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| 1 | Modeling study of regional severe hazes over mid-eastern China in January 2013 and its implications on pollution prevention and control显示文摘The Nested Air Quality Prediction Model System(NAQPMS)was used to investigate the temporal and spatial variations of PM2.5over tropospheric central eastern China in January 2013.The impact of regional transport and its implications on pollution prevention and control were also examined.Comparison between simulated and observed PM2.5showed NAQPMS was able to reproduce the evolution of PM2.5during heavy haze episodes.The results indicated that regional transport of PM2.5played an important role in regional haze episodes in the city cluster including Hebei,Beijing and Tianjin(HBT).The cross-city clusters transport outside HBT and transport among cities inside HBT contributed 20%–35%and 26%–35%of PM2.5as compared with local emission,in HBT respectively.To meet the Air Quality Standards for Grade II,90%,90%and65%of emissions would have to be cut down in Hebei,Tianjin and Beijing,if non-control strategy was taken in the surrounding city clusters of HBT.This implicated that control of emissions in one city cluster is not sufficient to reduce regional haze events,and joint efforts among city clusters are essential.Besides regional transports,two-way feedback between boundary-layer evolution and PM2.5also significantly contributed to the formation of heavy hazes,which contributed 30%of monthly average PM2.5concentration in HBT. | WANG ZiFa LI Jie WANG Zhe YANG WenYi TANG Xiao GE BaoZhu YAN PinZhong ZHU LiLi CHEN XueShun CHEN HuanSheng WAND Wei LI JianJun LIU Bing WANG XiaoYan WAND Wei ZHAO YiLin LU Ning SU DeBin | 2014 | Science China Earth Sciences2014，57，1： | 106 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 4 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 5 | Human colorectal cancer-specific CCAT1-L IncRNA regulates long-range chromatin interactions at the MYC locus显示文摘人的 8q24 基因沙漠包含多重 enhancers 形式织物特定的远程的染色质与 MYC oncogene 循环,但是染色质在 MYC 地点循环怎么被调整,仍然保持糟糕理解。这里,我们表明那长 noncoding RNA (lncRNA ) , CCAT1-L,从一个地点在人的 colorectal 癌症明确地被抄录 MYC 在上游的 515 kb。这 lncRNA 在 MYC transcriptional 规定起一个作用并且支持远程的染色质循环。重要地, CCAT1-L 地点位于强壮的超级提高以内并且离 MYC 空间地靠近。CCAT1-L 击倒在 MYC 倡导者和它的 enhancers 之间的减少的远程的相互作用。另外, CCAT1-L 与 CTCF 交往并且在这些环区域调制染色质符合构造。这些结果揭示一个重要角色一以前在在 MYC 地点的基因规定的 unannotated lncRNA。 | Jian-Feng Xiang Qing-Fei Yin Tian Chen Yang Zhang Xiao-Ou Zhang Zheng Wu Shaofeng Zhang Hai-Bin Wang Junhui Ge Xutiua Lu Li Yang Ling-Ling Chen | 2014 | Cell Research2014，24，5： | 67 |
| 6 | Geochemistry and petrogenesis of Jurassic high Sr/low Y granitoids in eastern China: Constrains on crustal thickness显示文摘The Jurassic high Sr/low Y granitoids in eastern China are characterized by high Sr/Y (27-166) and La/Yb (14-66) ratios, low abundance in Y (6-21μg/g) and Yb (0.5-2.0μg/g), comparable with those of adakites defined by Defant et al. Thus, they were recently considered as adakitic rocks by some researchers. Compared with the typical adakites in circum-Pacific margins, however, these high Sr/low Y granitoids have higher K2O (-3.5%) but lower A12O3 (-16.0%) as well as lower Mg#(-38) and δSrN (-1.23) values. Furthermore, they show relatively flat HREE patterns with Y/Yb values of -10 close to the chondritic value. These geochemical characteristics indicate a residue mineral assemblage of hornblende, garnet and plagioclase for these high Sr/low Y granitoids melt. Thus, they were generated by partial melting at 9-13 kbar (30-45 km in depth), similar to the Archaean high-Al TTG rather than the modern adakites. Generation of these high Sr/low Y granitoids cannot be considered as evidence for a thickened | Ge, XY Li, XH Chen, ZG Li, WP | 2002 | Chinese Science Bulletin2002，47，11： | 51 |
