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| 1 | Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice显示文摘AIM:To investigate the causal relationship between hypoadiponectinemia and colorectal carcinogenesis in in vivo experimental model,and to determine the con-tribution of adiponectin defi ciency to colorectal cancer development and proliferation.METHODS:We examined the influence of adiponectin defi ciency on colorectal carcinogenesis induced by the administration of azoxymethane(AOM)(7.5 mg/kg,in-traperitoneal injection once a week for 8 wk),by using adiponectin-knockout(KO) mice.RESULTS:At 53 wk after the fi rst AOM treatment,KOmice developed larger and histologically more progres-sive colorectal tumors with greater frequency com-pared with wild-type(WT) mice,although the tumor incidence was not different between WT and KO mice.KO mice showed increased cell proliferation of colorec-tal tumor cells,which correlated with the expression levels of cyclooxygenase-2(COX-2) in the colorectal tumors.In addition,KO mice showed higher incidence and frequency of liver tumors after AOM treatment.Thirteen percent of WT mice developed liver tumors,and these WT mice had only a single tumor.In contrast,50% of KO mice developed liver tumors,and 58% of these KO mice had multiple tumors.CONCLUSION:Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by AOM in mice.This study strongly suggests that hypoadiponectinemia could be involved in the pathogenesis for colorectal cancer and liver tumor in human subjects. | Tamao Nishihara Miyako Baba Morihiro Matsuda Masahiro Inoue Yasuko Nishizawa Atsunori Fukuhara Hiroshi Araki Shinji Kihara Tohru Funahashi Shinji Tamura Norio Hayashi Hiroyasu Iishi Iichiro Shimomura | 2008 | World Journal of Gastroenterology2008，14，42： | 12 |
| 2 | Clinical significance of visceral adiposity assessed by computed tomography: A Japanese perspective显示文摘Abdominal obesity,rather than total amount of fat,is linked to obesity-related disorders.Visceral adiposity is an important component of obesity-related disorders in Japanese individuals with a mild degree of adiposity compared with Western subjects.In 1983,our group reported techniques for body fat analysis using computed tomography(CT)and established the concept of visceral fat obesity in which intra-abdominal fat accumulation is an important factor in the development of obesity-related complications,such as diabetes,lipid disorders,hypertension and atherosclerosis.Our group also established ideal imaging conditions for determining abdominal fat area at the umbilical level CT scan.Visceral fat area(VFA)measured in a single slice at L4level correlated significantly with the total abdominal visceral fat volume measured on multislice CT scan.In a large-scale study of a Japanese population,the mean number of obesity-related cardiovascular risk factors(hypertension,low high-density lipoprotein cholesterolemia and/or hypertriglyceridemia,and hyperglycemia)was greater than 1.0 at 100 cm2 of VFA,irrespective of gender,age and body mass index.Our group also demonstrated that reduction of visceral fat accumulation subsequent to voluntary lifestyle modification,'Hokenshido',correlated with a decrease in the number of obesity-related cardiovascular risk factors.It is important to select the most appropriate subjects from the general population(e.g.,non-obese subjects with a cluster of risk factors for the metabolic syndrome)that are most suitable for body weight reduction,with the goal of preventing atherosclerotic cardiovascular diseases. | Miwa Ryo Ken Kishida Tadashi Nakamura Tohru Yoshizumi Tohru Funahashi Iichiro Shimomura | 2014 | World Journal of Radiology2014，6，7： | 11 |
| 3 | Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice显示文摘瞄准:在 Kupffer 房间的功能上检验 adiponectin 的效果,脂肪的多糖(LPS ) 的关键调节的人导致了肝损伤。方法:D-galactosamine (GalN ) 和 LPS intraperitoneally 被注入 adiponectin-/- 老鼠和野类型老鼠。Kupffer 房间,从 Sprague-Dawley 孤立老鼠,是 preincubated 与或没有 adiponectin,然后与 LPS 对待。结果:在猛烈老鼠, GalN/LPS 注射显著地降低了幸存率,显著地提起了丙氨酸转氨酶和肿瘤坏死 factor-alpha (TNF-alpha ) 的血浆层次并且显著地减少了与野类型老鼠相比的 IL-10 层次。在肝的 TNF-alpha 基因表示是哪个更高并且 IL-10 的那些比在野类型老鼠在猛烈老鼠是更低的。在有教养的 adiponectin-pre-treated Kupffer 房间, LPS 显著地降低了 TNF-alpha 层次并且在培养基和他们的各自的基因表示层次提起了 IL-10 层次,与没有 adiponectin-pre-treatment 的 Kupffer 房间相比。结论:Adiponectin supresses TNF-alpha 生产并且响应 LPS 刺激由 Kupffer 房间导致 IL-10 生产,并且 adiponectin 的缺乏提高导致 LPS 的肝损伤。 | Hitoshi Matsumoto Shinji Tamura Yoshihiro Kamada Shinichi Kiso Juichi Fukushima Akira Wada Norikazu Maeda Shinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2006 | World Journal of Gastroenterology2006，12，21： | 5 |
| 4 | Effect of Adiponectin on Murine Colitis Induced by Dextran Sulfate Sodium显示文摘 | Tamao Nishihara Morihiro Matsuda Hiroshi Araki Kazuya Oshima Shinji Kihara Tohru Funahashi Iichiro Shimomura | 2006 | Gastroenterology2006，，3： | 2 |
| 5 | Adiponectin Inhibits Murine Pancreatic Cancer Growth显示文摘 | Motohiko Kato Kenji Watabe Masahiko Tsujii Tohru Funahashi Iichiro Shimomura Tetsuo Takehara | 2014 | Digestive Diseases and Sciences2014，，6： | 2 |
