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| 1 | 自发性脑出血治疗指南美国心脏协会/美国卒中协会对医疗卫生专业人员发布的指南显示文摘目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medline进行规范的文献检索,利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南的草案进行发表前审阅。预期本指南在3年内完全更新。结果本文为脑出血患者的医疗诊治提供了循证指南。重点包括诊断、止血、血压管理、院内管理和护理、预防内科合并症、外科治疗、转归预测、康复、预防复发以及将来需要考虑的问题。结论脑出血是一种严重的疾病,早期积极救治可影响其转归。本指南为脑出血患者的目标导向治疗提供了一个框架。 | Lewis B. Morgenstem J. Claude Hemphill Ⅲ Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Jr Steven M. Greenberg James N. Huang R. Loch Macdonald Steven R. Messe Pamela H. Mitchell Magdy Selim Rafael J. Tamargo 王玉洁(译) 王健(译) 刘相玉(译) 谢丽丽(译) | 2010 | 国际脑血管病杂志2010，，8： | 259 |
| 2 | 自发性脑出血管理指南 美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的本指南旨在为自发性脑出血的诊断和治疗提供最新的全面推荐意见。方法利用PubMed进行规范化文献检索,检索时间至2013年8月底。撰写委员会成员通过远程电信会议讨论指南内容及推荐意见,采用美国心脏协会/美国卒中协会的疗效确定性水平和证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南草案进行发表前审阅。结果本文为急性脑出血患者的医疗诊治提供了循证指南,重点包括诊断、凝血功能障碍和血压管理、继发性脑损伤防治、颅内压控制、外科治疗的作用、转归预测、康复、二级预防以及将来需要考虑的问题。本指南已纳入最新的3期临床试验结果。结论脑出血是一种需要进行早期积极救治的危重疾病。本指南为脑出血患者的目标导向治疗提供了一个框架。 | J. Claude Hemphill Ⅲ Steven M. Greenberg Craig S. Anderson Kyra Beckelr Bernard R. Bendok Mary Cushman Gordon L. Fung Joshua N. Goldstein R. LochMacdonald Pamela H Mitchell, Phillip A Scott,Magdy H Selim, Daniel Woo 高圆圆 徐欣 | 2015 | 国际脑血管病杂志2015，23，10： | 444 |
| 3 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012显示文摘 | R. Phillip Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell | 2013 | Critical Care Medicine2013，，2： | 12 |
| 4 | Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Lewis B. Morgenstern J. Claude Hemphill Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Steven M. Greenberg James N. Huang R. Loch Macdonald Steven R. Messé Pamela H. Mitchell Magdy Selim Rafael J. Tamargo | 2010 | Stroke2010，，9： | 10 |
| 5 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012显示文摘 | R. P. Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell Derek | 2013 | Intensive Care Medicine2013，，2： | 7 |
| 6 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Critical Care Medicine2003，，4： | 7 |
| 7 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Critical Care Medicine2003，，4： | 6 |
| 8 | Borderline Resectable Pancreatic Cancer: Need for Standardization and Methods for Optimal Clinical Trial Design显示文摘 | Matthew H. G. Katz Robert Marsh Joseph M. Herman Qian Shi Eric Collison Alan P. Venook Hedy L. Kindler Steven R. Alberts Philip Philip Andrew M. Lowy Peter W. T. Pisters Mitchell C. Posner Jordan D. Berlin Syed A. Ahmad | 2013 | Annals of Surgical Oncology2013，，8： | 4 |
| 9 | 卒中一级预防指南美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘这份更新版指南旨在为既往无卒中或短暂性脑缺血发作史的人群提供适时的综合性卒中预防循证建议,包括危险因素控制、头颈部动脉粥样硬化性疾病的干预方法以及预防血栓形成和血栓栓塞性卒中的抗栓治疗。此外,本指南还提供了针对遗传和药理学检测以及在其他特殊情况下(包括镰状细胞疾病和卵圆孔未闭)进行卒中预防的建议。 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Edward C. Jauch Wesley S. Moore John A. Wilson 李迪 高一鹭 陈政弘 霍晓川 孙海欣 孙冬玲 茹小娟 江滨 | 2015 | 国际脑血管病杂志2015，23，6： | 4 |
| 10 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Intensive Care Medicine2003，，4： | 3 |
| 11 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 12 | Guidelines for the Primary Prevention of Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | James F. Meschia Cheryl Bushnell Bernadette Boden-Albala Lynne T. Braun Dawn M. Bravata Seemant Chaturvedi Mark A. Creager Robert H. Eckel Mitchell S.V. Elkind Myriam Fornage Larry B. Goldstein Steven M. Greenberg Susanna E. Horvath Costantino Iadecola Ed | 2014 | Stroke2014，，12： | 2 |