| 7 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 8 | The Reference Genome of Tea Plant and Resequencing of 81 Diverse Accessions Provide Insights into Its Genome Evolution and Adaptation显示文摘Tea plant is an important economic crop,which is used to produce the world's oldest and most widely consumed tea beverages.Here,we present a high-quality reference genome assembly of the tea plant(Camellia sinensis var.sinensis)consisting of 15 pseudo-chromosomes.LTR retrotransposons(LTR-RTs)account for 70.38%of the genome,and we present evidence that LTR-RTS play critical roles in genome size expansion and the transcriptional diversification of tea plant genes through preferential insertion in promoter regions and introns.Genes,particularly those coding for terpene biosynthesis pro-teins,associated with tea aroma and stress resistance were significantly amplified through recent tandem duplications and exist as gene clusters in tea plant genome.Phylogenetic analysis of the sequences of 81 tea plant accessions with diverse origins revealed three well-differentiated tea plant populations,support-ing the proposition for the southwest origin of the Chinese cultivated tea plant and its later spread to western Asia through introduction.Domestication and modern breeding left significant signatures on hundreds of genes in the tea plant genome,particularly those associated with tea quality and stress resis-tance.The genomic sequences of the reported reference and resequenced tea plant accessions provide valuable resources for future functional genomics study and molecular breeding of improved cul-tivars of tea plants. | Enhua Xia Wei Tong Yan Hou Yanlin An Linbo Chen Qiong Wu Yunlong Liu Jie Yu Fangdong Li Ruopei Li Penghui Li Huijuan Zhao Ruoheng Ge Jin Huang Ali Inayat Mallano Yanrui Zhang Shengrui Liu Weiwei Deng Chuankui Song Zhaoliang Zhang Jian Zhao Shu Wei Zhengzhu Zhang Tao Xia Chaoling Wei Xiaochun Wan | 2020 | Molecular Plant2020，13，7： | 51 |
| 9 | DK crush technique: modified treatment of bifurcation lesions in coronary artery显示文摘 | CHEN Shao-liang YE Fei ZHANG Jun-jie ZHU Zhong-sheng LIN Song SHAN Shou-jie LIU Zhi-zhong LIU Yan DUAN Bao-xiang GE Jun-bo | 2005 | Chinese Medical Journal2005，，20： | 35 |
| 10 | Plant DNA barcoding in China显示文摘Identification is the keystone of biology (Bell, 1986).However, to biologists and students of biology, the total numbers of species that must be identified far outnumber the names commonly used in English, Chinese, or other living languages.In addition, the identification cues vary greatly between different taxonomical groups.Even for the taxonomists with long training and experience, it is difficult to remember all specific terms for a given group, e.g., Orchidaceae or Poaceae, without help of floristic books or monographs.It takes much time and effort to train a taxonomist, at a time when fewer and fewer young students are interested in this 'classical' and 'out-of-style', but extremely important, discipline.Many students elect to learn the more 'advanced'' and 'modem' biological disciples like molecular biology and biochemistry.Thus, in China and therest of the world, taxonomists are themselves becoming 'endangered'.The rise of the DNA barcoding is expected to mitigate, at least in part, this dilemma. | De-Zhu LI jian-Quan LIU Zhi-Duan CHEN Hong WANG Xue-Jun GE Shi-Liang ZHOU Lian-Ming GAO Cheng-Xin FU Shi-Lin CHEN | 2011 | Journal of Systematics and Evolution2011，49，3： | 37 |
| 11 | Spatial and temporal variations and controlling factors of potential evapotranspiration in China:1956-2000显示文摘Based on the climatic data of 580 stations in China during 1956 and 2000, potential evapotranspiration are calculated using the Penman-Monteith Method recommended by FAO. The spatial and temporal distributions of the potential evapotranspiration over China and the temporal trends of the regional means for 10 major river basins and whole China are analyzed. Through a partial correlation analysis, the major climate factors which affect the temporal change of the potential evapotranspiration are analyzed. Major results are drawn as follows: 1) The seasonal and annual potential evapotranspiration for China as a whole and for most basins show decline tendencies during the past 45 years; for the Songhua River Basin there appears a slightly increasing trend. 