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| 1 | Diagnosis and management of insulinoma显示文摘Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general population.Common autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and coma.Diagnosis of suspected cases is based on standard endocrine tests,especially the prolonged fasting test.Non-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion.Invasive modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques.The range of techniques available for the localization of insulinomas means thatblind resection can be avoided.Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with surgery.In patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of life.In patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life. | Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi Ito Yasuhiro Ogawa Michiya Kobayashi Kazuhiro Hanazaki | 2013 | World Journal of Gastroenterology2013，19，6： | 78 |
| 2 | Carcinosarcoma of the liver with mesenchymal differentiation显示文摘We report an extremely rare case where a mesenchymal differentiation, especially embryonal sarcoma, was demonstrated in cholangiocarcinoma. At autopsy, a yellowish-white tumor (15 cm x 12 cm) was found in the right hepatic lobe, and there were several daughter nodules in both hepatic lobes. Histologically, most of the main tumor and all of the daughter nodules examined showed sarcomatous changes (spindle cells, pleomorphic cells and hyalization). Histologic examination of a part of the main tumor disclosed a focus of adenocarcinoma within the tumor. The frequent transitions between the adenocarcinomatous areas and the sarcomatous areas suggested that sarcomatous transformation occurred in the cholangiocarcinoma and then spread rapidly. Immunohistochemically, the adenocarcinomatous elements were positive for cytokeratin, carcinoembryonic antigen (CEA) and epithelial membrane antigen, and negative in the sarcomatous cells. Vimentin was positive only in the sarcomatous elements. The findings of the present case support the view that carcinosarcomas represent carcinomas that develop sarcomatous elements via metaplasia of the epithelial element. | Shinichi Sumiyoshi Masataka Kikuyama Yuji Matsubayashi Fujito Kageyama Yoshihiro Ide Yoshimasa Kobayashi Hirotoshi Nakamura | 2007 | World Journal of Gastroenterology2007，13，5： | 6 |
| 3 | Comparison of pancreatic acinar cell carcinoma and adenocarcinoma using multidetector-row computed tomography显示文摘AIM:To distinguish acinar cell carcinoma(ACC)from pancreatic adenocarcinoma(AC)by comparing their computed tomography findings.METHODS:Patients with ACC and AC were identified on the basis of results obtained using surgically resected pancreatectomy specimens.The preoperative computer tomographic images of 6 acinar cell carcinoma patients and 67 pancreatic adenocarcinoma patients in 4 phases(non-contrast,arterial,portal venous,and delayed phase)were compared.The scan delay times were 40,70,and 120 s for each contrast-enhanced phase.The visual pattern,tomographic attenuation value,and time attenuation curve were assessed and compared between AC and ACC cases using the 2test,Wilcoxon signed-rank test,and Mann Whitney U test.RESULTS:The adenocarcinomas tended to be hypodense in all 4 phases.The acinar cell carcinomas also tended to be hypodense in the 3 contrast-enhancedphases,although their computed tomographic attenuation values were higher.Further,5 of the 6 acinar cell carcinomas(83%)were isodense in the non-contrast phase.The time attenuation curve of the adenocarcinomas showed a gradual increase through the 4 phases,and all adenocarcinomas showed peak enhancement during the delayed phase.The time attenuation curve of the acinar cell carcinomas showed peak enhancement during the portal venous phase in 4 cases and during the arterial phase in 2 cases.None of the 6 acinar cell carcinomas showed peak enhancement during the delayed phase.CONCLUSION:The tumor density in the non-contrast phase and time attenuation curve pattern clearly differ between acinar cell carcinomas and adenocarcinomas,and multidetector-row computed tomography can thus distinguish these tumors. | Tatsuaki Sumiyoshi Yasuo Shima Takehiro Okabayashi Akihito Kozuki Toshio Nakamura | 2013 | World Journal of Gastroenterology2013，19，34： | 5 |
