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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | ZONAL DISINTEGRATION MECHANISM OF DEEP CRACK-WEAKENED ROCK MASSES UNDER DYNAMIC UNLOADING显示文摘Size and quantity of fractured zone and non-fractured zone are controlled by cracks contained in deep rock masses.Zonal disintegration mechanism is strongly dependent on the interaction among cracks.The strong interaction among cracks is investigated using stress super-position principle and the Chebyshev polynomials expansion of the pseudo-traction.It is found from numerical results that crack nucleation,growth and coalescence lead to failure of deep crack-weakened rock masses.The stress redistribution around the surrounding rock mass induced by unloading excavation is studied.The effect of the excavation time on nucleation,growth,inter-action and coalescence of cracks was analyzed.Moreover,the inffuence of the excavation time on the size and quantity of fractured zone and non-fractured zone was given.When the excavation time is short,zonal disintegration phenomenon may occur in deep rock masses.It is shown from numerical results that the size and quantity of fractured zone increase with decreasing excavation time,and the size and quantity of fractured zone increase with the increasing value of in-situ geostress. | Xiaoping Zhou Qihu Qian Bohu Zhang | 2009 | Acta Mechanica Solida Sinica2009，22，3： | 15 |
| 3 | Clinical Characteristics of Hospitalized Patients with SARS-CoV-2 and Hepatitis B Virus Co-infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)is a global pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).SARS-Co V-2 infection was first detected in Wuhan,China in late December 2019.The virus was spreading rapidly to other cities of China and accumulating cases had been reported(Li et al.2020). | Xiaoping Chen Qunqun Jiang Zhiyong Ma Jiaxin Ling Wenjia Hu Qian Cao Pingzheng Mo Lei Yao Rongrong Yang Shicheng Gao Xien Gui Wei Hou Yong Xiong Jinlin Li Yongxi Zhang | 2020 | Virologica Sinica2020，35，6： | 6 |
| 4 | Selection of DNA aptamer that specific binding human carcinoembryonic antigen in vitro显示文摘客观: 选择 carcinoembryonic 抗原(CEA ) 的特定的恰当的 amer,为癌症的最吸引人的分子之一指向治疗和成像。方法:在 vitro 选择的七个回合对净化的 CEA 蛋白质被执行。调停 Ligand 的目标纯化和 Co-immunoprecipitation 被采用验证恰当的 amer 的特定的绑定到净化并且本国的蛋白质独立。能绑两个的 ResultsrThe CEA 特定的恰当的 amer 净化,有高特性的本国的蛋白质被获得。结论: 这是 CEA 特定的 apatmer 被生产的第一次。在这的结果学习以后为 CEA-aptamer 的进一步的调查和申请提供初步的证据。 | Lifeng Wang Baorui Liu Haitao Yin Jia Wei Xiaoping Qian Lixia Yu | 2007 | Journal of Nanjing Medical University2007，21，5： | 5 |
| 5 | Experimental investigation of rigid confinement effects of radial strain on dynamic mechanical properties and failure modes of concrete显示文摘In this study,to confirm the effect of confining pressure on dynamic mechanical behavior and failure modes of concrete,a split Hopkinson pressure bar dynamic loading device was utilized to perform dynamic compressive experiments under confined and unconfined conditions.The confining pressure was achieved by applying a lateral metal sleeve on the testing specimen which was loaded in the axial direction.The experimental results prove that dynamic peak axial stress,dynamic peak lateral stress,and peak axial strain of concrete are strongly sensitive to the strain rate under confined conditions.Moreover,the failure patterns are significantly affected by the stress-loading rate and confining pressure.Concrete shows stronger strain rate effects under an unconfined condition than that under a confined condition.More cracks are created in concrete subjected to uniaxial dynamic compression at a higher strain rate,which can be explained by a thermal-activated mechanism.By contrast,crack generation is prevented by confinement.Fitting formulas of the dynamic peak stress and dynamic peak axial strain are established by considering strain rate effects(50–250 s-1)as well as the dynamic confining increase factor(DIFc). | Pengfei Liu Xiaoping Zhou Qihu Qian | 2021 | International Journal of Mining Science and Technology2021，31，5： | 4 |
