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| 1 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions显示文摘癌症房间被知道经历新陈代谢的 reprogramming 然而,支撑幸存和快速的增长 oncogenic 损害怎么在各种各样的强调条件下面协调新陈代谢的开关,尚待充分被阐明。这里,我们显示出葡萄糖或夫酸安的那剥夺,为癌症房间的二主要营养来源,被伴随由的戏剧性地激活的丝氨酸生合成小径(SSP ) 提高了 cMyc 表示。我们进一步鉴别那 cMyc 刺激了 SSP 激活由 transcriptionally 多重 SSP 酶的 upregulating 表示。而且,我们证明 cMyc 便于的 SSP 激活导致了提高的谷胱甘肽(GSH ) 生产,房间周期前进和 nucleic 酸合成,它在剥夺营养素的条件下面特别为房间幸存和增长是必要的。我们进一步揭开了那 phosphoserine 磷酸酶( PSPH ), SSP 小径的最后的限制率的酶,在 vitro 并且在 vivo 为 驾驶cMyc 的癌症前进是批评的,并且重要地, PSPH 的异常表示高度在 hepatocellular 与死亡被相关癌( HCC )病人,一般来说建议在这 调整cMyc 的酶,或 SSP 激活之间的一种潜在的原因的关系,并且癌症开发。一起拿,我们的结果表明 cMyc 的那异常表情导致提高的 SSP 激活,新陈代谢的开关的必要部分,在剥夺营养素的条件下面便于癌症前进。 | Linchong Sun Libing Song Qianfen Wan Gongwei Wu Xinghua Li Yinghui Wang Jin Wang Zhaoji Liu Xiuying Zhong Xiaoping He Shengqi Shen Xin Pan Ailing Li Yulan Wang Ping Gao Huiru Tang Huafeng Zhang | 2015 | Cell Research2015，25，4： | 33 |
| 2 | Bmi-1, stem cells and cancer显示文摘Bmi-1,一个 polycomb 基因家庭成员,在房间周期规定,房间不减,和房间老朽起一个重要作用。最近,众多的研究证明了 Bmi-1 涉及自强的规定和干细胞的区别。然而,位于这个生物过程下面的分子的机制仍然保持大部分不清楚。在现在的评论,我们作为基因表示的一个 transcriptional 管理者总结了 Bmi-1 的函数,与干细胞的特别参考。 | Lili Jiang Jun Li Libing Song | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 28 |
| 3 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 4 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 5 | Correlation between BRAF^(V600E) mutation and clinicopathological features in pediatric papillary thyroid carcinoma显示文摘In adults, the presence of the BRAF^(V600E) mutation in papillary thyroid cancer(PTC) has been demonstrated to be strongly associated with aggressive cancer-cell characteristics and poor patient prognosis. In contrast, the frequency of this mutation in pediatric PTC has undergone limited study, and the few available estimates range from 0 to 63%. Furthermore, the role of the BRAF^(V600E) mutation in pediatric PTC is controversial; thus, the present study aimed to investigate the prevalence and role of the BRAF^(V600E) mutation in48 pediatric patients with PTC, aged 3–13 years. Of these patients, 41 were diagnosed with classic PTC, five were found to have a follicular variant of PTC, and two to exhibit a diffuse sclerosing PTC variant. The BRAF^(V600E) mutation was identified to be present in 35.4% of the 48 analyzed patients, and in 41.5% of the patients diagnosed with classical PTC. Furthermore, the presence of the BRAF^(V600E) mutation was found to be associated with a patient age at diagnosis of less than ten years(P=0.011), the performance of a thyroidectomy(P=0.03), exhibited tumor multifocality(P=0.02) and/or extra-thyroidal invasion(P=0.003), and both a low MACIS(Metastases, Age, Completeness of resection, Invasion, Size)(P=0.036) and AMES(Age, Metastasis, Extent of tumor,Size)(P=0.001)score. Together, these data suggest that the presence of the BRAF^(V600E) mutation may be negatively correlated with partial aggressive clinicopathological features of pediatric PTC. | Jiangqiao Geng Huanmin Wang Yuanhu Liu Jun Tai Yaqiong Jin Jie Zhang Lejian He Libing Fu Hong Qin Yingluan Song Jinzhu Su Aiying Zhang Xin Wen Yongli Guo Xin Ni | 2017 | Science China(Life Sciences)2017，60，7： | 9 |
| 6 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 7 | miR-218 inhibits the invasive ability of glioma cells by direct downregulation of IKK-β显示文摘 | Libing Song Quan Huang Kun Chen Liping Liu Chuyong Lin Ting Dai Chunping Yu Zhiqiang Wu Jun Li | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 2 |
| 8 | HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression显示文摘 | De Huang Tingting Li Xinghua Li Long Zhang Linchong Sun Xiaoping He Xiuying Zhong Dongya Jia Libing Song Gregg L. Semenza Ping Gao Huafeng Zhang | 2014 | Cell Reports2014，，6： | 1 |