| 13 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 14 | Endothelin-1 activation in pediatric patients undergoing surgical coarctation of the aorta repair显示文摘AIM To determine endothelin-1(ET-1)concentration before and after surgical coarctectomy and evaluate its association with left ventricular geometric change.METHODSA prospective,cohort study of 24 patients aged 2 d to 10years with coarctation of the aorta undergoing surgical repair.A sub-cohort of patients with age<1 mo was classified as'neonates'.Echocardiograms were performed just prior to surgery and in the immediate post-op period to assess left ventricle mass index and relative wall thickness(RWT).Plasma ET-1 levels were assessed at both time points.Association between ET-1 levels and ventricular remodeling was assessed.RESULTSPatients<1 year demonstrated higher pre-op ET-1 than post-op(2.8 pg/m L vs 1.9 pg/m L,P=0.02).Conversely,patients>1 year had no change in ET-1 concentration before and after surgery(1.1 vs 1.4,NS).Pre-op,patients<1 year demonstrated significantly higher ET-1 than older children(2.8 vs 1.1,P=0.001).Post-op there was no difference between the age groups(1.9 vs 1.4,NS).Neither RWT nor left ventricle mass index(LVMI)varied from pre-op to post-op.The subset of neonates showed a strong positive correlation between pre-op ET-1 and RWT(r=0.92,P=0.001).Patients with ET-1>2 pg/m L preop demonstrated higher LVMI(65.7 g/m^(2.7) vs 38.5 g/m^(2.7),P=0.004)and a trend towards higher RWT(45%vs39%,P=0.07)prior to repair than those with lower ET-1concentration.CONCLUSIONET-1 concentration is significantly variable in the perioperative period surrounding coarctectomy.Older children and infants have different responses to surgical repair suggesting different mechanisms of activation. | Benjamin Steven Frank Tracy T Urban Suhong Tong Courtney Cassidy Max B Mitchell Christopher S Nichols Jesse A Davidson | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 15 | Boceprevir for Chronic HCV Genotype 1 Infection in Patients with Prior Treatment Failure to Peginterferon/Ribavirin, including Prior Null Response显示文摘 | John M. Vierling Mitchell Davis Steven Flamm Stuart C. Gordon Eric Lawitz Eric M. Yoshida Joseph Galati Velimir Luketic Jonathan McCone Ira Jacobson Patrick Marcellin Andrew J. Muir Fred Poordad Lisa D. Pedicone Janice Albrecht Clifford Brass Anita Y.M. H | 2013 | Journal of Hepatology2013，，： | 2 |
| 16 | Partial growth-hormone insensitivity: The role of growth-hormone receptor mutations in idiopathic short stature显示文摘 | Audrey D. Goddard Patrick Dowd Steven Chernausek Mitchell Geffner Joseph Gertner Raymond Hintz Nancy Hopwood Selna Kaplan Leslie Plotnick Alan Rogol Robert Rosenfield Paul Saenger Nellie Mauras Richard Hershkopf Morris Angulo Kenneth Attie | 1997 | The Journal of Pediatrics1997，，1： | 2 |
| 17 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012显示文摘 | R. P. Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell Derek | 2013 | Intensive Care Medicine2013，，2： | 2 |
| 18 | 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference显示文摘 | Mitchell M. Levy Mitchell P. Fink John C. Marshall Edward Abraham Derek Angus Deborah Cook Jonathan Cohen Steven M. Opal Jean-Louis Vincent Graham Ramsay | 2003 | Intensive Care Medicine2003，，4： | 1 |
| 19 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012显示文摘 | R. Phillip Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell | 2013 | Critical Care Medicine2013，，2： | 1 |
| 20 | A New Classification of Thoracolumbar Injuries: The Importance of Injury Morphology, the Integrity of the Posterior Ligamentous Complex, and Neurologic Status显示文摘 | Alexander R. Vaccaro Ronald A. Lehman R John Hurlbert Paul A. Anderson Mitchel Harris Rune Hedlund James Harrop Marcel Dvorak Kirkham Wood Michael G. Fehlings Charles Fisher Steven C. Zeiller D Greg Anderson Christopher M. Bono Gordon H. Stock Andrew K. B | 2005 | Spine2005，，20： | 1 |
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