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| 1 | Community structure of ammonia-oxidizing bacteria under long-term application of mineral fertilizer and organic manure in a sandy loam soil显示文摘 | Chu HY Fujii T Morimoto S Lin XG Yagi K Hu JL Zhang JB | 2007 | 中国生物学文摘2007，21，6： | 77 |
| 2 | 氧自由基清除剂对砷所致细胞DNA损伤的保护作用显示文摘目的 探讨砷引起细胞 DNA损伤和细胞毒性的机理。方法 用羟基自由基 (· OH/OH- )清除剂DMSO和过氧化氢 (H2 O2 )清除剂过氧化氢酶 (catalase,CAT)与不同浓度的砷共同处理人类早幼粒细胞系 HL6 0细胞和人淋巴细胞 ,用单细胞凝胶电泳 (SCGE)检测细胞 DNA损伤。结果 2 .4和 4.8μmol的砷分别引起了HL6 0和人淋巴细胞显著的 DNA损伤。DMSO和 CAT完全消除了低剂量砷引起的 DNA损伤 ,减少了 70 %以上的高剂量砷引起的 DNA损伤。结论 微量砷可引起人类细胞不同程度的 DNA损伤 ,DMSO和 CAT可保护或减轻细胞的这些损伤 ,表明砷通过活性氧自由基 ,主要是 H2 O2 和 O2 - ,引起人类细胞 | 李达圣 Kanehisa Morimoto Tatsuya Takeshita 吕玉泉 | 2001 | 中国地方病学杂志2001，20，4： | 19 |
| 3 | Long-term survival after resection of pancreatic cancer:A single-center retrospective analysis显示文摘AIM: To retrospectively analyze factors affecting the long-term survival of patients with pancreatic cancer who underwent pancreatic resection.METHODS: From January 2000 to December 2011,195 patients underwent pancreatic resection in our hospital.The prognostic factors after pancreatic resection were analyzed in all 195 patients.After excluding the censored cases within an observational period,the clinicopathological characteristics of 20 patients who survived ≥ 5(n = 20) and < 5(n = 76) years were compared.For this comparison,we analyzed the patients who underwent surgery before June 2008 and were observed for more than 5 years.For statistical analyses,the log-rank test was used to compare the cumulative survival rates,and the χ2 and Mann-Whitney tests were used to compare the two groups.The CoxHazard model was used for a multivariate analysis,and P values less than 0.05 were considered significant.A multivariate analysis was conducted on the factors that were significant in the univariate analysis.RESULTS: The median survival for all patients was 27.1 months,and the 5-year actuarial survival rate was 34.5%.The median observational period was 595 d.With the univariate analysis,the UICC stage was significantly associated with survival time,and the CA19-9 ≤ 200 U/m L,DUPAN-2 ≤ 180 U/m L,t u m o r s i ze ≤ 2 0 m m,R 0 re s e c t i o n,a b s e n c e o f lymph node metastasis,absence of extrapancreatic neural invasion,and absence of portal invasion were favorable prognostic factors.The multivariate analysis showed that tumor size ≤ 20 mm(HR = 0.40; 95%CI: 0.17-0.83,P = 0.012) and negative surgical margins(R0 resection)(HR = 0.48; 95%CI: 0.30-0.77,P = 0.003) were independent favorable prognostic factors.Among the 96 patients,20 patients survived for 5 years or more,and 76 patients died within 5 years after operation.Comparison of the 20 5-year survivors with the 76 non-survivors showed that lower concentrations of DUPAN-2(79.5 vs 312.5 U/mL,P = 0.032),tumor size ≤ 20 mm(35% vs 8%,P = 0.008),R0 resection(95% vs 61%,P = 0.004),and absence of lymph nodemetastases(60% vs 18%,P = 0.036) were significantly associated with the 5-year survival.CONCLUSION: Negative surgical margins and a tumor size ≤ 20 mm were independent favorable prognostic factors.Histologically curative resection and early tumor detection are important factors in achieving long-term survival. | Takehito Yamamoto Shintaro Yagi Hiromitsu Kinoshita Yusuke Sakamoto Kazuyuki Okada Kenji Uryuhara Takeshi Morimoto Satoshi Kaihara Ryo Hosotani | 2015 | World Journal of Gastroenterology2015，21，1： | 18 |