| 6 | THE ZONAL DISINTEGRATION MECHANISM OF SURROUNDING ROCK AROUND DEEP SPHERICAL TUNNELS UNDER HYDROSTATIC PRESSURE CONDITION: A NON-EUCLIDEAN CONTINUUM DAMAGE MODEL显示文摘A new non-Euclidean continuum damage model is proposed to investigate the zonal disintegration phenomenon of the surrounding rocks around deep spherical tunnels under hydrostatic pressure condition as well as the total elastic stress field distributions.The elastic stress fields of the surrounding rocks around deep spherical tunnels under hydrostatic pressure condition are obtained.If the elastic stresses of the surrounding rocks satisfy the strength criterion of the deep rock masses,the number,size and location of fractured and nonfractured zones are determined.The efect of physico-mechanical parameters of the surrounding rocks on the zonal disintegration phenomenon is studied and numerical computation is carried out.It is found from numerical results that the number,size and location of fractured and non-fractured zones are sensitive to the physico-mechanical parameters of the surrounding rocks. | Xiaoping Zhou Qinghong Hou Qihu Qian Yongxing Zhang | 2013 | Acta Mechanica Solida Sinica2013，26，4： | 4 |
| 7 | Fargeted elimination of mutant mitochondria DNA in MELAS-iPSCs by mitoTALENs显示文摘 | Yi Yang Han Wu Xiangjin Kang Yanhui Liang Ting Lan Tianjie Li Tao Tan Jiangyun Peng Quanjun Zhang Geng An Yali Liu Qian Yu Zhenglai Ma Ying Lian Boon Seng Soh Qingfeng Chen Ping Liu Yaoyong Chen Xiaofang Sun Rong Li Xiumei Zhen Yang Yu Xiaoping Li Yong Fan | 2018 | Protein & Cell2018，9，3： | 4 |
| 8 | Materials,preparation,performances and mechanism of polyurethane modified asphalt and its mixture:A systematic review显示文摘With the rapid development of asphalt pavement technology,it has attracted considerable attention to improving the durability of asphalt pavement.An effective action is to use modified asphalt with high performance and durability.Polyurethane(PU)has been used in asphalt pavement engineering to enhance the durability and service life of asphalt pavement because of its excellent high-temperature performance,toughness,wear resistance,aging resistance and oil resistance.However,PU modified asphalt technology is still in the exploratory stage.The preparation,modification mechanism and working performances of PU modified asphalt need to be further clarified.Therefore,this paper summarized the research progress of PU modified asphalt and its mixture.The composition of PU modified asphalt was introduced.The addition methods of PU materials and preparation process parameters of the PU modified asphalt were determined.The modification mechanism of PU on asphalt was discussed.The effects of polyurethane on asphalt were analyzed and the road performances of its mixture were evaluated.Finally,the development tendency towards PU modified asphalt and its mixture were forecasted. | Chaohui Wang Shuai Huang Qian Chen Xiaoping Ji Kaixi Duan | 2023 | Journal of Road Engineering2023，3，1： | 4 |