2) Consequently, the annual potential evapotranspirations averaged over 1980-2000 are lower than those for the first water resources assessment (1956-1979) in most parts of China. Exceptions are found in some areas of Shandong Peninsula, western and middle basins of the rivers in Southwest China, Ningxia Hui Autonomous Region as well as the source regions of the Yangtze and Yellow rivers, which may have brought about disadvantages to the exploration and utilization of water resources. 3) Generally, sunshine duration, wind speed and relative humidity have greater impact on the potential evapotranspiration than temperature. Decline tendencies of sunshine duration and/or wind speed in the same period appear to be the major causes for the negative trend of the potential evapotranspiration in most areas. | GAO Ge CHEN Deliang REN Guoyu CHEN Yu LIAO Yaoming | 2006 | Journal of Geographical Sciences2006，16，1： | 34 |
| 12 | Incidence and mortality of thyroid cancer in China, 2008-2012显示文摘Objective: To analyze the incidence and mortality rates of thyroid cancer(TC) in China from 2008 to 2012.Methods: Incident and death cases of TC were retrieved from the National Central Cancer Registry(NCCR)database collecting from 135 cancer registries in China during 2008-2012. The crude incidence and mortality rates of TC were calculated by area(urban/rural), region(eastern, middle, western), gender and age group(0, 1-4, 5-9,…, 85+). China census in 2000 and world Segi's population were applied for age-standardized rates. Joinpoint(Version 4.6.0.0) model was used for time-trend analysis.Results: The crude incidence rate of TC was 7.56/100,000 which ranked the seventh in overall cancers. The agestandardized incidence rates by China population(ASIRC) and by World population(ASIRW) were 6.25/100,000 and 5.52/100,000, respectively. The crude mortality of TC in China was 0.52/100,000. The age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were0.34/100,000 and 0.32/100,000, respectively. Incidence and mortality rates of TC were higher in females than in males and higher in urban areas than in rural areas. Eastern areas had the highest incidence followed by middle and western areas. TC incidence increased dramatically after age of 15 years, then peaked at 14.08/100,000 in the group of 50-54 years and finally decreased sharply after 55 years old. TC mortality increased with age in population,reaching the peak of 5.09/100,000 in sub-population aged 85 years or older. TC incidence increased by 4.73 times from 2.40/100,000 in 2003 to 13.75/100,000 in 2012 with an average annual increase of 20%, while TC mortality only increased slightly around 0.32/100,000 from 0.26/100,000 to 0.36/100,000.Conclusions: Appropriate targeted prevention, early detection and treatment programs can be carried out to curb the rapid growth trend of TC and control the disease burden. | Lingbin Du Runhua Li Minghua Ge Youqing Wang Huizhang Li Wanqing Chen Jie He | 2019 | Chinese Journal of Cancer Research2019，31，1： | 31 |
| 13 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 14 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 15 | 涡度相关法研究土壤水分状况对沙地杨树人工林生态系统能量分配和蒸散日变化的影响显示文摘为了解位于北京大兴区林场杨树人工林在不同的土壤水分环境条件下的水汽交换过程和能量的分配差异及其与环境因子关系,运用涡度相关(Eddycovariance,EC)法开路系统、常规微气象观测系统及土壤热通量板等设施对生态系统生长季内典型水分胁迫和无水分胁迫条件下蒸散日变化、能量分配以及与各环境因子的关系进行了测定分析和比较。结果表明,在水分严重胁迫日(以7月7日为例),蒸散日变化过程为单峰曲线,全天(24h)蒸散量为2·4mm;而在无水分胁迫典型日(以7月25日为例),蒸散日变化过程呈多峰曲线,全天蒸散量为4·5mm。能量平衡分析显示,无水分胁迫条件下潜热通量(LE)占净辐射通量(Rn)的比例远高于水分胁迫条件下潜热通量占净辐射通量的比例,说明水分充足时,能量的大部分用于蒸散。水分胁迫条件下蒸散速率与各环境因子的相关性均低于无水分胁迫条件下蒸散速率与环境因子的相关性。水分胁迫条件下,蒸散速率主要与净辐射和下垫面因子关系显著,而与其它因子的相关性较小;无水分胁迫条件下,蒸散速率与下垫面土体含水量和各气象因子均表现出较强的相关性。大气温度对于两个典型日蒸散速率的影响均很小;土壤含水量与水分胁迫日的蒸散速率几乎没有相关性,反应出土壤水分含量低至对蒸散几乎没有贡献了。 | 刘晨峰 张志强 查同刚 Ge Sun Chen Jiquan 朱金兆 申李华 张津林 陈军 崔令军 | 2006 | 生态学报2006，26，8： | 28 |
