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| 1 | Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration显示文摘房间通过 secreting 和释放蛋白质和泡与对方一起交流。许多房间能移居。在这研究,我们报导 migracytosis,为释放细胞的内容的房间迁居依赖者机制,和 migrasomes 的发现,调停的小囊的结构 migracytosis。当移居的房间移动,他们离开长管状的海滨,叫的收回纤维,在他们后面。大泡,包含众多的更小的泡,在收回纤维的尖端和交叉上成长。这些纤维,与主要房间身体连接泡,最后,裂缝,和泡被释放直到细胞外的空间或直接由包围房间收起。因为这些泡的形成是迁居依赖者,我们把他们称为 “ migrasomes”。我们也发现 cytosolic 内容能被搬运进 migrasomes 并且通过 migrasomes 免除了房间。我们把这迁居依赖者版本机制称为 “ migracytosis”。 | Liang Ma Ying Li Junya Peng Danni Wu Xiaoxin Zhao Yitong Cui Lilian Chen Xiaojun Yan Yanan Du Li Yu | 2015 | Cell Research2015，25，1： | 21 |
| 2 | The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals显示文摘Metabolic diseases are the most common and rapidly growing health issues worldwide.The massive population-based human genetics is crucial for the precise prevention and intervention of metabolic disorders.The China Metabolic Analytics Project(ChinaMAP)is based on cohort studies across diverse regions and ethnic groups with metabolic phenotypic data in China.Here,we describe the centralized analysis of the deep whole genome sequencing data and the genetic bases of metabolic traits in 10,588 individuals from the ChinaMAP.The frequency spectrum of variants,population structure,pathogenic variants and novel genomic characteristics were analyzed.The individual genetic evaluations of Mendelian diseases,nutrition and drug metabolism,and traits of blood glucose and BMI were integrated.Our study establishes a large-scale and deep resource for the genetics of East Asians and provides opportunities for novel genetic discoveries of metabolic characteristics and disorders. | Yanan Cao Lin Li Min Xu Zhimin Feng Xiaohui Sun Jieli Lu Yu Xu Peina Du Tiange Wang Ruying Hu Zhen Ye Lixin Shi Xulei Tang Li Yan Zhengnan Gao Gang Chen Yinfei Zhang Lulu Chen Guang Ning Yufang Bi Weiqing Wang The ChinaMAP Consortium | 2020 | Cell Research2020，30，9： | 20 |
| 3 | Direct intercellular communications dominate the interaction between adipose-derived MSCs and myofibroblasts aqainst cardiac fibrosis显示文摘 | Xiaokang Li Hui Zhao Chunxiao Qi Yang Zeng Feng Xu Yanan Du | 2015 | Protein & Cell2015，6，10： | 9 |
| 4 | Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities显示文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L. | Yanan Yang Yawen An Wei Wang Ning Du Jinghua Zhang Ziming Feng Jianshuang Jiang Peicheng Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 5 | TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness显示文摘TGF-β-induced factor homeobox 2(TGIF2)is a transcription regulator that plays essential roles in the regulation of development and cell fate decisions.Aberrant expression of TGIF family proteins has been observed in several cancers,including ovarian,esophageal,and colorectal cancers.Here,we report that TGIF2 mediates the EGFR–RAS–ERK signaling pathway to enhance the stemness of lung adenocarcinoma(LUAD)cells and,therefore,promote the progression and metastasis of LUAD.We found that high TGIF2 expression was closely correlated with tumor growth,lymph node metastasis,and survival of patients with LUAD.Mice bearing TGIF2-silenced H1299 xenografts developed smaller tumors and fewer lung metastases.Importantly,silencing TGIF2 decreased the cancer stem cell(CSC)-like properties in A549 and H1299 cells.Furthermore,we identified that TGIF2 binding to the OCT4 promoter promotes its expression.In both LUAD cells and in vivo LUAD mouse models,we revealed that EGFR–RAS–ERK signaling phosphorylated TGIF2 and increased its stability,which was important for TGIF2-promoted LUAD stemness since phosphorylation-deficient TGIF2 mutants lost these functions.Thus,our study revealed that an important factor,TGIF2,bridges EGFR signaling to the CSC characteristics of LUAD cells,which can be utilized as an effective target for LUAD therapy. | Renle Du Wenzhi Shen Yi Liu Wenjuan Gao Wei Zhou Jun Li Shuangtao Zhao Chong Chen Yanan Chen Yanhua Liu Peiqing Sun Rong Xiang Yi Shi Yunping Luo | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 7 |
