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| 1 | One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs显示文摘CRISPR/Cas9 系统是一个有效编辑基因的方法,但是编辑基因的动物的多数显示出 mosaicism,与编辑仅仅在房间的部分发生。这里,我们证明那单个基因或多重基因能被 Cas9 mRNA 和多重邻近的单个指南的 RNA 的 zygotic 注射完全在老鼠和猴子胚胎击倒(spaced 10-200 bp 分开) 指向仅仅一把单个钥匙每基因的 exon。个别地在 Y 染色体上跟随八基因的指向的删除的 F0 老鼠的 Phenotypic 分析在产生猛烈老鼠表明了这条途径的坚韧性。重要地,这条途径在高效率交付完全的基因大美人(Arntl 上的 100% 并且 91% 在 Prrt2 上) 在猴子胚胎。最后,我们能在一个单个步骤产生一只完全的 Prrt2 猛烈猴子,表明在很快建立编辑基因的猴子模型的这条途径的实用性。 | Erwei Zuo Yi-Jun Cai Kui Li Yu Wei Bang-An Wang Yidi Sun Zhen Liu Jiwei Liu Xinde Hu Wei Wei Xiaona Huo Linyu Shi Cheng Tang Dan Liang Yan Wang Yan-Hong Nie Chen-Chen Zhang Xuan Yao Xing Wang Changyang Zhou Wenqin Ying Qifang Wang Ren-Chao Chen Qi Shen Guo-Liang Xu Jinsong Li Qiang Sun Zhi-Qi Xiong Hui Yang | 2017 | Cell Research2017，27，7： | 21 |
| 2 | Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice显示文摘AIM To investigate the effects of taxol onSMMC-7721 human hepatoma and itsmechanisms.METHODS In vitro cell growth was assessedby trypan blue exclusion method.Experimentalhepatoma model was established by seedingSMMC-7721 cells subcutaneously into Balb/c(nu/nu)nude mice.In vivo tumor growth wasdetermined by measurement of tumor diameterwith Vernier calipers.The syntheses of DNA,RNA and protein were analyzed by incorporationof ~3H-thymidine,~3H-uridine and ~3H-leucinerespectively.Using light and electronmicroscopes to observe the morphologicalchanges of cells including mitosis andapoptosis.RESULTS Taxol was effective against SMMC-7721 human hepatoma cell growth in the rangesof 2.5 nmol/L-10 nmol/L with mitotic arrestand apoptosis in vitro.DNA,RNA and proteinsyntheses in cells were also obviouslysuppressed by in vitro treatment of taxol for72 h.Taxol at 2.5 nmol/L reduced ~3H-thymidineuptake to about 34% of the control value(P<0.05).Increasing the dose of taxol to20 nmol/L resulted in a greater decrease in ~3H-thymidine incorporation to 60% of the controlvalue(P<0.01).At a concentration of 20 nmol/L,the ~3H-uridine and ~3H-leucine uptakeswere reduced to 52%(P<0.05)and 63%(P<0.01),respectively.In vivo,taxolsignificantly inhibited SMMC-7721 tumor growthat 10 mg/kg,i.p.,once daily for 10 d.A morethan 90% decrease in tumor volume wasobserved by day 11(P<0.01)similarly withmitotic arrest and cell apoptosis.CONCLUSION Taxol has a marked anticanceractivity in SMMC-7721 human hepatoma both invitro and in nude mice.Its mechanisms might beassociated with mitotic arrest,subsequently,apoptosis of the hepatoma cells.No obvioustoxicity was observed with in vivoadministration of taxoi. | Jin Hui Yuan Ru Ping Zhang Ru Gang Zhang Li Xia Guo Xing Wang Wang Dan Luo Yong Xie Hong Xie | 2000 | World Journal of Gastroenterology2000，6，2： | 18 |
| 3 | Organochlorine Pesticides(OCPs) in Soils Along the Eastern Slope of the Tibetan Plateau显示文摘Soil samples collected from several sites along an altitudinal transect on the eastern slope of the Tibetan Plateau were analyzed for hexachlorobenzenes(HCHs) and dichlorodiphenyltrichloroethanes(DDTs).The results showed that HCHs and DDTs were found in the soil samples from the remote high altitude areas away from source regions,which confirmed the long-range atmospheric transport phenomenon of these organochlorine pesticides(OCPs) insecticides.The OCP concentrations in the soils had a significant negative correlation with altitude;they showed a trend to increase with decreasing altitude,but the increase was not continuous,being interrupted at some moderate-altitude sites on the transect.The distances from the source region,landforms,soil properties,and physical-chemical properties of OCPs were more important than total organic carbon content to the distribution of OCPs in soils disturbed by human activities.An analysis of the compositions of HCH isomers and DDTs revealed predominantly low ratios of α-HCH to γ-HCH,ranging from 0.06 to 4.79,which suggested current lindane inputs.On the other hand,low p,p-DDT/p,p-DDE and o,p-DDT/p,p-DDT ratios were observed,indicating mainly aged historical DDT residues in the study area. | XING Xin-Li QI Shi-Hua ZHANG Yuan YANG Dan J. O. ODHIAMBO | 2010 | Pedosphere2010，20，5： | 13 |
