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| 1 | Arsenic Disulfide Induced Apoptosis and Concurrently Promoted Erythroid Differentiation in Cytokine-Dependent Myelodysplastic Syndrome-progressed Leukemia Cell Line F-36p with Complex Karyotype Including Monosomy 7显示文摘Objective:Acute myeloid leukemia progressed from myelodysplastic syndrome(MDS/AML)is generally incurable with poor prognosis for complex karyotype including monosomy 7(-7).Qinghuang Powder(青黄散,QHP),which includes Qing Dai(Indigo naturalis)and Xiong Huang(realgar)in the formula,is effective in treating MDS or MDS/AML even with the unfavorable karyotype,and its therapeutic efficacy could be enhanced by increasing the Xiong huang content in the formula,while Xiong huang contains>90%arsenic disulfide(As_2S_2).F-36p cell line was established from a MDS/AML patient with complex karyotype including-7,and was in cytokine-dependent.The present study was to investigate the effects of AS_2S_2 on F-36p cells.Methods:Cell proliferation was measured by an3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Cell apoptosis was identified by Annexin V-staining.Cell viability was determined by a propidium iodide(PI)exclusion.Erythroid differentiation was evaluated by the expression of cell surface antigen CD235a(GpA).Results:After treatment with AS_2S_2,at concentrations of 0.5to 16μmol/L for 72 h,As_2S_2 inhibited the proliferation of F-36p cells.The 50%inhibitory concentrations(IC_(50))of As_2S_2against the proliferation of F-36p cells was 6μmol/L.The apoptotic cells significantly increased in a dose-dependent mannar(P<0.05).The cell viabilities were significantly inhibited by As_2S_2 dose-dependent in a dose-dependent manner(P<0.05).Significant increases of CD235a-positive cells were concurrently observed(P<0.05)also in a dosedependent manner.Conclusions:As_2S_2 could inhibit proliferation and viability,induce apoptosis,and concurrently promote erythroid differentiation dose-dependently in F-36p cells.AS_2S_2 can inhibit proliferation and viability,induce apoptosis,and concurrently promote erythroid differentiation in cytokine-dependent MDS-progressed human leukemia cell line F-36p with complex karyotype including-7.The data suggest that QHP and/or As_2S_2 could be a potential candidate in the treatment of MDS or MDS/AML even with unfavorable cytogenetics. | 胡晓梅 Sachiko Tanaka Kenji Onda 袁博 Hiroo Toyoda 麻柔 刘峰 Toshihiko Hirano | 2014 | Chinese Journal of Integrative Medicine2014，20，5： | 20 |
| 2 | Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism显示文摘AIM:To investigate the reasons for the occurrence of the pink-color sign of iodine-unstained lesions. METHODS:In chromoendoscopy, the pink-color sign of iodine-unstained lesions is recognized as useful for the diagnosis of esophageal squamous cell carcinoma. Patients with superficial esophageal neoplasms treated by endoscopic resection were included in the study. Areas of mucosa with and without the pink-color sign were evaluated histologically. The following histologic features that were possibly associated with the pinkcolor sign were evaluated. The keratinous layer and basal cell layer were classified as present or absent. Cellular atypia was classified as high grade, moderate grade or low grade, based on nuclear irregularity, mitotic figures, loss of polarity, chromatin pattern and nuclear/cytoplasmic ratio. Vascular change was assessed based on dilatation, tortuosity, caliber change and variability in shape. Vessels with these four findings were classified as positive for vascular change. Endoscopic images of the lesions were captured immediately after iodine staining, 2-3 min after iodine staining and after complete fading of iodine staining. Quantitative analysis of color changes after iodine staining was also performed. RESULTS:A total of 61 superficial esophageal neoplasms in 54 patients were included in the study. The lesions were located in the cervical esophagus in one case, the upper thoracic esophagus in 10 cases, the mid-thoracic esophagus in 33 cases, and the lower thoracic esophagus in 17 cases. The median diameter of the lesions was 20 mm (range:2-74 mm). Of the 61 lesions, 28 were