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| 1 | Enteral nutrition and immune modulation of acute pancreatitis显示文摘Enteral nutrition has been strongly recommended by major scientific societies for the nutritional management of patients with acute pancreatitis.Providing severe acute pancreatitis patients with enteral nutrition within the first 24-48 h of hospital admission can help improve outcomes compared to parenteral nutrition and no feeding.New research is focusing in on when and what to feed to best improve outcomes for acute pancreatitis patients.Early enteral nutrition have the potential to modulate the immune responses.Despite this consistent evidence of early enteral nutrition in patients with acute pancreatitis,clinical practice continues to vary due to individual clinician preference.Achieving the immune modulating effects of enteral nutrition heavily depend on proper placement of the feeding tube and managing any tube feeding associated complications.The current article reviews the immune modulating effects of enteral nutrition and pro-and prebiotics and suggests some practical tools that help improve the patient adherence and tolerance to the tube feeding.Proper selection of the type of the tube,close monitoring of the tube for its placement,patency and securing its proper placement and routine checking the gastric residual volume could all help improve the outcome.Using peptide-based and high medium chaintriglycerides feeding formulas help improving feeding tolerance. | Refaat A Hegazi Tiffany De Witt | 2014 | World Journal of Gastroenterology2014，20，43： | 24 |
| 2 | Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma显示文摘We elucidated the anti-inflammatory mechanisms of IL-38 in allergic asthma.Human bronchial epithelial cells and eosinophils were cocultured upon stimulation with the viral RLR ligand poly(I:C)/LyoVec or infection-related cytokine TNF-αto induce expression of cytokines/chemokines/adhesion molecules.House dust mite(HDM)-induced allergic asthma and humanized allergic asthma NOD/SCID murine models were established to assess anti-inflammatory mechanisms in vivo.IL-38 significantly inhibited induced proinflammatory IL-6,IL-1β,CCL5,and CXCL10 production,and antiviral interferon-βand intercellular adhesion molecule-1 expression in the coculture system.Mass cytometry and RNA-sequencing analysis revealed that IL-38 could antagonize the activation of the intracellular STAT1,STAT3,p38 MAPK,ERK1/2,and NF-κB pathways,and upregulate the expression of the host defense-related gene POU2AF1 and anti-allergic response gene RGS13.Intraperitoneal injection of IL-38 into HDM-induced allergic asthma mice could ameliorate airway hyperreactivity by decreasing the accumulation of eosinophils in the lungs and inhibiting the expression of the Th2-related cytokines IL-4,IL-5,and IL-13 in the bronchoalveolar lavage fluid(BALF)and lung homogenates.Histological examination indicated lung inflammation was alleviated by reductions in cell infiltration and goblet cell hyperplasia,together with reduced Th2,Th17,and innate lymphoid type 2 cell numbers but increased proportions of regulatory T cells in the lungs,spleen,and lymph nodes.IL-38 administration suppressed airway hyperreactivity and asthma-related IL-4 and IL-5 expression in humanized mice,together with significantly decreased CCR3^(+) eosinophil numbers in the BALF and lungs,and a reduced percentage of human CD4^(+)CRTH2^(+)Th2 cells in the lungs and mediastinal lymph nodes.Together,our results demonstrated the anti-inflammatory mechanisms of IL-38 and provided a basis for the development of a regulatory cytokine-based treatment for allergic asthma. | Xiaoyu Sun Tianheng Hou Edwin Cheung Tiffany Nga-Teng Iu Victor Wai-Hou Tam Ida Miu-Ting Chu Miranda Sin-Man Tsang Paul Kay-Sheung Chan Christopher Wai-Kei Lam Chun-Kwok Wong | 2020 | Cellular & Molecular Immunology2020，17，6： | 22 |