| 4 | Left atrial appendage morphology in patients with atrial fibrillation in China: implications for stroke risk assessment from a single center study显示文摘 | Kong Bin Liu Yu Hu He Wang Lei Fan Yang Mei Yang Liu Wanli Liao Jiafen Liu Dan Xing Dong Huang He | 2014 | Chinese Medical Journal2014，，24： | 12 |
| 5 | Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus显示文摘Our previous salivary study had demonstrated an apparent T helper 2(Th2)-predominance in saliva of oral lichen planus(OLP) patients and suggested a potential of salivary interleukin-4(IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-c(IFN-c) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP(40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age–sex-matched healthy volunteers as control group. IFN-c and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-c but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-c/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-c and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokinepredominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP. | Wen-Zhao Liu Ming-Jing He Long Long Dong-Liang Mu Ming-Shu Xu Xue Xing Xin Zeng Ga Liao Hong-Xia Dan Qian-Ming Chen | 2014 | International Journal of Oral Science2014，6，1： | 10 |
| 6 | Changes of Vertical Groundwater Recharge with Increase in Thickness of Vadose Zone Simulated by One-Dimensional Variably Saturated Flow Model显示文摘The thickness of vadose zone plays a critical role in vertical groundwater recharge. The decline of water table since the past decades due to long-term groundwater over-exploitation has resulted in deep vadose zone in North China Plain. One-dimensional variably saturated flow models were established by Hydrus-1D software and simulations were run under steady and continuous declining water table respectively to estimate the impact of increase in thickness of vadose zone on recharge process, quantity and recharge time. Luancheng area was selected to estimate recharge quantity considering steady and continuous declining water table. The simulation results show that the increase in thickness of vadose zone delays recharge process to water table. The recharge quantity decreases first and then remains stable with the decline of water table. Under the condition of declining water table, the evaluation of recharge by the flux at water table overestimates the recharge quantity. The average annual recharge rate of Luancheng area is 134 mm/a. | Siyuan Huo Menggui Jin Xing Liang Dan Lin | 2014 | Journal of Earth Science2014，25，6： | 10 |
| 7 | Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology(RSM)显示文摘Succinic acid is considered as an important platform chemical.Succinic acid fermentation with Actinobacillus succinogenes strain BE-1 was optimized by central composite design(CCD)using a response surface methodology(RSM).The optimized production of succinic acid was predicted and the interactive effects between glucose,yeast extract,and magnesium carbonate were investigated.As a result,a model for predicting the concentration of succinic acid production was developed.The accuracy of the model was confirmed by the analysis of variance(ANOVA),and the validity was further proved by verification experiments showing that percentage errors between actual and predicted values varied from 3.02%to 6.38%.In addition,it was observed that the interactive effect between yeast extract and magnesium carbonate was statistically significant.In conclusion,RSM is an effective and useful method for optimizing the medium components and investigating the interactive effects,and can provide valuable information for succinic acid scale-up fermentation using A.succinogenes strain BE-1. | Yun-jian ZHANG Qiang LI Yu-xiu ZHANG Dan WANG Jian-min XING | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，2： | 10 |
