|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 42,573 cases of hepatectomy in China: a multicenter retrospective investigation显示文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival. | Binhao Zhang Bixiang Zhang Zhiwei Zhang Zhiyong Huang Yifa Chen Minshan Chen Ping Bie Baogang Peng Liqun Wu Zhiming Wang Bo Li Jia Fan Lunxiu Qin Ping Chen Jingfeng Liu Zhe Tang Jun Niu Xinmin Yin Deyu Li Songqing He Bin Jiang Yilei Mao Weiping Zhou Xiaoping Chen | 2018 | Science China(Life Sciences)2018，61，6： | 39 |
| 2 | The Relationship between Jurassic Coal Measures and Sandstone-type Uranium Deposits in the Northeastern Ordos Basin,China显示文摘Outcrop and drill hole data show that the Jurassic coal measures in the northeastern Ordos Basin are composed mainly of the Yan'an Formation and the lowstand system tract of the Zhiluo Formation,and there is a regional unconformity between them. The Dongsheng uranium deposit is associated with the Jurassic coal measures. Research data indicate that the Jurassic coal measures in the study area have a certain hydrocarbon-generating capacity,although the metamorphic grade is low(Ro=0.40%–0.58%). In the Dongsheng region alone,the accumulative amount of generated coalbed methane(CBM) is about 2028.29 × 108 –2218.72 × 108 m^3; the residual amount is about 50.92 × 108 m^3,and the lost amount is about 1977 × 108 m^3. Analysis of the burial history of the host rocks and the evolutionary history of the Dongsheng uranium deposit suggests that the Jurassic coal measures generated hydrocarbon mainly from Middle Jurassic to Early Crataceous,which is the main mineralization phase of the Dongsheng uranium deposit. By the Late Cretaceous,a mass of CBM dissipated due to the strong tectonic uplift,and the Dongsheng uranium deposit stepped into the preservation phase. Therefore,the low-mature hydrocarbon-containing fluid in the Jurassic coal measures not only served as a reducing agent for the formation of sandstone-type uranium deposits,but also rendered the second reduction of paleo-interlayer oxidation zone and become the primary reducing agent for ore conservation. Regional strata correlation reveals that the sandstone-type uranium reservoir at the bottom of the Zhiluo Formation is in contact with the underlying industrial coal seams in the Yan'an Formation through incision or in the form of an unconformity surface. In the Dongsheng region with poorly developed fault systems,the unconformity surface and scour surface served as the main migration pathways for low-mature hydrocarbon-containing fluid migrating to the uranium reservoir. | JIAO Yangquan WU Liqun RONG Hui PENG Yunbiao MIAO Aisheng WANG Xiaoming | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 24 |
| 3 | EW-trending uplifts along the southern side of the central segment of the Altyn Tagh Fault, NW China: Insight into the rising mechanism of the Altyn Mountain during the Cenozoic显示文摘The Altyn Tagh Fault and the Altyn Mountain define respectively the tectonic and geographical northern edges of the Tibetan Plateau, and figure prominently in the growth and rising mechanism of the plateau. The rhombus-shaped Altyn Mountain has long been thought to have an intimate relation with the Altyn Tagh Fault; however, its formation mechanism remains unclear and debatable. In this paper, we focus on the EW-trending uplifts in the Altyn Mountain, and investigated three Cenozoic sedimentary sections in the vicinity of the EW-trending uplifts located along the southern side of the central segment of the Altyn Tagh Fault. Magnetostratigraphy and pollen analysis were used to constrain ages of the sediments. Clast composition of conglomerate and paleocurrents obtained from clast imbrications were applied to determine the provenance. We also established a geological section parallel to the Altyn Tagh Fault on sedimentary facies across the northwestern Qaidam Basin. The results indicate that these en-echelon EW-trending uplifts formed as early as ca. 36 Ma and were preferred to be under the control of basal shear of the Altyn Tagh Fault in the middle-lower crust, symbolizing the early uplift of the Altyn Mountain during the Cenozoic. Left-slip along the Altyn Tagh Fault occurring during the Miocene and afterwards displaced and altered these uplifts, shaping the Altyn Mountain to its present fabric. | WU Lei XIAO AnCheng WANG LiQun MAO LiGuang WANG Liang DONG YouPu XU Bo | 2012 | Science China Earth Sciences2012，55，6： | 21 |
