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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis显示文摘Fatty acid oxidation(FAO)has been proven to be an accomplice in tumor progression.Carnitine palmitoyltransferase 1C(CPT1C),a rate-limiting enzyme in FAO,mainly functions to catalyze fatty acid carnitinylation and guarantee subsequent entry into the mitochondria for FAO in colorectal cancer(CRC).Gene expression data and clinical information extracted from The Cancer Genome Atlas(TCGA)database show significantly higher expression of CPT1C in patients with metastatic CRC(P=0.005).Moreover,overexpression of CPT1C is correlated with worse relapse-free survival in CRC(HR 2.1,P=0.0006),while no statistical significance is indicated for CPT1A and CPT1B.Further experiments demonstrate that downregulation of CPT1C expression leads to a decrease in the FAO rate,suppression of cell proliferation,cell cycle arrest and repression of cell migration in CRC,whereas opposite results are obtained when CPT1C is overexpressed.Furthermore,an FAO inhibitor almost completely reverses the enhanced cell proliferation and migration induced by CPT1C overexpression.In addition,analysis of TCGA data illustrates a positive association between CPT1C expression and HIF1αlevel,suggesting that CPT1C is a transcriptional target of HIF1α.In conclusion,CPT1C overexpression indicates poor relapse-free survival of patients with CRC,and CPT1C is transcriptionally activated by HIF1α,thereby promoting the proliferation and migration of CRC cells. | Jing Li Wanwei Zheng Jie Wu Jun Zhang Bin Lv Wenshuai Li Jie Liu Xin Zhang Tiansheng Huang Zhongguang Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 1 |
| 3 | Towards Sustainable Development Goals:Study on the Consequences of Food Insecurity Among Global Population—Worldwide,2022显示文摘Summary What is already known about this topic?The global population is predicted to reach 8 billion by the end of 2022,which can delay the progress and exacerbate the challenges of achieving the Sustainable Development Goals(SDGs),especially the goal of“Zero Hunger.”What is added by this report?During the next 15 years,it is predicted that the world’s population will increase from 8 billion to 9 billion people.Although food insecurity is anticipated to decrease over the next three decades for most of the world,food insecurity is anticipated to increase in Africa.Accelerating population growth is projected to lead to larger percentages of infants with low birth weight and of children under 5 years old with stunted growth.What are the implications for public health practice?Rapid population growth will make it more difficult to achieve the SDGs for ending hunger and ensuring good health and well-being.It is important to develop foresight and adopt proactive planning that is guided by careful demographic analysis. | Ping He Wanwei Dai Yanan Luo Ruoxi Ding Xiaoying Zheng | 2022 | China CDC weekly2022，4，27： | 1 |
| 4 | Identification and construction of a novel biomimetic delivery system of paclitaxel and its targeting therapy for cancer显示文摘Dear Editor,Paclitaxel(PTX)is among the frst-line therapeutic agents against diverse malignancies.However,problems still exist concerning its poor water-solubility,multidrug resistance,lack of specific targeting ability and severe toxic effects,and these issues are far from fully resolved despite the various PTX formulations available on.the market,e.g.the gold standard,PTX albumin nanoparticles Abraxane I and PTX liposomes Lipusu.Some studies that try to solve the multiple problems faced by chemotherapy drug delivery,however,fell into the prevailing trap of overcomplicated formulation design which sacrifices the druggability.To better reconcile this paradox,a novel glycosylated liposomal PTX was designed,inspired by the cytomembrane glycosyls with important roles in.maintaining both membrane structure and physiological functions,3 such as enhan-cing membrane stability,evading immunological clearance,and recognizing corresponding receptors.Ginsenosides,as natural amphiphilic molecules,are structurally similar to cholesterol,contain glycosyl moieties,and are easily obtainable. | Xue Wang Wanwei Zheng Qing Shen Yahua Wang Yujen Tseng Zhongguang Luo Xiaoyou Wang Lei Shi Chong Li Jie Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 5 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 6 | TRIM34 attenuates colon inflammation and tumorigenesis by sustaining barrier integrity显示文摘Loss of the colonic inner mucus layer leads to spontaneously severe colitis and colorectal cancer.However,key host factors that may control the generation of the inner mucus layer are rarely reported.Here,we identify a novel function of TRIM34 in goblet cells(GCs)in controlling inner mucus layer generation.Upon DSS treatment,TRIM34 deficiency led to a reduction in Muc2 secretion by GCs and subsequent defects in the inner mucus layer.This outcome rendered TRIM34-deficient mice more susceptible to DSS-induced colitis and colitis-associated colorectal cancer.Mechanistic experiments demonstrated that TRIM34 controlled TLR signaling-induced Nox/Duox-dependent ROS synthesis,thereby promoting the compound exocytosis of Muc2 by colonic GCs that were exposed to bacterial TLR ligands.Clinical analysis revealed that TRIM34 levels in patient samples were correlated with the outcome of ulcerative colitis(UC)and the prognosis of rectal adenocarcinoma.This study indicates that TRIM34 expression in GCs plays an essential role in generating the inner mucus layer and preventing excessive colon inflammation and tumorigenesis. | Qiaoshi Lian Shanshan Yan Qi Yin Chenghua Yan Wanwei Zheng Wangpeng Gu Xinhao Zhao Weiguo Fan Xuezhen Li Liyan Ma Zhiyang Ling Yaguang Zhang Jie Liu Jinsong Li Bing Sun | 2021 | Cellular & Molecular Immunology2021，18，2： | 0 |
| 7 | Current State and Challenges of Rehabilitation Needs Among Elderly-China,1990-2019显示文摘Summary What is already known about this topic?Rehabilitation is an essential part of achieving health for all,whereas the estimates of rehabilitation needs,especially for elderly individuals in China,are not clear.What is added by this report?Compared with 1990,the prevalence and years of life lived with disability for health conditions in need of rehabilitation in China increased by 71.3%and 77.0%in 2019,respectively,at a rate much higher than the global average.What are the implications for public health practices?This study mainly presents scientific data and a systematic analysis of the current state and challenges of rehabilitation needs for elderly individuals(aged 60 and above)in China based on the World Health Organization Rehabilitation Need Estimator. | Xin Guo Jiakang Huo Wanwei Dai Zhongyan Wang Jian Du Xiaoying Zheng Erdan Dong | 2022 | China CDC weekly2022，4，39： | 0 |
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