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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 3 | A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo显示文摘排序 nexins (SNX )phosphoinositide 有约束力的蛋白质在在 vitro 排序各种各样的膜蛋白质被含有,但是在里面他们的 vivo 功能仍然保持大部分未知。我们以前报导 SNX10 是 SNX 家庭基因的一个独特成员因为它在房间举办 vacuolation 活动。我们在这研究由 loss-of-function 试金调查 SNX10 的生物功能并且证明 SNX10 在有教养的房间为主要的睫的形成被要求。在 zebrafish, SNX10 为内脏的机关的左右的 patterning 在 Kupffer 的泡和必需品涉及 ciliogenesis。机械学地, SNX10 与复杂的 V-ATPase 交往并且指向它到 ciliogenesis 被开始的中心体。象 SNX10 一样, V-ATPase 在 vitro 并且在 vivo 调整 ciliogenesis 并且对 SNX10 那么 synergistically 做。我们进一步发现 SNX10 和 V-ATPase 调整 Rab8a 的睫的 trafficking,它是睫的膜扩展的一个批评管理者。这些结果识别为 ciliogenesis 是关键的一条 SNX10/V-ATPase-regulated 小囊的 trafficking 小径,并且表明通过在各种各样的机关的睫形成的规定, SNX10/V-ATPase 在早胚胎的开发期间起一个必要作用。 | Yanqun Chen Bin Wu Liangliang Xu Huapeng Li Jianhong Xia Wenguang Yin Zhuo Li Dawei Shi Song Li Shuo Lin Xiaodong Shu Duanqing Pei | 2012 | Cell Research2012，22，2： | 4 |
| 4 | Selective synthesis of SnO_2 hollow microspheres and nano-sheets via a hydrothermal route显示文摘We report a mild template-free hydrothermal route for selective synthesis of SnO2 hollow microspheres and nano-sheets using SnCl2 and NaOH as initial materials.By switching the solvent from water to ethanol,the formed SnO2 nanostructures changed from nano-sheets to hollow microspheres.The obtained nano-sheets were single crystalline in structure.On the basis of the characterization of intermediate products,the formation of SnO2 hollow microspheres was ascribed to a crystal growth process,while the formation of SnO2 nano-sheets was ascribed to the oxidation of SnO2 sheets during the hydrothermal process.Further characterization of the SnO2 hollow microspheres and nano-sheets by X-ray photoelectron spectroscopy and UV-Vis absorption spectroscopy reveals different optical absorption properties and valence band electronic structures.In addition,the SnO2 nano-sheets and hollow microspheres exhibit different sensing properties.The present work provides a facile and simple template-free method for the synthesis of nano-structured SnO2. | LI Yue GUO YanQun TAN RuiQin CUI Ping LI Yong SONG WeiJie | 2010 | Chinese Science Bulletin2010，55，7： | 3 |
| 5 | Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice显示文摘Gynostemma pentaphyllum,also called'Southern Ginseng'in China,is a traditional Asian folk medicinal plant.Gypenosides(Gps)are the biologically active constituents of G.pentaphyllum,which have been reported with hypoglycemic activity.However,the underlying mechanisms are unclear.The effects of two Gps(Gp-Ⅰand Gp-Ⅱ)on type 2 diabetic mellitus(T2DM)mice,induced by high-fat and high-sugar diet and streptozotocin,were evaluated to explore the mechanism of their hypoglycemic actions.Gps reduced fasting blood glucose and serum lipids,as well as significantly improved T2DM mice glucose tolerance and insulin resistance(IR).After Gps treatment,the severity of liver injury was reduced and liver glycogen content increased.In addition,Gps promoted the phosphorylation of adenosine monophosphate-activated protein kinase(AMPK),and downregulated the key proteins phosphoenolpyruvate carboxy kinase and glucose-6 phosphatase,in the AMPK signaling pathway.Thus,our study suggests that Gps mediate hepatic gluconeogenesis and improve IR via activating AMPK signaling pathway in T2DM mice. | Mengxue Song Dehong Tan Bin Li Yanqun Wang Lin Shi | 2022 | Food Science and Human Wellness2022，11，5： | 1 |
| 6 | Service customization:To upgrade or to downgrade?An investigation of how option framing affects tourists’choice of package-tour services显示文摘 | LIYIN JIN YANQUN HE HAIYAN SONG | 2012 | Tourism Management2012，，33： | 1 |