classified as pink-color sign positive and 33 as pink-color sign negative. The histologic diagnosis was high-grade intraepithelial neoplasia (HGIN) or cancer invading into the lamina propria in 26 of the 28 pink-color sign positive lesions. There was a significant association between pink-color sign positive epithelium and HGIN or invasive cancer (P = 0.0001). Univariate analyses found that absence of the keratinous layer and cellular atypia were significantly associated with the pink-color sign. After Bonferroni correction, there were no significant associations between the pink-color sign and presence of the basal membrane or vascular change. Multivariate analyses found that only absence of the keratinous layer was independently associated with the pink-color sign (OR = 58.8, 95%CI:5.5-632).Quantitative analysis was performed on 10 superficial esophageal neoplasms with both pink-color sign positive and negative areas in 10 patients. Pink-color sign positive mucosa had a lower mean color value in the late phase (pinkish color) than in the early phase (yellowish color), and had similar mean color values in the late and final phases. These findings suggest that pinkcolor positive mucosa underwent color fading from the color of the iodine (yellow) to the color of the mucosa (pink) within 2-3 min after iodine staining. Pink-color sign negative mucosa had similar mean color values in the late and early phases (yellowish color), and had a lower mean color value in the final phase (pinkish color) than in the late phase. These findings suggest that pink-color sign negative mucosa did not undergo color fading during the 2-3 min after iodine staining, and underwent color fading only after spraying of sodium thiosulfate. CONCLUSION:The pink-color sign was associated with absence of the keratinous layer. This sign may be caused by early fading of iodine staining. | Ryu Ishihara Hiromitsu Kanzaki Hiroyasu Iishi Kengo Nagai Fumi Matsui Takeshi Yamashina Noriko Matsuura Takashi Ito Mototsugu Fujii Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Noriya Uedo Masaharu Tatsuta Yasuhiko Tomita Shingo Ishiguro | 2013 | World Journal of Gastroenterology2013，19，27： | 10 |
| 3 | Elastography for the pancreas: Current status and future perspective显示文摘Elastography for the pancreas can be performed by either ultrasound or endoscopic ultrasound(EUS). There are two types of pancreatic elastographies based on different principles, which are strain elastography and shear wave elastography. The stiffness of tissue is estimated by measuring the grade of strain generated by external pressure in the former, whereas it is estimated by measuring propagation speed of shear wave, the transverse wave, generated by acoustic radiation impulse(ARFI) in the latter. Strain elastography is difficult to perform when the probe, the pancreas and the aorta are not located in line. Accordingly, a fine elastogram can be easily obtained in the pancreatic body but not in the pancreatic head and tail. In contrast, shear wave elastography can be easily performed in the entire pancreas because ARFI can be emitted to wherever desired. However, shear wave elastography cannot be performed by EUS to date. Recently, clinical guidelines for elastography specialized in the pancreas were published from Japanese Society of Medical Ultrasonics. The guidelines show us technical knacks of performing elastography for the pancreas. | Natsuko Kawada Sachiko Tanaka | 2016 | World Journal of Gastroenterology2016，22，14： | 8 |
| 4 | Impact of time from diagnosis to chemotherapy in advanced gastric cancer: A Propensity Score Matching Study to Balance Prognostic Factors显示文摘BACKGROUND It is unclear whether treatment delay affects the clinical outcomes of chemotherapy in advanced gastric cancer(A-GC).AIM To assess whether treatment delay affects the clinical outcomes of chemotherapy in A-GC.METHODS This single-center retrospective study examined consecutive patients with A-GC between April 2012 and July 2018. In total, 110 patients with stage Ⅳ A-GC who underwent chemotherapy were enrolled. We defined the wait time(WT) as the interval between diagnosis and chemotherapy initiation. We