| 3 | DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker显示文摘Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)enables tumor vascular physiology to be assessed.Within the tumor tissue,contrast agents(gadolinium chelates)extravasate from intravascular into the extravascular extracellular space(EES),which results in a signal increase on T1-weighted MRI.The rate of contrast agents extravasation to EES in the tumor tissue is determined by vessel leakiness and blood flow.Thus,the signal measured on DCE-MRI represents a combination of permeability and perfusion.The semi-quantitative analysis is based on the calculation of heuristic parameters that can be extracted from signal intensity-time curves.These enhancing curves can also be deconvoluted by mathematical modeling to extract quantitative parameters that may reflect tumor perfusion,vascular volume,vessel permeability and angiogenesis.Because hepatocellular carcinoma(HCC)is a hypervascular tumor,many emerging therapies focused on the inhibition of angiogenesis.DCE-MRI combined with a pharmacokinetic model allows us to produce highly reproducible and reliable parametric maps of quantitative parameters in HCC.Successful therapies change quantitative parameters of DCE-MRI,which may be used as early indicators of tumor response to anti-angiogenesis agents that modulate tumor vasculature.In the setting of clinical trials,DCE-MRI may provide relevant clinical information on the pharmacodynamic and biologic effects of novel drugs,monitor treatment response and predict survival outcome in HCC patients. | Bang-Bin Chen Tiffany Ting-Fang Shih | 2014 | World Journal of Gastroenterology2014，20，12： | 15 |
| 4 | Advances in computed tomography and magnetic resonance imaging of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver cancer.Imaging is important for establishing a diagnosis of HCC and early diagnosis is imperative as several potentially curative treatments are available when HCC is small.Hepatocarcinogenesis occurs in a stepwise manner on a background of chronic liver disease or cirrhosis wherein multiple genes are altered resulting in a range of cirrhosisassociated nodules.This progression is related to increased cellularity,neovascularity and size of the nodule.An understanding of the stepwise progression may aid in early diagnosis.Dynamic and multiphase contrast-enhanced computed tomography and magnetic resonance imaging still form the cornerstone in the diagnosis of HCC.An overview of the current diagnostic standards of HCC in accordance to the more common practicing guidelines and their differences will be reviewed.Ancillary features contribute to diagnostic confidence and has been incorporated into the more recent Liver Imaging Reporting and Data System.The use of hepatocyte-specific contrast agents is increasing and gradually changing the standard of diagnosis of HCC;the most significant benefit being the lack of uptake in the hepatocyte phase in the earlier stages of HCC progression.An outline of supplementary techniques in the imaging of HCC will also be reviewed. | Tiffany Hennedige Sudhakar K Venkatesh | 2016 | World Journal of Gastroenterology2016，22，1： | 15 |
| 5 | 长白山温带森林挥发性有机物的排放通量显示文摘2010年夏季,在长白山温带森林开展了挥发性有机物(VOC)排放通量以及气象参数、PAR的综合测量.VOC排放通量采用松弛涡度积累(RelaxedEddyAccumulation)技术在森林冠层上进行测量.初步发现长白山阔叶林主要排放α-蒎烯、β-蒎烯、莰烯、香桧烯、月桂烯、蒈烯、柠檬烯、罗勒烯、松油烯、繖花烃、萜品油烯、三环烯等.研究表明,长白山阔叶混交林VOC排放有明显的日变化——早晚较低和中午前后较高.2010年夏季,单萜烯总排放通量的平均值为0.242mg·m·h-2-1,其变化范围为0.005~1.668mg·m·h-2-1;各成分排放通量的平均值(和最大值)分别为α-蒎烯0.072(0.234)、莰烯0.028(0.356)、月桂烯0.027(0.433)、蒈烯0.023(0.173)、柠檬烯0.037(0.197)、罗勒烯0.016(0.168)、萜品油烯0.053(0.320)、繖花烃0.067(0.755)mg·m·h-2-1.研究还发现VOC排放通量与气温之间存在一定的联系. | 白建辉 林凤友 万晓伟 Guenther Alex Turnipseed Andrew Duhl Tiffany | 2012 | 环境科学学报2012，32，3： | 14 |
