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| 1 | Bile acids as endogenous etiologic agents in gastrointestinal cancer显示文摘Bile acids are implicated as etiologic agents in cancer of the gastrointestinal (GI) tract, including cancer of the esophagus, stomach, small intestine, liver, biliary tract, pancreas and colon/rectum. Deleterious effects of bile acid exposure, likely related to carcinogenesis, include: induction of reactive oxygen and reactive nitrogen species; induction of DNA damage; stimulation of mutation; induction of apoptosis in the short term, and selection for apoptosis resistance in the long term. These deleterious effects have, so far, been reported most consistently in relation to esophageal and colorectal cancer, but also to some extent in relation to cancer of other organs. In addition, evidence is reviewed for an association of increased bile acid exposure with cancer risk in human populations, in specific human genetic conditions, and in animal experiments. A model for the role of bile acids in GI carcinogenesis is presented from a Darwinian perspective that offers an explanation for how the observed effects of bile acids on cells contribute to cancer development. | Harris Bernstein Carol Bernstein Claire M Payne Katerina Dvorak | 2009 | World Journal of Gastroenterology2009，15，27： | 38 |
| 2 | Alcoholic liver disease显示文摘Alcohol use disorders affect millions of individuals worldwide.Alcohol consumption is directly associated with liver disease mortality and accounts for elevated social and economic costs.Alcoholic liver disease(ALD) may take the form of acute involvement(alcoholic hepatitis)or chronic liver disease(steatosis,steatohepatitis,fibrosis and cirrhosis).The severity and prognosis of alcohol-induced liver disease depends on the amount,pattern and duration of alcohol consumption,as well as on the presence of liver inflammation,diet,nutritional status and genetic predisposition of an individual.While steatosis is an almost completely benign disease,liver cirrhosis is associated with marked morbidity,mortal-ity and life expectancy shortening.The median survival of patients with advanced cirrhosis is 1-2 years.Se-vere acute alcoholic hepatitis(AH)is associated with mortality as high as 50%.It has been managed with corticoids,pentoxifylline and enteral nutrition,although evidence based data are still conflicting.Some author suggest that pentoxifylline could be a better first-line treatment in patients with severe AH.Absolute abstinence is a basic condition for any treatment of acute or chronic ALD,the other therapeutical procedure being of a supportive nature and questionable significance.Acamprosate appears to be an effective treatment strategy for supporting continuous abstinence in alco-hol dependent patients.Patients with advanced liver cirrhosis who demonstrably abstain can be considered for liver transplantation,which leads to a markedly pro-longed life expectancy.The crucial step in ALD preven-tion is in the prevention of alcohol abuse,whereas the prevention of liver injury in active alcohol abusers is not clinically applicable. | Radan Bruha Karel Dvorak Jaromir Petrty | 2012 | World Journal of Hepatology2012，4，3： | 28 |
| 3 | Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis显示文摘AIM To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis(PSC) and ulcerative colitis(UC).METHODS Stool samples were collected and relevant clinical data obtained from 106 study participants, 43 PSC patients with(n = 32) or without(n = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16 S ribosomal RNA gene were sequenced on Illumina Mi Seq platform to cover low taxonomic levels. Data were further processed in QIIME employing Ma As Lin and LEf Se tools for analysis of the output data.RESULTS Microbial profiles in both PSC and UC were characterized by low bacterial diversity and significant change in global microbial composition. Rothia, Enterococcus, Streptococcus, Veillonella, and three other genera were markedly overrepresented in PSC regardless of concomitant inflammatory bowel disease(IBD). Rothia, Veillonella and Streptococcus were tracked to the species level to identify Rothia mucilaginosa, Streptococcus infantus, S. alactolyticus, and S. equi along with Veillonella parvula and V. dispar. PSC was further characterized by decreased abundance of Adlercreutzia equolifaciens and Prevotella copri. Decrease in genus Phascolarctobacterium was linked to presence of colonic inflammation regardless of IBD phenotype. Akkermansia muciniphila, Butyricicoccus pullicaecorum and Clostridium colinum were decreased in UC along with genus Roseburia. Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales.CONCLUSION PSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes(PSC-IBD and UC). | Lukas Bajer Miloslav Kverka Martin Kostovcik Peter Macinga Jiri Dvorak Zuzana Stehlikova Jan Brezina Pavel Wohl Julius Spicak Pavel Drastich | 2017 | World Journal of Gastroenterology2017，23，25： | 22 |