evaluated the influence of WT on overall survival(OS).RESULTS The mean OS was 303 d. The median WT was 17 d. We divided the patients into early and elective WT groups, with a 2-wk cutoff point. There were 46 and 64 patients in the early and elective WT groups, respectively. Compared with the elective WT group, the early WT group had significantly lower albumin(Alb)levels and higher neutrophil/lymphocyte ratios and C-reactive protein(CRP)levels but not a lower performance status. The elective WT group underwent more combination chemotherapy than did the early WT group. OS was different between the two groups(230 d vs 340 d, respectively). Multivariate analysis revealed that higher CRP levels, lower Alb levels and monotherapy were significantly related to a poor prognosis. To minimize potential selection bias,patients in the elective WT group were 1:1 propensity score matched with patients in the early WT group; no significant difference in OS was found(303 d vs 311 d, respectively, log-rank P = 0.9832).CONCLUSION A longer WT in patients with A-GC does not appear to be associated with a worse prognosis. | Tsutomu Nishida Aya Sugimoto Ryo Tomita Yu Higaki Naoto Osugi Kei Takahashi Kaori Mukai Tokuhiro Matsubara Dai Nakamatsu Shiro Hayashi Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 4 |
| 5 | Combination of two-hour post-endoscopic retrograde cholangiopancreatography amylase levels and cannulation times is useful for predicting post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘AIM To estimate the efficacy of 2 h post-endoscopic retrograde cholangiopancreatography(ERCP) serum amylase levels and other factors for predicting postERCP pancreatitis.METHODS This was a retrospective,single-center cohort study of consecutive patients who underwent ERCP from January 2010 to December 2013.Serum amylase levels were measured 2 h post-procedure,and patient- and procedure-related pancreatitis(PEP) risk factors wereanalyzed using a logistic model.RESULTS A total of 1520 cases(average age 72 ± 12 years,60% male) were initially enrolled in this study,and 1403 cases(725 patients) were ultimately analyzed after the exclusion of 117 cases.Fifty-five of these cases developed PEP.We established a 2 h serum amylase cutoff level of two times the upper limit of normal for predicting PEP.Multivariate analysis revealed that a cannulation time of more than 13 min [odds ratio(OR) 2.28,95%CI:1.132-4.651,P=0.0210] and 2 h amylase levels greater than the cutoff level(OR=24.1,95%CI:11.56-57.13,P<0.0001) were significant predictive factors for PEP.Forty-seven of the 55 patients who developed PEP exhibited 2 h amylase levels greater than the cutoff level(85%),and six of the remaining eight patients who developed PEP(75%) required longer cannulation times.Only 2 of the 1403 patients(0.14%) who developed PEP did not exhibit concerning 2 h amylase levels or require longer cannulation times.CONCLUSION These findings indicate that the combination of 2 h post-ERCP serum amylase levels and cannulation times represents a valuable marker for identifying patients at high risk for PEP. | Shiro Hayashi Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Takahiro Amano Aya Sugimoto Kei Takahashi Kaori Mukai Tokuhiro Matsubara Masashi Yamamoto Sachiko Nakajima Koji Fukui Masami Inada | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 4 |
| 6 | 多学科与正畸结合治疗重度牙周病及咬合错乱:附1例临床报告显示文摘伴有牙周组织破坏和咬合错乱的患者需要牙周、修复和正畸的结合治疗,对于此种患者正畸矫治是可行的,但同时需要消除炎症以及咬合干扰,为之后适宜的修复体提供良好的牙周环境。对于此种患者的正畸治疗需要稳定的支抗系统、合理的力系使用、稳定的保持以及治疗期间的菌斑控制。本病例报告描述了一位49岁伴有牙周组织破坏严重、多个牙缺失且咬合错乱的女性患者,正畸及牙周治疗后患者的咬合功能及面部美观得到较大改善,治疗中采用了诱导组织再生术、种植体修复以及上颌窦提升术。 | Sachiko Maeda Yoshinobu Maeda Yoshihiro Ono Kimio Nakamura Tokuo 王峰(译) | 2007 | 中国口腔医学继续教育杂志2007，10，4： | 4 |