| 6 | Reflections on a Science and Technology Agenda for 21st Century Disaster Risk Reduction Based on the Scientific Content of the 2016 UNISDR Science and Technology Conference on the Implementation of the Sendai Framework for Disaster Risk Reduction 2015–203显示文摘The first international conference for the post-2015 United Nations landmark agreements(Sendai Framework for Disaster Risk Reduction 2015–2030, Sustainable Development Goals, and Paris Agreement on Climate Change) was held in January 2016 to discuss the role of science and technology in implementing the Sendai Framework for Disaster Risk Reduction 2015–2030. The UNISDR Science and Technology Conference on the Implementation of the Sendai Framework for Disaster Risk Reduction 2015–2030 aimed to discuss and endorse plans that maximize science's contribution to reducing disaster risks and losses in the coming 15 years and bring together the diversity of stakeholders producing and using disaster risk reduction(DRR) science and technology. This article describes the evolution of the role of science and technology in the policy process building up to the Sendai Framework adoption that resulted in an unprecedented emphasis on science in the text agreed on by 187 United Nations member states in March 2015 and endorsed by the United Nations General Assembly in June 2015. Contributions assembled by the Conference Organizing Committee and teams including the conference concept notes and the conference discussions that involved a broad range of scientists and decision makers are summarized in this article. The conference emphasized how partnerships and networks can advance multidisciplinary research and bring together science, policy, and practice; how disaster risk is understood, and how risks are assessed and early warning systems are designed; what data, standards, and innovative practices would be needed to measure and report on risk reduction; what research and capacity gaps exist and how difficulties in creating and using science for effective DRR can be overcome. The Science and Technology Conference achieved two main outcomes:(1) initiating the UNISDR Science and Technology Partnership for the implementation of the Sendai Framework; and(2) generating discussion and agreement regarding the content and endorsement process of the UNISDR Science and Technology Road Map to 2030. | Amina Aitsi-Selmi Virginia Murray Chadia Wannous Chloe Dickinson David Johnston Akiyuki Kawasaki Anne-Sophie Stevance Tiffany Yeung | 2016 | International Journal of Disaster Risk Science2016，7，1： | 14 |
| 7 | Low-dose metformin treatment in the subacute phase improves the locomotor function of a mouse model of spinal cord injury显示文摘Metformin,a first-line drug for type-2 diabetes,has been shown to improve locomotor recovery after spinal cord injury.However,there are studies reporting no beneficial effect.Recently,we found that high dose of metformin(200 mg/kg,intraperitoneal)and acute phase administration(immediately after injury)led to increased mortality and limited locomotor function recovery.Consequently,we used a lower dose(100 mg/kg,i.p.)metformin in mice,and compared the effect of immediate administration after spinal cord injury(acute phase)with that of administration at 3 days post-injury(subacute phase).Our data showed that metformin treatment starting at the subacute phase significantly improved mouse locomotor function evaluated by Basso