| 9 | Effects of culture conditions on ligninolytic enzymes and protease production by Phanerochaete chrysosporium in air显示文摘由 Phanerochaete chrysosporium 的 ligninolytic 酶和朊酶的生产在不同文化条件下面被调查。媒介的不同数量在免费、使不能调动的文化被采用,和二种有点不同的 C/N 比率。小木质素过氧化物酶(嘴唇)(< 2U/L ) 与氮有限媒介在免费文化被检测(C/N 比率:56/2.2,在 mmol/L ) 锰过氧化物酶(MnP ) 最大值活动分别地是在 50 和 100 ml 媒介文化的 231 和 240 U/L。有 50 ml 氮有限媒介的使不能调动的文化在日子 5 上独立与 410 和 721 U/L 的最大的价值给了最高的 MnP 和嘴唇生产;然而,包含 100 ml 氮有限媒介的烧瓶仅仅与 290 U/L 的山峰价值生产了更少的 MnP。比较地,碳有限媒介(C/N 比率:28/44,在 mmol/L ) 在文化被采用,但是生产了小 MnP 和嘴唇。媒体类型在朊酶生产上有最大的影响。大量朊酶由于葡萄糖限制被生产。文化类型和中等体积由影响氧供应团结地影响朊酶活动。结果暗示浅使不能调动的文化是获得 ligninolytic 酶的高生产的一个可能的方法。 | XIONG Xiaoping WEN Xianghua BAI Yanan QIAN Yi | 2008 | Journal of Environmental Sciences2008，20，1： | 4 |
| 10 | THE CONSTITUTIVE RELATION OF CRACK-WEAKENED ROCK MASSES UNDER AXIAL-DIMENSIONAL UNLOADING显示文摘An accurate and effcient numerical method for solving the crack-crack interaction problem is presented. The method is mainly by means of the dislocation model, stress superposition principle and Chebyshev polynomial expansion of the pseudo-traction. This method can be applied to compute the stress intensity factors of multiple kinked cracks and multiple rows of periodic cracks as well as the overall strains of rock masses containing multiple kinked cracks under complex loads. Many complex computational examples are given. The dependence of the crack-crack interaction on the crack configuration, the geometrical and physical parameters, and loads pattern, is investigated. By comparison with numerical results under confining pressure unloading, it is shown that the crack-crack interaction under axial-dimensional unloading is weaker than those under confining pressure unloading. Numerical results for single faults and crossed faults show that the single faults are more unstable than the crossed faults. It is found from numerical results for different crack lengths and different crack spacing that the interaction among kinked cracks decreases with an increase in length of the kinked cracks and the crack spacing under axial-dimensional unloading. | Xiaoping Zhou Qihu Qian Yongxing Zhang | 2008 | Acta Mechanica Solida Sinica2008，21，3： | 4 |
| 11 | Upconversion nanoparticles@AgBiS_(2) core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers显示文摘UCNPs@AgBiS_(2) core-shell nanoparticles that AgBiS_(2) coated on the surface of upconversion nanoparticles (UCNPs) was successfully prepared through an ion exchange reaction. The photothermal conversion efficiency of AgBiS_(2) can be improved from 14.7% to 45% due to the cross relaxation between Nd ions and AgBiS_(2). The doping concentration of Nd ions played a critical role in the production of reactive oxygen species (ROS) and enhanced the photothermal conversion efficiency. The NaYF4:Yb/Er/Nd@NaYF4:Nd nanoparticles endows strong upcon-version emissions when the doped concentration of Nd ions is 1% in the inner core, which excites the AgBiS_(2) shell to produce ROS for photodynamic therapy (PDT) of cancer cells. As a result, the as-prepared NaYF4:Yb/Er/ Nd@NaYF4:Nd@AgBiS_(2) core-shell nanoparticles showed combined photothermal/photodynamic therapy (PTT/ PDT) against malignant tumors. This work provides an alternative near-infrared light-active multimodal nano-structures for applications such as fighting against cancers. | Zhaoyou Chu Tian Tian Zhenchao Tao Juan Yang Benjin Chen Hao Chen Wanni Wang Peiqun Yin Xiaoping Xia Hua Wang Haisheng Qian | 2022 | Bioactive Materials2022，7，11： | 3 |
| 12 | Effects of arsenic trioxide on drug transporting molecules in multidrug resistance malignant neoplasma MR2 cell line显示文摘客观:在药的表示上学习砷三氧化物(As_2O_3 ) 的效果搬运分子在多药抵抗恶意的瘤一根 acutepromyelocytic 白血病(APL ) MR_2 房间线。方法:对 all-trans retinoic 酸(ATRA ) 和 non-ATRA 抵抗的 MR_2 抵抗 APL 房间线 NB4 被使用。P-glycoprotein (Pgp ) 的表情,多药抵抗蛋白质(MRP ) 和肺抵抗相关的蛋白质(LRP ) 被检测 byimmunocytochemical 试金。结果: Pgp 的表示在 NB4 (10%-20%)比那在 MR_2 (30%-40%)是显著地更高的( P < 0.001 ),并且 MRP 的表示在 MR_2 也是更高的( 56.9 ±3 .4 ~ 21.2 ± 1.1 )比那在 NB_4 ( 20.6 ± 5.3 ~ 16.7 ± 1.2 )( P < 0.001 )。As_2O_3 变化 from0.5-2.0 μ m ol/L 能显著地减少 Pgp 和 MRP 的表情。在 MR_2 房间线的 Pgpand MRP 的表示否定地与行动 ofAs_2O_3 的剂量和持续时间被相关。结论:Pgp 和 MRP 可以是到 overcomedrug 抵抗的 As_2O_3 的敏感目标。ATRA 可能是 Pgp 和 MRP 的底层。 | Xiaoping Qian Baorui Liu Yang Yang Lifeng Wang Zhengyun Zou Weiwei Kong Juan Du | 2006 | Journal of Nanjing Medical University2006，20，3： | 3 |
