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| 1 | Generation of RAG 1- and 2-deficient rabbits by embryo microinjection of TALENs显示文摘 | Jun Song Juan Zhong Xiaogang Guo Yongqiang Chen Qingjian zou Jiao Huang Xiaoping Li Quanjun Zhang Zhiwu Jiang Chengcheng Tang Huaqiang Yang Tao Liu Peng Li Duanqing Pei Liangxue Lai | 2013 | Cell Research2013，23，8： | 15 |
| 2 | Formation of active oxygen species on single-atom Pt catalyst and promoted catalytic oxidation of toluene显示文摘Catalytic oxidation of toluene over noble metal catalysts is a representative reaction for elimination of volatile organic compounds(VOCs).However,to fully understand the activation of molecular oxygen and the role of active oxygen species generated in this reaction is still a challenging target.Herein,MgO nanosheets and single-atom Pt loaded MgO(Pt SA/MgO)nanosheets were synthesized and used as catalysts in toluene oxidation.The activation process of molecular oxygen and oxidation performance on the two catalysts were contrastively investigated.The Pt SA/MgO exhibited significantly enhanced catalytic activity compared to MgO.The oxygen vacancies can be easily generated on the Pt SA/MgO surface,which facilitate the activation of molecular oxygen and the formation of active oxygen species.Based on the experimental data and theoretical calculations,an active oxygen species promoted oxidation mechanism for toluene was proposed.In the presence of H2O,the molecular oxygen is more favorable to be dissociated to generate•OH on the oxygen vacancies of the Pt SA/MgO surface,which is the dominant active oxygen species.We anticipate that this work may shed light on further investigation of t10.1007/s12274-020-2765-1he oxidation mechanism of toluene and other VOCs over noble metal catalysts. | Shunzheng Zhao Yanfeng Wen Xijun Liu Xianyun Pen Fang Lü Fengyu Gao Xizhou Xie Chengcheng Du Honghong Yi Dongjuan Kang Xiaolong Tang | 2020 | Nano Research2020，13，6： | 12 |
| 3 | Joint utilization of genetic analysis and semi-cloning technology reveals a digenic etiology of Müllerian anomalies显示文摘Dear Editor,Identifying pathogenic gene mutations and their combination is critical but challenging in dissecting the etiology of complex diseases when more than one gene is involved.1 The digenic/oligogenic/omnigenic models,holding that more than one gene could act synergistically,appeal to a wide range of genes responsible for complex phenotypes.1,2,3,4 These genetic models advanced our understanding of genetic factors underlying complex phenotypes,yet an accordingly rapid and efficient experimental assay for identifying pathogenic combinations of genetic variants at animal model level is lacking and urgently needed. | Lingbo Wang Ying Zhang Xiaoyi Fu Shuangshuang Dong Shuyan Tang Ning Zhang Chengcheng Song Nan Yang Lin Zhang Hongyan Wang Huijuan Shi Li Jin Feng Zhang Jinsong Li Keqin Hua | 2020 | Cell Research2020，30，1： | 8 |
| 4 | Flower-like CuO hierarchical nanostructures: synthesis, characterization, and property显示文摘基于 Nanoflake 的象花的 CuO nanostructures 通过热分解被综合了[Cu (NH3 ) 4 ] 没有在低温度的任何表面活化剂和催化剂的 2+ 答案。产品被 X 光检查衍射(XRD ) 和地排放扫描电子显微镜学(FESEM ) 描绘。可能的形成过程基于聚集再结晶机制被建议。最后,获得的象花的 CuO 层次 nanostructures 在实验被用作光催化剂。这被发现 asprepared 玫瑰精 B 的 photocatalytic 分解上的象花的 CuO 层次 nanostructures 展览上级 photocatalytic 性质由于他们的层次结构。 | Jiarui HUANG Feng TANG Cuiping GU Chengcheng SHI Muheng ZHAI | 2012 | Frontiers of Optoelectronics2012，5，4： | 2 |