| 4 | Prospective study of differential diagnosis of hepatic tumors by pattern-based classification of contrast-enhanced sonography显示文摘AIM: To prospectively evaluate the usefulness of a pattern-based classification of contrast-enhanced sonographic findings for differential diagnosis of hepatic tumors. METHODS: We evaluated the enhancement pattern of the contrast-enhanced sonography images in 586 patients with 586 hepatic lesions, consisting of 383 hepatocellular carcinomas, 89 metastases, and 114 hemangiomas. After injecting a galactose-palmitic acid contrast agent, lesions were scanned by contrast- enhanced harmonic gray-scale sonography in three phases: arterial, portal, and late. The enhancement patterns of the initial 303 lesions were classified retrospectively, and multiple logistic regression analysis was used to identify enhancement patterns that allowed differentiation between hepatic tumors. We then used the pattern-based classification of enhancement we had retrospectively devised to prospectively diagnose 283 liver tumors. RESULTS: Seven enhancement patterns were found to be significant predictors of different hepatic tumors. The presence of homogeneous or heterogeneous enhancement both in the arterial and portal phase was the typical enhancement pattern for hepatocellular carcinoma, while the presence of peritumoral vessels in the arterial phase and ring enhancement or a perfusion defect in the portal phase was the typical enhancement pattern for metastases, and the presence of peripheral nodular enhancement both in the arterial and portal phase was the typical enhancement pattern forhemangioma. The sensitivity, specificity, and accuracy of prospective diagnosis based on the combinations of enhancement patterns, respectively, were 93.2%, 96.2%, and 94.0% for hepatocellular carcinoma, 87.9%, 99.6%, and 98.2% for metastasis, and 95.6%, 94.1%, and 94.3% for hemangioma. CONCLUSION: The pattern-based classification of the contrast-enhanced sonographic findings is useful for differentiating among hepatic tumors. | Kazushi Numata Tetsuo Isozaki Manabu Morimoto Kazuya Sugimori Reiko Kunisaki Toshio Morizane Katsuaki Tanaka | 2006 | World Journal of Gastroenterology2006，12，39： | 18 |
| 5 | Quality of ulcer healing in gastrointestinal tract:Its pathophysiology and clinical relevance显示文摘In this paper,we review the concept of quality of ulcer healing(QOUH) in the gastrointestinal tract and its role in the ulcer recurrence.In the past,peptic ulcer disease(PUD) has been a chronic disease with a cycle of repeated healing/remission and recurrence.The main etiological factor of PUD is Helicobacter pylori(H.pylori),which is also the cause of ulcer recurrence.However,H.pylori-negative ulcers are present in 12%-20% of patients;they also recur and are on occasion intractable.QOUH focuses on the fact that mucosal and submucosal structures within ulcer scars are incompletely regenerated.Within the scars of healed ulcers,regenerated tissue is immature and with distorted architecture,suggesting poor QOUH.The abnormalities in mucosal regeneration can be the basis for ulcer recurrence.Our studies have shown that persistence of macrophages in the regenerated area plays a key role in ulcer recurrence.Our studies in a rat model of ulcer recurrence have indicated that proinflammatory cytokines trigger activation of macrophages,which in turn produce increased amounts of cytokines and chemokines,which attract neutrophils to the regenerated area.Neutrophils release proteolytic enzymes that destroy the tissue,resulting in ulcer recurrence.Another important factor in poor QOUH can be deficiency of endogenous prostaglandins and a deficiency and/or an imbalance of endogenous growth factors.Topically active mucosal protective and antiulcer drugs promote high QOUH and reduce inflammatory cell infiltration in the ulcer scar.In addition to PUD,the concept of QOUH is likely applicable to inflammatory bowel diseases including Crohn's disease and ulcerative colitis. | Tetsuo Arakawa Toshio Watanabe Tetsuya Tanigawa Kazunari Tominaga Yasuhiro Fujiwara Kenichi Morimoto | 2012 | World Journal of Gastroenterology2012，18，35： | 16 |
