Ye Hang-Yu Zhou Hanxiao Sun Xiaoyu Li Liu Yu Yong-Qiang Deng Rui-Ting Li Meng-Li Cheng Bo He Jia Zhou Xiao-Feng Li Aiping Wu Chengqi Yi Cheng-Feng Qin | 2021 | Cell Research2021，31，4： | 5 |
| 3 | Liquid biopsies:DNA methylation analyses in circulating cell-free DNA显示文摘Analysis of patient's materials like cells or nucleic acids obtained in a minimally invasive or noninvasive manner through the sampling of blood or other body fluids serves as liquid biopsies, which has huge potential for numerous diagnostic applications. Circulating cell-free DNA(cfDNA) is explored as a prognostic or predictive marker of liquid biopsies with the improvements in genomic and molecular methods. DNA methylation is an important epigenetic marker known to affect gene expression. cfDNA methylation detection is a very promising approach as abnormal distribution of DNA methylation is one of the hallmarks of many cancers and methylation changes occur early during carcinogenesis. This re?view summarizes the various investigational applications of cfDNA methylation and its oxidized de?rivatives as biomarkers for cancer diagnosis, prenatal diagnosis and organ transplantation monitoring.The review also provides a brief overview of the technologies for cfDNA methylation analysis based on next generation sequencing. | Hu Zeng Bo He Chengqi Yi Jinying Peng | 2018 | Journal of Genetics and Genomics2018，45，4： | 4 |
| 4 | Distribution,fractionation,and contamination assessment of heavy metals in offshore surface sediments from western Xiamen Bay,China显示文摘Surface sediment samples were collected at 21 offshore sites in western Xiamen Bay, Southeast China.Total concentrations of Li, V, Cr, Co, Ni, Cu, Zn, Sr, Mn,Pb, Ba, Fe, and Ti were determined by inductively coupled plasma-optical emission spectrometry; Hg was determined by atomic fluorescence spectrometry. A modified BCR sequential extraction procedure was used to extract fractions of the above elements. Concentrations of Pb, Cr, and Hg at most sites met the primary standard criteria of Marine Sediment Quality except site S12 for Pb and S7 for Cr, while concentrations of Zn at 17 sites and Cu at seven sites exceeded the criteria. The mean concentration of Hg was three times higher than the background, with a possible source being the Jiulong River. Fe, Ti, Ba, Co, V, and Li dominated the residual phase, mainly from terrestrial input.Ni, Cr, Pb, and Hg in the non-residual phase varied largely between sites. Sr, Mn, Cu, and Zn were mainly in the nonresidual fraction. Most sites showed considerable ecological risk; exceptions were site S7(very high) and sites S10,S11, and S14(moderate). Cu showed moderate-to-high pollution and Pb exhibited no-to-low pollution, while other metals had a non-pollution status according to their ratios of secondary phase to primary phase(RSP). Results of two assessment methods showed moderate pollution and a veryhigh ecological risk for Cu, Zn, Ni, and Cr at site S7, which might be due to the local sewage treatment plant. | Qiuli Yang Gongren Hu Ruilian Yu Haixing He Chengqi Lin | 2016 | Acta Geochimica2016，35，4： | 2 |
| 5 | Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis显示文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear. | Tiantian Wang Lin Yang Zejun Liang Lin Wang Feijing Su Xiangxiu Wang Xuanhe You Chengqi He | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 6 | Boundary correspondence under μ(z)-homeomor-phisms 显示文摘 | Chen Jixiu Chen Zhiguo & He Chengqi | 1996 | Michigan Math J1996，43，： | 1 |
| 7 | Distortion estimates of quasiconformal mappings显示文摘 | He Chengqi | 1984 | Sci Sinica Ser A1984，27，： | 1 |
| 8 | Boundary correspondence under μ(z) homeomorphisms显示文摘 | Chen Jixiu Chen Zhiguo He Chengqi | 1996 | Michigan Math J1996，43，： | 1 |
| 9 | Changes in plasma calcitonin gene-related peptide and serum neuron specific enolase in rats with acute cerebral ischemia after low-frequency electrical stimulation with different waveforms and intensities显示文摘Following acute cerebral ischemia in rats,plasma calcitonin gene-related peptide decreased and the level of serum neuron specific enolase and the volume of the infarction increased.Square-wave and triangular-wave electrical stimulation with low or high intensities could increase the plasma calcitonin gene-related peptide,decrease the serum neuron specific enolase and reduce the infarction volume in the brain in rats with cerebral ischemia.There was no significant difference between different wave forms and intensities.The experimental findings indicate that low-frequency electrical stimulation with varying waveforms and intensities can treat acute cerebral ischemia in rats. | Qiang Gao Yonghong Yang Shasha Li Jing He Chengqi He | 2011 | Neural Regeneration Research2011，6，28： | 1 |
| 10 | Rehabilitation of shoulder paresis caused by herpes zoster according to the International Classification of Functioning, Disability and Health A case report显示文摘We describe the case of a 73-year-old man with left shoulder paresis caused by a herpes zoster infection of the left C5 dermatomes. The patient had been affected by pain for 10 days, a skin rash on his left shoulder and back for 5 days, and weakness of his left shoulder for 2 days before admission. Electromyography revealed denervation discharges from the left supraspinatus, infraspinatus and deltoid muscles, which was compatible with radiculopathy showing after zoster infection. The patient was examined in accordance with the International Classification of Functioning, Disability and Health, and treated with range-of-movement and strengthening exercises as well as activities of daily living and social participation. At 14 months after the onset of the condition, muscle strength had returned to normal. Electromyography revealed that motor unit action potentials were largely normal. These results indicate that the rehabilitation of paresis caused by herpes zoster can obtain positive results with suitable movement training. | Qiang Gao Yonghong Yang Chengqi He Shaxin Liu | 2011 | Neural Regeneration Research2011，6，26： | 1 |