Mouse Scale(BMS)scoring.Immunohistochemical studies also revealed significant inhibitions of microglia/macrophage activation and astrogliosis at the lesion site.Furthermore,metformin treatment at the subacute phase reduced neutrophil infiltration.These changes were in parallel with the increased survival rate of spinal neurons in animals treated with metformin.These findings suggest that low-dose metformin treatment for subacute spinal cord injury can effectively improve the functional recovery possibly through anti-inflammation and neuroprotection.This study was approved by the Institute Animal Care and Use Committee at the University of Texas Medical Branch(approval No.1008041C)in 2010. | Wen-Ye Song Han Ding Tiffany Dunn Jun-Ling Gao Javier Allende Labastida Caitlin Schlagal Guang-Zhi Ning Shi-Qing Feng Ping Wu | 2021 | Neural Regeneration Research2021，16，11： | 12 |
| 8 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012显示文摘 | R. Phillip Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell | 2013 | Critical Care Medicine2013，，2： | 12 |
| 9 | 亚热带竹林挥发性有机物排放的模拟显示文摘2012年7月至2013年1月,采用松弛涡度积累(Relaxed Eddy Accumulation)技术在我国浙江省亚热带竹林测量了挥发性有机物(BVOC)冠层尺度的排放通量,同步测量了气象参数、太阳辐射(总辐射、直接辐射、光合有效辐射PAR)。利用PAR能量平衡原理,建立了冠层尺度异戊二烯和单萜烯排放的经验模式,经验模式对于日变化、季节变化有较好的模拟。采用不同方法对经验模式进行检验,一般而言,BVOC的模拟值高于测量值。经验模式与MEGANv2.1全球生物排放模式对BVOC排放有比较一致的模拟结果,标准状况下(温度t=30℃、PAR=1 500μmol·m^(-2)·s^(-1)排放因子较接近(异戊二烯分别为4.00和3.60 mg·m^(-2)·h^(-1),单萜烯分别为0.12和0.16 mg·m^(-2)·h^(-1))。经验模式的计算结果表明:竹林BVOC排放主要集中于夏季(7-9月)且以异戊二烯为主(占BVOC排放的87.3%~95.8%)。利用经验模式计算了BVOC排放对各个因子(PAR、水汽、S/Q-散射因子,散射辐射/总辐射)变化的敏感性:当各个因子增加率大于40%时,异戊二烯对PAR的变化最敏感,其次是水汽因子,再次是S/Q;单萜烯对S/Q的变化最敏感,其次是水汽因子,再次是PAR;单萜烯比异戊二烯对S/Q的变化更敏感;异戊二烯和单萜烯对各因子变化的响应是非线性的。冠层尺度上BVOC的排放量与卫星测量的HCHO柱浓度(molec·cm^(-1))之间有良好的线性关系:异戊二烯排放量(mg·m^(-2)·h^(-1))=3.93×10^(-16)HCHO-2.81,单萜烯排放量(mg·m^(-2)·h^(-1))=1.24×10^(-17)HCHO-0.05。对比我国不同生态系统实测的排放通量、排放因子,异戊二烯排放以亚热带竹林最高,其次为温带森林,草地最低;单萜烯排放以温带森林最高,亚热带竹林次之,草地最低。 | 白建辉 DUHL TIFFANY 余树全 王彬 郝楠 | 2015 | 生态环境学报2015，24，12： | 9 |
| 10 | Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation显示文摘The cysteine protease caspase-1(Casp-1)contributes to innate immunity through the assembly of NLRP3,NLRC4,AIM2,and NLRP6 inflammasomes.Here we ask whether caspase-1 activation plays a regulatory role in house dust mite(HDM)-induced experimental allergic airway inflammation.We report enhanced airway inflammation in caspase-1-deficient mice exposed toHDMwith a marked eosinophil recruitment,increased expression of IL-4,IL-5,IL-13,aswell as full-length and bioactive IL-33.Furthermore,mice deficient for NLRP3 failed to control eosinophil influx in the airways and displayed augmented Th2 cytokine and chemokine levels,suggesting that the NLPR3 inflammasome complex controls HDM-induced inflammation.IL-33 neutralization by administration of soluble ST2 receptor inhibited the enhanced allergic inflammation,while administration of recombinant IL-33 during challenge phase enhanced allergic inflammation in caspase-1-deficient mice.Therefore,we show that caspase-1,NLRP3,and ASC,but not NLRC4,contribute to the upregulation of allergic lung inflammation.Moreover,we cannot exclude an effect of caspase-11,because caspase-1-deficient mice are deficient for both caspases.Mechanistically,absence of caspase-1 is associated with increased expression of IL-33,uric acid,and spleen tyrosine kinase(Syk)production.This study highlights acritical role of caspase-1 activation andNLPR3/ASCinflammasomecomplex in the down-modulation of IL-33 in vivo and in vitro,thereby regulating Th2 response in HDM-induced allergic lung inflammation. | Fahima Madouri Noelline Guillou Louis Fauconnier Tiffany Marchiol Nathalie Rouxel Pauline Chenuet Aurelie Ledru Lionel Apetoh Franc¸ois Ghiringhelli Mathias Chamaillard Song Guo Zheng Fabrice Trovero Valerie F.J.Quesniaux Bernhard Ryffel Dieudonnee Togbe | 2015 | Journal of Molecular Cell Biology2015，7，4： | 8 |