| 6 | Dynamic Changes of Adiponectin and S100A8 Levels by the Selective Peroxisome Proliferator–Activated Receptor-γ Agonist Rivoglitazone显示文摘 | Aki Hiuge-Shimizu Norikazu Maeda Ayumu Hirata Hideaki Nakatsuji Kouichi Nakamura Akira Okuno Shinji Kihara Tohru Funahashi Iichiro Shimomura | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，4： | 2 |
| 7 | Adenomyoepithelioma of the breast with malignant transformation and repeated local recurrence:A case report显示文摘BACKGROUND Adenomyoepithelioma(AME)of the breast is a rare type of benign breast tumor.Many AMEs show benign behavior,but reports of the malignant type are rare.We present the case of a patient with AME with repeated local recurrences and further malignant transformation.CASE SUMMARY A 53-year-old woman visited our hospital with a 16-mm palpable mass in the right breast.A core needle biopsy was performed.The pathological diagnosis was AME.Lumpectomy with a safety margin was performed without axillary lymph node dissection(ALND).Two years later,local recurrence developed,and the patient again underwent lumpectomy with a safety margin.The pathology showed malignant AME,and the margin was negative.Eight months later,local recurrence developed again in the same location,and a total mastectomy was performed without ALND.The pathological diagnosis was malignant AME.The patient was disease-free for three years posttreatment.CONCLUSION The treatment of AME requires caution,as it may exhibit repeated recurrences after local excision as well as malignant transformation. | Goshi Oda Tsuyoshi Nakagawa Mio Mori Tomoyuki Fujioka Iichiro Onishi | 2021 | World Journal of Clinical Cases2021，9，29： | 2 |
| 8 | Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer显示文摘 | Morihiro Matsuda Iichiro Shimomura | 2013 | Obesity Research & Clinical Practice2013，，： | 1 |
| 9 | Hypoadiponectinemia accelerates hepatic tumor formation in a nonalcoholic steatohepatitis mouse model显示文摘 | Yoshihiro Kamada Hitoshi Matsumoto Shinji Tamura Juichi Fukushima Shinichi Kiso KojiFukui Takumi Igura Norikazu Maeda $hinji Kihara Tohru Funahashi Yuji Matsuzawa Iichiro Shimomura Norio Hayashi | 2007 | Journal of Hepatology2007，，4： | 1 |
| 10 | Adenovirus-mediated gene transfer of adiponectin reduces the severity of collagen-induced arthritis in mice显示文摘 | Kosuke Ebina Kazuya Oshima Morihiro Matsuda Atsunori Fukuhara Kazuhisa Maeda Shinji Kihara Jun Hashimoto Takahiro Ochi Nirmal K. Banda Hideki Yoshikawa Iichiro Shimomura | 2008 | Biochemical and Biophysical Research Communications2008，，2： | 1 |
| 11 | cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 ( A di p ose M ost Abundant Gene Transcript 1)显示文摘 | Kazuhisa Maeda Kousaku Okubo Iichiro Shimomura Tohru Funahashi Yuji Matsuzawa Kenichi Matsubara | 1996 | Biochemical and Biophysical Research Communications1996，，2： | 1 |
| 12 | Usefulness of lipoprotein ratios in assessing carotid atherosclerosis in Japanese type 2 diabetic patients显示文摘 | Naoto Katakami Hideaki Kaneto Takeshi Osonoi Miyoko Saitou Mitsuyoshi Takahara Fumie Sakamoto Kaoru Yamamoto Tetsuyuki Yasuda Taka-aki Matsuoka Munehide Matsuhisa Yoshimitsu Yamasaki Iichiro Shimomura | 2010 | Atherosclerosis2010，，2： | 1 |
| 13 | Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity显示文摘 | Yukio Arita Shinji Kihara Noriyuki Ouchi Masahiko Takahashi Kazuhisa Maeda Jun-ichiro Miyagawa Kikuko Hotta Iichiro Shimomura Tadashi Nakamura Koji Miyaoka Hiroshi Kuriyama Makoto Nishida Shizuya Yamashita Kosaku Okubo Kenji Matsubara Masahiro Muraguchi Y | 1999 | Biochemical and Biophysical Research Communications1999，，1： | 1 |
| 14 | Importance of adipocytokines in obesity-related diseases显示文摘 | Yuji M Iichiro S Shinji K | 2003 | Horm Res2003，60，： | 1 |
| 15 | Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein显示文摘 | Hitoshi N Iichiro S Ken K | 2002 | Diabetes2002，51，： | 1 |
| 16 | cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 ( A di p ose M ost Abundant Gene Transcript 1)显示文摘 | Kazuhisa Maeda Kousaku Okubo Iichiro Shimomura Tohru Funahashi Yuji Matsuzawa Kenichi Matsubara | 1996 | Biochemical and Biophysical Research Communications1996，，2： | 1 |
| 17 | Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer 显示文摘 | Morihiro M Iichiro S | 2013 | ORCP2013，7，5： | 1 |
| 18 | Levee Failure Caused by Seepage and Preventive Measures显示文摘 | Iichiro KOHNO Makoto NISHIGAKI Yuji TAKESHITA | 1987 | Natural Disaster Science1987，9，2： | 1 |
| 19 | Levee Failure Caused by Seepage and Preventive Measures显示文摘 | Iichiro KOHNO Makoto NISHIGAKI Yuji TAKESHITA | 1981 | Natural Disaster Science1981，9，2： | 1 |
| 20 | Overexpression of Sterol Regulatory Element-binding Protein-Ia in Mouse Adipose Tissue Produces Adipocyte Hypertrophy, Increased Fatty Acid Secretion, and Fatty Liver显示文摘 | Jay DH Iichiro S Shinji I | 2008 | The Journal of Biological Chemistry2008，278，36： | 1 |
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