| 6 | Contrast enhanced ultrasound of hepatocellular carcinoma显示文摘Sonazoid(Daiichi Sankyo,Tokyo,Japan),a secondgeneration of a lipid-stabilized suspension of a perfluorobutane gas microbubble contrast agent,has been used clinically in patients with liver tumors and for harmonic gray-scale ultrasonography(US)in Japan since January 2007.Sonazoid-enhanced US has two phases of contrast enhancement:vascular and late.In the late phase of Sonazoid-enhanced US,we scanned the whole liver using this modality at a low mechanical index(MI)without destroying the microbubbles, and this method allows detection of small viable hepatocellular carcinoma(HCC)lesions which cannot be detected by conventional US as perfusion defects in the late phase.Re-injection of Sonazoid into an HCC lesion which previously showed a perfusion defect in the late phase is useful for confirming blood flow intothe defects.High MI intermittent imaging at 2 frames per second in the late phase is also helpful in differentiation between necrosis and viable hypervascular HCC lesions.Sonazoid-enhanced US by the coded harmonic angio mode at a high MI not only allows clear observation of tumor vessels and tumor enhancement, but also permits automatic scanning with Sonazoidenhanced three dimensional(3D)US.Fusion images combining US with contrast-enhanced CT or contrastenhanced MRI have made it easy to detect typical or atypical HCC lesions.By these methods,Sonazoidenhanced US can characterize liver tumors,grade HCC lesions histologically,recognize HCC dedifferentiation, evaluate the efficacy of ablation therapy or transcatheter arterial embolization,and guide ablation therapy for unresectable HCC.This article reviews the current developments and applications of Sonazoid-enhanced US and Sonazoid-enhanced 3D US for diagnosing and treating hepatic lesions,especially HCC. | Kazushi Numata Manabu Morimoto Masaaki Kondo Yosuke Kunishi Tomohiko Sasaki Akito Nozaki Katsuaki Tanaka | 2010 | World Journal of Radiology2010，2，2： | 15 |
| 7 | 应用单细胞凝胶电泳比较研究砷对人类细胞DNA的损伤显示文摘目的 探讨不同细胞对砷的基因毒性反应及其机理 ;探讨快速、敏感及经济的细胞基因毒性检测方法。方法 应用单细胞凝胶电泳 (Single cell gel electrophoresis,SCGE)或彗星试验 (com et assay)比较研究。结果 细胞 DNA损伤与砷处理量间呈显著的剂量反应关系和时效关系。受试细胞对砷的基因毒性反应的敏感性强弱顺序为 :PMA- HL 6 0 >DMSO- HL 6 0 >HL 6 0 >淋巴细胞。人工计数彗星尾分级频数与计算机自动测量彗星尾 DNA泳动量的结果完全一致 ,用非参数 Mann- Whitney多变量检验分析彗星尾分级频数的显著性与参数Tukey多变量检验分析量彗星尾 DNA泳动量的显著性完全相同 ,而且不同浓度的砷与 5级彗星尾频数的相关性比其与阳性彗星尾总数间的更为显著。结论 微量砷即可引起细胞不同程度的 DNA损伤 ,不同细胞亚群对砷的基因毒性反应不同。 SCGE是一个简便、快速、敏感及经济的细胞基因毒性检测方法 ,可应用于各级水平的环境与人类疾病 (砷污染 ) | 李达圣 Kanehisa Morimoto Tatsuya Takeshita 吕玉泉 | 2001 | 中国地方病学杂志2001，20，3： | 15 |
| 8 | Differentiation of focal liver lesions using three-dimensional ultrasonography: Retrospective and prospective studies显示文摘AIM: To differentiate focal liver lesions based on enhancement patterns using three-dimensional ultrasonography (3D US) with perflubutane-based contrast agent.METHODS: Two hundred and eighty two patients with focal liver lesions,including 168 hepatocellular carcinomas (HCCs),63 metastases,40 hemangiomas and 11 focal nodular hyperplasias (FNHs),were examined by 3D US with perflubutane-based contrast agent.Tomographic ultrasound images and sonographic angiograms were reconstructed.Among 282 lesions,enhancement patterns of 163 lesions between January 2007 