| 16 | Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy显示文摘The incidence and mortality of hepatocellular carcinoma(HCC) have fallen dramatically in China and elsewhere over the past several decades. Nonetheless, HCC remains a major public health issue as one of the most common malignant tumors worldwide and one of the leading causes of death caused by cancer in China. Hepatocarcinogenesis is a very complex biological process associated with many environmental risk factors and factors in heredity, including abnormal activation of cellular and molecular signaling pathways such as Wnt/β-catenin, hedgehog, MAPK, AKT, and ERK signaling pathways, and the balance between the activation and inactivation of the proto-oncogenes and anti-oncogenes, and the differentiation of liver cancer stem cells. Molecule-targeted therapy, a new approach for the treatment of liver cancer, blocks the growth of cancer cells by interfering with the molecules required for carcinogenesis and tumor growth, making it both specific and selective. However, there is no one drug completely designed for liver cancer, and further development in the research of liver cancer targeted drugs is now almost stagnant. The purpose of this review is to discuss recent advances in our understanding of the molecular mechanisms underlying the development of HCC and in the development of novel strategies for cancer therapeutics. | Chuan Chen Ge Wang | 2015 | World Journal of Hepatology2015，7，15： | 28 |
| 17 | Networked Control Systems:A Survey of Trends and Techniques显示文摘Networked control systems are spatially distributed systems in which the communication between sensors, actuators,and controllers occurs through a shared band-limited digital communication network. Several advantages of the network architectures include reduced system wiring, plug and play devices,increased system agility, and ease of system diagnosis and maintenance. Consequently, networked control is the current trend for industrial automation and has ever-increasing applications in a wide range of areas, such as smart grids, manufacturing systems,process control, automobiles, automated highway systems, and unmanned aerial vehicles. The modelling, analysis, and control of networked control systems have received considerable attention in the last two decades. The ‘control over networks’ is one of the key research directions for networked control systems. This paper aims at presenting a survey of trends and techniques in networked control systems from the perspective of ‘control over networks’, providing a snapshot of five control issues: sampled-data control, quantization control, networked control, event-triggered control, and security control. Some challenging issues are suggested to direct the future research. | Xian-Ming Zhang Qing-Long Han Xiaohua Ge Derui Ding Lei Ding Dong Yue Chen Peng | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 25 |
| 18 | Constructal design progress for eight types of heat sinks显示文摘This review paper summarizes constructal design progress performed by the authors for eight types of heat sinks with ten performance indexes being taken as the optimization objectives,respectively,by combining the methods of theoretical analysis and numerical calculation.The eight types of heat sinks are uniform height rectangular fin heat sink,non-uniform height rectangular fin heat sink,inline cylindrical pin-fin heat sink(ICPHS),plate single-row pin fin heat sink(PSRPHS),plate inline pin fin heat sink(PIPHS),plate staggered pin fin heat sink(PSPHS),single-layered microchannel heat sink(SLMCHS)with rectangular cross sections and double-layered microchannel heat sink(DLMCHS)with rectangular cross sections,respectively.And the ten performance indexes are heat transfer rate maximization,maximum thermal resistance minimization,minimization of equivalent thermal resistance which is defined based on the entransy dissipation rate(equivalent thermal resistance for short),field synergy number maximization,entropy generation rate minimization,operation cost minimization,thermo-economic function value minimization,pressure drop minimization,enhanced heat transfer factor maximization and efficiency evaluation criterion number maximization,respectively.The optimal constructs of