| 6 | De novo assembly and comparative analysis of root transcriptomes from different varieties of Panax ginseng C. A. Meyer grown in different environments显示文摘Panax ginseng C. A. Meyer is an important traditional herb in eastern Asia. It contains ginsenosides, which are primary bioactive compounds with medicinal properties. Although ginseng has been cultivated since at least the Ming dynasty to increase production, cultivated ginseng has lower quantities of ginsenosides and lower disease resistance than ginseng grown under natural conditions. We extracted root RNA from six varieties of fifth-year P. ginseng cultivars representing four different growth conditions, and performed Illumina paired-end sequencing. In total, 163,165,706 raw reads were obtained and used to generate a de novo transcriptome that consisted of 151,763 contigs(76,336 unigenes), of which 100,648 contigs(66.3%) were successfully annotated. Differential expression analysis revealed that most differentially expressed genes(DEGs) were upregulated(246 out of 258, 95.3%) in ginseng grown under natural conditions compared with that grown under artificial conditions. These DEGs were enriched in gene ontology(GO) terms including response to stimuli and localization. In particular, some key ginsenoside biosynthesis-related genes, including HMG-Co A synthase(HMGS), mevalonate kinase(MVK), and squalene epoxidase(SE), were upregulated in wild-grown ginseng. Moreover, a high proportion of disease resistance-related genes were upregulated in wild-grown ginseng. This study is the first transcriptome analysis to compare wild-grown and cultivated ginseng, and identifies genes that may produce higher ginsenoside content and better disease resistance in the wild; these genes may have the potential to improve cultivated ginseng grown in artificial environments. | ZHEN Gang ZHANG Lei DU YaNan YU RenBo LIU XinMin CAO FangRui CHANG Qi DENG Xing Wang XIA Mian HE Hang | 2015 | Science China(Life Sciences)2015，58，11： | 6 |
| 7 | Black phosphorus inverter devices enabled by in-situ aluminum surface modification显示文摘Two-dimensional black phosphorus (BP) generally exhibits a hole-dominated transport characteristic when configured as field-effect transistor devices. The effective control of charge carrier type and concentration is very crucial for the application of BP in complementary electronics. Herein, we report a facile and effective electron doping methodology on BP, through in situ surface modification with aluminum (Al). The electron mobility of few-layer BP is found to be largely enhanced to ~ 10.6 cm^2·V^–1·s^–1 by over 6 times after aluminum modification. In situ photoelectron spectroscopy characterization reveals the formation of Al–P covalent bond at the interface, which can also serve as local gate to tune the transport properties in BP layers. Finally, a spatially-controlled aluminum doping technique is employed to establish a p–n homojunction on a single BP flake, and hence to realize the complementary inverter devices, where the highest gain value of ~ 33 is obtained. | Yue Zheng Zehua Hu Cheng Han Rui Guo Du Xiang Bo Lei Yanan Wang Jun He Min Lai Wei Chen | 2019 | Nano Research2019，12，3： | 5 |
| 8 | Analysis of magnetotail flux rope events by ARTEMIS observations显示文摘Three earthward flowing magnetic flux ropes observed in the duskside plasma sheet at geocentric solar magnetospheric coordinate X~–55 Re by P1 and P2 of acceleration,reconnection,turbulence and electrodynamics of moon’s interaction with the sun mission during 13:00–15:00 UT on July 3,2012,were studied.The morphologies of the flux ropes were studied in detail based on Grad-Shfranov reconstruction method and electronic pitch angle distribution data.It is found that(1)the flux rope cross-sectional dimensions are 1.0 Re×0.78 Re,1.3 Re×0.78 Re,and 2.5 Re×1.25 Re,respectively.The magnetic field lines were asymmetric about the center with field line compression on both sides of the current sheet at the leading region;(2)the electron energy flux data presented asymmetry with larger electron flux and lower temperature in the precursor region.The flux ropes were blocked by the resistance of compressed particle density in the front central plasma sheet and the enhanced magnetic field on its sides;and(3)it is found that the flux rope has a layered structure.From inside out,event 1 can be divided into three regions,namely electronic depletion core region,closed field line region,and the caudal area possible with fields connected with the ionosphere.It suggests that the flux ropes cannot merge with the tail magnetic field lines near the lunar orbit.Especially,the flux rope asymmetrical shape reflects the different reconnection processes that caused it on both sides of the magnetic structure.The events shown in this paper support the multiple X-line magnetic reconnection model for flux ropes with in situ observations. | TIAN AnMin SHI QuanQi ZONG QiuGang DU Jian FU SuiYan DAI YaNan | 2014 | Science China(Technological Sciences)2014，57，5： | 5 |