| 5 | Study on mechanism of low-temperature oxidation of n-hexanal catalysed by 2D ultrathin Co_(3)O_(4) nanosheets显示文摘Achieving high catalytic performance with lower possible cost and higher energetic efficiency is critical for catalytic oxidation of volatile organic compounds(VOCs).However,traditional thermocatalysts generally undergo low catalytic activity and fewer active sites.Herein,this paper synthesizes nearly all-surface-atomic,ultrathin two-dimensional(2D)Co_(3)O_(4) nanosheets to address these problems through offering a numerous active sites and high electron mobility.The 2D Co_(3)O_(4) nanosheets(1.70 nm)exhibit catalyzation to the total oxidation of n-hexanal at the lower temperature of r90%=202℃,and at the space velocity of 5.0×10^(4) h^(-1).It is over 1.2 and 6 times higher catalytic activity than that of 2D CoO nanosheets(1.71 nm)and bulk Co_(3)O_(4) counterpart,respectively.Transient absorption spectroscopy analysis shows that the oxygen vacancy defect traps electrons,thereby preventing the recombination with holes,increasing the lifetime of electrons,and making electron-holes reach a nondynamic equilibrium.The longer the electron lifetime is,the easier the oxygen vacancy defects capture electrons.Furthermore,the defects combine with oxygen to form active oxygen components.Compared with the lattice oxygen involved in the reaction of bulk Co_(3)O_(4),the nanosheets change the catalytic reaction path,which effectively reduces the activation energy barrier from 34.07 to 27.15 kJ/mol.The changed surface disorder,the numerous coordinatively-unsaturated Co atoms and the high ratio of O_(ads)/O_(lat) on the surface of 2D Co_(3)O_(4) nanosheets are responsible for the catalytic performance. | Leilei Miao Xiaolong Tang Shunzheng Zhao Xizhou Xie Chengcheng Du Tian Tang Honghong Yi | 2022 | Nano Research2022，15，2： | 2 |
| 6 | Hepatitis B virus regulation of Raf1 promoter activity through activation of transcription factor AP-2α显示文摘 | Jialin Qu Jianbo Li Ke Chen Dongdong Qin Kai Li Yanrui Sheng Chengcheng Zou Sen Wang Ailong Huang Hua Tang | 2013 | Archives of Virology2013，，4： | 1 |
| 7 | 高速公路不同形式防眩设施的综合评判显示文摘基于“七五”国家重点科技项目分专题《防眩设施结构形式的研究》的研究成果,运用一种改进的层次分析法。 | Tang Chengcheng (Research Institute of Highway,Beijing) | 1997 | 公路交通科技1997，14，2： | 1 |
| 8 | Near field analysis for periodic diffractive gratings using Fourier modal method显示文摘 | Gao Fuhua Wang Chengcheng Tang Xionggui | 2006 | Microelectronic Engineering2006，83，： | 1 |
| 9 | Self-reporting fluorescence deciphers the antibacterial nature of cationic amphiphiles:Monomer or aggregate?显示文摘Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process.Herein,three bola-type cationic amphiphiles with aggregation-induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate.The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton.The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three amphiphiles with bacteria.The aggregates with cationic charges first attach to bacterial surface,and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane.Further,our results reveal the vital role of stability of aggregates during antimicrobial process,shedding light on the rational design of high-efficient antimicrobials. | Chengcheng Zhou Zeyu Ding Weijiang Guan Ben Zhong Tang | 2023 | Aggregate2023，4，5： | 0 |
| 10 | RAYDATA总部办公室显示文摘RayData是一家对城市数据进行整合和可视化的公司,其北京总部位于由SOM设计事务所进行设计的保利国际广场。RayData总部办公室位于椭圆形摩天大楼的19层,并邀请了奥地利建筑工作室Studio Precht进行室内设计。设计团队所打造的空间融合了建筑物本身的两个独特特征:椭圆形用于营造内部柔和感,菱形外墙启发了该空间的折线形布局。 | Fei Tang Precht(设计) Chun Chen(设计) Zizhi Yu(设计) Chengcheng Liu(设计) Yanyan Gu(设计) Mei Li(设计) Chris Precht(设计) CreatARimages(摄影) 舒禹(编译) | 2020 | 现代装饰2020，，7： | 0 |
| 11 | Generation of multi-gene knockout rabbits using the Cas9/gRNA system显示文摘The prokaryotic clustered regularly interspaced short palindromic repeat(CRISPR)-associated system(Cas)is a simple,robust and efficient technique for gene targeting in model organisms such as zebrafish,mice and rats.In this report,we applied CRISPR technology to rabbits by microinjection of Cas9 mRNA and guided RNA(gRNA)into the cytoplasm of pronuclear-stage embryos.We achieved biallelic gene knockout(KO)rabbits by injection of 1 gene(IL2rg)or 2 gene(IL2rg and RAG1)Cas9 mRNA and gRNA with an efficiency of 100%.We also tested the efficiency of multiple gene KOs in early rabbit embryos and found that the efficiency of simultaneous gene mutation on target sites is as high as 100%for 3 genes(IL2rg,RAG1 and RAG2)and 33.3%for 5 genes(IL2rg,RAG1,RAG2,TIKI1 and ALB).Our results demonstrate that the Cas9/gRNA system is a highly efficient and fast tool not only for single-gene editing but also for multi-gene editing in rabbits. | Quanmei Yan Quanjun Zhang Huaqiang Yang Qingjian Zou Chengcheng Tang Nana Fan Liangxue Lai | 2014 | Cell Regeneration2014，3，1： | 0 |