| 4 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 5 | Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis显示文摘 | Yongting Luo Hongxia Duan Yining Qian Liqun Feng Zhenzhen Wu Fei Wang Jing Feng Dongling Yang Zhihai Qin Xiyun Yan | 2017 | Cell Research2017，27，3： | 18 |
| 6 | Comparison of anti-atherosclerotic effects of two different extracts from leaves of Mallotus furetianus显示文摘Objective:To compare the anti-atherosclerotic effects of two different extracts from the leaves of Mallotus fiiretianus by using rat model of atherosclerosis.Methods:The air-flriefl powdered Mallotus fiiretianus leaves were extracted with ethanol and then evaporated.The ethanol extract was experienced Diaion HP-20 CC with a gradient of MeOH and H2O(50:50,100:0,v/v) and two fractions,Mallotus fiiretianus A(Mf A) and Mallotus fiiretianus B(MfB) were obtained.RaLs were divided into control,atherosclerosis and vitamin E,Mf A and Mf B treated groups.Atherosclerotic model was established by administering u loading dose of vitamin D3 and feeding standard diet enriched with 2%cholesterol,0.5%porcine chelate,0.2%methimazole,5%sugar,10%pork fat. Vitamin E(0.20 g/kg),Mf A(0.053 g/kg),Mf B(0.057 g/kg)(with the potential) were administered to interfere with the development of atherosclerosis.After 9 weeks,rats were sacrificed and the blood lipid as well as composition of bile was examined.In addition,the thoracic aorta was harvested to evaluate histological changes and the intima-media thickness ratio.Results: Atherosclerosis model was successfully established,administration of vitamin E,Mf A and Mf B increased excretion of total bilirubin in bile,decreased triglycridc(TO),total cholesterol(TC), low density lipoprotein-cholesterol(LDL-C) level,enhanced ratio of high density lipoprotein-cholesterol and LDL-C in blood,improved histological changes and diminished intimamedia thickness ratio of thoracic aorta in atherosclerotic rats.As for the difference in antiatherosclerotic effects between Mf A and MfB,Mf A may be more powerful in declining TG level and Mf B may be more effective in decreasing TC level.Conclusions:The two different extracts. Mf A and Mf B can prevent the development of atherosclerosis.In detail,Mf A is more effective in regulating TG level and Mf B is more powerful in modulating TC.level in atherosclerotic rats. | Liu Yueli Wang Liqun Wu Haitao Lin Lianbo Yi Xinan | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 15 |
| 7 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 8 | Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most common causes of cancer worldwide.Although many studies have focused on oncogene characteristics,the genomic landscape of Chinese HCC patients has not been fully clarified.Methods:A total of 165 HCC patients,including 146 males and 19 females,were enrolled.The median age was 55 years(range,27-78 years).Corresponding clinical and pathological information was collected for further analysis.A total of 168 tumor tissues from these patients were selected for next-generation sequencing(NGS)-based 450 panel gene sequencing.Genomic alterations including single nucleotide variations(SNV),short and long insertions and deletions(InDels),copy number variations,and gene rearrangements were analyzed.Tumor mutational burden(TMB)was measured by an algorithm developed in-house.The top quartile of HCC was classified as TMB high.Results:A total of 1,004 genomic alterations were detected from 258 genes in 168 HCC tissues.TMB values were identified in 160 HCC specimens,with a median TMB of 5.4 Muts/Mb(range,0-28.4 Muts/Mb)and a 75%TMB of 7.7 Muts/Mb.The most commonly mutated genes were TP53,TERT,CTNNB1,AXIN1,RB1,TSC2,CCND1,ARID1A,and FGF19.SNV was the most common mutation type and C:G>T:A and guanine transformation were the most common SNVs.Compared to wild-type patients,the proportion of Edmondson grade III-IV and microvascular invasion was significantly higher in TP53 mutated patients(P<0.05).The proportion of tumors invading the hepatic capsule was significantly higher in TERT mutated patients(P<0.05).The proportion of Edmondson grade I-II,alpha fetoprotein(AFP)<25μmg/L,and those without a history of hepatitis B was significantly higher in CTNNB1 mutated patients(P<0.05).CTNNB1 mutations were associated with TMB high in HCC patients(P<0.05).Based on correlation analysis,the mutation of TP53 was independently correlated with microvascular invasion(P=0.002,OR=3.096)and Edmondson grade III-IV(P=0.008,OR=2.613).The mutation of TERT was independently correlated