| 9 | Golgi phosphoprotein 3 ( GOLPH3 ) promotes hepatocellular carcinoma cell aggressiveness by activating the NF ‐κ B pathway显示文摘 | Ting Dai Dongsheng Zhang Muyan Cai Chanjuan Wang Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Dan Xie Jun Li Libing Song | 2015 | Pathol2015，，3： | 1 |
| 10 | Multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers显示文摘The mutation detections of KRAS and BRAF genes are of significant importance to predict the responses to anti-cancer therapy and develop new drugs. In this paper, we developed a multi-step fluorescence resonance energy transfer (FRET) assay for multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers (CCP). The newly established detection system could detect as low as 2% mutant DNAs in DNA admixtures. By triggering the emission intensity change of CCP and the dyes labeled in the DNA, four possible statuses (three mutations and one wildtype) can be differentiated in one extension reaction. The detection efficiency of this new method in clinical molecular diagnosis was validated by determining KRAS and BRAF mutations of 51 formalin-fixed paraffin-embedded (FFPE) ovary tissue samples. Furthermore, the result of the CCP-based multi-step FRET assay can be directly visualized under UV light so that no expensive instruments and technical expertise are needed. Thus, the assay provides a sensitive, reliable, cost-effective and simple method for the detection of disease-related gene mutations. | XING BaoLing SONG JinZhao GE SuMei TANG ZhengHua LIU MengLu YANG Qiong Lü FengTing LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，8： | 1 |
| 11 | MicroRNA-3Oe* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-K B/I K Bct negative feedback loop 显示文摘 | Lili Jiang Chuyong Lin Libing Song | 2012 | J Clin Invest2012，122，1： | 1 |
| 12 | Pre-judgment and Incomplete Allocation Approach for Query Result Cache显示文摘Query result caching is a crucial technique employed in search engines, reducing the response time and load of the search engines. As search engines continuously update their indexes, the query results in long-lived cache entries may become stale. It is important to provide the refresh mechanism to enhance the degree of freshness of cached results. We present a pre-judgment approach to improve the freshness of the result cache and design an incomplete allocation algorithm. We introduce the queryTime-to-live(TTL) and term-TTL structure to pre-judge the result cache. The query-TTL is used to pre-check the likelihood of a cache hit and term-TTL is applied to maintain all terms of the latest posting list. For the cache structure, we design a Queue-Hash structure and develop the corresponding incomplete allocation algorithm. The preliminary results demonstrate that our approaches can improve the freshness of cached results and decrease processing overhead compared with no pre-judgment approaches. | QIAN Libing JI Zhenzhou FU Zhongchuan WU Qianqian SONG Guangjia | 2016 | Chinese Journal of Electronics2016，25，6： | 1 |
| 13 | Sensitivity assessment of Phytophthora nicotianae to fungicides of fluazinam and its mixture with carboxylic acid amide显示文摘Tobacco black shank caused by Phytophthora parasitica var.nicotianae(Breda de Hean)is one of the most serious diseases in tobacco growing,and few effective fungicides are available currently.The purpose of this study was to assess the feasibility of using fluazinam to treat tobacco black shank disease.In vitro toxicities of fluazinam to 62 isolates of P.nicotianae were determined by mycelial growth rate method.The EC50 values ranged from 0.294 6 to 2.389 9 μg/mL with a mean of 1.084 0 μg/mL.The sensitivity distribution was unimodal,and there was no resistant isolate in P.nicotianae population.The carboxylic acid amide(CAA)fungicides were single-site in action and activity to oomycetes.The synergistic interactions were tested by Wadley method between fluazinam and dimethomorph,flumorph,mandipropamid,respectively.The