| 7 | Surgically treated diaphragmatic perforation after radiofrequency ablation for hepatocellular carcinoma显示文摘We review 6 cases of diaphragmatic perforation, with and without herniation, treated in our institution. All patients with diaphragmatic perforation underwent radiofrequency ablation(RFA) treatments for hepatocellular carcinoma(HCC) performed at Kurume University Hospital and Tobata Kyoritsu Hospital. We investigated the clinical profiles of the 6 patients between January 2003 and December 2013. We further describe the clinical presentation, diagnosis, and treatment of diaphragmatic perforation. The change in the volume of liver and the change in the Child-Pugh score from just after the RFA to the onset of perforation was evaluated using a paired t-test. At the time of perforation, 4 patients had herniation of the viscera, while the other 2 patients had no herniation. The majority of ablated tumors were located adjacent to the diaphragm, in segments 4, 6, and 8. The average interval from RFA to the onset of perforation was 12.8 mo(range, 6-21 mo). The median Child-Pugh score at the onset of perforation(8.2) was significantly higher compared to the median Child-Pugh score just after RFA(6.5)(P = 0.031). All patients underwent laparotomy and direct suture of the diaphragm defect, with uneventful post-surgical recovery. Diaphragmatic perforation after RFA is not a matter that can be ignored. Clinicians should carefully address this complication by performing RFA for HCC adjacent to diaphragm. | Sachiko Nagasu Koji Okuda Ryoko Kuromatsu Yoriko Nomura Takuji Torimura Yoshito Akagi | 2017 | World Journal of Gastrointestinal Surgery2017，9，12： | 3 |
| 8 | 为什么要研究回儒世界观?(一)显示文摘大约15年前,我和威廉·柴提克(William Chittick)以及我们尊敬的同行杜维明教授开始研究回儒文本。从那时起,我们就和中国研究伊斯兰教的学者和学生们往来甚密。显然,很多中国学者并不认为回儒学说与伊斯兰主流学说是一脉相承的。这很可能是因为20世纪的某些事件中断了回儒思想的传播。由于维持其宗教传统的教育体制不复存在,中国穆斯林不得不重新学习自己的宗教传统。他们主要依靠外部资料,而且往往是西方历史学家的作品。 | 村田幸子(Sachiko Murata) 著宋悦 译任军(校) | 2012 | 回族研究2012，，3： | 3 |
| 9 | Effect of ONO-4057 and tacrolimus on ischemia-reperfusion injury of the liver显示文摘AIM: To investigate the effects of a novel Leukotriene B4 receptor antagonist and/or tacrolimus on ischemia-reperfusion in a rat liver model. METHODS: Male Lewis rats were pretreated with ONO-4057 (100 mg/kg) and/or tacrolimus (1 mg/kg) orally, and divided into four experimental groups; group 1 (control), group 2 (ONO-4057), group 3 (tacrolimus), group 4 (ONO-4057 + tacrolimus). RESULTS: There was a tendency for long survival in the groups treated with tacrolimus alone and ONO-4057 plus tacrolimus. Post-reperfusion serum aspartate aminotransferase levels decreased more signif icantly in ONO-4057 plus tacrolimus group (P < 0.01), than in the tacrolimus alone group (P < 0.05), compared to controls. CONCLUSION: This study demonstrated that pretreat-ment with ONO-4057 in combination with tacrolimus produced additive effects in a rat model of liver isch-emia-reperfusion injury. | Takayuki Takeichi Shinji Uemoto Sachiko Minamiguchi Izumi Takeyoshi Yukihiro Inomata Koichi Tanaka Eiji Kobayashi | 2009 | World Journal of Gastroenterology2009，15，45： | 3 |
| 10 | Delayed perforation: A hazardous complication of endoscopic resection for non‐ampullary duodenal neoplasm显示文摘 | Takuya Inoue Noriya Uedo Takeshi Yamashina Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Ryu Ishihara Hiroyasu Iishi Masaharu Tatsuta Hidenori Takahashi Hidetoshi Eguchi Hiroaki Ohigashi | 2014 | Digestive Endoscopy2014，，2： | 3 |
| 11 | Enhanced plasma ghrelin levels in Helicobacter py/ori-colonized, interleukin-1-receptortype 1-homozygous knockout (IL-1R1-/-) mice显示文摘AIM: Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor, and it plays a role in stimulating the growth hormone secretion, food intake, body weight gain and gastric motility. Eradication of Helicobacterpylori (H pylori) was shown to be associated with increase of the body weight. On the other hand, H pylori infection evokes the release of gastric IL-lp. The present study was designed to investigate the involvement of the gastric IL-1 signal in the ghrelin dynamics in Hpylori-colonized mice. METHODS: Twelve-week-old female IL-1-receptor type 1-homozygous-knockout mice (IL-1R1-/-') and their wild-type littermates (WT) were orally inoculated with H pylori (Hp group), while other cohorts received oral inoculation of culture medium (Cont group). Thirteen weeks after the inoculation, the mice were examined. The plasma and stomach ghrelin levels and the gastric preproghrelin mRNA were measured. RESULTS: Although the WT mice with H pylori infection showed a significantly decreased body