| 13 | Analysis on the types of chemokines expressed by the murine thymic epithelial cell line MTEC1显示文摘Six kinds of chemokines including SDF-1α, IP-10, KG, RANTES, MCP-1 and Lymphotactin have been amplified using the primers designed by ourselves with RT-PCR from the total RNA of a medullary-type murine thymic epithelial cell line MTEC1 cells. The amplified cDNA fragments of the chemokines have been identified by nucleotide sequencing and Northern blot analysis. The results demonstrate that there are two different splicing forms of SDF-1 mRNA existing in MTEC1. The concentrated culture supernatant of MTEC1 shows an intermediate level of chemotaxis to CD4-CD8- thymocytes, which conforms to the biological function of SDF-1. | Laiping Xie Xiaoping Qian Sunyou Gong Weifeng Chen | 2000 | Chinese Science Bulletin2000，45，12： | 3 |
| 14 | STABILITY ANALYSIS OF TWO-DIMENSIONAL LANDSLIDES SUBJECTED TO SEISMIC LOADS显示文摘In the past, the pseudo-static method used to be the most common for evaluating the stability of landslides under seismic loads, in which static forces acting on the center of gravity of a sliding body are used to consider the effects of earthquake. However, seismic loads of rock and soil differ from time and location to time and location. Obviously, it is irrational for the pseudo-static approach to be applied to solving dynamic problems. In this paper, a displacementpseudo-dynamic model is proposed to assess seismic stability of landslides, in which the sinusoidalcosinusoidal wave is applied to simulating earthquake displacement, and an 'amplification factor'of peak seismic displacement is referred to as the amplification of seismic wave when it propagates from the bottom to the top of the landslide. The effects of physico-mechanical behaviors of a sliding body on seismic stability of soil slopes are taken into account as well as inertia forces and damping forces. The sensitivity analyses on the permanent displacement and the dynamic factor of safety of landslides are studied in detail. Moreover, a large-scale Tangjiashan landslide that occurred in Wenchuan earthquake is investigated to verify the robustness and precision of the present method.It is found that the results from the present method is in good agreement with those from the previous method. | Xiaoping Zhou Qihu Qian Hao Cheng Haipeng Zhang | 2015 | Acta Mechanica Solida Sinica2015，28，3： | 3 |
| 15 | Hyperthermia enhances the anticancer-drug induced cytotoxicity in hepatocellular carcinoma cell line SMMC-7721显示文摘Objective: Hyperthermia is an attractive addition to multidisciplinary approaches to clinical cancer treatment. The efficiency of hyperthermia depends on the elevation of the temperature and the duration of treatment. It has been reported that in vitro and in vivo hyperthermia enhanced the cytotoxic effect of certain anticancer drugs. However, this enhancement varies, depending on the drug used and the scheduling of treatments. Thus, the combination effect of chemotherapy and hyperthermia remains unclear. In this study, we aimed to investigate whether concurrent exposure of human hepatocellular carcinoma cells SMMC-7721 to chemotherapeutic agents andhyperthermia could increase anticancer effects. Methods: Two chemotherapeutic agents, cisplatin and hydroxycamptothecin, were