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| 1 | XA23 Is an Executor R Protein and Confers Broad-Spectrum Disease Resistance in Rice显示文摘 | Chunlian Wang Xiaoping Zhang Yinglun Fan Ying Gao Qinlong Zhu Chongke Zheng Tengfei Qin Yanqiang Li Jinying Che Mingwei Zhang Bing Yang Yaoguang Liu Kaijun Zhao | 2015 | Molecular Plant2015，8，2： | 55 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 4 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 5 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 6 | Somatic Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana显示文摘Brassinosteroids(BRs),a group of plant steroidal hormones,play critical roles in many aspects of plant growth and development.Previous studies showed that BRI1-mediated BR signaling regulates cell division and differentiation during Arabidopsis root development via interplaying with auxin and other phytohormones.Arabidopsis somatic embryogenesis receptor-like kinases(SERKs),as co-receptors of BRI1,were found to play a fundamental role in an early activation step of BR signaling pathway.Here we report a novel function of SERKs in regulating Arabidopsis root development.Genetic analyses indicated that SERKs control root growth mainly via a BR-independent pathway.Although BR signaling pathway is completely disrupted in the serk1 bak1 bkk1 triple mutant,the root growth of the triple mutant is much severely damaged than the BR deficiency or signaling null mutants.More detailed analyses indicated that the triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport,cell cycle,endodermis development and root meristem differentiation,which were not observed in null BR biosynthesis mutant cpd and null BR signaling mutant bri1-701. | Junbo Du Hongju Yin Shasha Zhang Zhuoyun Wei Baolin Zhao Jinghua Zhang Xiaoping Gou Honghui Lin Jia Li | 2012 | Journal of Integrative Plant Biology2012，54，6： | 22 |
| 7 | Sequencing of Cultivated Peanut, Arachis hypogaea, Yields Insights into Genome Evolution and Oil Improvement显示文摘Cultivated peanut (Arachis hypogaea) is an allotetraploid crop planted in Asia, Africa, and America for edible oil and protein. To explore the origins and consequences of tetraploidy, we sequenced the allotetraploid A. hypogaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes. We annotated 39 888 A-subgenome genes and 41 526 B-subgenome genes in allotetraploid peanut. The A. hypogaea subgenomes have evolved asymmetrically, with the B subgenome resembling the ancestral state and the A subgenome undergoing more gene disruption, loss, conversion, and transposable element proliferation, and having reduced gene expression during seed development despite lacking genome-wide expression dominance. Genomic and transcriptomic analyses identified more than 2 500 oil metabolism-related genes and revealed that most of them show altered expression early in seed development while their expression ceases during desiccation, presenting a comprehensive map of peanut lipid biosynthesis. The availability of these genomic resources will facilitate a better understanding of the complex genome architecture, agronomically and economically important genes, and genetic improvement of peanut. | Xiaoping Chen Qing Lu Hao Liu Jianan Zhang Yanbin Hong Haofa Lan Haifen Li Jinpeng Wang Haiyan Liu Shaoxiong Li Manish K.Pandey Zhikang Zhang Guiyuan Zhou Jigao Yu Guoqiang Zhang Jiaqing Yuan Xingyu Li Shijie Wen Fanbo Meng Shanlin Yu Xiyin Wang Kadambot H.M.Siddique Zhong-Jian Liu Andrew H.Paterson Rajeev K.Varshney Xuanqiang Liang | 2019 | Molecular Plant2019，12，7： | 23 |