| 4 | Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis显示文摘AIM: To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.METHODS: A cohort of 154 patients with confirmed liver cirrhosis(112 ethylic, 108 men, age 34-72 years)were enrolled in the study. Hepatic venous pressure gradient(HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay(ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.RESULTS: The mean value of HVPG was 16.18 ± 5.6 mm Hg. Compared to controls, the plasma levels of osteopontin in cirrhotic patients were significantly higher(P < 0.001). The plasma levels of osteopontin were positively related to HVPG(P = 0.0022, r = 0.25) and differed among the individual Child-Pugh groups of patients. The cut-off value of 80 ng/m L osteopontin distinguished patients with significant portal hypertension(HVPG above 10 mm Hg) at 75% sensitivity and 63% specificity. The mean follow-up of patients was 3.7 ± 2.6 years. The probability of cumulative survival was 39% for patients with HVPG > 10 mm Hg and 65% for those with HVPG ≤ 10 mm Hg(P = 0.0086, odds ratio(OR), 2.92, 95% confidence interval(CI): 1.09-7.76). Osteopontin showed a similar prognostic value to HVPG. Patients with osteopontin values above 80 ng/m L had significantly lower cumulative survival compared to those with osteopontin ≤ 80 ng/m L(37% vs 56%, P = 0.00035; OR = 2.23, 95%CI: 1.06-4.68).CONCLUSION: Osteopontin is a non-invasive parameter of portal hypertension that distinguishes patients with clinically significant portal hypertension. It is a strong prognostic factor for survival. | Radan Bruha Marie Jachymova Jaromir Petrtyl Karel Dvorak Martin Lenicek Petr Urbanek Tomislav Svestka Libor Vitek | 2016 | World Journal of Gastroenterology2016，22，12： | 20 |
| 5 | Supersonic Flow Structure in the Entrance Part of a Mixing Chamber of 2D Model Ejector显示文摘The paper deals with experimental and numerical results of investigation into supersonic and transonic flow past a two-dimensional model ejector. Results of optical measurements show a flow structure and flow parameter development in the entrance part of the mixing chamber of the ejector. Numerical results are obtained by means of both the straight solution of shock waves in supersonic flow field using classical relations of parameters of shock waves and the Fluent 6 program. Results of numerical solutions are compared with experimental pictures of flow fields. Flow structure development in the mixing chamber is analysed in detail. | Vaclav Dvorak Pavel Safarik | 2003 | Journal of Thermal Science2003，12，4： | 8 |
| 6 | Sequencing a Juglans regia×J.microcarpa hybrid yields high-quality genome assemblies of parental species显示文摘Members of the genus Juglans are monecious wind-pollinated trees in the family Juglandaceae with highly heterozygous genomes,which greatly complicates genome sequence assembly.The genomes of interspecific hybrids are usually comprised of haploid genomes of parental species.We exploited this attribute of interspecific hybrids to avoid heterozygosity and sequenced an interspecific hybrid Juglans microcarpa×J.regia using a novel combination of single-molecule sequencing and optical genome mapping technologies.The resulting assemblies of both genomes were remarkably complete including chromosome termini and centromere regions.Chromosome termini consisted of arrays of telomeric repeats about 8 kb long and heterochromatic subtelomeric regions about 10 kb long.The centromeres consisted of arrays of a centromere-specific Gypsy retrotransposon and most contained genes,many of them transcribed.Juglans genomes evolved by a whole-genome-duplication dating back to the Cretaceous-Paleogene boundary and consist of two subgenomes,which were fractionated by numerous short gene deletions evenly distributed along the length of the chromosomes.Fractionation was shown to be asymmetric with one subgenome exhibiting greater gene loss than the other.The asymmetry of the process is ongoing and mirrors an asymmetry in gene expression between the subgenomes.Given the importance of J.microcarpa×J.regia hybrids as potential walnut rootstocks,we catalogued disease resistance genes in the parental genomes and studied their chromosomal distribution.We also estimated the molecular clock rates for woody perennials and deployed them in estimating divergence times of Juglans genomes and those of other woody perennials. | Tingting Zhu Le Wang Frank M.You Juan C.Rodriguez Karin R.Deal Limin Chen Jie Li Sandeep Chakraborty Bipin Balan Cai-Zhong Jiang Patrick J.Brown Charles ALeslie Mallikarjuna KAradhya Abhaya M.Dandekar Patrick E.McGuire Daniel Kluepfel Jan Dvorak Ming-Cheng Luo | 2019 | Horticulture Research2019，6，1： | 7 |