| 8 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 9 | Residues of Organochlorine Pesticides(OCPs) in Agricultural Soils of Zhangzhou City,China显示文摘A soil survey was conducted in Zhangzhou City,an important agricultural region in south of the Fujian Province,China.93 surface soil samples were collected in the paddy fields,vegetable lands,orchards and tea plantations from Zhangzhou City.An additional soil profile was sampled in a paddy field as previous research had indicated high concentrations of organochlorine pesticides(OCPs) in the paddy fields.Dichlorodiphenyltrichloroethanes(DDTs) ranged from 0.64-78.07 ng g 1 dry weight and hexachlorocyclohexanes(HCHs) ranged from 0.72-30.16 ng g 1 dry weight in the surface soil of the whole study region.Ratios of α-HCH/γ-HCH < 4 and o,p-DDT/p,p-DDT > 1 in all soil samples suggested that lindane and dicofol were widely applied in this region in the past.Concentrations of HCHs and DDTs in soils from the four land use types followed the orders:paddy fields > vegetable lands > tea plantations > orchards and tea plantations > orchards > paddy fields > vegetable lands,respectively.Analyses of the data showed no correlation(r < 0.1) between elevation and OCPs contents in paddy fields,orchards and vegetable lands,indicated no significantly different features in distribution of HCHs and DDTs in the soils from low lying plains and mountains and the unsystematic usage of OCPs,and highlighted the fragmented nature of agricultural production in Zhangzhou,as well as the reemission of OCPs from the soils,where high OCPs concentrations were found,in Longhai of Zhangzhou.In addition,no obvious relationship between the OCPs and total organic carbon(TOC)(r < 0.3) was observed in the soil profile.The mean contribution of dicofol in total DDTs was 66% in the whole Zhangzhou region.The approximate burdens of HCHs and DDTs in the surface layer of 0-20 cm were 0.44 and 1.55 t,respectively.The storage of both HCHs and DDTs in soil surface layer(0-20 cm) accounts for 40% burden of the soil layer of 0-50 cm(1.10 t HCHs and 3.87 t DDTs),in which the highest concentrations of OCPs were observed in soil profile. | YANG Dan QI Shi-Hua ZHANG Jia-Quan TAN Ling-Zhi ZHANG Jun-Peng ZHANG Yuan XU Feng XING Xin-Li HU Ying CHEN Wei YANG Jun-Hua XU Mei-Hui | 2012 | Pedosphere2012，22，2： | 7 |
| 10 | Formation and causes of NO_x pollution on the east side of the Taihang Mountains in China显示文摘Tropospheric column amounts of NO 2 from OMI/Aura products were applied to investigate the seasonal variation of NO x on the east side of the Taihang Mountains (ESTM) in China. The NO 2 concentration varied seasonally, with winter maxima and summer minima. To explore the causes of the heavy NO 2 pollution in this region, wind field simulations were conducted by using the Fifth-Generation NCAR/Penn State Mesoscale Model (MM5). MM5 simulations showed that wind directions in the ESTM region were dominated by northeasterly and northwesterly winds throughout the year and to a lesser degree by southwesterlies. Elevated NO 2 concentrations (higher than 50×10 15 molec/cm 2 ) occurred in three meteorological situations: convergent wind fields (5 days), northeasterly winds (2 days), and calm days (1 day) in January. Although the local anthropogenic NO x emission strength was not so high as that in other developed areas, the calms and frequent occurrence of convergent wind fields, as well as unfavorable terrains for diffusion, resulted in the accumulation of atmospheric pollutants and hence heavy NO x pollution. Furthermore, long-distance NO x transportation from the Beijing-Tianjin-Tangshan region to the ESTM area could be seen when the wind was from a northeasterly direction, especially under high wind speeds. | TIAN HeZhong WANG Yan ZHAO Dan CHAI FaHe XING ZiShan CHENG Ke | 2011 | Chinese Science Bulletin2011，56，19： | 6 |
| 11 | Soil concentrations and soil-air exchange of organochlorine pesticides along the Aba profile, east of the Tibetan Plateau, western China显示文摘MianzhuAba 侧面,西藏的高原的东方,被选择沿着一个高度的坡度学习 organochlorine 杀虫剂(OCP ) 的出现。在表面土壤的 Dichlorodiphenyltrichloroethanes (DDT ) , hexachlorocyclohexanes (HCH ) 和 Aldrin,狄氏剂和 Endrin (Drins ) 在冬季(三月) 和夏天(7 月) 被检测。 | Hongxia LIU Shihua QI Dan YANG Ying HU Feng LI Jia LIU Xinli XING | 2013 | Frontiers of Earth Science2013，7，4： | 6 |
| 12 | Effect of nanoheat stimulation mediated by magnetic nanocomposite hydrogel on the osteogenic differentiation of mesenchymal stem cells显示文摘Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe_3O_4 nanoparticles into chitosan/polyethylene glycol(PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field(AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells(MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications. | Zheng Cao Dan Wang Yongsan Li Wensheng Xie Xing Wang Lei Wao Yen Wei Xiumei Wang Lingyun Zhao | 2018 | Science China(Life Sciences)2018，61，4： | 5 |