| 7 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 8 | Simultaneous Desorption of Polycyclic Aromatic Hydrocarbons and Heavy Metals from Contaminated Soils by Rhamnolipid Biosurfactants显示文摘Hydrophobic organic compounds(HOCs)and heavy metals(HMs)are toxins that usually coexist in natural environments.Due to the differences in their properties,it remains challenging to simultaneously remove HMs and HOCs.In this study,the removal of phenanthrene(Phe)and lead(Pb)from co-contaminated soils by single rhamnolipid(RL)and mixed RL-sophorolipid(SL)biosurfactants were evaluated via soil column experiments.Biosurfactant micelle sizes were determined by dynamic light scattering,and the mechanisms of micelle solubilization were studied.The effects of biosurfactant concentrations,pH,washing agent salinity and the ageing time of polluted soils on Phe and Pb desorption efficiencies were also assessed.The substantial removal of Phe and Pb using mixed RL-SL systems,when molar fractions of RLs were 0.7,was attributed to large mixed micelle formation and lower sorption losses of these systems.The optimal pH value was 6.0,while Phe desorption was favoured at high RLs and low ionic strengths.However,the RLs concentration and ionic strength had no obvious influence on Pb removal.In addition,both Phe and Pb desorption decreased with increased ageing of the polluted soils.Combined RL-SL biosurfactants can be effective for simultaneously removing HOCs and HMs from polluted soils. | WU Liang SONG Dandan YAN Lele LIANG Shengkang YANG Yanqun PENG Changsheng SHANG Yujun WANG Xiuli DONG Xueliang | 2020 | Journal of Ocean University of China2020，19，4： | 0 |
| 9 | Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine显示文摘Persistent asymptomatic(PA)SARS-CoV-2 infections have been identified.The immune responses in these patients are unclear,and the development of effective treatments for these patients is needed.Here,we report a cohort of 23 PA cases carrying viral RNA for up to 191 days.PA cases displayed low levels of inflammatory and interferon response,weak antibody response,diminished circulating follicular helper T cells(cTfh),and inadequate specific CD4+and CD8+T-cell responses during infection,which is distinct from symptomatic infections and resembling impaired immune activation.Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses,resulting in successful viral clearance.Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months,indicating long-term protection.Therefore,our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections. | Shaofu Qiu Zhao Chen Airu Zhu Qiuhui Zeng Hongbo Liu Xiaoqing Liu Feng Ye Yingkang Jin Jie Wu Chaojie Yang Qi Wang Fangli Chen Lan Chen Sai Tian Xinying Du Qingtao Hu Jinling Cheng Canjie Chen Fang Li Jing Sun Yanqun Wang Jingxian Zhao Jincun Zhao Hongbin Song | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 10 | Study on Agricultural Socialized Service System in Guangdong Province显示文摘This paper analyzed the current situation of the construction of agricultural socialized service system in Guangdong Province and summarizes five typical services,namely the public service,' company + base + farmer ',' company + research institute + base +farmer',' specialized cooperative + farmer',and ' government + enterprise + farmer'.In view of the existing problems in the construction of agricultural socialized service system in Guangdong Province,it came up with recommendations including making proper top level design,strengthening the construction efforts,actively cultivating service entities,improving the structure of information service system,and establishing and improving rural financial system. | Yanqun LIU Yuping LI Weihong LIANG Qidao SONG Lu YE Xiaoli QIN | 2017 | Asian Agricultural Research2017，9，12： | 0 |
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