| 4 | CT/^(99m)Tc-GSA SPECT fusion images demonstrate functional differences between the liver lobes显示文摘AIM: To evaluate the functional differences between the 2 liver lobes in non-cirrhotic patients by using computed tomography/99mTc-galactosyl human serum albumin (CT/99mTc-GSA) single-photon emission computed tomography (SPECT) fusion images. METHODS: Between December 2008 and March 2012, 264 non-cirrhotic patients underwent preoperative liver function assessment using CT/99mTc-GSA SPECT fusion images. Of these, 30 patients, in whom the influence of a tumor on the liver parenchyma was estimated to be negligible, were selected. Specifically, the selected patients were required to meet either of the following criteria: (1) the presence of an extrahepatic tumor; or (2) presence of a single small intrahepatic tumor. These 30 patients were retrospectively analyzed to calculate the percentage volume (%Volume) and the percentage function (%Function) of each lobe. The ratio between the %Function and %Volume (function-to-volume ratio) of each lobe was also calculated, and the ratios were compared between the 2 lobes. Furthermore, the correlations between the function-to-volume ratio and each of 2 liver parameters [lobe volume and diameter ratio of the left portal vein to the right portal vein (LPV-to-RPV diameter ratio)] were investigated. RESULTS: The median values of %Volume and %Function were 62.6% and 67.1% in the right lobe, with %Function being significantly higher than %Volume (P < 0.01). The median values of %Volume and %Function were 31.0% and 28.7% in the left lobe, with %Function being significantly lower than %Volume (P < 0.01). The function-to-volume ratios of the right lobe (1.04-1.14) were significantly higher than those of the left lobe (0.74-0.99) (P < 0.01). The function-to-volume ratio showed no significant correlation between the lobe volume in either lobe. In contrast, the function-to-volume ratio showed significant correlations with the LPV-to-RPV diameter ratio in both lobes (right lobe: negative correlation, rs = -0.37, P = 0.048; left lobe: positive correlation, r s = 0.71, P < 0.001). The function-to-volume ratio in the left lobe tended to be higher, and that in the right lobe tended to be lower, in accordance with the increase in the LPV-to-RPV diameter ratio. CONCLUSION: CT/99mTc-GSA SPECT fusion images demonstrated that the function of the left lobe was significantly decreased compared with that of the right lobe in non-cirrhotic livers. | Tatsuaki Sumiyoshi Yasuo Shima Ryoutarou Tokorodani Takehiro Okabayashi Akihito Kozuki Yasuhiro Hata Yoshihiro Noda Yoriko Murata Toshio Nakamura Kiminori Uka | 2013 | World Journal of Gastroenterology2013，19，21： | 3 |
| 5 | 一种新的成纤维性肝星状细胞失活因子诱导小鼠肝纤维化消退显示文摘【据《Hepatology》2019年9月报道】题:一种新的成纤维性肝星状细胞失活因子诱导小鼠肝纤维化消退(作者Nakano Y等)肝星状细胞是肝纤维化进程中的关键细胞,可被多种炎症刺激激活,转化为肌成纤维细胞样细胞,产生过多的胶原蛋白。尽管许多人试图抑制肝星状细胞的活化或抑制活化的肝星状细胞的胶原产生,但它们的临床应用尚未建立。近年来,肝星状细胞失活被报道为实验性肝纤维化逆转的机制之一。 | 闫琪 高普均 NAKANO Y KAMIYA A SUMIYOSHI H | 2020 | 临床肝胆病杂志2020，36，1： | 2 |
