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| 1 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 2 | A review on 2D MoS_(2) cocatalysts in photocatalytic H_(2) production显示文摘Owing to their unique physicochemical,optical and electrical properties,two-dimensional(2D)MoS_(2) cocatalysts have been widely applied in designing and developing highly efficient composite photocatalysts for hydrogen generation under suitable light irradiation.In this review,we first elaborated on the fundamental aspects of 2D MoS_(2) cocatalysts to include the structural design principles,synthesis strategies,strengths and challenges.Subsequently,we thoroughly highlighted and discussed the modification strategies of 2D MoS_(2) H2-evolution cocatalysts,including doping heteroatoms(e.g.metals,non-metals,and co-doping),designing interfacial coupling morphologies,controlling the physical properties(e.g.thickness,size,structural defects or pores),exposing the reactive facets or edge sites,constructing cocatalyst heterojunctions,engineering the interfacial bonds and confinement effects.In the future,the forefront challenges in understanding and in precise controlling of the active sites at molecular level or atomic level should be carefully studied,while various potential mechanisms of photogenerated-electrons interactions should be proposed.The applications of MoS_(2) cocatalyst in the overall water splitting are also expected.This review may offer new inspiration for designing and constructing novel and efficient MoS_(2)-based composite photocatalysts for highly efficient photocatalytic hydrogen evolution. | Zizhan Liang Rongchen Shen Yun Hau Ng Peng Zhang Quanjun Xiang Xin Li | 2020 | Journal of Materials Science & Technology2020，56，21： | 12 |
| 3 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 4 | Design and application of active sites in g-C_(3)N_(4)-based photocatalysts显示文摘With the development in photocatalysis field,photocatalysts have received increasing attention due to their important role in environmental pollution and energy crisis.As a nonmetallic photocatalyst,graphitic carbon nitride(g-C3N4)has been widely recognized because of its excellent optical properties,low cost,and environment friendliness.In the g-C3N4 intrinsic frameworks,carbon atom tends to be the reducing active site,while nitrogen atom tends to be the oxidizing active site and reducing active site according to the difference of electronegativity.However,the quantity and quality of these active sites are affected by many factors,including C N covalent bonds,surface properties,etc.Active sites play an important role in photocatalysis;however,this role is not detailed in most reports.In this review,we proposed the following possible mechanisms of active sites in improving the photocatalytic activity of traditional g-C_(3)N_(4) based on its intrinsic:morphology regulation,carrier migration,surface active treatment,and substrate adsorption.The following factors affecting the active sites of g-C_(3)N_(4),including basal engineering and hybrid engineering,were also investigated.The roles of these active sites in improving the photocatalytic activity of g-C_(3)N_(4)-based photocatalytic materials,including morphology regulation,surface treatment,heteroatom doping,and interfacial interaction,were also expounded.Current challenges and future development of g-C_(3)N_(4)-based photocatalysts that are rich in active surface sites were also discussed.This review provides an in-depth understanding of g-C_(3)N_(4)-based photocatalysts. | Yang Li Xin Li Huaiwu Zhang Jiajie Fan Quanjun Xiang | 2020 | Journal of Materials Science & Technology2020，56，21： | 4 |
| 5 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 6 | Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation显示文摘Interspecies chimera through blastocyst complementation could be an alternative approach to create human organs in animals by using human pluripotent stem cells.A mismatch of the major histocompatibility complex of vascular endothelial cells between the human and host animal will cause graft rejection in the transplanted organs.Therefore,to achieve a transplantable organ in animals without rejection,creation of vascular endothelial cells derived from humans within the organ is necessary.In this study,to explore whether donor xeno-pluripotent stem cells can compensate for blood vasculature in host animals,we generated rat-mouse chimeras by injection of rat embryonic stem cells(rESCs)into mouse blastocysts with deficiency of Flk-1 protein,which is associated with endothelial and hematopoietic cell development.We found that rESCs