| 8 | A novel fractional wavelet transform and its applications显示文摘The wavelet transform (WT) and the fractional Fourier transform (FRFT) are powerful tools for many applications in the field of signal processing.However,the signal analysis capability of the former is limited in the time-frequency plane.Although the latter has overcome such limitation and can provide signal representations in the fractional domain,it fails in obtaining local structures of the signal.In this paper,a novel fractional wavelet transform (FRWT) is proposed in order to rectify the limitations of the WT and the FRFT.The proposed transform not only inherits the advantages of multiresolution analysis of the WT,but also has the capability of signal representations in the fractional domain which is similar to the FRFT.Compared with the existing FRWT,the novel FRWT can offer signal representations in the time-fractional-frequency plane.Besides,it has explicit physical interpretation,low computational complexity and usefulness for practical applications.The validity of the theoretical derivations is demonstrated via simulations. | SHI Jun ZHANG NaiTong LIU XiaoPing | 2012 | Science China(Information Sciences)2012，55，6： | 20 |
| 9 | Spatial Evolution and Locational Determinants of High-tech Industries in Beijing显示文摘Using datasets on high-tech industries in Beijing as empirical studies, this paper attempts to interpret spatial shift of high-tech manufacturing firms and to examine the main determinants that have had the greatest effect on this spatial evolution. We aimed at merging these two aspects by using firm level databases in 1996 and 2010. To explain spatial change of the high-tech firms in Beijing, the Kernel density estimation method was used for hotspot analysis and detection by comparing their locations in 1996 and 2010, through which spatial features and their temporal changes could be approximately plotted. Furthermore, to provide quantitative results, Ripley′s K-function was used as an instrument to reveal spatial shift and the dispersion distance of high-tech manufacturing firms in Beijing. By employing a negative binominal regression model, we evaluated the main determinants that have significantly affected the spatial evolution of high-tech manufacturing firms and compared differential influence of these locational factors on overall high-tech firms and each sub-sectors. The empirical analysis shows that high-tech industries in Beijing, in general, have evident agglomeration characteristics, and that the hotspot has shifted from the central city to suburban areas. In combination with the Ripley index, this study concludes that high-tech firms are now more scattered in metropolitan areas of Beijing as compared with 1996. The results of regression model indicate that the firms′ locational decisions are significantly influenced by the spatial planning and regulation policies of the municipal government. In addition, market processes involving transportation accessibility and agglomeration economy have been found to be important in explaining the dynamics of locational variation of high-tech manufacturing firms in Beijing. Research into how markets and the government interact to determine the location of high-tech manufacturing production will be helpful for policymakers to enact effective policies toward a more efficient urban spatial structure. | ZHANG Xiaoping HUANG Pingting SUN Lei WANG Zhaohong | 2013 | Chinese Geographical Science2013，23，2： | 19 |
