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| 1 | Building an Earth Observations Data Cube: lessons learned from the Swiss Data Cube (SDC) on generating Analysis Ready Data (ARD)显示文摘Pressures on natural resources are increasing and a number of challenges need to be overcome to meet the needs of a growing population in a period of environmental variability.Some of these environmental issues can be monitored using remotely sensed Earth Observations(EO)data that are increasingly available from a number of freely and openly accessible repositories.However,the full information potential of EO data has not been yet realized.They remain still underutilized mainly because of their complexity,increasing volume,and the lack of efficient processing capabilities.EO Data Cubes(DC)are a new paradigm aiming to realize the full potential of EO data by lowering the barriers caused by these Big data challenges and providing access to large spatio-temporal data in an analysis ready form.Systematic and regular provision of Analysis Ready Data(ARD)will significantly reduce the burden on EO data users.Nevertheless,ARD are not commonly produced by data providers and therefore getting uniform and consistent ARD remains a challenging task.This paper presents an approach to enable rapid data access and pre-processing to generate ARD using interoperable services chains.The approach has been tested and validated generating Landsat ARD while building the Swiss Data Cube. | Gregory Giuliani Bruno Chatenoux Andrea De Bono Denisa Rodila Jean-Philippe Richard Karin Allenbach Hy Dao Pascal Peduzzi | 2017 | Big Earth Data2017，1，1： | 7 |
| 2 | Compound screening platform using human induced pluripotent stem cells to identify small molecules that promote chondrogenesis显示文摘Articular cartilage,which is mainly composed of collagen Ⅱ,enables smooth skeletal movement.Degeneration of collagen Ⅱ can be caused by various events,such as injury,but degeneration especially increases over the course of normal aging.Unfortunately,the body does not fully repair itself from this type of degeneration,resulting in impaired movement.Microfracture,an articular cartilage repair surgical technique,has been commonly used in the clinic to induce the repair of tissue at damage sites.Mesenchymal stem cells(MSC)have also been used as cell therapy to repair degenerated cartilage.However,the therapeutic outcomes of all these techniques vary in different patients depending on their age,health,lesion size and the extent of damage to the cartilage.The repairing tissues either form fibrocartilage or go into a hypertrophic stage,both of which do not reproduce the equivalent functionality of endogenous hyaline cartilage.One of the reasons for this is inefficient chondrogenesis by endogenous and exogenous MSC.Drugs that promote chondrogenesis could be used to induce self-repair of damaged cartilage as a non-invasive approach alone,or combined with other techniques to greatly assist the therapeutic outcomes.The recent development of human induced pluripotent stem cell(iPSCs),which are able to self-renew and differentiate into multiple cell types,provides a potentially valuable cell resource for drug screening in a“more relevant”cell type.Here we report a screening platform using human iPSCs in a multi-well plate format to identify compounds that could promote chondrogenesis. | Sheng-Lian Yang Erica Harnish Thomas Leeuw Uwe Dietz Erika Batchelder Paul SWright Jane Peppard Paul August Cecile Volle-Challier Francoise Bono Jean-Marc Herbert Juan Carlos Izpisua Belmonte | 2012 | Protein & Cell2012，3，12： | 3 |
| 3 | The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer显示文摘 | Craig P. Carden Adam Stewart Parames Thavasu Emma Kipps Lorna Pope Mateus Crespo Susana Miranda Gerhardt Attard Michelle D. Garrett Paul A. Clarke Paul Workman Johann S. de Bono Martin Gore Stan B Kaye Udai Banerji | 2012 | Molecular Cancer Therapeutics2012，，7： | 2 |
| 4 | Intermittent Androgen Deprivation for Locally Advanced and Metastatic Prostate Cancer: Results from a Randomised Phase 3 Study of the South European Uroncological Group显示文摘 | Fernando E.C. Calais da Silva Aldo V. Bono Peter Whelan Maurizio Brausi Anton Marques Queimadelos Jose A. Portillo Martin Ziya Kirkali Fernando M.V. Calais da Silva Chris Robertson | 2009 | European Urology2009，，6： | 2 |