| 11 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012显示文摘 | R. P. Dellinger Mitchell M. Levy Andrew Rhodes Djillali Annane Herwig Gerlach Steven M. Opal Jonathan E. Sevransky Charles L. Sprung Ivor S. Douglas Roman Jaeschke Tiffany M. Osborn Mark E. Nunnally Sean R. Townsend Konrad Reinhart Ruth M. Kleinpell Derek | 2013 | Intensive Care Medicine2013，，2： | 7 |
| 12 | Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification显示文摘Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement. | Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay Nor Azhari Mohd Zam Puay Hoon Tan Min-Han Tan | 2011 | Chinese Journal of Cancer2011，30，2： | 6 |
| 13 | Nanomaterials for treating cardiovascular diseases:A review显示文摘Nanomaterials such as nanostructured surfaces,nanoparticles,and nanocomposites represent new viable sources for future therapeutics for cardiovascular diseases.The special properties of nanomaterials such as their intrinsic physiochemical properties,surface energy and surface topographies could actively enhance desirable cellular responses within the cardiovascular system,projecting a growing potential for clinical translation.Recent progress on nanomaterials opened up new opportunities for treating cardiovascular diseases.Successful translation of nanomaterials into cardiovascular applications requires a comprehensive understanding of both nanomaterials and biomedicine,and,thus,it is critical to stress current advancements on both sides.In this review,the authors introduced crucial fabrication techniques for promising nanomaterials for cardiovascular applications.This review highlighted the key elements to consider for their fabrication,properties and applications.The important concerns relevant to cardiovascular nanomaterials,such as cellular responses to nanomaterials and the toxicity of nanomaterials,are also discussed.This review provided an overview of necessary knowledge and key concerns on nanomaterials specific for treating cardiovascular diseases,from the perspectives of both material science and biomedicine. | Wensen Jiang Dana Rutherford Tiffany Vuong Huinan Liu | 2017 | Bioactive Materials2017，2，4： | 6 |
| 14 | Prevention of recurrent hepatitis B infection after liver transplantation显示文摘BACKGROUND:Recurrence of hepatitis B virus(HBV) infection after liver transplantation can lead to graft loss and a reduction in long-term survival.The purpose of this review is to summarize the current therapeutic options for preventing HBV recurrence in liver transplant recipients.DATA SOURCES:Up to January 2013,studies that were published in MEDLINE and EMBASE on prevention of HBV recurrence after liver transplantation were reviewed.RESULTS:There have been remarkable advancements in the past two decades on the prevention of HBV recurrence after liver transplantation,from the discovery of hepatitis B immune globulin(HBIG) and lamivudine monotherapy to the combination therapy using HBIG and lamivudine.With the development of newer and stronger antiviral agents,the need for life-long HBIG is doubtful.With their low resistance profile,oral antiviral prophylaxis using these new agents alone is sufficient and is associated with excellent outcome.CONCLUSIONS:Restoration of host HBV immunity with adoptive immunity transfer and vaccination may represent the ultimate strategy to withdraw prophylactic treatment and to achieve a drug free regimen against HBV recurrence after liver transplantation. | Tiffany CL Wong James YY Fung Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 5 |