| 12 | Integrated Photothermal Nanoreactors for Effi cient Hydrogenation of CO_(2)显示文摘To alleviate the energy crisis and global warming,photothermal catalysis is an attractive way to effi ciently convert CO_(2)and renewable H_(2) into value-added fuels and chemicals.However,the catalytic performance is usually restricted by the trade-off between the dispersity and light absorption property of metal catalysts.Here we demonstrate a simple SiO 2-protected metal-organic framework pyrolysis strategy to fabricate a new type of integrated photothermal nanoreactor with a comparatively high metal loading,dispersity,and stability.The core-satellite structured Co@SiO_(2)exhibits strong sunlight-absorptive abil-ity and excellent catalytic activity in CO_(2)hydrogenation,which is ascribed to the functional separation of diff erent sizes of Co nanoparticles.Large-sized plasmonic Co nanoparticles are mainly responsible for the light absorption and conversion to heat(nanoheaters),whereas small-sized Co nanoparticles with high intrinsic activities are responsible for the catalysis(nanoreactors).This study provides a new concept for designing effi cient photothermal catalytic materials. | Jiahui Shen Rui Tang Zhiyi Wu Xiao Wang Mingyu Chu Mujin Cai Chengcheng Zhang Liang Zhang Kui Yin Le He Chaoran Li | 2022 | Transactions of Tianjin University2022，28，4： | 0 |
| 13 | Generation of pigs with humanized type Ⅱ collagen by precise human COL2A1 gene knock-in显示文摘Osteoarthritis(OA)is the most common chronic disease,characterized by progressive cartilage breakdown,subchondral bone sclerosis,and aberrant bone outgrowth(Yucesoy et al.,2015;Hussain et al.,2016).OA is one of the leading causes of cartilage damage.Patients with severe cartilage damage require transplantation of articular cartilage to improve their quality of life.Type Ⅱ collagen is a major component of articular cartilage and intervertebral discs and plays an important role in the structure and strength of connective tissues that support muscles and joints(Byers,1994). | Ting Lan Yuling Zheng Yangyang Suo Yuhui Wei Hui Shi Quanmei Yan Zhenpeng Zhuang Huangyao Chen Quanjun Zhang Nana Fan Yu Zhao Zhen Ouyang Chengdan Lai Zhaoming Liu Jizeng Zhou Chengcheng Tang Nam-Hyung Kim Qingjian Zou Xiaomin Wang | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 14 | Near-threshold-voltage operation in flash-based high-precision computing-in-memory to implement Poisson image editing显示文摘We propose a NOR flash-based computing-in-memory(CIM)to implement high-precision(32-bit)Poisson image editing,including the gradient operations and Laplace operation.To meet the requirements of image processing,CIM operation schemes and reliabilities are carefully studied and optimized,showing that the power consumption at the near-threshold-voltage(NTV)region can be as low as 40 fJ/bit,which is two orders lower than working at the saturation region.High-temperature retention,as well as various disturbs,are also analyzed.The proposed CIM scheme can be applied as an energy-efficient approach to construct the high-precision image processing accelerator. | Yang FENG Bing CHEN Mingfeng TANG Yueran QI Maoying BAI Chengcheng WANG Hai WANG Xuepeng ZHAN Junyu ZHANG Jing LIU Jixuan WU Jiezhi CHEN | 2023 | Science China(Information Sciences)2023，66，12： | 0 |
