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| 1 | Improved Base Editor for Efficiently Inducing Genetic Variations in Rice with CRISPR/Cas9- Guided Hyperactive hAID Mutant显示文摘 | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 46 |
| 2 | A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice显示文摘Dear Editor,Gene-targeting technologies using sequence specific nucleases have been widely adopted to induce genetic modifications in both plant molecular biology research and crop improvement,of which generating targeted point mutation for gain-of-function phenotype is of great value.Although tremendous efforts have been made in developing geneinsertion or replacement approaches by | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Honghui Lin Huanbin Zhou | 2017 | Science China(Life Sciences)2017，60，5： | 28 |
| 3 | Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘 | Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 26 |
| 4 | Somatic Embryogenesis Receptor Kinases Control Root Development Mainly via Brassinosteroid-Independent Actions in Arabidopsis thaliana显示文摘Brassinosteroids(BRs),a group of plant steroidal hormones,play critical roles in many aspects of plant growth and development.Previous studies showed that BRI1-mediated BR signaling regulates cell division and differentiation during Arabidopsis root development via interplaying with auxin and other phytohormones.Arabidopsis somatic embryogenesis receptor-like kinases(SERKs),as co-receptors of BRI1,were found to play a fundamental role in an early activation step of BR signaling pathway.Here we report a novel function of SERKs in regulating Arabidopsis root development.Genetic analyses indicated that SERKs control root growth mainly via a BR-independent pathway.Although BR signaling pathway is completely disrupted in the serk1 bak1 bkk1 triple mutant,the root growth of the triple mutant is much severely damaged than the BR deficiency or signaling null mutants.More detailed analyses indicated that the triple mutant exhibited drastically reduced expression of a number of genes critical to polar auxin transport,cell cycle,endodermis development and root meristem differentiation,which were not observed in null BR biosynthesis mutant cpd and null BR signaling mutant bri1-701. | Junbo Du Hongju Yin Shasha Zhang Zhuoyun Wei Baolin Zhao Jinghua Zhang Xiaoping Gou Honghui Lin Jia Li | 2012 | Journal of Integrative Plant Biology2012，54，6： | 22 |
| 5 | Cas9-NG Greatly Expands the Targeting Scope of the Genome-Editing Toolkit by Recognizing NG and Other Atypical PAMs in Rice显示文摘CRISPR technologies enabling precise genome manipulation are valuable for gene function studies and molecular crop breeding. However, the requirement of a protospacer adjacent motif (PAM)y such as NGG and TTN, for Cas protein recognition restricts the selection of targetable genomic loci in practical applications of CRISPR technologies. Recently Cas9-NG, which recognizes a minimal NG PAM, was reported to expand the targeting space of genome editing in human cells, but it remains unclear whether this Cas9 variant can be used in plants. In this study, we evaluated the nuclease activity of Cas9-NG toward various NGN PAMs by targeting endogenous genes in transgenic rice. We found that Cas9-NG edits all NGG, NGA, NGT, and NGC sites with impaired activity, while the gene-edited plants were dominated by monoallelic mutations. Cas9-NG-engineered base editors were then developed and used to generate O s B Z R I gainof- function plants that can not be created by other available Cas9-engineered base editors. Moreover, we showed that a Cas9-NG-based transcriptional activator efficiently upregulated the expression of endogenous target genes in rice. In addition, we discovered that Cas9-NG recognizes NAC, NTG, NTT, and NCG apart from NG PAM. Together, these findings demonstrate that Cas9-NG can greatly expand the targeting scope of genome-editing tools, showing great potential for targeted genome editing, base editing, and genome regulation in plants. | Bin Ren Lang Liu Shaofang Li Yongjie Kuang Jingwen Wang Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2019 | Molecular Plant2019，12，7： | 18 |
| 6 | Oxidation behavior of Mo-Si-B alloys at medium-to-high temperatures显示文摘Continuous exploration of high-temperature structural materials is being driven by the needs of gasturbine engines capable of withstanding the high-temperature environment.Relatively low melting points of currently applied superalloys restrain the further improvement of service tempe ratures.With higher melting tempe ratures above 2000℃,Mo-Si-B alloys are regarded as a new generation of ultrahightemperature structural materials.However,oxidation is a concern for the industrial application of Mo-Si-B alloys.Therefore,an in-depth understanding of the oxidation mechanisms may contribute to solving this issue,whereas relevant reviews about their recent advances are lacking.In the current work,a comprehensively systematic review about the oxidation behaviors of Mo-Si-B alloys is described for this purpose. | Kunming Pan Yanping Yang Shizhong Wei Honghui Wu Zhili Dong Yuan Wu Shuize Wang Laiqi Zhang Junping Lin Xinping Mao | 2021 | Journal of Materials Science & Technology2021，，1： | 5 |