and October 2007 were analyzed retrospectively.Then from November 2007 to May 2008,compared with contrast-enhanced (CE) 2D US,CE 3D US was performed on 119 lesions for prospective differential diagnosis.Sensitivity,specificity,area under receiver operating characteristic curve (Az) and inter-reader agreement were assessed.RESULTS: With the tridimensional view,dominant enhancement patterns were revealed as diffuse enhancement or peripheral ring-like enhancement,followed with washout change for HCCs or metastases,respectively,and peripheral nodular enhancement or diffuse enhancement with spoke-wheel arteries,followed by persistent enhancement for hemangiomas or FNHs,respectively.At CE 3D US,the prospective differentiation of lesions showed sensitivity 92% (mean for two readers),specificity 91% and Az value 0.95 for HCCs,84%,97%,and 0.95 for metastases,91%,98%,and 0.98 for hemangiomas and 80%,99%,and 0.99 for FNHs,respectively,while good to excellent inter-reader agreement was achieved.No significant difference exists between prospective diagnosis accuracy at CE 3D US and that at CE 2D US.CONCLUSION: CE 3D US provides a spatial perspective for liver tumor enhancement,and could help in differentiating focal liver lesions. | Kazushi Numata Manabu Morimoto Akito Nozaki Michio Ueda Masaaki Kondo Satoshi Morita Katsuaki Tanaka | 2010 | World Journal of Gastroenterology2010，16，17： | 12 |
| 9 | Risk factors for intraoperative perforation during endoscopic submucosal dissection of superficial esophageal squamous cell carcinoma显示文摘AIM To identify the risk factors and clarify the subsequent clinical courses.METHODS This study retrospectively analyzed consecutive patients with esophageal squamous cell carcinoma( ESCC) treated using endoscopic submucosal dissection(ESD) between April 2008 and October 2012. We divided the ESCC lesions into perforation cases and non-perforation cases, and compared characteristics and endoscopic findings between the two groups. 'Intraoperative perforation' was defined as the detection of a perforation site during ESD and the presence of mediastinal emphysema.RESULTS In total, 147 patients with 156 ESCC lesions were treated by ESD. Intraoperative perforation was recorded for nine lesions(5.8%) from nine patients. Multivariate analysis identified mucosal deficiency larger than 75% of the circumference of the esophagus as an independent risk factor for intraoperative perforation(OR = 7.37, 95%CI: 1.45-37.4, P = 0.016). The predominant site of perforation was the left wall [6/9(67%)]. Six of nine perforation sites were successfully closed by clips during the procedures. Two of nine cases required drainage for pleural effusions; however, all nine cases recovered with conservative treatment and without surgical intervention. At the median follow up of 42 mo after ESD, no cases of local recurrence or distant organ metastasis had been observed.CONCLUSION This study suggests that mucosal deficiency larger than 75% of the luminal circumference is a risk factor for intraoperative perforation during ESD for ESCC. | Masaaki Noguchi Tomonori Yano Tomoji Kato Tomohiro Kadota Maomi Imajoh Hiroyuki Morimoto Shozo Osera Atsushi Yagishita Tomoyuki Odagaki Yusuke Yoda Yasuhiro Oono Hiroaki Ikematsu Kazuhiro Kaneko | 2017 | World Journal of Gastroenterology2017，23，3： | 12 |