| 6 | Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel显示文摘AIM To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto(DKT) associated with transient receptor potential ankyrin 1(TRPA1) channels in intestinal myofibroblasts. METHODS Inflammatory and fibrotic changes were detected in a2,4,6-trinitrobenzenesulfonic acid(TNBS) chronic colitis model of wild-type and TRPA1-knockout(TRPA1-KO) mice via pathological staining and immunoblotting analysis.Ca^(2+) imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast(In Myo Fib) cell TRPA1 channel function.Profibrotic factors and transforming growth factor (TGF) -β1-associated signaling were tested in an In Myo Fib cell line by q PCR and immunoblotting experiments.Samples from non-stenotic and stenotic regions of the intestines of patients with Crohn’s disease (CD) were used for pathological analysis. RESULTS Chronic treatment with TNBS caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice.A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO mice.The active ingredients of DKT,i.e.,hydroxyα-sanshool and 6-shogaol,induced Ca^(2+) influxes in In Myo Fib,and this was antagonized by co-treatment with a selective TRPA1 channel blocker,HC-030031.DKT counteracted TGF-β1-induced expression of TypeⅠcollagen andα-smooth muscle actin (α-SMA) ,which were accompanied by a reduction in the phosphorylation of Smad-2 and p38-mitogen-activated protein kinase (p38-MAPK) and the expression of myocardin.Importantly,24-h incubation with a DKT active component Japanese Pepper increased the m RNA and protein expression levels of TRPA1 in In Myo Fibs,which in turn negatively regulated collagen synthesis.In the stenotic regions of the intestines of CD patients,TRPA1 expression was significantly enhanced.CONCLUSION The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis,and benefit inflammatory bowel disease treatment. | Keizo Hiraishi Lin-Hai Kurahara Miho Sumiyoshi Yao-Peng Hu Kaori Koga Miki Onitsuka Daibo Kojima Lixia Yue Hidetoshi Takedatsu Yu-Wen Jian Ryuji Inoue | 2018 | World Journal of Gastroenterology2018，24，35： | 2 |
| 7 | Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism显示文摘 | Yoshiyuki Kimura Maho Sumiyoshi Kei-ichi Samukawa Noriko Satake Masahiro Sakanaka | 2008 | European Journal of Pharmacology2008，，2： | 2 |
| 8 | Clinical significance of vascular endothelial growth factor expression in gastric cancer显示文摘 | KAKEJI Y KOGA T SUMIYOSHI Y | 2002 | J Exp Clin Cancer Res2002，21，： | 1 |
| 9 | Effects of orthostatic self-training on head-up tilt testing for the prevention of tilt-induced neurocardiogenic syncope: comparison of pharmacological therapy显示文摘 | Abe H Sumiyoshi M Kohshi K | 2003 | Clin Exp Hypertens2003，25，3： | 1 |
| 10 | Estimation of angiogenesis with anti-CD105 immunostaining in the process of colorectal cancer development 显示文摘 | Akagi K Ikeda Y Sumiyoshi Y | 2002 | Surgery2002，131，1： | 1 |
| 11 | Infectious Japanese encephalitis vires RNA can be synthesized from in vitro-ligated cDNA templates显示文摘 | Sumiyoshi H Hoke C Trent D W | 1992 | J Virol1992，66，9： | 1 |
| 12 | Carcinoembryonic antigen (CEA) in gallbladder bile and mucosa in cholecystolithia- sis显示文摘 | Akiyama H Yamamoto M Sumiyoshi H | 1986 | Acta Chit Scand1986，152，： | 1 |
| 13 | Receptors in memory function显示文摘 | Yasund F Serotonin1A | 2004 | Am J Psychiatry2004，161，： | 1 |
| 14 | Silica aerogels in high energy physics 显示文摘 | SUMIYOSHI T ADACHI I ENOMOTO R | 1998 | J Non-Cryst Solids1998，255，36： | 1 |
| 15 | Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templlates显示文摘 | Sumiyoshi H Hoke CH Tren DW | 1992 | J Virol1992，66，9： | 1 |
| 16 | Enhancement of cognitive performance in schizophrenia by addition of Tandospirone to neuroleptic treatment显示文摘 | Matsui M Nohara S | 2001 | Am J Psychiatry2001，158，： | 1 |
| 17 | Infectious Japanese encephalitis virus RNA can be synthesized from in vitro-ligated cDNA templates 显示文摘 | Sumiyoshi H Hoke C Trent D W | 1992 | Journal of Virology1992，66，： | 1 |
| 18 | Smads regulate collagen gel contraction by human dermal fibroblasts 显示文摘 | Sumiyoshi K Nakao A Setoguchi Y | 2003 | Br J Dermatol2003，149，： | 1 |
| 19 | Facilitating action of asiaticoside at low doses on burn wound repair and its mecha- nism显示文摘 | Kimura Y Sumiyoshi M Samukawa K | 2008 | Eur J Pharmacol2008，584，23： | 1 |
| 20 | Characterization of a highly attenuated Japanese encephalitis virus generated from molecularly cloned cDNA 显示文摘 | Sumiyoshi H Tignor GH Shope RE | 1995 | J lnfec Dis1995，171，5： | 1 |
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