| 11 | Effects of Pulsed Electromagnetic Fields on Bone Mass and Wnt/β-Catenin Signaling Pathway in Ovariectomized Rats显示文摘 | Jun Zhou Hongchen He Lin Yang Shiju Chen Hua Guo Lu Xia Huifang Liu Yuxi Qin Chuan Liu Xiaofei Wei Yujing Zhou Chengqi He | 2012 | Archives of Medical Research2012，，4： | 1 |
| 12 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 13 | Boundary correspondence under μ(z) homeomorphisms显示文摘 | Chen Jixiu Chen Zhiguo He Chengqi | 1996 | Michigan Math J1996，43，： | 1 |
| 14 | Effects of cervical low-frequency electrical stimulation with various waveforms and densities on body mass,liver and kidney function,and death rate in ischemic stroke rats显示文摘Low-frequency electrical stimulation has resulted in favorable effects in the treatment of post-stroke dysphagia.However,the safety of cervical low-frequency electrical stimulation remains unclear because of numerous nerves and blood vessels in the neck.In the present study,rats with ischemic stroke underwent low-frequency electrical stimulation,and systemic and local effects of electrical stimulation at different densities and waveforms were investigated.Electrical stimulation resulted in no significant effects on body mass,liver or kidney function,or mortality rate.In addition,no significant adverse reaction was observed,despite overly high intensity of low-frequency electrical stimulation,which induced laryngismus,results from the present study suggested that it is safe to stimulate the neck with a low-frequency electricity under certain intensities. | Yonghong Yang Chengqi He Lin Yang Qiang Gao Shasha Li Jing He | 2011 | Neural Regeneration Research2011，6，4： | 0 |
| 15 | Central swallowing in normal adults using functional magnetic resonance imaging显示文摘BACKGROUND:While brain-imaging studies in healthy adults have indicated that multiple cortical regions are involved in swallowing,these functional imaging techniques have not been extensively applied to the complete understand neurophysiology of swallowing in China.A full understanding of normal swallowing neurophysiology is important for improving functional outcomes for dysphagia due to neurologic disorders or damage with increasing age.Thus the interpretations of the functional contributions of various brain areas in swallowing should be scientifically researched. OBJECTIVE:To identify the activation and characteristic of swallowing center in healthy adults using functional magnetic resonance imaging. DESIGN,TIME AND SETTING:An uncontrolled neuroimaging study was performed at the Outpatient Clinic,Department of Radiology,West China Hospital of Sichuan University between March and November 2008. PARTICIPANTS:Ten healthy right-handed volunteers,aged over 20 years with a mean age of(34.2±8.1) years,a range of 25-45 years and including five males and five females participated.A medical history was obtained from all potential subjects and all subjects were free of systemic diseases and neurological disorders. METHODS:The healthy volunteers were examined with event-related functional magnetic resonance imaging of blood oxygenation level-dependent while laryngeal swallow-related movements were recorded.Subjects were scanned during voluntary saliva swallowing and water bolus swallowing activation tasks.Data was processed using the General Linear Model.A voxel by voxel group comparison was performed using random effect analysis.Any cluster with a corrected P<0.05 for spatial extent was considered significant. MAIN OUTCOME MEASURES:The cerebral cortical activation maps of voluntary swallowing of saliva and swallowing of water bolus in healthy adults were observed. RESULTS:A multifocal cortical representation of swallowing was in the precentral gyrus,postcentral gyrus,insula,anterior cingulate gyrus,thalamus,basal ganglia and cerebellum,in a bilateral and asymmetrical manner,predominantly on the left hemisphere in the volunteers(P<0.05). CONCLUSION:Activation of the cortex during normal swallowing tasks may be functionally linked to basal nuclei,thalamus,and cerebellum,greatly appearing in the left hemisphere. | Shasha Li Cheng Luo Chengqi He Qiyong Gong Dong Zhou | 2009 | Neural Regeneration Research2009，4，4： | 0 |
| 16 | Electrical stimulation upregulates angiopoietin-1/Tie-2 mRNA expression in a rat model of focal cerebral ischemia显示文摘Angiopoietin-1/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2(Tie-2) is a newly discovered signaling pathway of angiogenesis.Angiogenesis benefits recovery of neurological functions such as swallowing.In the present study,a rat model of dysphagia following stroke was induced by middle cerebral artery occlusion to investigate the influence of low frequency electrical stimulus with bidirectional square waves and triangular waves on angiopoietin-1/Tie-2 mRNA expression.Reverse transcription-polymerase chain reaction results showed that low frequency electrical stimulus significantly improved the neurological scores of the model rats,and increased angiopoietin-1/Tie-2 mRNA expression.This demonstrates that low frequency electrical stimulation can ameliorate neurological function in rats with focal brain ischemia,potentially through regulation of angiopoietin-1/Tie-2 expression in the angiogenesis pathway. | Shasha Li Yonghong Yang Qiang Gao Jing He Chengqi He | 2010 | Neural Regeneration Research2010，5，19： | 0 |
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