| 7 | SHY2 as a node in the regulation of root meristem development by auxin, brassinosteroids, and cytokinin显示文摘In multicellular organisms,the balance be-tween cell division and differentiation determines organ size,and represents a central unknown in devel-opmental biology.In Arabidopsis roots,this balance is mediated between cytokinin and auxin through a reg-ulatory circuit converging on the IAA3/SHORT HYPO-COTYL 2(SHY2)gene.Here,we show that crosstalk between brassinosteroids(BRs)and auxin occurs in the vascular transition zone to promote root meristem de-velopment.We found that BR increases root meristem size by up-regulating expression of the PINFORMED 7(PIN7)gene and down-regulating expression of the SHY2 gene.In addition,BES1 could directly bind to the pro-moter regions of both PIN7 and SHY2,indicating that PIN7 and SHY2 mediate the BR-induced growth of the root meristem by serving as direct targets of BES1.Moreover,the PIN7 overexpression and loss-of-function SHY2 mutant were sensitive to the effects of BR and could partially suppress the short-root phenotypes associated with deficient BR signaling.Interestingly,BRs could inhibit the accumulation of SHY2 protein in response to cytokinin.Taken together,these findings suggest that a complex equilibrium model exists in which regulatory interactions among BRs,auxin,and cytokinin regulate optimal root growth. | Taotao Li Xinke Kang Wei Lei Xiuhong Yao Lijuan Zou Dawei Zhang Honghui Lin | 2020 | Journal of Integrative Plant Biology2020，62，10： | 5 |
| 8 | Novel cyclen-based linear polymer as a high-affinity binding material for DNA condensation显示文摘A novel cyclen-based linear polyamine (POGEC) was designed and synthesized from the reaction between 1,3-propanediol diglycidyl ether and 1,7-bis(diethoxyphosphory)-1,4,7,10-tetraazacyclod-odecane. High-affinity binding between POGEC and DNA was demonstrated by agarose gel electrophoresis and scanning electron microscopy (SEM). Moreover,the formed POGEC/DNA complex (termed polyplex) could be disassociated to release the free DNA through addition of the physiological concentration of NaCl solution. Fluorescence spectrum was used to measure the high-affinity binding and DNA condensation capability of POGEC. Circular dichroism (CD) spectrum indicates that the DNA conformation did not change after binding to POEGC. | XIANG YongZhe WANG Na ZHANG Ji LI Kun ZHANG ZhongWei LIN HongHui YU XiaoQi | 2009 | Science China Chemistry2009，52，4： | 3 |
| 9 | Chlorine dioxide treatment decreases respiration and ethylene synthesis in fresh‐cut ‘ H ami’ melon fruit显示文摘 | Qin Guo Xin Lv Fei Xu Yuli Zhang Jide Wang Honghui Lin Bin Wu | 2013 | Int J Food Sci Technol2013，，9： | 2 |
| 10 | Revealing complex optical phenomena through vectorial metrics显示文摘Advances in vectorial polarization-resolved imaging are bringing new capabilities to applications ranging from fundamental physics through to clinical diagnosis.Imaging polarimetry requires determination of the Mueller matrix(MM)at every point,providing a complete description of an object’s vectorial properties.Despite forming a comprehensive representation,the MM does not usually provide easily interpretable information about the object’s internal structure.Certain simpler vectorial metrics are derived from subsets of the MM elements.These metrics permit extraction of signatures that provide direct indicators of hidden optical properties of complex systems,while featuring an intriguing asymmetry about what information can or cannot be inferred via these metrics.We harness such characteristics to reveal the spin Hall effect of light,infer microscopic structure within laser-written photonic waveguides,and conduct rapid pathological diagnosis through analysis of healthy and cancerous tissue.This provides new insight for the broader usage of such asymmetric inferred vectorial information. | Chao He Jintao Chang Patrick S.Salter Yuanxing Shen Ben Dai Pengcheng Li Yihan Jin Samlan Chandran Thodik Mengmeng Li Aziz Tariq Jingyu Wang Jacopo Antonello Yang Dong Ji Qi Jianyu Lin Daniel S.Elson Min Zhang Honghui He Hui Ma Martin J.Booth | 2022 | Advanced Photonics2022，4，2： | 2 |
| 11 | ZnO nanorod light-emitting diodes fhbricated by electrochemical approaches 显示文摘 | Guo Honghui Zhou Jianzhang Lin Zhonghua | 2008 | Electrochemistry Communications2008，，10： | 1 |