could differentiate into vascular endothelial and hematopoietic cells in the rat-mouse chimeras.The whole yolk sac(YS)of Flk-1^EGFP/ECFP rat-mouse chimera was full of rat blood vasculature.Rat genes related to vascular endothelial cells,arteries,and veins,blood vessels formation process,as well as hematopoietic cells,were highly expressed in the YS.Our results suggested that rat vascular endothelial cells could undergo proliferation,migration,and self-assembly to form blood vasculature and that hematopoietic cells could differentiate into B cells,T cells,and myeloid cells in rat-mouse chimeras,which was able to rescue early embryonic lethality caused by Flk-1 deficiency in mouse. | Xiaomin Wang Hui Shi Juanjuan Zhou Qingjian Zou Quanjun Zhang Shixue Gou Pengfei Chen Lisha Mou Nana Fan Yangyang Suo Zhen Ouyang Chengdan Lai Quanmei Yan Liangxue Lai | 2020 | Journal of Genetics and Genomics2020，47，5： | 2 |
| 7 | Generation of ApoE deficient dogs via combination of embryo injection of CRISPR/Cas9 with somatic cell nuclear transfer显示文摘Atherosclerotic cardiovascular disease is the leading cause of death in the world which is resulted from complex interactions among multiple genetic and environmental factors(WHO).Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipids in the arterial wall(Gofman and Lindgren,1950).Tremendous clinical and experimental efforts have | Chong Feng Xiaomin Wang Hui Shi Quanmei Yan Min Zheng Jing Li Quanjun Zhang Yumin Qin Yougang Zhong Jidong Mi Liangxue Lai | 2018 | Journal of Genetics and Genomics2018，45，1： | 2 |
| 8 | Review of Water-Assisted Crystallization for TiO_2 Nanotubes显示文摘TiO_2 nanotubes(TNTs) have drawn tremendous attention owing to their unique architectural and physical properties. Anodizing of titanium foil has proven to be the most efficient method to fabricate well-aligned TNTs,which, however, usually produces amorphous TNTs and needs further thermal annealing. Recently, a water-assisted crystallization strategy has been proposed and investigated by both science and engineering communities. This method is very efficient and energy saving, and it circumvents the drawbacks of thermal sintering approach. In this paper, we review the recent research progress in this kind of lowtemperature crystallization approach. Here, various synthetic methods are summarized, and the mechanisms of the amorphous–crystalline transformation are analyzed. The fundamental properties and applications of the low-temperature products are also discussed. Furthermore, it is proved that the water-assisted crystallization approach is not only applicable to TNTs but also to crystallizing other metal oxides. | Xiaoyi Wang Dainan Zhang Quanjun Xiang Zhiyong Zhong Yulong Liao | 2018 | Nano-Micro Letters2018，10，4： | 1 |
| 9 | Pervasive hybridization during evolutionary radiation of Rhododendron subgenus Hymenanthes in mountains of southwest China显示文摘Radiations are especially important for generating species biodiversity in mountainous ecosystems.The contribution of hybridization to such radiations has rarely been examined.Here,we use extensive genomic data to test whether hybridization was involved in evolutionary radiation within Rhododendron subgenus Hymenanthes,whose members show strong geographic isolation in the mountains of southwest China.We sequenced genomes for 143 species of this subgenus and 93 species of four other subgenera,and found that Hymenanthes was monophyletic and radiated during the late Oligocene to middle Miocene.Widespread hybridization events were inferred within and between the identified clades and subclades.This suggests that hybridization occurred both early and late during diversification of subgenus Hymenan thes,although the extent to which hybridization,speciation through mixing-isolation-mixing or hybrid speciation,accelerated the diversification needs further exploration.Cycles of isolation and contact in such and other montane ecosystems may have together promoted species radiation through hybridization between diverging populations and species.Similar radiation processes may apply to other montane floras in this region and elsewhere. | Yazhen Ma Xingxing Mao Ji Wang Lei Zhang Yuanzhong Jiang Yuying Geng Tao Ma Liming Cai Shuangquan Huang Pete Hollingsworth Kangshan Mao Minghui Kang Yiling Li Wenlu Yang Haolin Wu Yang Chen Charles C.Davis Nawal Shrestha Richard H.Ree Zhenxiang Xi Quanjun Hu Richard I.Milne Jianquan Liu | 2022 | National Science Review2022，9，12： | 1 |
