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| 1 | Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis显示文摘AIM To reveal better diagnostic markers for differentiating neuroendocrine tumor(NET) from solid-pseudopapillary neoplasm(SPN), focusing primarily on immunohistochemical analysis.METHODS We reviewed 30 pancreatic surgical specimens of NET(24 cases) and SPN(6 cases). We carried out comprehensive immunohistochemical profiling using 9 markers: Synaptophysin, chromogranin A, pancytokeratin, E-cadherin, progesterone receptor,vimentin, α-1-antitrypsin, CD10, and β-catenin.RESULTS E-cadherin staining in NETs, and nuclear labeling of β-catenin in SPNs were the most sensitive and specific markers. Dot-like staining of chromogranin A might indicate the possibility of SPNs rather than NETs. The other six markers were not useful because their expression overlapped widely between NETs and SPNs. Moreover, two cases that had been initially diagnosed as NETs on the basis of their morphological features, demonstrated SPN-like immunohistochemical profiles. Careful diagnosis is crucial as we actually found two confusing cases showing disagreement between the tumor morphology and immunohistochemical profiles.CONCLUSION E-cadherin, chromogranin A, and β-catenin were the most useful markers which should be employed for differentiating between NET and SPN. | Yusuke Ohara Tatsuya Oda Shinji Hashimoto Yoshimasa Akashi Ryoichi Miyamoto Tsuyoshi Enomoto Kaishi Satomi Yukio Morishita Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，38： | 19 |
| 2 | Three-dimensional imaging identified the accessory bile duct in a patient with cholangiocarcinoma显示文摘The development of diagnostic imaging technology, such as multidetector computed tomography(MDCT) and magnetic resonance cholangiopancreatography(MRCP), has made it possible to obtain detailed images of the bile duct. Recent reports have indicated that a 3-dimensional(3D) reconstructed imaging system would be useful for understanding the liver anatomy before surgery. We have investigated a novel method that fuses MDCT and MRCP images. This novel system easily made it possible to detect the anatomical relationship between the vessels and bile duct in the portal hepatis. In this report, we describe a very rare case of extrahepatic cholangiocarcinoma associated with an accessory bile duct from the caudate lobe connecting with the intrapancreatic bile duct. We were unable to preoperatively detect this accessory bile duct using MDCT and MRCP. However, prior to the second operation, we were able to clearly visualise the injured accessory bile duct using our novel 3D imaging modality. In thisreport, we suggest that this imaging technique can be considered a novel and useful modality for understanding the anatomy of the portal hepatis, including the hilar bile duct. | Ryoichi Miyamoto Yukio Oshiro Shinji Hashimoto Keisuke Kohno Kiyoshi Fukunaga Tatsuya Oda Nobuhiro Ohkohchi | 2014 | World Journal of Gastroenterology2014，20，32： | 6 |
| 3 | Anti-neuronal autoantibody in Hashimoto’s encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients显示文摘 | Takashi Oide Takahiko Tokuda Masahide Yazaki Megumi Watarai Shigeaki Mitsuhashi Kazuma Kaneko Takao Hashimoto Shinji Ohara Shu-ichi Ikeda | 2003 | Journal of the Neurological Sciences2003，，1： | 1 |
| 4 | Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice显示文摘 | Kosuke Ebina Kazuya Oshima Morihiro Matsuda Atsunori Fukuhara Kazuhisa Maeda Shinji Kihara Jun Hashimoto Takahiro Ochi Nirmal K. Banda Hideki Yoshikawa Iichiro Shimomura | 2008 | Biochemical and Biophysical Research Communications2008，，2： | 1 |
| 5 | Statistical Process Monitoring Based on Dissimilarity of Process Data显示文摘 | Kano Manabu Hasebe Shinji Hashimoto Iori | 2002 | AIChE2002，48，6： | 1 |
| 6 | Anti-High-Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis显示文摘 | Koichi Suda Yuko Kitagawa Soji Ozawa Yoshiro Saikawa Masakazu Ueda Masahito Ebina Shingo Yamada Satoru Hashimoto Shinji Fukata Edward Abraham Ikuro Maruyama Masaki Kitajima Akitoshi Ishizaka | 2006 | World Journal of Surgery2006，，9： | 1 |
| 7 | Telomere shortening and karyotypic alterations in hepatocytes in long‐term transplanted human liver allografts显示文摘 | Wulamujiang Aini Aya Miyagawa‐Hayashino Tatsuaki Tsuruyama Seiji Hashimoto Shinji Sumiyoshi Munetaka Ozeki Keiji Tamaki Shinji Uemoto Hironori Haga | 2012 | Transplant International2012，，9： | 1 |
| 8 | Expressions of Insulin-Like Growth Factor Receptor-1 and Insulin-Like Growth Factor Binding Protein 3 in Advanced Non–Small-Cell Lung Cancer显示文摘 | Young Hak Kim Shinji Sumiyoshi Seiji Hashimoto Katsuhiro Masago Yosuke Togashi Yuichi Sakamori Chiyuki Okuda Tadashi Mio Michiaki Mishima | 2012 | Clinical Lung Cancer2012，，： | 1 |