| 12 | ZnO nanorod light-emitting diodes fabricated by electrochemical approaches 显示文摘 | Honghui Guo Jianzhang Zhou Zhonghua Lin | 2008 | Electrochem Commun2008，10，： | 1 |
| 13 | A coevolutionary framework of business-IT alignment via the lens of enterprise architecture显示文摘Due to the turbulent external business environment, the complexity of internal relations of the organization and the emergence of subversive IT roles, the business-IT alignment(BITA)has become increasingly difficult. The unsuccessful realization of BITA will lead to the waste of organizational resources, the reduction of return on investment and eventually the loss of competitive advantage. In recent years, coevolution has received widespread attention due to its ability to describe the dynamic relationship between IT and business. Multiple principles such as quickening learning action loops and adopt suitable organizing principles for achieving business and IT coevolution(BITC) are obtained. However, the continuous BITC is still hard to be achieved because of the lack of complete BITC management. This paper focuses on the management process of the BITC and how to perform it gradually. A coevolution framework combines the enterprise architecture(EA) approach with the coevolution analysis is proposed, which contains the design of EA, the sensing and governance of the misalignment and the procedure of the EA misalignment prevention.The steps for the governance and prevention of misalignment are discussed in particular. Through comparison with the principles,characteristics and methods of coevolution in the literature, the proposed framework is evaluated. The results show that the proposed framework is effective for BITC implementation. | LIN Menglong YI Shuanghui ZHANG Mengmeng CHEN Tao CHEN Honghui ZHANG Xiaoxue | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 1 |
| 14 | Role of salicylic acid in plant abiotic stress显示文摘 | YUAN Shu LIN Honghui | 2008 | Z Naturforsch2008，63，： | 1 |
| 15 | BAK1 and BKK1 Regulate Brassinosteroid-Dependent Growth and Brassinosteroid-Independent Cell-Death Pathways显示文摘 | Kai He Xiaoping Gou Tong Yuan Honghui Lin Tadao Asami Shigeo Yoshida Scott D. Russell Jia Li | 2007 | Current Biology2007，，13： | 1 |
| 16 | OTS_1-dependent deSUMOylation increases tolerance to high copper levels in Arabidopsis显示文摘The conjugation of SUMO(small ubiquitin-like modifier) to protein substrates is a reversible process(SUMOylation/deSUMOylation) that regulates plant development and stress responses. The essential metal copper(Cu) is required for normal plant growth, but excess amounts are toxic. The SUMO E_3 ligase, SIZ_1, and SIZ_1-mediated SUMOylation function in plant tolerance to excess Cu. It is unknown whether deSUMOylation also contributes to Cu tolerance in plants. Here, we report that OTS_1, a protease that cleaves SUMO from its substrate proteins,participates in Cu tolerance in Arabidopsis thaliana(Arabidopsis). OTS_1 loss-of-function mutants(ots_(1-2) and ots_(1-3))displayed increased sensitivity to excess Cu. Redox homeostasis and the balance between SUMOylation and deSUMOylation were disrupted in the ots_(1-3) mutant under excess Cu conditions. The ots_(1-3) mutant accumulated higher levels of Cu in both shoots and roots compared to wild type.Specific Cu-related metal transporter genes were upregulated due to the loss-of-function of OTS_1, which might explain the high Cu levels in ots_(1-3). These results suggest that the SUMOylation/deSUMOylation machinery is activated in response to excess Cu, and modulates Cu homeostasis and tolerance by regulating both Cu uptake and detoxification. Together, our findings provide insight into the biological function and regulatory role of SUMOylation/deSUMOylation in plant tolerance to Cu. | Erbao Zhan Huapeng Zhou Sha Li Lei Liu Tinghong Tan Honghui Lin | 2018 | Journal of Integrative Plant Biology2018，60，4： | 1 |
| 17 | BAK1 and BKK1 Regulate Brassinosteroid-Dependent Growth and Brassinosteroid-Independent Cell-Death Pathways显示文摘 | Kai He Xiaoping Gou Tong Yuan Honghui Lin Tadao Asami Shigeo Yoshida Scott D. Russell Jia Li | 2007 | Current Biology2007，，13： | 1 |
| 18 | Plant regeneration through somatic embryogenesis from callus cultures of Dioscorea zingiberensis 显示文摘 | Yuan Shu Yan Yingcai Lin Honghui | 2005 | PCTOC2005，80，2： | 1 |
| 19 | Chlorine dioxide treatment decreases respiration and ethylene synthesis in fresh‐cut ‘ H ami’ melon fruit显示文摘 | Qin Guo Xin Lv Fei Xu Yuli Zhang Jide Wang Honghui Lin Bin Wu | 2013 | Int J Food Sci Technol2013，，9： | 1 |
| 20 | Plant regeneration through somatic embryogenesis from callus cultures of Dioscorea zingiberensis显示文摘 | Yuan Shu Yan Yingcai Lin Honghui | 2005 | Plant Cell Tissue and Organ Culture2005，80，： | 1 |
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