| 9 | Mechanical microenvironments as key cellular regulator in the liver显示文摘Tissue stiffness, shear stress, and interstitial pressure make up major factors of liver mechanical microenvironment, which play the key regulatory role to control cell behaviors in the liver and progress of liver diseases. In this review, we focus on the characteristics of liver mechanical microenvironments and summarize cellular responses to mechanobiological changes during liver pathogenesis, especially in hepatic fibrosis and cirrhosis. A better understanding of the indispensable contributions of mechanical cues to liver homeostasis and pathogenesis is significant to identify new therapeutic targets for liver diseases such as hepatic fibrosis or cirrhosis. | Zhifeng You Lyu Zhou Wenjing Li Chenyu Huang Yanan Du | 2019 | Acta Mechanica Sinica2019，35，2： | 3 |
| 10 | Rapid,visual,and equipment-free point-of-care testing for Staphylococcus aureus by direct recombinase polymerase amplification with SYBR GreenΙ显示文摘Food-borne diseases mainly caused by bacterial pathogens and the safety of genetically modified(GM)food have become global concerns[1].As a leading bacterial pathogen,Staphylococcus aureus can not only cause a variety of diseases[2]but also contaminate different kinds of animal food products[3].In addition,GM foods whose impact on human health and the natural environment is still a matter of controversy have gradually entered the commercial markets[4].Therefore,many countries have decided to implement labeling regulations for authorized genetically modified organisms(GMOs)to protect the consumers’right to know[5].Hence,it is critical to develop a rapid,simple,equipment-free,and on-site testing method to detect the GM contents in food samples and pathogen to ensure food safety. | Xiaorui Fan Fangti Han Binan Zhao Yan Xu Xiao Zhao Xinyi Pu Yanan Du Qi Zhang Xiaoxia Zhang Wanjing Zhang Wenjing Wu Zhiwei Chen Kai Zhao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 3 |
| 11 | A time sequence protocol to achieve the effect of fair exchange without trusted third party显示文摘A fair exchange protocol allows two parties to exchange items in a fair way, such that either both parties obtain the other's item or neither party does. In this paper, we propose a time sequence protocol for exchanging participants' warrants without a trusted third party(TTP). Then, each participant is able to sign a proxy signature on behalf of its opponent. Owing to the proxy signature's restriction, the scheme achieves the desired effect of fair exchange of digital signatures. Our scheme is based on a time sequence rather than computation, and can be realized without the use of a TTP, thus differing from the existing fair exchange schemes. Compared with a concurrent signature, the proposed scheme does not need to release a keystone to wake the signatures when they exchange information fairly. The only advantage to the initial party is that it has the right to determine whether the exchanged warrants are valid before a designated time. However, because of the properties of proxy signatures, the initial party ultimately derives no benefit from this advantage. After the designated time, there is no additional advantage to benefit the initial party. | He Du Jian Wang Yanan Liu | 2014 | Chinese Science Bulletin2014，59，7： | 3 |
| 12 | Biomaterials as carrier, barrier and reactor for cell-based regenerative medicine显示文摘房间治疗在过去的几十年在再生药获得了巨大的成功。然而,质问例如房间损失,死亡并且在移植以后有免疫力拒绝仍然坚持。Biomaterials 作为搬运人被设计了为本地织物新生把房间送到理想的区域;当保护的障碍从宿主免疫者攻击移植了细胞;或当刺激的反应堆招待房间招募, homing 和区别。与 biomaterials 的帮助,在治疗效率的改进与平淡的免费基于房间的治疗相比在退化疾病的众多的动物模型被表明了。帮助房间治疗推进的 biomaterial 的新兴的临床的应用为复杂疾病在再生治疗甚至痊愈加亮他们的大诺言,它被没有通过由常规治疗学的途径认识到。 | Chunxiao Qi Xiaojun Yan Chenyu Huang Alexander Melerzanov Yanan Du | 2015 | Protein & Cell2015，6，9： | 2 |