| 13 | Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population:a Case-control Study显示文摘Objective To study the risk environmental and psycho-social factors associated to prostate cancer(PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios(OR) and 95% confidence intervals(95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa(OR=0.39, 95% CI: 0.28-0.53; OR=0.59, 95% CI: 0.40-0.87, respectively). Family history of PCa(OR=7.16, 95% CI: 2.01-25.49), history of prostate diseases(OR=2.28, 95% CI: 1.53-3.41), alcohol consumption(OR=1.97, 95% CI: 1.33-2.90), red meat consumption(OR=1.74, 95% CI: 1.20-2.52), barbecued(OR=2.29, 95% CI: 1.11-4.73) or fried(OR=2.35, 95% CI: 1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks(OR=1.61, 95% CI: 1.00-2.59), marital separation(OR=1.94, 95% CI: 1.29-2.91), self-contained suffering(OR=2.37, 95% CI: 1.58-3.55), and high sensitivity to the personal comments(OR=1.73, 95% CI: 1.18-2.54) were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population. | LI Mei Ling LIN Ji HOU Jian Guo XU Lei CUI Xin Gang XU Xing Xing YU Yong Wei HAN Xue WANG Guo Min GUO Jian Ming XU Dan Feng THOMPSON Timothy C CAO Guang Wen ZHANG Hong Wei | 2014 | Biomedical and Environmental Sciences2014，27，9： | 5 |
| 14 | Evolution of urban black and odorous water:The characteristics of microbial community and driving-factors显示文摘Urban black blooms that are primarily caused by organic carbon are deleterious environmental problems.However,detailed studies on the microbial characteristics that form urban black blooms are lacking.In this study,we observed the composition,diversity,and function of bacterial community in the overlying water and sediments during the occurrence and remediation of urban black blooms using high-throughput 16S rRNA gene amplicon sequencing analysis.First,we found that pivotal consortia in the overlying water increased significantly during the formation of black blooms,including the genera Acidovorax,Brevundimonas,Pusillimonas,and Burkholderiales involved in the degradation of refractory organics,as well as the genera Desulfovibrio,Dechloromonas,and Rhizobium related to the production of black and odorous substances.An RDA analysis revealed that chemical oxygen demand,dissolved oxygen,and oxidation reduction potential were related to the changes in microbial community composition.Furthermore,aeration was found to accelerate the removal of ammonia nitrogen and enhance the function of microbial community by stimulating the growth of order Planktomycetes during the remediation of black blooms,but aeration substantially damaged the microbial diversity and richness.Therefore,the health of the aquatic ecosystem should be comprehensively considered when aeration is applied to restore polluted waterbodies.Notably,we observed a large number of pathogenic bacteria in urban black blooms,which emphasizes the importance of treating domestic sewage so that it is harmless.Together,these findings provide new insights and a basis to prevent and manage urban black blooms. | Dan Zhang Huilan Yang Shuhuan Lan Chen Wang Xudong Li Yunxiao Xing Hua Yue Qiulin Li Ling Wang Yifei Xie | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 15 | Increased mitochondrial fission drives the reprogramming of fatty acid metabolism in hepatocellular carcinoma cells through suppression of Sirtuin 1显示文摘Background:Mitochondria are dynamic organelles that constantly change their morphology through fission and fusion processes.Recently,abnormally increased mitochondrial fission has been observed in several types of can-cer.However,the functional roles of increased mitochondrial fission in lipid metabolism reprogramming in cancer cells remain unclear.This study aimed to explore the role of increased mitochondrial fission in lipid metabolism in hepa-tocellular carcinoma(HCC)cells.Methods:Lipid metabolism was determined by evaluating the changes in the expressions of core lipid metabolic enzymes and intracellular lipid content.The rate of fatty acid oxidation was evaluated by[PH]-labelled oleic acid.The mito-chondrial morphology in HCC cells was evaluated by fluorescent staining.The expression of protein was determined by real-time PCR,imnmunohistochemistry and Western blotting.Results:Activation of mitochondrial fission