| 10 | Distribution of heavy metals in sediments of the Pearl River Estuary,Southern China:Implications for sources and historical changes显示文摘The distribution of heavy metals(Pb,Zn,Cd and As) in sediments of the Pearl River Estuary was investigated.The spatial distribution of heavy metals displayed a decreasing pattern from the turbidity maxima to both upstream and downstream of the estuary,which suggested that suspended sediments played an important role in the trace metal distribution in the Pearl River Estuary.In addition,metal concentrations were higher in the west part of the estuary which received most of the pollutants from the Pearl River.In the sediment cores,fluxes of heavy metals were consistent with a predominant anthropogenic input in the period 1970-1990.From the mid-1990s to the 2000s,there was a significant decline in heavy metal pollution.The observed decline has shown the result of pollution control in the Pearl River Delta.However,it is noteworthy that the metal concentrations in the most recent sediment still remained considerably high.Taken together,the enrichment of heavy metals in sediments was largely controlled by anthropogenic pollution. | Feng Ye Xiaoping Huang Dawen Zhang Lei Tian Yanyi Zeng | 2012 | Journal of Environmental Sciences2012，24，4： | 18 |
| 11 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 12 | Structure and function of interleukin-17 family cytokines显示文摘The recently identified interleukin-17(IL-17)cytokines family,which comprises six members in mammals(IL-17A–F),plays essential roles in the host immunity against infectious diseases and chronic inflammatory diseases.The three-dimensional structures containing IL-17A or IL-17F have become available and revealed the unique structural features of IL-17s as well as their receptors.Molecular modeling in this review shows that IL-17s may adopt a“cysteine knot”fold commonly seen in nerve growth factor(NGF)and other neurotrophins.Further modeling analysis unmasks a signature interaction feature of the IL-17F/IL-17RA complex,where a small loop of IL-17RA slots into the deep groove of the interface of IL-17F homodimer.This is quite different from the interaction between the best known four-helix cytokines and their cognate receptors.On the other hand,structure of IL-17A and its monoclonal antibody(CAT-2200)shows that,albeit that the antigenic epitope of IL-17A resides outside of the IL-17A homodimer interface,its physical proximity to the receptor binding groove may explain that antibody blockage would be achieved by interfering with the ligand-receptor interaction.This review is to summarize the advance in understanding the structure and function of IL-17 family cytokines,focusing mainly on IL-17A,IL-17F and IL-17E,in the hope of gaining better knowledge of immunotherapeutic strategies against various inflammatory diseases. | Xiaoping Zhang Pornpimon Angkasekwinai Chen Dong Hong Tang | 2011 | Protein & Cell2011，2，1： | 17 |
| 13 | What Happened in the Trans-North China Orogen in the Period 2560-1850 Ma?显示文摘Trans 北方中国造山带(TNCO ) 是东方、西方的块沿着混合了形成一个协调 NorthChina 古地台(NCC ) 的一条 Paleoproterozic continent-continentcollisional 带。最近地质,结构,有在东方块的西方的边缘下面的海洋的岩石圈的东方指导俯冲的 geochemical 和 theorogen 沿着东方块的西方的边缘是大陆人边缘或日本类型弧的同位素的数据表演,由旧海洋与西方的块被分开,。在 2550-2520 妈, deepsubduction 引起了媒介降低的外壳的部分融化,生产被侵入进形成 granitoid plutons 在的外壳的上面的层次的丰富的 granitoid 岩浆低 --tomedium 等级花岗石绿岩岩层。在 2530-2520 妈,海洋的岩石圈的俯冲引起了披风楔的部分融化,它在弧在下地壳和普遍 mafic 和次要的 felsic 火山作用在 mafic 岩浆的 plating 下面导致了,形成绿岩集合的部分。普遍 mafic 驾驶到 felsic 火山作用的扩展在造山带导致了发展 ofback 弧或 intra 弧盆。在 2520-2475 妈,俯冲引起了形成大量 tonalitic-trondhjemitic-granodioritic (TTG ) 的下地壳的进一步偏爱的融化岩浆酌。背弧盆的在这时候后面的进一步的扩展,阵发性的 granitoidmagmatism 发生了,导致 2360 妈,的炮兵阵地~ 2 250 妈 2110-21760 妈和~ 2 在造山带的 050 Magranites。当代的火山沉积的岩石在背弧 orintra 弧盆发展了。在 2150-1920 妈,造山带经历了几前紧张的事件,一条海洋的山脉的可能到期的 tosubduction,导致是的 mafic 女同性恋的炮兵阵地随后变形了到角闪岩和媒介 -- 到高压的 mafic granulites。在 1880-1820 妈,在东方、西方的块之间的海洋被俯冲完全消费,并且关门海洋导致了 continent-arc-continent 碰撞,它引起了大规模推进和等斜褶皱并且搬运了一些岩石进更低的外壳的层次或上地幔形成 granulites 或 eclogites 。山峰变态被 exhumation/uplift 跟随,导致在岩石中的不对称褶皱和 symplectic 质地的普遍开发。 | Guochun ZHAO LIU Shuwen Min SUN LI Sanzhong Simon WILDE Xiaoping XIA Jian ZHANG Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 16 |