| 7 | Transonic Instability in Entrance Part of Mixing Chamber of High-Speed Ejector显示文摘The paper deals with experimental and numerical study of flow structure in two-dimensional model of supersonic ejector. Schlieren pictures of flow structure were taken, static pressure distributions on side wall were measured and Fluent software to calculate the flow structure in supersonic ejector was used. For certain region of back pressure ratio pb/p02 and stagnation pressure ratio of both streams p01/p02 the terminal shock wave is close to the trailing edge of the primary flow nozzle and a transonic instability occurs. The instability causes the movement of position of boundary layer separation, the structure of shock waves changes and all flow structure oscillates. The movie of these regimes during schlieren experiments was taken and relevant numerical modelling was performed. | Vaclav Dvorak Pavel Safarik | 2005 | Journal of Thermal Science2005，14，3： | 5 |
| 8 | Role of interleukin-6 in Barrett's esophagus pathogenesis显示文摘Barrett's esophagus (BE) is a metaplastic lesion of the distal esophagus arising as a consequence of chronic gastroesophageal reflux disease. Multiple studies show that BE is associated with increased risk of esophageal adenocarcinoma (EAC). Epidemiological studies and animal models demonstrate that chronic inflammation triggered by repeated exposure to refluxate predisposes to the development of BE and EAC. The chronic inflammation is associated with cytokine alterations. Interleukin 6 (IL-6) is a cytokine that stimulates cell proliferation and apoptosis resistance is frequently increased in different cancers. Importantly, IL-6 and transcriptional factor signal transducer and activator of transcription 3 (STAT3) that is activated by IL-6 are also increased in BE and EAC. This review critically appraises the role of IL-6/STAT3 pathway in progression of BE to EAC from the published evidence currently available. | Katerina Dvorak Bohuslav Dvorak | 2013 | World Journal of Gastroenterology2013，19，15： | 4 |
| 9 | Pneumatic Measurements Downstream of a Radial Turbine Nozzle Cascade显示文摘This paper deals mainly with pneumatic measurements on a radial turbine nozzle cascade.The full radial cascade guarantees the exit flow field periodicity downstream of it.A special traversing mechanism with a five -hole conical probe moving along a circular path behind the cascade was used for flow field investigation in this type of cascade with very low aspect ratio.The analyses of results of 2D and 3D pneumatic measurements including loss coefficient values are presented. | Martin LUXA Rudolf DVORAK David SIMURDA Jan VIMMR | 2010 | Journal of Thermal Science2010，19，1： | 3 |
| 10 | Vortices and Vortical Structures in InternalAerodynamics显示文摘The paper aims at summarizing the author’s recent phenomenological study of the orthe, developmeot and identification of vortical structures in internal aerodynamics.A connection between evolution of these structures and flow separation in closed cUrVed channels is also discussed. It has been shown that in real fluids the individual vortex cores very soon lose their identity and merge into a new dissipative structure, the properties of which still have to be defined. | Rudolf Dvorak (Institute of Thermomechanics, Academy of Sciences of the Czech Republic, Prague, Czech Republic) | 1997 | Journal of Thermal Science1997，6，2： | 2 |
| 11 | Aegilops tauschii single nucleotide polymorphisms shed light on the origins of wheat D‐genome genetic diversity and pinpoint the geographic origin of hexaploid wheat显示文摘 | Jirui Wang Ming‐Cheng Luo Zhongxu Chen Frank M. You Yuming Wei Youliang Zheng Jan Dvorak | 2013 | New Phytol2013，，3： | 2 |
| 12 | Green roof vegetation for North American ecoregions: A literature review显示文摘 | Bruce Dvorak Astrid Volder | 2010 | Landscape and Urban Planning2010，，4： | 2 |
| 13 | 国际脊髓损伤脊柱损伤基础数据集显示文摘收集脊柱损伤的信息对于脊髓损伤患者的诊断和治疗非常重要,设立脊髓损伤患者脊柱损伤基础数据集是为了规范脊柱损伤相关信息的收集方式和报告内容,学习并使用国际脊髓损伤脊柱损伤基础数据集,有助于规范和统一我国脊髓损伤患者脊柱损伤信息的收集,为相关治疗提供依据。本文将介绍国际脊髓损伤脊柱损伤基础数据集的研发过程,数据元素的内容以及数据编码的应用实例。 | Marcel F. Dvorak Peter C.Wing Michael G.Fehlings Alexander R. Vaccaro Eyal Itshayek Fin Biering-Sorensen Vanessa K.Noonan 王一吉(译) 周红俊(译) 李建军(译) 刘根林(译) 郑樱(译) 郝春霞(译) 张缨(译) 卫波(译) 康海琼(译) 逯晓蕾(译) | 2014 | 中国康复理论与实践2014，20，2： | 2 |
| 14 | Link-age mapping of an Ava I PCR-RFLP within the porcine un-eoupling protein 3 gene显示文摘 | Knoll A Putnova J Dvorak J | 2000 | Animal Genetics2000，31，2： | 1 |
| 15 | Vascular permeability factor/vascular endothelial growth,microvascular hypermeability and angiogenesis:review显示文摘 | Brown LF Detmar M | 1995 | Am Med J1995，146，： | 1 |
| 16 | Three-dimensional movements of the upper cervical spine显示文摘 | Dvorak J Duranceau J | 1988 | Spine1988，13，7： | 1 |
| 17 | Tumor cells secrete vascular permeability factor that promotes accumulation of ascites fluid显示文摘 | Senger DR Galli SJ Dvorak AM | 1983 | Science1983，219，4587： | 1 |
| 18 | Comparison of operative and nonoperative treatment for thoracolumbar burst fractures in patients without neurological deficit: A systematic review显示文摘 | Thomas KC Bailey CS Dvorak MF etal | 2007 | Neurosurg Spine2007，6，1： | 1 |
| 19 | Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hypermeability in angiogenesis 显示文摘 | Dvorak HF Nagy JA Feng D | 1999 | Curt Top Microbiol Immunol1999，23，7： | 1 |
| 20 | More about arc-fault circuit interrupters显示文摘 | GREGORYGD WONG K DVORAK R F | 2004 | IEEE Transactions on Industry Applications2004，40，4： | 1 |
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