significantly promoted de novo fatty acid synthesis in HCC cells through upregulating the expression of lipogenic genes fatty acid synthase(FASN),acetyl-CoA carboxylasel(ACCI),and elonga-tion of very long chain fatty acid protein 6(ELOVL6),while suppressed fatty acid oxidation by downregulating carnitine palmitoyl transferase 1A(CPTIA)and acyl-CoA oxidase 1(ACOX1).Consistently,suppressed mitochondrial fission exhibited the opposite effects.Moreover,in vitro and in vivo studies revealed that mitochondrial fission-induced lipid metabolism reprogramming significantly promoted the proliferation and metastasis of HCC cells.Mechanistically,mito-chondrial fission increased the acetylation level of sterol regulatory element-binding protein 1(SREBPI)and peroxisome proliferator-activated receptor coaC-tivator 1 alpha(PGC-1a)by suppressing nicotinamide adenine dinucleotide(NAD+)/Sirtuin 1(SIRTI)signaling.The elevated SREBP1 then upregulated the expression of FASN,ACC1 and ELOVL6 in HCC cells,while PGC-1c/PPARa sup-pressed the expression of CPTIA and ACOXL Conclusions:Increased mitochondrial fission plays a crucial role in the repro-gramming of lipid metabolism in HCC cells,which provides strong evidence for the use of this process as a drug target in the treatment of this malignancy. | Dan Wu Yi Yang Yiran Hou Zifeng Zhao Ning Liang Peng Yuan Tao Yang Jinliang Xing Jibin Li | 2022 | Cancer Communications2022，42，1： | 4 |
| 16 | UV-B-induced photomorphogenesis in Arabidopsis显示文摘Ultraviolet-B(UV-B)is a relatively minor component of sunlight,but can induce stress-related physiological pro-cesses or UV-B-specifi c photomorphogenic responses in plants.In the last decade,signifi cant progress has been made in understanding the UV-B photomorphogenic pathway,including identifi cation of the key components in the pathway,molecular characterization of UV-B pho-toreceptor and perception mechanism,and elucidation of the signal transduction mechanisms from the photo-activated UV-B receptor to downstream gene expression.This review summarizes the key players identifi ed to date in the UV-B photomorphogenic pathway and their roles in mediating UV-B signal transduction. | Jigang Li Li Yang Dan Jin Cynthia D.Nezames William Terzaghi Xing Wang Deng | 2013 | Protein & Cell2013，4，7： | 4 |
| 17 | Introducing tree neighbouring relationship factors in forest pattern spatial analysis:weighted Delaunay triangulation method显示文摘It is important to quantify and analyze forest spatial patterns for studying biological characteristics,population interaction and the relationship between the population and environment.In this study,the forest spatial structure unit was generated based on the Delaunay triangulation model(DTM),and the weights were generated using the comprehensive values of the tree diameter at breast height,total height and crown width.The distance between neighbors determined by the DTM was weighted to transform the original coordinates of trees into logical coordinates.Then,a weighted spatial pattern(WSP)was developed.After weighting,the neighboring trees were replaced,the replacement ratio was 38.3%,and there was 57.4%of the central tree.Correlation analysis showed that the uniform angle index of the WSP was significantly correlated with the tree size standard deviation under uniformity(r=0.932)and randomness(r=0.711).The DTM method not only considers the spatial distance between trees,but also considers the non-spatial attributes of trees.By changing the spatial topological relation between trees,this method further improves the spatial structure measurement of forest. | Jianjun Li Kaiwen Zhu Shuai Liu Dan Li Gui Zhang Xing Liu Weiming Yang | 2021 | Journal of Forestry Research2021，32，5： | 4 |