| 9 | Neuroendocrine carcinoma of the extrahepatic bile duct: A case report显示文摘Neuroendocrine carcinoma(NEC) originating from the gastrointestinal hepatobiliary-pancreas is a rare, invasive, and progressive disease, for which the prognosis is extremely poor. The patient was a 72-year-old man referred with complaints of jaundice. He was diagnosed with middle extrahepatic cholangiocarcinoma(cT 4N1M0, c Stage Ⅳ). He underwent a right hepatectomy combined with extrahepatic bile duct and portal vein resection after percutaneous transhepatic portal vein embolization. Microscopic examination showed a large-cell neuroendocrine carcinoma according to the WHO criteria for the clinicopathologic classification of gastroenteropancreatic neuroendocrine tumors. Currently, the patient is receiving combination chemotherapy with cisplatin and etoposide for postoperative multiple liver metastases. Although NEC is difficult to diagnose preoperatively, it should be considered an uncommon alternative diagnosis. | Yukio Oshiro Ryozo Gen Shinji Hashimoto Tatsuya Oda Taiki Sato Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，30： | 1 |
| 10 | Explanation for the failure of neoadjuvant chemotherapy to improve outcomes after radiotherapy for locally advanced uterine cervical cancer from the standpoint of the tumor regression rate显示文摘 | Kiyoshi Ohara Hajime Tsunoda Yumiko Oishi Tanaka Kayoko Ohnishi Keiko Nemoto Takayuki Hashimoto Nobuyoshi Fukumitsu Masaharu Hata Shinji Sugahara Koichi Tokuuye Hiroyuki Yoshikawa Yasuyuki Akine | 2007 | Radiation Medicine2007，，2： | 1 |
| 11 | Soluble Fas molecule in the serum of patients with systemic lupus erythematosus显示文摘 | Yoshiaki Tokano Sachiko Miyake Nobuhiko Kayagaki Kazuhisa Nozawa Shinji Morimoto Miyuki Azuma Hideo Yagita Yoshinari Takasaki Ko Okumura Hiroshi Hashimoto | 1996 | Journal of Clinical Immunology1996，，5： | 1 |
| 12 | Optimal operation policy for multi-effect batch distillation system显示文摘 | HASEBE Shinji NODA Masaru HASHIMOTO Iori | 1997 | Computers Chem Eng1997，21，1： | 1 |
| 13 | Histological and prognostic importance of CD 44+/ CD 24+/ E p CAM + expression in clinical pancreatic cancer显示文摘 | Yusuke Ohara Tatsuya Oda Masato Sugano Shinji Hashimoto Tsuyoshi Enomoto Keiichi Yamada Yoshimasa Akashi Ryoichi Miyamoto Akihiko Kobayashi Kiyoshi Fukunaga Yukio Morishita Nobuhiro Ohkohchi | 2013 | Cancer Sci2013，，8： | 1 |
| 14 | Proton Beam Therapy for Hepatocellular Carcinoma Patients with Severe Cirrhosis显示文摘 | Masaharu Hata Koichi Tokuuye Shinji Sugahara Nobuyoshi Fukumitsu Takayuki Hashimoto Kayoko Ohnishi Keiko Nemoto Kiyoshi Ohara Yasushi Matsuzaki Yasuyuki Akine | 2006 | Strahlentherapie und Onkologie2006，，12： | 1 |
| 15 | Synthesis of an Agarose - Gelatin Conjugate for Use as a Tissue Engineering Scaffold显示文摘 | Shinji Sakai Ichiro Hashimoto Kowakami | 2007 | Journal of Bioscience and Bioengineering2007，103，1： | 1 |
| 16 | Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report显示文摘BACKGROUND Hepatocellular carcinoma(HCC)accompanied by portal vein tumour thrombus(PVTT)presents an aggressive disease course,worsening liver function reserve,and a high recurrence rate.Clinical practice guidelines recommend systemic therapy as the first-line option for HCC with portal invasion.However,to achieve longer survival in these patients,the treatment strategy should be concluded with removal of the tumour by locoregional therapy.We experienced a case of initially unresectable HCC with main PVTT converted to radical hepatectomy after lenvatinib treatment.CASE SUMMARY A 59-year-old male with chronic hepatitis C infection visited our clinic as a regular post-surgery follow-up.Contrast-enhanced abdominal computed tomography revealed a liver mass diffusely located at the lateral segment with a massive PVTT extending from the umbilical portion to the main and contralateral third-order portal branches.With the diagnosis of unresectable HCC with Vp4(main trunk/contralateral branch)PVTT,lenvatinib was started at 12 mg/d.The computed tomography taken 3 mo after starting lenvatinib showed regression of the PVTT,which had retreated to the contralateral first-order portal branch.He tolerated the full dose without major adverse effects.With cessation of lenvatinib for 7 d,radical left lobectomy and PVTT thrombectomy were conducted.The patient’s postoperative course was uneventful.Microscopically,the primary lesion showed fibrotic changes,with moderately to poorly differentiated tumour cells surrounded by granulation tissues in some areas.The majority of the PVTT showed necrosis.He was alive without recurrence for 8 mo.CONCLUSION This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment. | Kazuhiro Takahashi Jaejeong Kim Amane Takahashi Shinji Hashimoto Manami Doi Kinji Furuya Ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda | 2021 | World Journal of Hepatology2021，13，3： | 1 |
| 17 | A new statistical process monitoring method using principal component analysis显示文摘 | Manabu Kano Shinji Hasebe Iori Hashimoto | 2001 | Computers and Chemical Engineering2001，25，： | 1 |
| 18 | Pseudo-Meigs’ Syndrome Caused by Ovarian Metastasis from Colon Cancer: Report of a Case显示文摘 | Tomonori Ohsawa Hideyuki Ishida Hiroshi Nakada Shigehisa Inokuma Daijyo Hashimoto Hajime Kuroda Shinji Itoyama | 2003 | Surgery Today2003，，5： | 1 |
| 19 | Human information sensor显示文摘 | Katsuya Morinaka Kazuhiko Hashimoto Shinji Tanaka | 1998 | Sensors and Actuators1998，66，： | 1 |
| 20 | Evolution of multivariate statistical process control:application of independent component analysis and external analysis显示文摘 | Manabu Kano Shinji Hasebe Iori Hashimoto Hiromu Ohno | 2004 | Computers and Chemical Engineering2004，59，： | 1 |
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