| 14 | U-Pb Zircon Dating of the Granitic Conglomerates of the Hutuo Group:Affinities to the Wutai Granitoids and Significance to the Tectonic Evolution of the Trans-North China Orogen显示文摘与在中间的最好、古典的剖面图 Trans 北方 ChinaOrogen 分割的邻近的 Fuping 和 Hengshan Complexesrepresents 联系的 Wutai 建筑群,通常划分了成东方、西方的块。Unconformably overlying Wutai andFuping 建筑群 Hutuo 组在这个区域被看作最年轻的岩石地层单位并且为解释前寒武纪的历史以及 theTrans 北方中国造山带的全面进化重要。在这个组的沉积岩的起源的知识的缺乏妨碍了 depositional 和构造意义的理解。LA-ICP-MS 被使用为花岗石的卵石获得 U-Pb 锆石年龄, Hutuo 组的最低岩石层位学的岩石,它,与结合了以前的岩石层位学, geochronological,结构、变形的数据,在沉积起源和这个区域的构造进化上提供新限制。Hutuo 的顺序从更低的底砾岩 andvolcaniclastic 岩石(Doucun 亚群) 向上组织范围,通过碎屑沉积物,板岩,白云石和云石(Dongye 亚群) ,到在顶(Guojiazhai 亚群) 的沙岩和集团企业。从在 Doucun 亚群底砾岩保存的花岗石的卵石的锆石给加权的mean~( 207 )在 2517 妈和 2566 妈之间的Pb/~( 206 ) Pb 年龄,它与为迟了的 ArcheanWutai Granitoids 的那些一样,显示卵石从 Wutai 花岗石的侵入( 2566-2515 妈)被导出。基于新数据和以前的研究,与在 Hutuo 组为 volcanics 获得的 2087 ±9 妈的火的锆石结晶化年龄结合了, Hutuo 组在在东方块的西方的边缘下面在西方的块的东方指导俯冲期间在 theWutai 弧后面发展了的subduction相关的制动火箭弧低岬盆环境被扔。这盆经历了长寿沉积并且最后在~ 1 期间关上了导致了北方中国古地台的最后的合并的 850 妈 collisional 事件。 | Jian ZHANG Guochun ZHAO LI Sanzhong Min SUN LIU Shuwen Xiaoping XIA Yanhong HE | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 15 |
| 15 | ZONAL DISINTEGRATION MECHANISM OF DEEP CRACK-WEAKENED ROCK MASSES UNDER DYNAMIC UNLOADING显示文摘Size and quantity of fractured zone and non-fractured zone are controlled by cracks contained in deep rock masses.Zonal disintegration mechanism is strongly dependent on the interaction among cracks.The strong interaction among cracks is investigated using stress super-position principle and the Chebyshev polynomials expansion of the pseudo-traction.It is found from numerical results that crack nucleation,growth and coalescence lead to failure of deep crack-weakened rock masses.The stress redistribution around the surrounding rock mass induced by unloading excavation is studied.The effect of the excavation time on nucleation,growth,inter-action and coalescence of cracks was analyzed.Moreover,the inffuence of the excavation time on the size and quantity of fractured zone and non-fractured zone was given.When the excavation time is short,zonal disintegration phenomenon may occur in deep rock masses.It is shown from numerical results that the size and quantity of fractured zone increase with decreasing excavation time,and the size and quantity of fractured zone increase with the increasing value of in-situ geostress. | Xiaoping Zhou Qihu Qian Bohu Zhang | 2009 | Acta Mechanica Solida Sinica2009，22，3： | 15 |
| 16 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 17 | Influence of different mining layouts on the mechanical properties of coal显示文摘Non-pillar mining,top-coal caving and protected coal seam mining are the most popular mining methods in coal exploitation,and the different mining layouts will change the stress state and failure mechanism of coal in front of the working face.In this paper,mining-induced mechanical behaviors under three mining layouts have been simulated in the laboratory to investigate the effects of mining layouts on the deformation and strength of coal.Furthermore,the coal failure mechanism under different mining layouts is analyzed microscopically.The experimental results indicate that the stage characteristics of the coal deformation are obvious.Under the serial action of non-pillar mining,top-coal caving and protected coal seam mining layouts,the values of radial deformation,volume strain and Poisson's ratio increase,while the peak strength and deformation modulus decrease at the same buried depth,and the peak strength under non-pillar mining,top-coal caving and protected coal seam mining is about 3.0,2.5 and 2.0 times of the initial confining pressure,respectively.The results also indicate that the trend of the coal deformation decreases with the increase of the buried depth under the same mining layout,while the strength and deformation modulus increase,and the failure mechanism under three mining layouts is dominated with shear/tensile failure. | Xie Heping Zhao Xiaoping Liu Jianfeng Zhang Ru Xue Dongjie | 2012 | International Journal of Mining Science and Technology2012，22，6： | 14 |