with tumor invasion of the liver capsule(P=0.001,OR=3.030),and the mutation of CTNNB1 was independently correlated with AFP(<25μmg/L)(P=0.009,OR=3.414).Conclusions:The most frequently mutated genes of HCC patients in China were TP53,TERT,and CTNNB1,which mainly lead to the occurrence and development of HCC by regulating the P53 pathway,Wnt pathway,and telomere repair pathway.There were more patients with microvascular invasion and Edmondson III-IV grade in TP53 mutated patients and more patients with hepatic capsule invasion in TERT mutated patients,while in CTNNB1 mutated patients,there were more patients with Edmondson I-II grade,AFP<25μmg/L,and a non-hepatitis B background.Also,the TMB values were significantly higher in CTNNB1 mutated patients than in wild type patients. | Shuo Wang Huasheng Shi Tao Liu Manjiang Li Sanshun Zhou Xuan Qiu Zusen Wang Weiyu Hu Weidong Guo Xiaoqian Chen Honglin Guo Xiaoliang Shi Junping Shi Yunjin Zang Jingyu Cao Liqun Wu | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 8 |
| 9 | Cenozoic tectonic and sedimentary evolution of southern Qaidam Basin, NE Tibetan Plateau and its implication for the rejuvenation of Eastern Kunlun Mountains显示文摘The Eastern Kunlun Mountains play an important role in the growth and eastward extrusion of the Tibetan Plateau. Tectonic and sedimentary study of the Cenozoic Qaidam Basin, especially the southern part, provides key evidence for understanding their evolution. Here we present evidence including isopach maps, seismic sections and sedimentary analysis of single well to illustrate the sedimentary development of the basin and the structural features of its southern margin. The Qaidam Basin extended across Qiman Tagh-Eastern Kunlun Mountains in the early Cenozoic and withdrew northward at ca. 35.5 Ma, and then buckled as an EW striking elliptical depression since ca. 14.9 Ma, with the main depocenter migrating eastward. Our results support the view that the Kumukol and Hoh Xil basins joined the Qaidam Basin in the early Cenozoic time and we propose the Eastern Kunlun Mountains uplifted in the mid-Miocene. | MAO LiGuang XIAO AnCheng WU Lei LI BenLiang WANG LiQun LOU QianQian DONG YouPu QIN SuHua | 2014 | Science China Earth Sciences2014，57，11： | 7 |
| 10 | Distribution and risk factors of hand, foot, and mouth disease in Changchun, northeastern China显示文摘Hand,foot,and mouth disease(HFMD)is a public health problem,and there have been increasing numbers of outbreaks in China's Mainland since 2008.Over17,000 HFMD cases have been reported in Changchun between 2008 and 2011.This study characterized the temporal and spatial distribution of the disease and identified the risk factors for HFMD.The main findings were as follows:(i)there were significant differences in HFMD incidence among age groups,with 86.8%of reported cases in children younger than 5 years old,and boys showed a higher incidence than girls(\6 years);(ii)The disease affected the whole region and spanned a large geographic area,but there was a higher incidence in urban areas(median=242 per 10,000 persons)and urban–rural border areas(median=135 per 10,000 persons),compared with rural areas(median=75 per 10,000 persons);and(iii)the incidence of HFMD in Changchun was significantly associated with the distance to the nearest freeway,GDP per capita,and the type of township. | Li Yan Xinlou Li Yaqin Yu Sake J.de Vlas Yapin Li Dandan Wang Yanli Li Yuan Yin Jing Wu Hong Liu Hong Yang Bo Li Liqun Fang Wuchun Cao | 2014 | Chinese Science Bulletin2014，59，5： | 7 |
| 11 | Relations of Uranium Enrichment and Carbonaceous Debris within the Daying Uranium Deposit, Northern Ordos Basin显示文摘Carbonaceous debris(CD)is widely distributed in the sandstone of the Daying Uranium Deposit,northern Ordos Basin,and coexists with uranium minerals,which provides a favorable case for studying their relationship.Vitrinite reflectance(VR),macerals,moisture,volatile matter,ash,total sulfur(S_t)and uranium concentration of CD within the sandstone were studied.The results show that VR ranges from 0.372%Ro to 0.510%Ro with an average value of 0.438%Ro,indicating that CD is in the stage of lignite.The contents of vitrinite(V),inertinite(I)and minerals range from 83.18%–99.48%,0–7.70%,and 0.34%–15.72%,respectively,with the corresponding average value of 95.51%,1.34%,and 3.15%,respectively which indicates that V is the major maceral.Moisture on air dried basis(M_(ad)),volatile matter yield on dry,ash-free basis(V_(daf)),ash yield on dried