| 10 | Clinical impact of surveillance for head and neck cancer in patients with esophageal squamous cell carcinoma显示文摘AIM To evaluate the clinical impact of surveillance for head and neck(HN) region with narrow band imaging(NBI) in patients with esophageal squamous cell carcinoma(ESCC).METHODS Since 2006, we introduced the surveillance for HN region using NBI for all patients with ESCC beforetreatment, and each follow-up. The patients with newly diagnosed stage Ⅰ to Ⅲ ESCC were enrolled and classified into two groups as follows: Group A(no surveillance for HN region); between 1992 and 2000), and Group B (surveillance for HN region with NBI; between 2006 and 2008). We comparatively evaluated the detection rate of superficial head and neck squamous cell carcinoma (HNSCC), and the serious events due to metachronous advanced HNSCC during the follow-up.RESULTS A total 561 patients(group A: 254, group B: 307) were enrolled. Synchronous superficial HNSCC was detected in 1 patient (0.3%) in group A, and in 12 (3.9%) in group B (P=0.008). During the follow up period, metachronous HNSCC were detected in 10 patients(3.9%) in group A and in 30 patients(9.8%) in group B(P = 0.008). All metachronous lesions in group B were early stage, and 26 patients underwent local resection, however, 6 of 10 patients (60%) in group A lost their laryngeal function and died with metachronous HNSCC.CONCLUSION Surveillance for the HN region by using NBI endoscopy increase the detection rate of early HNSCC in patients with ESCC, and led to decrease serious events related to advanced metachronous HNSCC. | Hiroyuki Morimoto Tomonori Yano Yusuke Yoda Yasuhiro Oono Hiroaki Ikematsu Ryuichi Hayashi Atsushi Ohtsu Kazuhiro Kaneko | 2017 | World Journal of Gastroenterology2017，23，6： | 12 |
| 11 | Role of bile acids in the regulation of the metabolic pathways显示文摘Recent studies have revealed that bile acids(BAs)are not only facilitators of dietary lipid absorption but also important signaling molecules exerting multiple physiological functions.Some major signaling pathways involving the nuclear BAs receptor farnesoid X receptor and the G protein-coupled BAs receptor TGR5/M-BAR have been identified to be the targets of BAs.BAs regulate their own homeostasis via signaling pathways.BAs also affect diverse metabolic pathways including glucose metabolism,lipid metabolism and energy expenditure.This paper suggests the mechanism of controlling metabolism via BA signaling and demonstrates that BA signaling is an attractive therapeutic target of the metabolic syndrome. | Hiroki Taoka Yoko Yokoyama Kohkichi Morimoto Naho Kitamura Tatsuya Tanigaki Yoko Takashina Kazuo Tsubota Mitsuhiro Watanabe | 2016 | World Journal of Diabetes2016，7，13： | 11 |
| 12 | Post-operative albumin-bilirubin grade predicts long-term outcomes among Child–Pugh grade A patients with hepatocellular carcinoma after curative resection显示文摘Background: Although Child–Pugh grade A patients with hepatocellular carcinoma(HCC) are candidates for curative resection, some may have a poor prognosis. The albumin-bilirubin(ALBI) grade, a measure of liver function based on albumin and bilirubin, has the potential to detect Child–Pugh grade A HCC patients with poor prognosis. Because components of the ALBI grade can be measured easily even after surgery, we explored the predictive values of ALBI in patient prognosis after HCC resection. Methods: In this retrospective case-control study, we included 136 HCC patients who underwent curative resection between January 2004 and December 2013 at our hospital. ALBI grade was calculated from laboratory data recorded the day before surgery and at post-operative day 5. Results: Pre-and post-operative ALBI grade predicted patients' long-term outcomes( P = 0.020 and P < 0.001, respectively, for overall survival, and P = 0.012 and P = 0.015, respectively, for recurrence-free survival). Post-operative ALBI grade was