applied. The MTT assay was performed to evaluate the growth inhibition of SMMC-7721 induced by anticancer drugs with and without hyperthermia. Flow cytometric analysis was used for the assessment of apoptosis after treatments. Results: The percentages of growth inhibition of SMMC-7721 induced by cisplatin(10 μg/ml) alone, hydroxycamptothecin (1 μg/ml) alone, hyperthermia alone, cisplatin and hyperthermia, hydroxycamptothecin and hyperthermia, were 20.77%, 13.65%, 32.46%, 62.76%, 71.89%, respectively. The percentages of apoptosis of five treatments are 5.56%, 3.96%, 10.16%, 24.32%, 20.42%, respectively. Conclusion: While both hyperthermia and anticancer drugs can individually induce apoptosis and anti-proliferation effect, the combination of the two treatments induce significantly higher apoptosis and cytotoxicity than hyperthermia or anticancer drugs treatment alone. These data suggest a synergistic benefit when hyperthermia and anticancer drugs used concurrently. | Yang Yang Baorui Liu Xiaoping Qian | 2006 | Journal of Nanjing Medical University2006，20，5： | 3 |
| 16 | p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer显示文摘The Rho family of GTPases is strictly regulated by a large family of GTPase-activating proteins(GAPs)that stimulate the relatively weak intrinsic GTP-hydrolyzing activity of Rho GTPases.p190A is a potent and widely expressed GAP that acts on RhoA GTPases.p190A is frequently mutated in endometrial cancer,but the contribution of p190A mutations to endometrial tumorigenesis remains unclear.Here we identified that p190A is an upstream regulator of the Hippo-YAP signaling pathway,which is a critical regulator of cell proliferation,apoptosis,and cell fate.p190A knockout in endometrial cancer cells promoted cell proliferation,migration,and epithelial–mesenchymal transition(EMT),which were partially dependent on YAP activation.Wild-type p190A,but not endometrial cancer-associated mutants,suppressed the nuclear localization,transcriptional activity,and malignant transformation function of YAP.Moreover,the nuclear localization of YAP was enhanced in p190A-mutated endometrial cancer.These findings reveal novel molecular mechanisms underlying Hippo-YAP pathway-driven endometrial tumorigenesis and elucidate the potential for therapy targeting the Hippo-YAP pathway in p190A-mutated endometrial cancer. | Xiaoli Wen Jing Wan Qizhi He Mengfei Wang Shuangdi Li Mei Jiang Zhen Qian Binya Liu Wen Lu Kai Wang Kun Gao Xiaoping Wan | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 17 | Functional analysis of three genetic disorder related PITX2 mutants显示文摘The autosome dominant disorders, ring dermoid of the cornea (RDC), iris hypolasia (IH) and Axenfeld-Rieger syndrome (ARS), are allelic disor- ders, as all three can result from mutations of the transcriptional factor PITX2. Among three disorder phenotypes, ARS is the most severe, IH is milder than ARS, and RDC is the mildest. Missense muta- tions of the PITX2 homeodomain identified in RDC (R62H), IH (R84W) and ARS patients (T68P) were introduced into PITX2 cDNA by site-directed mutagenesis. PITX2 mutant proteins expressed in eucaryotic cells were stable and localized to the nu- cleus. Analysis of these mutant PITX2 proteins by DNA-binding shift and transactivation studies dem- onstrated that the R62H had the most activity in both studies, and the R84W still retained somewhat func- tions, whereas the T68P proved to be non-functional. These results are consistent with previous hypothesis that varying amount of residual PITX2 mutant activity could underline the severity of these phenotypes. | WANG Guo LIU Xiaoping PAN Qian LIANG Desheng WU Qianling DAI Heping ZHU Feizhou XIA Kun XIA Jiahui | 2006 | Chinese Science Bulletin2006，51，2： | 3 |