basis(A_d)and S_t mostly range from 7.95%–16.09%,44.70%–66.54%,4.84%–26.24% and 0.24%–1.12%,respectively,while their average values are 12.43%,53.41%,16.57% and 0.77%,respectively.It suggests that CD is of medium-high moisture,super-high volatile matter,low-medium ash and low sulfur.Uranium concentration ranges from 29 ppm to 92 ppm with an average value of 50 ppm,and uranium concentration increases with the decreased distance to CD.On the whole,M_(ad )and V_(daf) decrease with increasing burial depth,which indicates that CD experienced the burial metamorphism.However,M_(ad) and V_(daf) obviously decrease in uranium-rich areas whereas A_d and S_(t )noticeably increase.Comprehensive studies suggest that there is a certain relationship between uranium enrichment and CD.CD in the stage of lignite helps the adsorption of uranium.On one hand,radioactivity uranium enrichment makes organic matter maturation increase with a decrease in moisture and volatile matter.On the other hand,an increase in organic matter maturation,caused by radioactivity uranium enrichment,results in an increase in uranium minerals,which is instructive in the study of regional uranium mineralization and metallogenic regularity. | Fan Zhang Yangquan Jiao Liqun Wu Hui Rong Longhui Wang | 2019 | Journal of Earth Science2019，30，1： | 6 |
| 12 | Quasi-phase-matching-division multiplexing holography in a three-dimensional nonlinear photonic crystal显示文摘Nonlinear holography has recently emerged as a novel tool to reconstruct the encoded information at a new wavelength,which has important applications in optical display and optical encryption.However,this scheme still struggles with low conversion efficiency and ineffective multiplexing.In this work,we demonstrate a quasi-phasematching(QPM)-division multiplexing holography in a three-dimensional(3D)nonlinear photonic crystal(NPC).3D NPC works as a nonlinear hologram,in which multiple images are distributed into different Ewald spheres in reciprocal space.The reciprocal vectors locating in a given Ewald sphere are capable of fulfilling the complete QPM conditions for the high-efficiency reconstruction of the target image at the second-harmonic(SH)wave.One can easily switch the reconstructed SH images by changing the QPM condition.The multiplexing capacity is scalable with the period number of 3D NPC.Our work provides a promising strategy to achieve highly efficient nonlinear multiplexing holography for high-security and high-density storage of optical information. | Pengcheng Chen Chaowei Wang Dunzhao Wei Yanlei Hu Xiaoyi Xu Jiawen Li Dong Wu Jianan Ma Shengyun Ji Leran Zhang Liqun Xu Tianxin Wang Chuan Xu Jiaru Chu Shining Zhu Min Xiao Yong Zhang | 2021 | Light(Science & Applications)2021，10，8： | 5 |
| 13 | Effects of different tillage and straw retention practices on soil aggregates and carbon and nitrogen sequestration in soils of the northwestern China显示文摘Soil tillage and straw retention in dryland areas may affect the soil aggregates and the distribution of total organic carbon. The aims of this study were to establish how different tillage and straw retention practices affect the soil aggregates and soil organic carbon(SOC) and total nitrogen(TN) contents in the aggregate fractions based on a long-term(approximately 15 years) field experiment in the semi-arid western Loess Plateau, northwestern China. The experiment included four soil treatments, i.e., conventional tillage with straw removed(T), conventional tillage with straw incorporated(TS), no tillage with straw removed(NT) and no tillage with straw retention(NTS), which were arranged in a complete randomized block design. The wet-sieving method was used to separate four size fractions of aggregates, namely, large macroaggregates(LA, >2000 μm), small macroaggregates(SA, 250–2000 μm), microaggregates(MA, 53–250 μm), and silt and clay(SC, <53 μm). Compared to the conventional tillage practices(including T and TS treatments), the percentages of the macroaggregate fractions(LA and SA) under the conservation tillage practices(including NT and NTS treatments) were increased by 41.2%–56.6%, with the NTS treatment having the greatest effect. For soil layers of 0–5, 5–10 and 10–30 cm, values of the mean weight diameter(MWD) under the TS and NTS treatments were 10.68%, 13.83% and 17.65%, respectively. They were 18.45%, 19.15% and 14.12% higher than those under the T treatment, respectively. The maximum contents of the aggregate-associated SOC and TN were detected in