| 13 | The calibration and initial results of the HeI D3 line flash spectrum obtained during the 2008 total solar eclipse显示文摘The flash spectra in the HeI D3 line were obtained during the 2008 total solar eclipse. This paper describes the instrument and the calibration of the obtained flash spectrum, and presents our initial results. The average integrated intensity is Eave = 8.13×1013 erg·cm-1· s-1·ster-1 at h = 1100 km, which confirms that the HeI D3 emission is negatively correlated with the solar activity. The surface brightness reaches a maximum of F ave = 8.25×105 erg·cm-2·s-1·ster-1 at about h ≈ (1290 ± 75) km and then decreases exponentially with height when h >1800 km with an exponential index β = 1.63×10-8 cm-1. | LI Hui JI HaiSheng NI HouKun ZHANG HaiYing ZHANG YaNan LIU HongRui DENG YuanYong WANG DongGuang DU QiuSheng ZHOU TuanHui LI JingWei SHEN JinHua | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，11： | 2 |
| 14 | Study on behaviors of functionally graded shape memory alloy cylinder显示文摘For better controllability in actuations,it is desirable to create Functionally Graded Shape Memory Alloys(FG-SMAs)in the actuation direction.It can be achieved by applying different heat treatment processes to create the gradient along the radius of a SMA cylinder.Analytical solutions are derived to predict the macroscopic behaviors of such a functionally graded SMA cylinder.The Tresca yield criterion and linear hardening are used to describe the different phase transformations with different gradient parameters.The numerical results for an example of the model exhibit different pseudo-elastic behaviors from the non-gradient case,as well as a variational hysteresis loop for the transformation,providing a mechanism for easy actuation control.When the gradient disappears,the model can degenerate to the non-gradient case. | Bingfei Liu Qingfei Wang Rui Zhou Chunzhi Du Yanan Zhang Pan Zhang | 2017 | Acta Mechanica Solida Sinica2017，30，6： | 2 |
| 15 | Stable confinement of Fe/Fe_(3)C in Fe,N-codoped carbon nanotube towards robust zinc-air batteries显示文摘Catalytic oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)have garnered great attention as the key character in metal-air batteries.Herein,we developed a superior nonprecious bifunctional oxygen electrocatalyst,fabricated through spatial confinement of Fe/Fe_(3)C nanocrystals in pyridinic N and Fe-Nx rich carbon nanotubes(Fe/Fe_(3)C-N-CNTs).During ORR,the resultant electrocatalyst exhibits positive onset pote ntial of 1.0 V(vs.RHE),large half-wave potentials of 0.88 V(vs.RHE),which is more positive than Pt/C(0.98 V and 0.83 V,respectively).Remarkably,Fe/Fe_(3)C-N-CNTs exhibits outstanding durability and great methanol tolerance,exceeding Pt/C and most reported nonprecious metal-based oxygen reduction electrocatalysts.Moreover,Fe/Fe_(3)C-N-CNTs show a markedly low potential at j=10 mA/cm^(2),small Tafel slopes and extremely high stability for OER.Impressively,the Fe/Fe_(3)C-N-CNTs-based Zn-air batteries demonstrate high power density of 183 mW/cm^(2)and robust charge/discharge stability.It is revealed that the spatial confinement effect can impede the aggregation and corrosion of Fe/Fe_(3)C nanocrystals.Meanwhile,Fe/Fe_(3)C and Fe-Nx play synergistic effect on boosting the ORR/OER activity,which provides an important guideline for construction of inexpensive nonprecious metal-carbon hybrid nanomaterials. | Lingbo Zong Xin Chen Shuming Dou Kaicai Fan Zumin Wang Wenjun Zhang Yunmei Du Jie Xu Xiaofei Jia Qi Zhang Xia Li Yida Deng Yanan Chen Lei Wang | 2021 | Chinese Chemical Letters2021，32，3： | 2 |
| 16 | In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units显示文摘The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartments.Emerging organoid technology offers new opportunities for osteochondral regeneration.In this study,we developed gelatin-based microcryogels customized using hyaluronic acid(HA)and hydroxyapatite(HYP),respectively for inducing cartilage and bone regeneration(denoted as CH-Microcryogels and OS-Microcryogels)through in vivo self-assembly into osteochondral organoids.The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs,while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure.Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation,while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response,by regulating specific signaling pathways.Finally,the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit,inducing simultaneous regeneration of both articular cartilage and subchondral bone.In conclusion,this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering. | Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing | 2023 | Bioactive Materials2023，，9： | 2 |