| 18 | THE EFFECTS OF THREE-DIMENSIONAL PENNY-SHAPED CRACKS ON ZONAL DISINTEGRATION OF THE SURROUNDING ROCK MASSES AROUND A DEEP CIRCULAR TUNNEL显示文摘In this study, it was assumed that three-dimensional penny-shaped cracks existed in deep rock masses. A new non-Euclidean model was established, in which the effects of pennyshaped cracks and axial in-situ stress on zonal disintegration of deep rock masses were taken into account. Based on the non-Euclidean model, the stress intensity factors at tips of the pennyshaped cracks were determined. The strain energy density factor was applied to investigate the occurrence of fractured zones. It was observed from the numerical results that the magnitude and location of fractured zones were sensitive to micro- and macro-mechanical parameters, as well as the value of in-situ stress. The numerical results were in good agreement with the experimental data. | Xiaoping Zhou Qihu Qian Hanfei Song | 2015 | Acta Mechanica Solida Sinica2015，28，6： | 2 |
| 19 | Bone-targeting melphalan prodrug with tumor-microenvironment sensitivity: Synthesis, in vitro and in vivo evaluation显示文摘Bone tumor is a refractory neoplastic growth of tissue in bone. According to the unique environment and phys-chemical characteristics of bone tissues, the chemotherapeutic agents are unlikely to prolong the survival of patients and often associated with systemic side effects. The bone targeting drug delivery via systemic administration may provide both better treatment efficacy and less frequent administration. In this study, we describe the synthesis, in vitro and in vivo evaluation of novel melphalan-bisphosphonate hybrids, with a tumor microenvironment sensitive linkage, which could be enzymatic activation under tumor microenvironment conditions. We have also evaluated the in vitro targeting efficiency of these prodrugs via the affinity of hydroxyapatite(HA) and cellular proliferation. The in vivo distribution suggested the bisphosphonate conjugated prodrugs with high bone selectivity. | Can Chen Yiyan Li Xiaoping Yu Qinglin Jiang Xiaohong Xu Qian Yang Zhiyong Qian | 2018 | Chinese Chemical Letters2018，29，11： | 2 |
| 20 | A multifunctional biomedical patch based on hyperbranched epoxy polymer and MXene显示文摘Biomedical patches play fundamental roles in various applications such as wound closure and tissue regeneration.The hybrid patches integrating versatile properties will prominently improve the therapeutic effects in clinical applications.Herein,an epoxy network loading curcumin and Ti3 C2 TxMXenes were developed as a hybrid biomedical patch.The hybrid patch was basically prepared through an epoxy/thiol curing chemistry,and its topological structure can be destructed and rearranged as a vitrimer does due to the active transesterification at high temperature.The resulted hybrid patch exhibits shape-morphing capability,multi-substrate adhesion,self-healing ability,and photothermal effects under 980 nm near infrared(NIR).Additionally,the asprepared hybrid patch possesses strong UV-shielding,excellent oxidation resistance(ROS scavenging efficiency was 89.3%in3 min),highly effective antibacterial vitality(more than 99%)against S.aureus and E.coli,and good cytocompatibility.As a proof of concept,the present multifunctional hybrid patch broadens the potential applications in the biomedical field. | ZOU Yang JIN Xin ZHANG XiaoPing KONG XiaoLing ZHANG Qian XIE XianHua LIU ChangJun KE LinNan LIU WenGuang WANG Wei | 2021 | Science China(Technological Sciences)2021，64，12： | 2 |
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