| 15 | Identification of Ca2+ signaling components in neural stem/progenitor cells during differentiation into neurons and glia in intact and dissociated zebrafish neurospheres显示文摘The development of the CNS in vertebrate embryos involves the generation of different sub-types of neurons and glia in a complex but highly-ordered spatio-temporal manner. Zebrafish are commonly used for exploring the development, plasticity and regeneration of the CNS, and the recent development of reliable protocols for isolating and culturing neural stem/progenitor cells(NSCs/NPCs) from the brain of adult fish now enables the exploration of mechanisms underlying the induction/specification/differentiation of these cells. Here, we refined a protocol to generate proliferating and differentiating neurospheres from the entire brain of adult zebrafish. We demonstrated via RT-qPCR that some isoforms of ip3 r, ryr and stim are upregulated/downregulated significantly in differentiating neurospheres, and via immunolabelling that 1,4,5-inositol trisphosphate receptor(IP3 R) type-1 and ryanodine receptor(RyR) type-2 are differentially expressed in cells with neuron-or radial glial-like properties. Furthermore, ATP but not caffeine(IP3 R and RyR agonists, respectively), induced the generation of Ca^(2+) transients in cells exhibiting neuron-or glial-like morphology. These results indicate the differential expression of components of the Ca^(2+) -signaling toolkit in proliferating and differentiating cells. Thus, given the complexity of the intact vertebrate brain, neurospheres might be a useful system for exploring neurodegenerative disease diagnosis protocols and drug development using Ca^(2+) signaling as a read-out. | Man Kit Tse Ting Shing Hung Ching Man Chan Tiffany Wong Mike Dorothea Catherine Leclerc Marc Moreau Andrew L.Miller Sarah E.Webb | 2018 | Science China(Life Sciences)2018，61，11： | 4 |
| 16 | 性发育异常性腺肿瘤患者术后生存质量评估研究显示文摘目的评估性发育异常(DSD)性腺肿瘤患者术后生存质量(QOL),以期对该疾病的长期健康管理提供参考。方法对2006年1月至2015年12月北京协和医院妇产科收治的24例DSD肿瘤患者进行术后随访并提供心理支持,使用WHOQOL-BREF量表(包含生理领域、心理领域、社会关系领域、环境领域4部分)评估QOL。结果 DSD肿瘤患者初治平均年龄为(19.25±4.75)岁(13~29岁),社会性别均为女性,术后均规律随访(4.79±2.36)年(1~10年)至今。纳入15例(62.50%)46,XY单纯性腺发育不全(46,XY PGD),6例(25.00%)雄激素不敏感综合征(AIS),3例(12.50%)XO/XY性腺发育不全(Mixed GD),各疾病类型DSD肿瘤患者QOL心理领域评分均低于其他领域,Mixed GD心理领域评分最低。DSD肿瘤患者QOL评分高于一般DSD患者及一般成年城市人口,差异有统计学意义(P<0.05)。患者中良性肿瘤11例,恶性肿瘤13例,两组间QOL评分比较,差异无统计学意义(P>0.05)。结论通过接受长期的、个体化的、优化的手术药物治疗和心理支持,DSD肿瘤患者可获得较理想的QOL。 | 黄禾 Tiffany Tian 田秦杰 | 2017 | 生殖医学杂志2017，26，6： | 4 |
| 17 | Clinical and molecular characteristics of East Asian patients with von Hippel–Lindau syndrome显示文摘Background: Von Hippel–Lindau(VHL) syndrome is a dominantly inherited multisystem cancer syndrome caused by a heterozygous mutation in the VHL tumor suppressor gene. Previous studies suggested that similar populations of Caucasian and Japanese patients have similar genotype or phenotype characteristics. In this comprehensive study of East Asian patients, we investigated the genetic and clinical characteristics of patients with VHL syndrome.Methods: To create a registry of clinical characteristics and mutations reported in East Asian patients with VHL syndrome, we conducted a comprehensive review of English language and non?English language articles identi?fied through a literature search. Publications in Japanese or Chinese language were read by native speakers of the language, who then performed the data extraction.Results: Of 237 East Asian patients with VHL syndrome, 154 unique kindreds were identified for analysis. Analyzed by kindred, missense mutations were the most common(40.9%, 63/154), followed by large/complete deletions(32.5%, 50/154) and nonsense