| 10 | Phylotranscriptomics of Swertiinae(Gentianaceae)reveals that key floral traits are not phylogenetically correlated显示文摘Establishing how lineages with similar traits are phylogenetically related remains critical for understanding the origin of biodiversity on Earth.Floral traits in plants are widely used to explore phylogenetic relationships and to delineate taxonomic groups.The subtribe Swertiinae(Gentianaceae)comprises more than 350 species with high floral diversity ranging from rotate to tubular corollas and possessing diverse nectaries.Here we performed phylogenetic analysis of 60 species from all 15 genera of the subtribe Swertiinae sensu Ho and Liu,representing the range of floral diversity,using data from the nuclear and plastid genomes.Extensive topological conflicts were present between the nuclear and plastome trees.Three of the 15 genera represented by multiple species are polyphyletic in both trees.Key floral traits including corolla type,absence or presence of lobe scales,nectary type,nectary position,and stigma type are randomly distributed in the nuclear and plastome trees without phylogenetic correlation.We also revealed the likely ancient hybrid origin of one large clade comprising 10 genera with diverse floral traits.These results highlight the complex evolutionary history of this subtribe.The phylogenies constructed here provide a basic framework for further exploring the ecological and genetic mechanisms underlying both species diversification and floral diversity. | Chunlin Chen Brad R.Ruhfel Jialiang Li Zefu Wang Lushui Zhang Lei Zhang Xingxing Mao Ji Wang Dashan He Yue Luo Quanjun Hu Yuanwen Duan Xiaoting Xu Zhenxiang Xi Jianquan Liu | 2023 | Journal of Integrative Plant Biology2023，65，6： | 1 |
| 11 | Thermal insulation design for efficient and scalable solar water interfacial evaporation and purification显示文摘In recent years, solar desalination and water evaporation/purification with various artificial architectures have drawn significant attention. Herein, we introduce a rational design structure for efficient solar water evaporation and purification, focusing on the balance between water transportation and thermal insulation.Natural wood after a simple flame treatment on the surface was utilized as the solar absorber, with a high solar absorbance(~90 %), good hydrophilicity, and excellent heat localization abilities. Besides,a thermal insulator(polystyrene foam) was used to further reduce the thermal loss, and the optimized ratio between the water path and thermal insulator was obtained. A set of floating foam-flamed-wood(F-F-wood) devices were fabricated with a high evaporation rate of 3.92 kgm-2 h-1, exhibiting photothermal purification abilities from seawater and wastewater containing organic dyes and heavy metals. This study sheds light on the rational design of scalable and low-cost devices for solar water evaporation and purification. | Jiahui Chen Dainan Zhang Song He Gengpei Xia Xiaoyi Wang Quanjun Xiang Tianlong Wen Zhiyong Zhong Yulong Liao | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 12 | Enhanced chemical trapping and catalytic conversion of polysulfides by diatomite/MXene hybrid interlayer for stable Li-S batteries显示文摘Lithium-Sulfur (Li-S) batteries with high theoretical energy density are promising energy storage systems in the next decades, while the lithium polysulfides (LiPSs) shuttling caused by the sluggish sulfur redox reaction severely lowers the practical performance. The use of interlayer between the cathode and separator has been widely investigated to physically or chemically block the LiPSs, while the introduction of catalytic materials is a more effective strategy to accelerate the conversion of LiPSs. MXene with rich surface chemistry has shown its potential for facilitating the catalytic conversion, however, the aggregation of MXene sheets usually leads to the loss of the catalytic active sites. Herein, we report a diatomite/MXene (DE/MX) hybrid material as the bifunctional interlayer for improving the adsorption/conversion of LiPSs in Li-S batteries. The diatomite with porous structure and rich silica-hydroxyl functional groups could trap LiPSs effectively, while prevent the aggregation of MXene. The DE/MX based interlayer showed bifunctions of enhancing the chemical adsorption and promoting the conversion of LiPSs. The Li-S batteries with the DE/MX interlayer delivered an improved cycling stability with a low capacity decay of 0.059% per cycle over 1000 cycles at 1.0 C. Moreover, stable 200 cycles can be realized with a high sulfur loading electrode up to 6.0 mg cm^(−2). This work provides an effective strategy to construct bifunctional interlayers for hindering the shuttling of LiPSs and boosting the practical application of Li-S batteries. | Zehui Fan Chen Zhang Wuxing Hua Huan Li Yan Jiao Jingyi Xia Chuan-Nan Geng Rongwei Meng Yingxin Liu Quanjun Tang Ziyang Lu Tongxin Shang Guowei Ling Quan-Hong Yang | 2021 | Journal of Energy Chemistry2021，30，11： | 1 |