| 15 | DeepPrimitive: Image decomposition by layered primitive detection显示文摘The perception of the visual world through basic building blocks, such as cubes, spheres, and cones gives human beings a parsimonious understanding of the visual world. Thus, efforts to find primitive-based geometric interpretations of visual data date back to 1970 s studies of visual media. However, due to the difficulty of primitive fitting in the pre-deep learning age, this research approach faded from the main stage and the vision community turned primarily to semantic image understanding. In this paper, we revisit the classical problem of building geometric interpretations of images, using supervised deep learning tools. We build a framework to detect primitives from images in a layered manner by modifying the YOLO network an RNN with a novel loss function is then used to equip this network with the capability to predict primitives with a variable number of parameters. We compare our pipeline to traditional and other baseline learning methods, demonstrating that our layered detection model has higher accuracy and performs better reconstruction. | Jiahui Huang Jun Gao Vignesh Ganapathi-Subramanian Hao SU Yin Liu Chengcheng Tang Leonidas J.Guibas | 2018 | Computational Visual Media2018，4，4： | 0 |
| 16 | Dual-Wavelength Photosensitive Nano-in-Micro Scaffold Regulates Innate and Adaptive Immune Responses for Osteogenesis显示文摘The immune response of a biomaterial determines its osteoinductive effect.Although the mechanisms by which some immune cells promote regeneration have been revealed,the biomaterial-induced immune response is a dynamic process involving multiple cells.Currently,it is challenging to accurately regulate the innate and adaptive immune responses to promote osteoinduction in biomaterials.Herein,we investigated the roles of macrophages and dendritic cells(DCs)during the osteoinduction of biphasic calcium phosphate(BCP)scaffolds.We found that osteoinductive BCP directed M2 macrophage polarization and inhibited DC maturation,resulting in low T cell response and efficient osteogenesis.Accordingly,a dual-targeting nano-in-micro scaffold(BCP loaded with gold nanocage,BCP-GNC)was designed to regulate the immune responses of macrophages and DCs.Through a dual-wavelength photosensitive switch,BCP-GNC releases interleukin-4 in the early stage of osteoinduction to target M2 macrophages and then releases dexamethasone in the later stage to target immature DCs,creating a desirable inflammatory environment for osteogenesis.This study demonstrates that biomaterials developed to have specific regulatory capacities for immune cells can be used to control the early inflammatory responses of implanted materials and induce osteogenesis. | Qin Zhao Miusi Shi Chengcheng Yin Zifan Zhao Jinglun Zhang Jinyang Wang Kailun Shen Lingling Zhang Hua Tang Yin Xiao Yufeng Zhang | 2021 | Nano-Micro Letters2021，13，2： | 0 |
| 17 | Attack Detection for Spoofed Synchrophasor Measurements Using Segmentation Network显示文摘Synchrophasor measurements are essential to realtime situational awareness of the smart grid but vulnerable to cyber-attacks during the process of transmission and invocation.To ensure data security and mitigate the impact of spoofed synchrophasor measurements,this work proposes a novel object detection method using a Weight-based One-dimensional Convolutional Segmentation Network(WOCSN)with the ability of attack behavior identification and time localization.In WOCSN,automatic data feature extraction can be achieved by onedimensional convolution from the input signal,thereby reducing the impact of handcrafted features.A weight loss function is designed to distribute the contribution for normal and attack signals.Then,attack time is located via the proposed binary method based on pixel segmentation.Furthermore,the actual synchrophasor data collected from four locations are used for the performance evaluation of the WOCSN.Finally,combined with designed evaluation metrics,the time localization ability of WOCSN is validated in the scenarios of composite attacks with different spoofed intensities and time-sensitivities. | Wei Qiu Chengcheng Li Qiu Tang Kaiqi Sun Yilu Liu Wenxuan Yao | 2022 | CSEE Journal of Power and Energy Systems2022，8，5： | 0 |
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