| 17 | A low dose cell therapy system for treating osteoarthritis:In vivo study and in vitro mechanistic investigations显示文摘Mesenchymal stem cells(MSCs)can be effective in alleviating the progression of osteoarthritis(OA).However,low MSC retention and survival at the injection site frequently require high doses of cells and/or repeated injections,which are not economically viable and create additional risks of complications.In this study,we produced MSC-laden microcarriers in spinner flask culture as cell delivery vehicles.These microcarriers containing a low initial dose of MSCs administered through a single injection in a rat anterior cruciate ligament(ACL)transection model of OA achieved similar reparative effects as repeated high doses of MSCs,as evaluated through imaging and histological analyses.Mechanistic investigations were conducted using a co-culture model involving human primary chondrocytes grown in monolayer,together with MSCs grown either within 3D constructs or as a monolayer.Co-culture supernatants subjected to secretome analysis showed significant decrease of inflammatory factors in the 3D group.RNA-seq of co-cultured MSCs and chondrocytes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis revealed processes relating to early chondrogenesis and increased extracellular matrix interactions in MSCs of the 3D group,as well as phenotypic maintenance in the co-cultured chondrocytes.The cell delivery platform we investigated may be effective in reducing the cell dose and injection frequency required for therapeutic applications. | Bin Wang Wei Liu Jiao Jiao Li Senlin Chai Dan Xing Hongsheng Yu Yuanyuan Zhang Wenjin Yan Zhihong Xu Bin Zhao Yanan Du Qing Jiang | 2022 | Bioactive Materials2022，7，1： | 2 |
| 18 | A truncated mutation of MucA in Pseudomonas aeruginosa from a bronchiectasis patient affects T3SS expression and inflammasome activation显示文摘Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic airway infection in bronchiectasis patients and is closely associated with poor prognosis.Strains isolated from chronically infected patients typically have a mucoid phenotype due to the overproduction of alginate.In this study,we isolate a P.aeruginosa strain from the sputum of a patient with bronchiectasis and find that a truncated mutation occurred in mucA,which is named mucA117.mucA117 causes the strain to transform into a mucoid phenotype,downregulates the expression of T3SS and inflammasome ligands such as fliC and allows it to avoid inflammasome activation.The truncated mutation of the MucA protein may help P.aeruginosa escape clearance by the immune system,enabling long-term colonization. | Yanan Liu Lin Du Yongzhang Zhu Xuefei Liu Ning Zhou Congcong Li Qingtian Li Ping He | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 19 | I-Difl~:Improved Matching Algorithm to Different Time Stamp Map~显示文摘 | Du Qingfeng Zhao Yanan | 2013 | Joumal of Tongji University(Natural Science)2013，41，10： | 1 |
| 20 | Quantum fireworks algorithm for optimal cooperation mechanism of energy harvesting cognitive radio显示文摘For acquiring high energy efficiency and the maximal throughput, a new time slot structure is designed for energy harvesting(EH) cognitive radio(CR). Considering the CR system with EH and cooperative relay, a best cooperative mechanism(BCM)is proposed for CR with EH. To get the optimal estimation performance, a quantum fireworks algorithm(QFA) is designed to resolve the difficulties of maximal throughput and EH, and the proposed cooperative mechanism is called as QFA-BCM. The proposed QFA combines the advantages of quantum computation theory with the fireworks algorithm(FA). Thus the QFA is able to obtain the optimal solution and its convergence performance is proved. By using the new cooperation mechanism and computing algorithm, the proposed QFA-BCM method can achieve comparable maximal throughput in the new timeslot structure. Simulation results have proved that the QFA-BCM method is superior to previous non-cooperative and cooperative mechanisms. | GAO Hongyuan DU Yanan LI Chenwan | 2018 | Journal of Systems Engineering and Electronics2018，29，1： | 1 |
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