mixture containing dimethomoph:Huazinam at 1:2 ratio showed additive actions,with the synergy ratio of 1.2.The mixture containing flumorph and fluazinam at 1:5 ratio had the highest synergy ratio(SR 2.07).Mandipropamid and fluazinam had an additive interaction and the proportion of 2:1 had the lowest EC50 value(0.020 7 μg/mL).This study demonstrated the sensitivity of P.nicotianae to fluazinam,and provided the experimental foundation to use fluazinam for tobacco black shank management. | MU Wenjun LI Qi CHEN Xiuhua LI Haijiang DONG Kunle WANG Jianwei ZHANG Youwu FENG Xiaohu ZHANG Zhigao WANG Libing SONG Jizhen | 2018 | 烟草科技2018，51，A01： | 1 |
| 14 | miR-182 as a Prognostic Marker for Glioma Progression and Patient Survival显示文摘 | Lili Jiang Pu Mao Libing Song Jueheng Wu Jieting Huang Chuyong Lin Jie Yuan Lianghu Qu Shi-Yuan Cheng Jun Li | 2010 | The American Journal of Pathology2010，，： | 1 |
| 15 | Spatial-five coordination promotes the high efficiency of CoN_(4) moiety in graphene-based bilayer for oxygen reduction electrocatalysis: A density functional theory study显示文摘The searching of highly efficient catalysts for oxygen reduction reaction(ORR) has attracted particular attention. In this work, we construct the graphene-based bilayers BG/X that consists by the CoN_(4) embedded graphene as the upper layer and the X modified graphene as the bottom layer(X = Si, P, S). The interfacial bonding between CoN_(4) site and the X dopant is spontaneously formed due to the strong pd hybridization, which changes the Co ligand from the planar-four N_(4) coordination into spatial-five N_(4)+X one. The additive glue atom weakens too strong adsorptions of the ORR intermediates on CoN_(4) site and thereby improves the ORR activities in comparison with the monolayer counterpart. From the free energy profiles, the overpotentials η are 0.47, 0.49 and 0.45 V for BG/Si_(a), BG/P_(a) and BG/S_(a), respectively,being comparable to that of state-of-the-art Pt material. Besides, the kinetic barriers for the bilayers are less than 0.75 eV, an indicative of the room temperature activity. Furthermore, the combination of thermodynamic and kinetic analysis ensures the preference of 4e^(-)-OOH associative mechanism over 2e^(-)-H_(2)O_(2) mechanism, being beneficial for membrane stability against the H_(2)O_(2) corrosion. Therefore,the graphene-based bilayers deliver the high efficiencies for oxygen reduction electrocatalysis.Therefore, the interfacial bonding in the graphene-based bilayers provides an interesting strategy to suppress the poisoning phenomenon for the material design from atom scale. | Libing Yu Qiuyan Huang Jing Wu Erhong Song Beibei Xiao | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 16 | Bmi-1,a Polycomb Group Protein,Plays an Essential Role in Tumorigenesis and Metastasis显示文摘Dysregulation of polycomb group protein Bmi-1 expression has been linked with an invasive phenotype of certain human cancers and poor prognosis of patients; however, the underlying mechanisms are | Libing SONG Jun LI Wenting LIAO Yan FENG Wanli LIU Yixin ZENG Musheng ZENG | 2009 | 中国肺癌杂志2009，12，6： | 0 |
| 17 | Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsqpbwkk9qf0x960u0.ffgz.tsg.suse.edu.cn/10.1038/cr.2012.174,published online 18 December 2012 With this letter we the authors of article1 published in Cell Research request for correction to the paper.In the article above referred,it has come to our attention that the representative tube formation images of negative control(NC)was mistakenly used in the Fig.7G during figure assembly. | Libing Song Chuyong Lin Hui Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2021 | Cell Research2021，31，10： | 0 |