| 18 | Anticipation,anti-glaucoma drug treatment response and phenotype of a Chinese family with glaucoma caused by the Pro370Leu myocilin mutation显示文摘AIM: To describe the anticipation and anti-glaucoma drugs response of a Chinese family with juvenile-onset open angle glaucoma(JOAG) caused by the Pro370Leu myocilin(MYOC) mutation. ·METHODS: Fifteen members of a three-generation Chinese family with JOAG were recruited to this study. They all underwent ophthalmic common examinations. Patients suspected to have JOAG got an assessment of visual field and optical coherence tomography. Intraocular pressures(IOPs) of four patients were measured at 8,10,12,14,17 o'clock respectively after using anti-glaucoma drugs. Mutation screening of all MYOC gene coding exons of the participants was performed by using direct sequencing of PCR products. ·RESULTS: Clinical examinations and pedigree analysis revealed eight family members were suffered from JOAG. Apparent genetics anticipation phenomenon was observed in this family. Their clinical features included elevated IOP of 35-55mmHg,loss of visual field,thinning of retinal nerve fiber layer,and glaucomatous optic disc damage. Noticeably,their intraocular pressure levels could be controlled within normal range at 8 and 10 o'clock by anti-glaucoma drugs,but their IOPs would elevate >21mmHg after 12 o'clock. Seven patients received trabeculectomy produced thin-walled,pale,and saccate filtering blebs maintaining lower intraocular pressure efficiently. Mutation screening indentified aheterozygous C→T missense mutation in the MYOC gene at position 1 109 in exon 3,corresponding to a substitution of a highly conserved proline to leucine at codon 370 in the olfactomedin domain of MYOC. ·CONCLUSION: The clinical characteristics of JOAG in this family were 1) genetics anticipation; 2) high IOP; 3) temporay response to anti-glaucoma drugs; 4) filtering surgery produced thin-walled and saccate filtering blebs,helping maintain lower IOP. | Chun-Mei Li Yue-Hong Zhang Rong-Hua Ye Chang-Xian Yi Yi-Min Zhong Dan Cao Xing Liu | 2014 | International Journal of Ophthalmology(English edition)2014，7，1： | 3 |
| 19 | Reliability and Numerical Analysis of a Robot Safety System显示文摘This paper discusses a model for a repairable robot safety system composed of a safety component and two redundant robots according to a semi-group approach.The development of the model is divided into three phases:(Ⅰ)The use of pure analysis to prove the uniqueness of a classical solution to the model;(Ⅱ)The verification of this uniqueness by providing a non-negative solution to the model;and(Ⅲ)the formulation of reliability indices for the model,along with numerical examples to explain the results.The existence,uniqueness,and exponential stability of the solution of the repairable robot safety system is studied using Volterra-type integral-differential-equation theory,and the spectral distribution of the ACP operator is discussed.Moreover,the authors propose a method to investigate the steady-state indicator of the robot safety system with the safety component working,and with or without the component revolving,to make use of the correspondence of the eigenvector to the eigenvalue zero.The authors show that the robot’s operation,with or without the safety component revolving and with fractional motion,is superior to that with the safety component working.The novelty of the approach lies in its examination of a unique solution to the system and its exponential stability based on C0-semi-group theory,the co-final relative theory,and the functional analysis method. | QIAO Xing MA Dan | 2019 | Journal of Systems Science & Complexity2019，32，4： | 3 |
| 20 | Impact of Enterprise Ownership and Size on Registered Hematotoxicity in Benzene-exposed Workers显示文摘Benzene is a classified as a human carcinogen that can cause myelodysplastic syndrome and acute myelogenous leukemia[1]. This compound is also a potent toxin suppressing the bone marrow. Accordingly, benzene causes serious hematological adverse effects, such as pancytopenia and aplastic anemia. In the 1920s, the carcinogenicity of benzene was identified in humans, in which it was shown to cause acute myelocytic leukemia (AML)[2]. The reports highlighting the first cases of hematopoietic disease associated with benzene appeared in China in the late 1950s[3]. Moreover, benzene exposure is likely to result in AML, having been identified as a Group Ⅰ carcinogen by the International Agency for Research on Cancer (1987)[4]. A meta-analysis has determined the links existing between childhood leukemia and the numbers of latent benzene exposure metrics[5]. | WANG Bo Shen HAN Lei YANG Dan Dan ZHANG Juan YIN Li Hong ZHANG Meng Ying XU Kai XING Cai Hong ZHU Bao Li PU Yue Pu | 2018 | Biomedical and Environmental Sciences2018，31，12： | 3 |
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