weight as compared with that of the animals without H pylori infection, H pylori infection did not influence the body weight of the IL-1R1-knockout (IL-1R1-/-) mice. In the H pylori-infected IL-1R1-/-mice, the total and active ghrelin levels in the plasma were significantly increased, and the gastric ghrelin level was decreased. No significant differences were noted in the gastric preproghrelin mRNA expression. CONCLUSION: Ghrelin secretion triggered by H pylori infection might be suppressed by IL-1β, the release of which is also induced by the infection, resulting in the body weight loss of mice with H pylori infection. | Yuka Abiko Hidekazu Suzuki Tatsuhiro Masaoka Sachiko Nomura Kumiko Kurabayashi Hiroshi Hosoda Kenji Kangawa Toshifumi Hibi | 2005 | World Journal of Gastroenterology2005，11，27： | 3 |
| 12 | Expression and function of interleukin-8 in human hepatocellular carcinoma显示文摘 | Jun Akiba Hirohisa Yano Sachiko Ogasawara Koichi Higaki M. Kojiro | 2001 | International Journal of Oncology2001，，2： | 2 |
| 13 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 14 | Microstructure of hydroxyapatite- and octacalcium phosphate-coatings formed on magnesium by a hydrothermal treatment at various pH values显示文摘 | Masanari Tomozawa Sachiko Hiromoto | 2010 | Acta Materialia2010，，1： | 2 |
| 15 | Growth Rate of Locally Recurrent Hepatocellular Carcinoma After Transcatheter Arterial Chemoembolization: Comparing the Growth Rate of Locally Recurrent Tumor with That of Primary Hepatocellular Carcinoma显示文摘 | Mikio Tezuka Keiji Hayashi Kazunori Kubota Sachiko Sekine Yoichi Okada Hiroyasu Ina Tetsuya Irie | 2007 | Digestive Diseases and Sciences2007，，3： | 2 |
| 16 | Accumulation of Somatic Mutations in TP53 in Gastric Epithelium with Helicobacter pylori infection显示文摘 | Takahiro Shimizu Hiroyuki Marusawa Yuko Matsumoto Tadashi Inuzuka Atsuyuki Ikeda Yosuke Fujii Sachiko Minamiguchi Shin’ichi Miyamoto Tadayuki Kou Yoshiharu Sakai Jean E. Crabtree Tsutomu Chiba | 2014 | Gastroenterology2014，，： | 2 |
| 17 | Clinically diagnosed late-onset fulminant Wilson's disease without cirrhosis: A case report显示文摘A 64-year-old woman was referred to our hospital with jaundice of the bulbar conjunctiva and general fatigue. After admission, she developed hepatic encephalopathy and was diagnosed with fulminant hepatitis based on the American Association for the Study of Liver Disease(AASLD) position paper. Afterwards, additional laboratory findings revealed that serum ceruloplasmin levels were reduced, urinary copper levels were greatly elevated and Wilson's disease(WD)-specific routine tests were positive, but the Kayser-Fleischer ring was not clear. Based on the AASLD practice guidelines for the diagnosis and treatment of WD, the patient was ultimately diagnosed with fulminant WD. Then, administration of penicillamine and zinc acetate was initiated; however, the patient unfortunately died from acute pneumonia on the 28 th day of hospitalization. At autopsy, the liver did not show a bridging pattern of fibrosis suggestive of chronic liver injury. Here, we present the case of a patient with clinically diagnosed late-onset fulminant WD without cirrhosis, who had positive disease-specific routine tests. | Takahiro Amano Tokuhiro Matsubara Tsutomu Nishida Hiromi Shimakoshi Akiyoshi Shimoda Aya Sugimoto Kei Takahashi Kaori Mukai Masashi Yamamoto Shiro Hayashi Sachiko Nakajima Koji Fukui Masami Inada | 2018 | World Journal of Gastroenterology2018，24，2： | 2 |
| 18 | Metformin Inhibits Cytokine-Induced Nuclear Factor κB Activation Via AMP-Activated Protein Kinase Activation in Vascular Endothelial Cells显示文摘 | Yoshiyuki Hattori Kunihiro Suzuki Sachiko Hattori Kikuo Kasai | 2006 | Hypertension2006，，6： | 2 |
| 19 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 20 | Comparison of EMR and endoscopic submucosal dissection for en bloc resection of early esophageal cancers in Japan显示文摘 | Ryu Ishihara Hiroyasu Iishi Noriya Uedo Yoji Takeuchi Sachiko Yamamoto Takuya Yamada Eriko Masuda Koji Higashino Motohiko Kato Hiroyuki Narahara Masaharu Tatsuta | 2008 | Gastrointestinal Endoscopy2008，，6： | 2 |
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