associated with patients' surgical factors of repeated hepatic resection( P = 0.012), intra-operative bleeding( P = 0.006), and surgery duration( P = 0.033). Furthermore, post-operative ALBI grade, rather than pre-operative ALBI grade, was an independent predictive factor of long-term outcome of Child–Pugh grade A patients with HCC. Conclusions: Post-operative ALBI grade is useful to predict the prognosis in patients after HCC resection. | Masataka Amisaki Ei Uchinaka Masaki Morimoto Naruo Tokuyasu Teruhisa Sakamoto Soichiro Honjo Hiroaki Saito Yoshiyuki Fujiwara | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，6： | 9 |
| 13 | 砷对人淋巴细胞DNA氧化损伤的作用显示文摘目的 探讨砷 (As)引起植物血凝集素 (PHA)刺激和无刺激人外周血淋巴细胞DNA氧化性损伤。方法 用 10 μmol/L砷处理细胞 2h ,经单细胞凝胶电泳 (SCGE ,或彗星试验 ) FPG(甲酰胺基嘧啶 DNA糖基化酶 )消化法检测砷引起的DNA碱基损伤。结果 砷引起的DNA链断裂的修复过程与过氧化氢 (H2 O2 )引起的修复过程类似。FPG消化产生的单链断裂 ,或砷引起的碱基损伤在PHA刺激淋巴细胞较未刺激细胞显著。在PHA刺激的淋巴细胞 ,砷和H2 O2 引起的DNA链断裂 2h分别修复 63 %和 68% ,但在未刺激细胞分别修复大约 3 4 %和 4 3 %。在PHA刺激的淋巴细胞 ,砷和H2 O2引起的碱基损伤 2h分别修复 4 0 %和 4 9% ,但在未刺激细胞分别修复大约 19%和 2 1%。结论 微量砷可引起人类细胞DNA氧化性损伤。损伤的碱基主要是嘌呤或甲酰胺基嘧啶。未分裂 (刺激 )淋巴细胞修复砷与H2 O2 | 李达圣 Kanehisa Morimoto Tatsuya Takeshita 吕玉泉 | 2002 | 中华预防医学杂志2002，36，1： | 9 |
| 14 | MUC5AC/β-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors显示文摘AIM:To clarify differences in mucin phenotype, prolif-erative activity and oncogenetic alteration among subtypes of colorectal laterally spreading tumor (LST). METHODS:LSTs, defined as superficial elevated lesions greater than 10 mm in diameter with a low vertical axis, were macroscopically classified into two subtypes:(1) a granular type (Gr-LST) composed of superficially spreading aggregates of nodules forming a flat-based lesion with a granulonodular and uneven surface; and (2) a non-granular type (NGr-LST) with a flat smooth surface and an absence of granulonodular formation. A total of 69 LSTs, comprising 36 Gr-LSTs and 33 NGr-LSTs, were immunohistochemically stained with MUC2, MUC5AC,MUC6, CD10 (markers of gastrointestinal cell lineage), p53, β-catenin and Ki-67 antibodies, and examined for alteration in exon 1 of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and exon 15 of v-raf murine sarcoma viral oncogene homologue B1 (BRAF) by poly-merase chain reaction followed by direct sequencing. RESULTS:Histologically, 15 Gr-LST samples were adenomas with low-grade dysplasia (LGD), 12 were high-grade dysplasia (HGD) and 9 were adenocarcinomas invading the submucosa (INV), while 12 NGr-LSTs demonstrated LGD, 14 HGD and 7 INV. In the proximal colon, MUC5AC expression was significantly higher in the Gr-type than the NGr-type. MUC6 was expressed only in NGr-LST. MUC2 or CD10 did not differ. P53 expression demonstrated a significant stepwise increment in progression through LGD-HGD-INV with both types of LST. Nuclear β-catenin expression was significantly higher in the NGr-type. Ki-67 expression was signifi-cantly higher in the Gr-type in the lower one third zone of the tumor. In proximal, but not distal colon tumors, the incidence of KRAS provided mutation was signifi-cantly higher in the Gr-type harboring a specific mutational pattern (G12V). BRAF mutations (V600E) were detected only in two Gr-LSTs. CONCLUSION:The two subtypes of LST, especially in the proximal colon, have differing phenotypes of gastrointestinal cell lineage, proliferation and activation of Wnt/β-catenin or RAS/RAF/extracellular signal-regulated kinase signaling. | Kosaburo Nakae Hiroyuki Mitomi Tsuyoshi Saito Michiko Takahashi Takashi Morimoto Yasuhiro Hidaka Naoto Sakamoto Takashi Yao Sumio Watanabe | 2012 | World Journal of Gastroenterology2012，18，39： | 8 |