the SA fraction, with the greatest effect being observed for the NTS treatment. The SOC and TN contents were significantly higher under the NTS and TS treatments than under the T treatment. Also, the increases in SOC and TN levels were much higher in the straw-retention plots than in the straw-removed plots. The macroaggregates(including LA and SA fractions) were the major pools for SOC and TN, regardless of tillage practices, storing 3.25–6.81 g C/kg soil and 0.34–0.62 g N/kg soil. Based on the above results, we recommend the NTS treatment as the best option to boost soil aggregates and to reinforce carbon and nitrogen sequestration in soils in the semi-arid western Loess Plateau of northwestern China. | WU Jun Yeboah STEPHEN CAI Liqun ZHANG Renzhi QI Peng LUO Zhuzhu LI Lingling XIE Junhong DONG Bo | 2019 | Journal of Arid Land2019，11，4： | 5 |
| 14 | Architectural Units and Groundwater Resource Quantity Evaluation of Cretaceous Sandstones in the Ordos Basin,China显示文摘Sandstone is a common lithology in a number of groundwater reservoirs. Studying the skeleton sandstone architectural units, therefore, lays the basis for characterizing aquifer systems, groundwater quality, and resource evaluation. This comprehensive analysis of Cretaceous aquiferous sandstones in the Ordos basin, China, shows that there exists a basin-scale skeleton sandstone in the Luohe Formation which contains 11 isolated barrier beds, 12 small skeleton sandstone bodies in Huanhe Formation, and 3 in the Luohandong Formation. The spatial structure and superimposed relationship as well as the medium properties of these skeleton sandstones and isolated barrier beds can be shown by 3D visualization models. Simultaneously, resource quantity can be evaluated with the 3D inquiry functions. The comparison between property models and structural models indicates that the salinity of groundwater of the Luohe Formation has a close connection with the locations of isolated barrier beds that contain abundant gypsum. Through quantitative calculation, groundwater resource of the Cretaceous Luohe and Luohandong formations is estimated to be 1.6×10^(12) m^3, and the total groundwater resource of the Cretaceous system in the Ordos basin is more than 2×10^(12) m^3. | WU Liqun JIAO Yangquan ZHU Peimin LEI Xinrong WANG Yonghe | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 5 |
| 15 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 16 | Occurrence, thermal evolution and primary migration processes derived from studies of organic matter in the Lucaogou source rock at the southern margin of the Junggar Basin, NW China显示文摘The Lucaogou Formation carbonate-rich oil shale source rock is exposed at the southern margin of the Junggar Basin, Xinjiang, NW China. We have sampled it in detail and conducted microstructural, mineralogical and geochemical studies, including thin section petrography, UV fluorescence petrography, X-ray diffraction, vitrinite reflectance, bitumen reflectance, fluid inclusion analysis and Raman spectroscopy. Organic matter is disseminated through the carbonate-bearing siltstone source rocks and concentrated in numerous bedding parallel stylolites and in two sets of carbonate veins, one along bedding parallel fractures and the other cross-cutting stylolites and bedding. The research about maturity of organic matter finds vitrinite reflectance values increase from the dispersed kerogen (0.64%) to the stylolites (the one of oriented vitrinite is 0.72% and the one of migrated bitumen is 2.38%); Homogenization temperatures of fluid inclusions in veins containing hydrocarbon fluid inclusions show an increase from 178.5℃ in the bedding parallel veins to 222℃ in the cross-cutting veins, confirmed by Raman spectroscopy. These results support a model of progressive heating accompanied by fluid loss during later stages of thermal maturation of source rock and the onset of primary migration. Obviously, the occurrence of organic matter is the trace of hydrocarbon primary migration, and the bedding lamination surfaces and cross-cutting fissures are the principal pathways of hydrocarbon-bearing fluids migration. Bedding lamination surfaces evolved into stylolites along the earliest primary migration pathways, followed by bedding parallel and cross-cutting fissures. | JIAO YangQuan WU LiQun HE MouChun ROGER Mason WANG MinFang XU ZhiCheng | 2007 | Science China Earth Sciences2007，50，z2： | 4 |