| 18 | Genome-Wide Expression Pattern Analyses of the Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases显示文摘像受体的蛋白质 kinases (RLK ) 是在房间房间和房间环境通讯起关键作用的 transmembrane 蛋白质的一个大组。基于细胞外的领域结构, RLK 被分类进超过 21 个亚科,充满白氨酸的重复 RLK (LRR-RLKs ) 在象 Arabidopsis 和米饭那样的植物在之中属于最大的亚科。在 Arabidopsis,有近似 223LRR-RLKs,但是哪个中的仅仅大约 60 个机能上地迄今为止被描述了。为了系统地在调整调查 LRR-RLKs 的 theroles,种生长,开发,和压力改编,我们产生了 promoter::GUS 为在 Arabidopsis 的所有 223 LRR-RLK 基因的转基因的植物并且在各种各样的发展舞台分析了他们的详细表达式模式。Theresults 提供 forfunctionally 阐明的珍贵资源这个大、必要的发信号的蛋白质亚科。 | Yunzhe Wu Qingqing Xun Yi Guo Jinghua Zhang Kaili Cheng Tao Shi Kai He Suiwen Hou Xiaoping Gou Jia Li | 2016 | Molecular Plant2016，9，2： | 13 |
| 19 | U-Pb Age and Hf Isotope Study of Detrital Zircons from the Wanzi Supracrustals:Constraints on the Tectonic Setting and Evolution of the Fuping Complex,Trans-North China Orogen显示文摘在 Trans 北方中国造山带的中间的片断定位了, FupingComplex 在理解北方 ChinaCraton (NCC ) 的进化历史被看作一个批评区域。建筑群由各种各样的高级、多样地使变形的岩石组成,包括灰色的片麻岩,基本 granulite,角闪岩,有细密纹理的片麻岩和大理石,变形了到上面的角闪岩或 granulite 外形。它能被划分成四个岩石单位:Fuping TTG 片麻岩, Longquanguan augen, Wanzi 在上 crustals,和 Nanying 花岗石的片麻岩。从 FupingComplex 的 Wanzi 在上 crustals 的大约 200 由岩屑形成的锆石的 U-Pb 年龄和 Hfisotope 作文被分析了。边界给的变形锆石上的数据 1.82-1.84 Ga 变老,相应于 NCC 的最后的合并事件为在~ 2 .10 和~ 2 .51 Ga 的火的锆石核心产量二年龄人口的数据,与在第 2.5a 2.9 Ga 之间散布的一些继承年龄。这些结果建议 Wanzi 在上 crustals 从 Fuping TTGgneisses (~ 2 .5 Ga ) 和 Nanying 花岗石的片麻岩(2.0-2.1 Ga ) 被导出并且在 2.10 and1.84 Ga 之间扔了。有~ 2 .51 Ga 年龄的所有锆石有起始的ε _(Hf ) 从 +1.4 珍视到 +10.9 的 positive,建议在通过从披风的少年材料的增加的~ 2 .5 Ga 的一个重要外壳的生长事件。为由岩屑形成的锆石的 Hf 同位素数据进一步暗示 2.8 Ga 岩石是在下地壳的重要部件,它与从为东方块的 Nd 同位素数据的一个建议一致。 2.10 Ga 人口的锆石有起始的ε_( Hf ) -4.9 to+6.1 的价值,作为在 2.1 Ga.These 结果与次要的少年材料贡献外壳的再融化混合解释了为西方的块从那是不同的,支持 Fuping 建筑群是在在东方块的西方的边缘的构造活跃环境的 emplaced 。 | Xiaoping XIA Min SUN Guochun ZHAO WU Fuyuan XU Ping Jian ZHANG Yanhong HE ZHANG Jiheng | 2006 | Acta Geologica Sinica(English Edition)2006，80，6： | 12 |
| 20 | Relationship between nutrients and plankton biomass in the turbidity maximum zone of the Pearl River Estuary显示文摘Nutrients,dissolved and particulate organic carbon and plankton(bacterio-,phyto-and zoo-)were compared in the turbidity maximum zone(TMZ) and adjacent areas(non-TMZ) in the Pearl River estuary.Our results showed that high levels of suspended substances had marked effect on dynamics of nutrients and plankton in the TMZ.Based on the cluster analysis of total suspended solids(TSS) concentrations,all stations were divided into two groups,TMZ with average TSS of 171 mg/L and non-TMZ of 45 mg/L.Suspended substances adsorbed PO^(3-)_4 and dissolved organic carbon,resulting in higher particulate phosphorus and organic carbon(POC)and lower PO^(3-)_4 and DOC in the TMZ,compared to the non-TMZ.However,suspended substances had limited effect on nitrogenous nutrients.Phytoplankton growth was light-limited due to high concentrations of suspended substances in the TMZ and a peak of phytoplankton abundance appeared in the non-TMZ.In contrast,the highest bacterial abundance occurred in the TMZ,which was likely partly responsible for low DOC levels.Two peaks of zooplankton abundance observed in the TMZ and non-TMZ in the Pearl River estuary were primarily supported by bacteria and phytoplankton,respectively.Our finding implied that high levels of suspended solids in the TMZ affect the trophic balance. | Zhen Shi Jie Xu Xiaoping Huang Xia Zhang Zhijian Jiang Feng Ye Ximei Liang | 2017 | Journal of Environmental Sciences2017，29，7： | 12 |
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