| 15 | Successful initial ablation therapy contributes to survival in patients with hepatocellular carcinoma显示文摘AIM: To evaluate the outcome predictors of percu- taneous ablation therapy in patients with unresectable hepatocellular carcinoma (HCC), especially to identify whether the initial treatment response contributes to the survival of the patients. METHODS: The study cohort included 153 patients with single (102) and two or three (51) HCC nodules 5 cm or less in maximum diameter. As an initial treatment, 110 patients received radiofrequency ablation and 43 patients received percutaneous ethanol injection. RESULTS: The Kaplan-Meier estimates of overall 3- and 5-year survival rates were 75% and 59%, respectively. The log-rank test revealed statistically significant differences in the overall survivals according to Child- Pugh class (P = 0.0275), tumor size (P = 0.0130), serum albumin level (P = 0.0060), serum protein induced by vitamin K absence or antagonist Ⅱ level (P = 0.0486), and initial treatment response (P = 0.0130). The independent predictors of survival were serum albumin level (risk ratio, 3.216; 95% CI, 1.407-7.353; P = 0.0056) and initial treatment response (risk ratio, 2.474; 95% CI, 1.076-5.692; P = 0.0330) based on the Cox proportional hazards regression models. The patients had a serum albumin level 3.5 g/dL and the 3- and 5-year survival rates of 86% and 82%. CONCLUSION: In HCC patients treated with percutaneous ablation therapy, serum albumin level and initial treatment response are the independent outcome predictors. | Manabu Morimoto Kazushi Numata Kazuya Sugimori Kazuhito Shirato Atsushi Kokawa Hiroyuki Oka Kingo Hirasawa Ryonho Koh Hiromi Nihommatsu Katsuaki Tanaka | 2007 | World Journal of Gastroenterology2007，13，7： | 8 |
| 16 | A minimally invasive multiple percutaneous drainage technique for acute necrotizing pancreatitis显示文摘BACKGROUND: In approximately 20% of patients, necrotizing pancreatitis is complicated with severe acute pancreatitis, with high morbidity and mortality rates. Minimally invasive step-up approach is both safe and effective, but sometimes requires multiple access sites.METHODS: A 62-year-old woman was admitted with diabetic ketoacidosis, and initial computed tomography(CT) revealed no evidence of acute pancreatitis. She was clinically improved with insulin therapy, fl uid administration, and electrolyte replacement. However, on the 14 th day of admission, she developed a high-grade fever, and CT demonstrated evidence of acute necrotizing pancreatitis with a large collection of peripancreatic fl uid. Percutaneous transgastric drainage was performed and a 14 French gauge(Fr) pigtail catheter was placed 1 week later, which drained copious pus. Because of persistent high-grade fever and poor clinical improvement, multiple 8 and 10 Fr pigtail catheters were placed via the initial drainage route, allowing the safe and effective drainage of the extensive necrotic tissue that was occupying the bilateral anterior pararenal space.RESULTS: After drainage, the patient recovered well and the last catheter was removed on day 123 of admission.CONCLUSIONS: Multiple percutaneous drainage requires both careful judgment and specialist skills. The perforation of the colon and small bowel as well as the injury of the kidney and major vessels can occur. The current technique appears to be safe and minimally invasive compared with other drainage methods in patients with extended, infected necrotic pancreatic pseudocysts. | Takero Terayama Toru Hifumi Nobuaki Kiriu Hiroshi Kato Yuichi Koido Yoshiaki Ichinose Kohei Morimoto Kuroda Yasuhiro | 2014 | World Journal of Emergency Medicine2014，5，4： | 7 |