| 5 | Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth显示文摘Taxane efficacy in triple negative breast cancer(TNBC)is limited by insufficient tumor accumulation and severe off-target effects.Nanomedicines offer a unique opportunity to enhance the anti-cancer potency of this drug.Here,1,000 nm×400 nm discoidal polymeric nanoconstructs(DPN)encapsulating docetaxel(DTXL)and the near infrared compound Iipid-Cy5 were engineered.DPN were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol)template with a polymer mixture comprising poly(lactic-co-glycolic acid)(PLGA)and poly(ethylene glycol)diacrylate(PEG-DA)chains together with therapeutic and imaging agents.The resulting“multi-passage”DPN exhibited higher DTXL loading,Iipid-Cy5 stability,and stiffness as compared to the conventional'single-passage'approach.Confocal microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL thereof.Empty DPN had no toxicity on TNBC cells,whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL(IC_(50)=2.6 nM±1.0 nM vs.7.0 nM±1.09 nM at 72 h).In orthotopic murine models,DPN accumulated in TNBC more efficiently than free-DTXL.With only 2 mg/kg DTXL,intravenously administered every 2 days for a total of 13 treatments,DTXL-DPN induced tumor regression and were associated to an overall 80%survival rate as opposed to a 30%survival rate for free-DTXL,at 120 days.All untreated mice succumbed before 90 days.Collectively,this data demonstrates that vascular confined multi-passage DPN,biomimicking the behavior of circulating platelets,can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses. | Alessia Felici Daniele Di Mascolo Miguel Ferreira Simone Lauciello Luca Bono Andrea Armirotti Arunkumar Pitchaimani Anna Lisa Palange Paolo Decuzzi | 2022 | Nano Research2022，15，1： | 2 |
| 6 | Global Entrepreneurship Monitor: Data Collection Design and Implementation 1998–2003显示文摘 | Paul Reynolds Niels Bosma Erkko Autio Steve Hunt Natalie De Bono Isabel Servais Paloma Lopez-Garcia Nancy Chin | 2005 | Small Business Economics2005，，3： | 2 |
| 7 | Relationship of Core Self-evaluations Traits-self-esteem, Generalized Self-efficacy, locus of Control, and Emotional Stability-with Job Satisfaction and Job Performance : A Meta-analysis显示文摘 | JUDGE T A BONO J E | 2001 | Journal of Applied Psychology2001，86，1： | 1 |
| 8 | Relationship of core self-evalua- tions traits self-esteem,generalized self-efficacy , lo- cus of control, and emotional stability-with job satis- faction and job performance: A meta-analysis 显示文摘 | Judge T A Bono J E | 2001 | Journal of Applied Psychology2001，86，1： | 1 |
| 9 | Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer 显示文摘 | de Bono JS Seller HI Montgomery RB | 2008 | Clin Cancer Res2008，14，19： | 1 |
| 10 | The role and results of proximal modularity in primary total hip replacement 显示文摘 | Bono JV | 2002 | Instr Course Lect2002，51，： | 1 |
| 11 | Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer显示文摘 | Joensuu H Kellokumpu-Lehtinen P L Bono P | 2006 | N Engl J Med2006，354，8： | 1 |
| 12 | Coronary artery stents and non-cardiac surgery 显示文摘 | Howard-Alpe GM de Bono J Hudsmith L | 2007 | Br J Anaesth2007，98，5： | 1 |
| 13 | Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits显示文摘 | Groszer M Keays DA Deacon RM de Bono JP Prasad-Muleare S Gaub S et at | | 0，，05： | 1 |
| 14 | Fabrication of Double Shell Targets with a Glass Inner Capsule Supported by SiO2 Aerogel for Shots on the Omega Laser in 2006 显示文摘 | Bono M Bennett D Castro C | 2006 | Fusion Science and Technology2006，51，4： | 1 |
| 15 | lnterspinous process devices in the lumbar spine显示文摘 | Bono CM Vaccaro AR | 2007 | J Spinal Disord Tech2007，20，3： | 1 |
| 16 | A second locus for riega syndrome maps to chromosome 13 q14 显示文摘 | Elizabeth A Del Bono | 1996 | Am J Hum Genet1996，59，： | 1 |
| 17 | High LYVE-1 p- ositive lymphatic vessel numbers are associated with poor outcome in breast cancer显示文摘 | BONO P WASENIUS V M HEIKKILA P | 2004 | Clin Cancer Res2004，10，： | 1 |
| 18 | The mitogenic effect of H2O2 for vascular smooth muscle cells is mediated by anincrease of the affinity of basic fibroblast growth factor for its receptor显示文摘 | Herbert JM Bono F Savi P | 1996 | FEBS Lett1996，395，1： | 1 |
| 19 | Melamine-urea-formal- dehyde(MUF) resin :The effect of the number of reaction sta- ges and mole ratio on resin properties显示文摘 | BONO A YEO K B SIAMBUN N J | 2003 | Technology2003，，： | 1 |
| 20 | Intravesical adjuvant chemotherapy for superficial transitional cell bladder carcinoma: results of 2 European Organization for Research and Treatment of Cancer randomized trails with mitomycin C and doxorubicin com- paring early versus delayed Instillations and short-term versus long-term treatment 显示文摘 | Bouffioux CH Kurth KH Bono A | 1995 | J Urol1995，153，32： | 1 |
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