| 17 | Comparative study of the effects of Danhong injection with different doses on ischemic stroke: A substudy of hospital-based Danhong injection registry显示文摘OBJECTIVE: To compare the effects of Danhong injection(DHI) with different doses on ischemic stroke.METHODS: Chinese hospital registered DHI study is a perspective observational study, in which a total of 1292 patients with ischemic stroke were treated with DHI. Two different doses of DHI were used in the present study. The patients were matched by acute phase of ischemic stroke(within 2 weeks after onset), partial anterior circulation infraction, sex, age, and National Institute of Health Stroke Scale(NIHSS) score. Finally 148 patients were grouped into the 20 or 40 mL DHI group with 74 in each. The primary endpoint was the improvement of NIHSS score at 14-day after treatment.RESULTS: Of the 148 patients with ischemic stroke,the 74 in the 40 mL DHI group had clinically important improvements in the NIHSS score. The baseline and 14-day NIHSS score for the 40 mL DHI group were 6.6 ± 4.3 and 2.4 ± 2.5 respectively, versus 6.3± 5.7 and 3.6 ± 4.2, for the 20 mL DHI group(change from baseline in the 40 mL DHI group vs change from baseline in the 20 mL DHI group,-1.49points; P = 0.029). Improvements were maintained after the baseline characteristics and other drugs were controlled(P = 0.012). No adverse events were observed.CONCLUSION: Effects of DHI on partial anterior circulation infarction in patients with acute phase of ischemic stroke is dose-dependent; however, further studies with larger sample sizes are needed to validate our findings(Chinese Clinical Trial Register,Number: ChiCTR-ONC-13003230). | Du Yawei Wang Xiaoxia Zhong Liqun Wu Shengxian | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
| 18 | B7-DC (PD-L2) costimulation of CD4^(+) T-helper 1 response via RGMb显示文摘The role of B7-DC in T-cell responses remains controversial because both coinhibitory and costimulatory functions have been reported in various experimental systems in vitro and in vivo.In addition to interacting with the coinhibitory receptor PD-1,B7-DC has also been shown to bind repulsive guidance molecule b(RGMb).The functional consequences of the B7-DC/RGMb interaction,however,remain unclear.More than a decade ago,we reported that replacement of a murine B7-DC mutant lysine with serine(K113S)at positive 113 resulted in a loss of binding capacity to PD-1.Nevertheless,K113S remained costimulatory for T cells in vitro,implicating a dual functionality for B7-DC in T-cell responses.Here we show that recombinant K113S protein interacts with RGMb with a similar affinity to wild-type B7-DC.More importantly,K113S costimulates CD4^(+)T-cell responses via RGMb and promotes Th1 polarization.RGMb is expressed on the surface of naive mouse T cells,macrophages,neutrophils and dendritic cells.Finally,K113S/RGMb costimulation suppresses Th2-mediated asthma and ameliorates small airway inflammation and lung pathology in an experimental mouse model.Our findings indicate that RGMb is a costimulatory receptor for B7-DC.These findings from the K113S variant provide not only a possible explanation for the B7-DC-triggered contradictory effects on T-cell responses,but also a novel approach to investigate the B7-DC/PD-1/RGMb axis.Recombinant K113S or its derivatives could potentially be developed as an agonist for RGMb to costimulate the Th1 response without triggering PD-1-mediated T-cell inhibition. | Xinxin Nie Wenni Chen Ying Zhu Baozhu Huang Weiwei Yu Zhanshuai Wu Sizheng Guo Yiping Zhu Liqun Luo Shengdian Wang Lieping Chen | 2018 | Cellular & Molecular Immunology2018，15，10： | 3 |
| 19 | CHARACTERISTICS OF DROPLET TRANSFER IN CO_2 LASER-MIG HYBRID WELDING WITH SHORTCIRCUITING MODE显示文摘有 4.5 公里厚度的 LF6 铝合金盘子在这个实验被焊接。焊接被使用 CO_2 激光执行 -- 米格式飞机同等在扁平的位置的轴的混合焊接。试验性的结果显示常规米格式飞机弧的固有的微滴转移周期时间在激光的电路 theshort 模式由于在 CO_2 激光横梁和米格式飞机弧之间的相互作用被改变 -- 焊接的米格式飞机混血儿。因为到电极和基础材料的 CO_2 激光的预热行动,米格式飞机弧的微滴转移频率在混合焊接进程被增加。当激光力量被增加到某个度时,微滴转移频率由于导致激光的锁眼的效果被减少。而且,通过分析 MIGwelding 电流和弧电压,波形和微滴的特征在微滴转移的频率上在混合焊接过程,激光精力的效果和在激光横梁和弧之间的行动点转,焊接外观在细节被调查。 | LEI Zhenglong CHEN Yanbin LI Liqun WU Lin | 2006 | Chinese Journal of Mechanical Engineering2006，19，2： | 3 |
| 20 | Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry显示文摘Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment. | Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang Shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He Xueli Cai Maimai Ti Osama O Zaidat | 2022 | Stroke & Vascular Neurology2022，7，2： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员