| 17 | CREATE TRANSGENIC RABBITS BY MICROINJECTING HUMAN apoA-Ⅱ GENE INTO FERTILIZED EGGS显示文摘Objective To create transgenic rabbits by microinjecting human apolipoprotein A-Ⅱ (apoA-Ⅱ) gene into one-cell embryos, to study apoA-Ⅱ gene function on plasma lipoprotein metabolism and atherosclerosis. Methods Superovulation and synchronization of estrus were induced in female Japanese White Rabbits by injecting hormone, then mating with male. After collected the fertilized eggs, the human apoA-Ⅱ gene was microinjected into the male pronucleus of eggs. The injected eggs were transferred into recipient female rabbits. Last, extract DNA from the new borns ear and determine whether the newborns were transgenic by polymerase chain reaction (PCR) or Southern blot analysis. Results A total of 822 embryos with microinjection of human apoAⅡ gene were implanted into 28 recipient rabbits. The number of surviving newborns was 37. 3 transgenic positive surviving founders were found with human apoA-Ⅱ. | 刘恩岐 Shuji Kitajima Masatoshi Morimoto | 2004 | Journal of Pharmaceutical Analysis2004，16，1： | 7 |
| 18 | Role of matricellular proteins in cardiac tissue remodeling after myocardial infarction显示文摘After onset of myocardial infarction(MI),the left ventricle(LV) undergoes a continuum of molecular,cellular,and extracellular responses that result in LV wall thinning,dilatation,and dysfunction.These dynamic changes in LV shape,size,and function are termed cardiac remodeling.If the cardiac healing after MI does not proceed properly,it could lead to cardiac rupture or maladaptive cardiac remodeling,such as further LV dilatation and dysfunction,and ultimately death.Although the precise molecular mechanisms in this cardiac healing process have not been fully elucidated,this process is strictly coordinated by the interaction of cells with their surrounding extracellular matrix(ECM) proteins.The components of ECM include basic structural proteins such as collagen,elastin and specialized proteins such as fibronectin,proteoglycans and matricellular proteins.Matricellular proteins are a class of non-structural and secreted proteins that probably exert regulatory functions through direct binding to cell surface receptors,other matrix proteins,and soluble extracellular factors such as growth factors and cytokines.This small group of proteins,which includesosteopontin,thrombospondin-1/2,tenascin,periostin,and secreted protein,acidic and rich in cysteine,shows a low level of expression in normal adult tissue,but is markedly upregulated during wound healing and tissue remodeling,including MI.In this review,we focus on the regulatory functions of matricellular proteins during cardiac tissue healing and remodeling after MI. | Yutaka Matsui Junko Morimoto Toshimitsu Uede | 2010 | World Journal of Biological Chemistry2010，1，5： | 7 |
| 19 | 间歇和连续静脉输注法莫替丁对消化性溃疡患者胃酸的影响显示文摘 | Yozo Watanabe Hidenori Tsumura Hiroshi Sasaki Toshio Morimoto 孙钢 | 2000 | 中华消化杂志2000，20，5： | 6 |
| 20 | 砷与5-氮胞苷对人淋巴细胞DNA损伤的联合作用显示文摘为探讨砷和 5 -氮胞苷对人淋巴细胞 DNA损伤及修复的联合作用 ,应用单细胞凝胶电泳 (SCGE)技术比较研究了 5 -氮胞苷与砷同时和前后作用于人类淋巴细胞产生的联合毒性 ,结果显示 10 μmol/ L 5 -氮胞苷和 10 μmol/ L砷单独处理人淋巴细胞 2 h引起明显的 DNA泳动 (彗星尾 ) ,但两试剂引起的 DNA泳动 (彗星尾 )间无显著差异 ,5 -氮胞苷前处理与砷后处理 2 h引起的彗星尾与其单独处理组比较非常显著 ,砷前处理与 5 -氮胞苷后处理引起的彗星尾与其单独处理组比较无显著性差异 ,但较对照组差异显著。 10 μmol/ L 5 -氮胞苷和 10 μmol/ L砷分别单独处理 2 h引起了人淋巴细胞显著的 DNA损伤 (链断裂 ) ,5 -氮胞苷与砷在对淋巴细胞 DNA的损伤上表现为单纯相加作用。 5 -氮胞苷前处理显著增加了细胞对砷的基因毒性的敏感性 ,或砷后处理显著增加了 5 -氮胞苷引起的 DNA损伤 ,5 -氮胞苷后处理 2 h显著抑制了细胞对砷所致 | 李达圣 MORIMOTO Kanehisa TAKESHITA Tatsuya 吕玉泉 | 2002 | 地方病通报2002，17，1： | 5 |
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