| 13 | Design and fabrication of a six-dimensional wrist force/torque sensor based on E-type membranes compared to cross beams显示文摘 | Qiaokang Liang Dan Zhang Quanjun Song | | 0，，43： | 1 |
| 14 | Improved empirical DC I-V model for 4H-SiC MESFETs显示文摘A novel empirical large signal direct current(DC) I-V model is presented consider-ing the high saturation voltage,high pinch-off voltage,and wide operational range of drain voltage for 4H-SiC MESFETs.A comparison of the presented model with Statz,Materka,Curtice-Cubic,and recently reported 4H-SiC MESFET large signal I-V models is made through the Levenberg-Marquardt method for fitting in nonlin-ear regression.The results show that the new model has the advantages of high accuracy,easily making initial value and robustness over other models.The more accurate results are obtained by the improved channel modulation and saturation voltage coefficient when the device is operated in the sub-threshold and near pinch-off region.In addition the new model can be implemented to CAD tools di-rectly,using for design of 4H-SiC MESFET based RF&MW circuit,particularly MMIC(microwave monolithic integrate circuit). | CAO QuanJun ZHANG YiMen ZHANG YuMing LV HongLiang WANG YueHu TANG XiaoYan GUO Hui | 2008 | Science in China(Series F)2008，51，8： | 1 |
| 15 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 16 | Sampled-data synchronization of coupled harmonic oscillators with controller failure and communication delays显示文摘In this letter,a distributed protocol for sampled-data synchronization of coupled harmonic oscillators with controller failure and communication delays is proposed,and a brief procedure of convergence analysis for such algorithm over undirected connected graphs is provided.Furthermore,a simple yet generic criterion is also presented to guarantee synchronized oscillatory motions in coupled harmonic oscillators.Subsequently,the simulation results are worked out to demonstrate the efciency and feasibility of the theoretical results. | Jin Zhou Hua Zhang Lan Xiang Quanjun Wu | 2013 | Theoretical & Applied Mechanics Letters2013，3，6： | 1 |
| 17 | InfluenceofperformanceofmodifiedasphaltbynativerockGasphalt显示文摘 | FanLiang Shen Quanjun Zhang Yanyan | 2007 | JournalofBuidingMaterials2007，10，4： | 1 |
| 18 | Synthesis and surface modification of uniform barium borate nanorods for lubrication显示文摘 | Ning Liu Yumei Tian Lianxiang Yu Quanjun Li Fanyu Meng Yunhui Zheng Guangyu Zhang Zhihui Liu Jing Li Fuming Jiang | 2007 | Journal of Alloys and Compounds2007，，1： | 1 |
| 19 | Estimating soil erosion changes in the Wenchuan earthquake disaster area using geo-spatial information technology显示文摘 | Zhang Bing Jiao Quanjun Wu Yanhong | 2009 | Journal of Applied Remote Sensing2009，3，03： | 1 |
| 20 | Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model显示文摘Tumor lymph node(LN)metastasis seriously affects the treatment prognosis.Studies have shown that nanoparticles with size of sub-50 nm can directly penetrate into LN metastases after intravenous administration.Here,we speculate through introducing targeting capacity,the nanoparticle accumulation in LN metastases would be further enhanced for improved local treatment such as photothermal therapy.Trastuzumabtargeted micelles(<50 nm)were formulated using a unique surfactantstripping approach that yielded concentrated phthalocyanines with strong near-infrared absorption.Targeted micellar phthalocyanine(T-MP)was an effective photothermal transducer and ablated HT-29 cells in vitro.A HER2-expressing colorectal cancer cell line(HT-29)was used to establish an orthotopic mouse model that developed metastatic disease in mesenteric sentinel LN.T-MP accumulated more in the LN metastases compared to the micelles conjugated with control IgG.Following surgical resection of the primary tumor,minimally invasive photothermal treatment of the metastatic LN with T-MP,but not the control micelles,extended mouse survival.Our findings demonstrate for the first time that targeted small-sized nanoparticles have potential to enable superior paradigms for dealing with LN metastases. | Hai‑Yi Feng Yihang Yuan Yunpeng Zhang Hai‑Jun Liu Xiao Dong Si‑Cong Yang Xue‑Liang Liu Xing Lai Mao‑Hua Zhu Jue Wang Qin Lu Quanjun Lin Hong‑Zhuan Chen Jonathan F.Lovell Peng Sun Chao Fang | 2021 | Nano-Micro Letters2021，13，11： | 1 |
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