| 18 | Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair显示文摘BRCA2,a clinical prognostic factor,is significantly up-regulated in mRNA level,while its protein expression is often decreased in sporadic breast cancer.However,how BRCA2 protein expressions are suppressed in these tumors remains unknown.In this study,we demonstrated that miR-1245 directly suppressed BRCA23′-UTR and translation,impaired homologous recombination(HR)-mediated repair,reduced DNA damage-induced Rad51 nuclear foci,and rendered cells hypersensitive to g-irradiation(IR),ul-timately inducing high chromosomal abnormalities in normal breast cells and breast cancer cells.Conversely,inhibiting miR-1245 in breast cancer cells enhanced BRCA2 levels and induced resistance to IR.Furthermore,we demonstrated that c-myc up-regulated miR-1245 expression via direct binding to the miR-1245 promoter,which led to down-regulation of BRCA2 and reduction in HR efficiency.Significantly,miR-1245 levels in primary breast tumors correlated with c-myc overexpression and BRCA2 suppression.These findings uncover a BRCA2 regulatory and signaling pathway in sporadic breast cancer and support a functionally and clinically relevant epigenetic mechanism in cancer pathogenesis. | Libing Song Ting Dai Yingjun Xie Chanjuan Wang Chuyong Lin Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Jun Li | 2012 | Journal of Molecular Cell Biology2012，4，2： | 0 |
| 19 | Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning显示文摘The alum-borneol nanoemulsion(ABN),which combines the mineral medicine alum and the botanical medicine borneol,has been applied for approximately 40 years in the clinical treatment of burns,scalds,radiation dermatitis and shingles,and has a good curative effect.However,the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation,which greatly affects the efficacy of the drug.In this study,polyvinylpyrrolidone(PVP)was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF)by electrospinning.The results showed that the stable system with good drug dispersion was 2:3(alum:borneol).The dissolution content of borneol from the ABPF was about 80%in 4 h,which was much higher than that of the alum-borneol liquid(ABL)and ABN.The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN.The composite fiber markedly increased the drug content of borneol,which was 800 times of that in ABN.The fiber had a higher solubility than the nanoemulsion in vitro,which is of great importance for the development of new forms for the clinical application of alum and borneol. | HUANG Libing LIU Yueqi SANG Xinyu SONG Jinghui HU Ping LIU Yong | 2021 | Chemical Research in Chinese Universities2021，37，3： | 0 |
| 20 | Electrochemical Regulation of Antibacterial Activity Using Ferrocene-Containing Antibiotics显示文摘The widespread use of antibiotics causes the accumulation of a large amount of antibiotics in the environment.Excessively active antibiotics in the environment results in the emergence of bacterial resistance.Building smart antibiotics capable of reversible regulation between active and inactive states on demand is a promising approach to address this issue.Herein,a ferrocene-containing quaternary ammonium compound has been developed for electrochemical redox-controlled bacterial inhibition.The reversible switch of the reduced and oxidized ferrocene groups between hydrophobic and hydrophilic states triggers the assembly and disassembly of the micelles while modulating the interactions of antibiotic molecules with the bacteria membrane,providing a new way to regulate antibacterial activity.In addition,the alternate use of reduced and oxidized antibiotics exhibits a favorable effect in preventing bacterial resistance.Thus,an unconventional strategy is offered to prevent the build-up of active bactericide in the environment and decrease bacterial resistance. | Song Shen Yiming Huang Anran Yuan Fengting Lv Libing Liu Shu Wang | 2021 | CCS Chemistry2021，3，11： | 0 |
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