mutations(11.7%, 18/154). Compared with a previously reported study of both East Asian and non?East Asian patients, we found several key differences. First, missense and frameshift mutations in the VHL gene occurred less commonly in our population of East Asian patients(40.9% vs. 52.0%; P = 0.012 and 8.4% vs. 13.0%; P < 0.001, respectively). Second, large/complete deletions were more common in our population of East Asian patients(32.5% vs. 10.5%; P < 0.001). Third, phenotypically, we observed that, in our population of East Asian patients with VHL syndrome, the incidence of retinal capillary hemangioblastoma was lower, whereas the incidence of renal cell carcinoma was higher.Conclusions: Evidence suggests that the genotypic and phenotypic characteristics of East Asian patients with VHL syndrome differ from other populations. This should be considered when making screening recommendations for VHL syndrome in Asia. | Meihua Wong Ying-Hsia Chu Hwei Ling Tan Hideharu Bessho Joanne Ngeow Tiffany Tang Min-Han Tan | 2016 | Chinese Journal of Cancer2016，35，9： | 3 |
| 18 | Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products显示文摘Neuronal injuries such as stroke,traumatic brain injury,and spinal cord injury are leading causes of major disability and death.Chronic therapy for these neuronal injuries requires the promotion of axonal regeneration from the remaining neurons(Schwab and Strittmatter,2014).However,the local environment in the central nervous | Tiffany K.Fan Usha Gundimeda William J.Mack Rayudu Gopalakrishna | 2016 | Neural Regeneration Research2016，11，4： | 3 |
| 19 | Clinical factors affecting rejection rates in liver transplantation显示文摘BACKGROUND: With improvements in survival, liver transplant recipients now suffer more morbidity from long-term immunosuppression. Considerations were given to develop individualized immunosuppression based on their risk of rejection. METHOD: We retrospectively analyzed the data of 788 liver transplants performed during the period from October 1991 to December 2011 to study the relationship between acute cellular rejection(ACR) and various clinical factors. RESULTS: Multivariate analysis showed that older age(P=0.04,OR=0.982), chronic hepatitis B virus infection(P=0.005, OR=0.574), living donor liver transplantation(P=0.02, OR=0.648) and use of interleukin-2 receptor antagonist on induction(P<0.001, OR=0.401) were associated with fewer ACRs. Patients with fulminant liver failure(P=0.004, OR=4.05) were more likely to develop moderate to severe grade ACR. CONCLUSIONS: Liver transplant recipients with older age,chronic hepatitis B virus infection, living donor liver transplantation and use of interleukin-2 receptor antagonist on induction have fewer ACR. Patients transplanted for fulminant liver failure are at higher risk of moderate to severe grade ACR.These results provide theoretical framework for developing individualized immunosuppression. | Kin Pan Au See-Ching Chan Kenneth Siu-Ho Chok William Wei Sharr Wing-Chiu Dai Sui-Ling Sin Tiffany Cho-Lam Wong Chung-Mau Lo | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，4： | 3 |
| 20 | Chemotherapy of ovarian cancer in elderly patients显示文摘Epithelial ovarian cancer is primarily a disease of older women. Advanced age is risk factor for decreased survival. Optimal surgery and the safe and effective administration of chemotherapy are essential for prolonged progression-free and overall survival(OS). In this article, the available regimens in both the primary treatment and relapsed setting are reviewed. | Tiffany A.Troso-Sandoval Stuart M.Lichtman | 2015 | Cancer Biology & Medicine2015，12，4： | 3 |
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