the eight types of heat sinks with different constraints and based on the different optimization objectives are compared with each other.The results indicated that the optimal constructs mostly are different based on different optimization objectives under the same boundary condition.The optimization objective should be suitable chosen based on the focus when the constructal design for one heat sink is performed.The results obtained herein have some important theoretical significances and application values,and can provide scientific bases and theoretical guidelines for the thermal design of real heat sinks and their applications. | CHEN LinGen YANG AiBo FENG HuiJun GE YanLin XIA ShaoJun | 2020 | Science China(Technological Sciences)2020，63，6： | 25 |
| 19 | A new way to generate seismic waves for continental crustal exploration显示文摘An airgun experiment was conducted in a reservoir,with the total volume of the airgun array being 6000 cubic inch. The energy released by one excitation was estimated to be 6.68×106 J,which corresponded to a 3.4 kg TNT explosion. A 180 km long profile composed of 100 portable short period seismometers was deployed as a receiver system of the airgun signals. Two remarkable results can be drawn from the experiment: (1) the airgun explosion is harmless to the dam and the fish,and this kind of airguns can be regarded as a green and environmental protection seismic source on land; (2) seismic wave gener-ated by this airgun source can be recorded by permanent stations with offset larger than 200 km. And the wave amplitudes recorded by nearby and remote stations are equivalent to the wave generated by 800 kg dynamite explosion. The airguns can be used as a light to illuminate the continental crustal structure of an area of about 100000 km2. | CHEN Yong ZHANG XianKang QIU XueLin GE HongKui LIU BaoJin WANG BaoShan | 2007 | Chinese Science Bulletin2007，52，16： | 24 |
| 20 | Operative link on gastritis assessment stage is an appropriate predictor of early gastric cancer显示文摘AIM: To assess the predictive value of Operative Link on Gastritis Assessment(OLGA) and Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM) stages in gastric cancer.METHODS: A prospective study was conducted with 71 patients with early gastric cancer(EGC) and 156 patients with non-EGC. All patients underwent endoscopic examination and systematic biopsy. Outcome measures were assessed and compared, including the Japanese endoscopic gastric atrophy(EGA) classification method and the modified OLGA method as well as the modified OLGIM method. Helicobacter pylori(H. pylori) status was determined for all study participants. Stepwise logistic regression modeling was performed to analyze correlations between EGC and the EGA, OLGA and OLGIM methods.RESULTS: For patients with EGC and patients with non-EGC, the proportions of moderate-to-severe EGA cases were 64.8% and 44.9%, respectively(P = 0.005), the proportions of OLGA stages Ⅲ-Ⅳ cases were 52.1% and 22.4%, respectively(P < 0.001), and the proportions of OLGIM stages Ⅲ-Ⅳ cases were42.3% and 19.9%, respectively(P < 0.001). OLGA stage and OLGIM stage were significantly related to EGA classification; specifically, logistic regression modeling showed significant correlations between EGC and moderate-to-severe EGA(OR = 1.95, 95% CI: 1.06-3.58, P = 0.031) and OLGA stages Ⅲ-Ⅳ(OR = 3.14, 95%CI: 1.71-5.81, P < 0.001), but no significant correlation between EGC and OLGIM stages Ⅲ-Ⅳ(P = 0.781). H. pylori infection rate was significantly higher in patients with moderate-to-severe EGA(75.0% vs 54.1%, P = 0.001) or OLGA/OLGIM stages Ⅲ-Ⅳ(OLGA: 83.6% vs 55.8%, P < 0.001; OLGIM: 83.6% vs 57.8%, P < 0.001).CONCLUSION: OLGA classification is optimal for EGC screening. A surveillance program including OLGA stage and H. pylori infection status may facilitate early detection of gastric cancer. | Ying Zhou Hai-Yan Li Jing-Jing Zhang Xiao-Yu Chen Zhi-Zheng Ge Xiao-Bo Li | 2016 | World Journal of Gastroenterology2016，22，13： | 24 |
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